엔로플록사신 액제의 닭유래 병원세균에 대한 시험관내 항균효과 시험

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study the antimicrobial spectrum and sensitivity of a liquid formulation of enrofloxacin against the major six pathogenic bacteria isolated from the diseased poultry in Korea were evaluated in comparison with ciprfloxacin (CFX), gentamicin (GM) and penicillin (PC). A liquid form of enrofloxacin, a test material and ciprofloxacin showed at least 83% antibacterial activity against all of six test pathogenic microorganisms at the fixed concentration of 10 ㎍/㎖. Gentamicin and penicillin revealed much lower antibacterial activity at the same condition. We evaluated the liquid form of enrofloxacin as having widespread antibacterial spectrum against poultry infections. The liquid form of enrofloxacin showed potent antibacterial activity, with the MIC range being 0.12∼2 ㎍/㎖ against Gram positives, 0.06∼2 ㎍/㎖ against Gram negatives and 0.5∼2 ㎍/㎖ against Mycoplasma spp. These values were equivalent to or somewhat higher than those of ciprofloxacin, but much lower than those of gentamicn and penicillin. This new liquid form of enrofloxacin would find its way in application of mixing with drinking water for the prevention and treatment of diverse infections in chickens.

엔로플록사신 액제의 닭 호흡기 및 소화기 감염증에 대한 예방 및 치료효과

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

We evaluated the efficacy of the liquid form of enrofloxacin against poultry respiratory and digestive infections, the major problems in the poultry industry, from diverse diagnosis viewpoints. Results obtained through this study were as follows: 1. The liquid form of enrofloxacin showed good acceptability to poultry owing to no abhorrence to the drug by chickens, which indicated its suitability for mixing in drinking water. 2. The application of the enrofloxacin formulation improved the productivity of the chicken farm to a great extent by lowering the death toll of chicken raised in the farm. 3. The use of the drug shortened the days to the market, and increased the body weight at the time of marketing. 4. Preventive and therapeutic effects of the liquid enrofloxacin were observed higher than ampicillin, a major antibiotic used in poultry farming. From above results, the liquid form of enrofloxacin would find its use for the prevention and treatment of digestive and respiratory infections, let alone the growth promotion and feed efficiency, especially in the chicken farming practice.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

진폐진행정도에 따른 혈청내 구리와 아연 농도의 변동

박정래,박종욱,이수일,이철호,오차재,김창원,조병만,김돈균 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목 적 : 진폐증은 분진으로 인해 인체의 면역기전이 작용하여 폐섬유화가 진행되는 질환으로, 인체의 면역기전에 작용하는 구리와 아연은 진폐증의 병리적인 진행과정인 폐섬유화에 관여한다. 본 연구의 목적은 초기진폐증 유소견자와 진행된 진폐증 환자의 혈청 구리와 아연의 농도를 정상인과 비교함으로써 체내 구리와 아연의 농도가 진폐증의 섬유화의 진행정도에 따라 변동함을 밝히고, 이를 이용하여 폐섬유화의 진행정도를 추정할 수 있는 지표를 제시하고자 한다. 방 법 : 진폐정밀기관에 내원한 초진내 원자 100명과 진폐요양기관에 입원한 진폐증 환자 100명을 선정한 후 흥부사진소견을 ILO 분류법의 진폐진행정도에 따라 각각 세 군(Stage Vl, V2, V3 & Stage Pl, P2, P3)으로 구분한 후 각 군의 혈청구리와 아연의 농도를 비교분석하였다. 대조군으로는 폐결핵, 심근경색, 뇌경색을 경험한 적이 없는 일반인 100명을 선정하였다. 결 과 : 초진내 원자군의 혈청 구리농도는 섬유화의 진행단계에 따른 유의한 차이를 보였으며, Stage V3에서 가장 높았다. 입원환자군에서는 혈청 구리농도가 대조군과 유의한 차이를 보이지 않는데 (p=0, 152), 이는 입원환자의 불량한 영양상태와 건강상태 때문인 것으로 추정된다. 초진내원자군과 입원환자군의 혈청 아연농도는 섬유화의 진행에 따라 통계적인 차이를 보였으며, Stage V2와 Stage P2, P3에서 각각 대조군에 비해 유의하게 낮았다. 혈청 아연과 구리농도의 비또한 양군에서 섬유화의 진행에 따라 의미있게 높았는데, 섬유화가 현저히 진행된 단계 (Stage V3, Stage P2, P3)에서 대조군과 의미있는 차이를 보였다. 결 론 : 초진내 원자와 입원환자의 혈청 Cu/zrl 비는 섬유화의 진행정도가 현저할수록 대조군에 비해 유의하게 높게 나타났다. 진폐증 환자들의 혈청 Cu/zn 비는 진폐증의 폐섬유화의 진행정도를 추정함에 있어 상당히 유용한 지표로 이용될 수 있으며, 폐섬유화의 진행과정에서의 혈청 구리와 아연의 작용기전을 이용한 치료방법의 마련에도 도움이 될 것으로 판단한다. Objectives : Copper and Zinc, the trace elements of a living body, take a part in immunologic mechanism and induce the pulmonary fibrosis which is the pathologic progress of pneumoconiosis. This study was performed to assist the identification of the pathologic process of pulmonary fibrosis in pneumoconiosis. Methods : The subjects of thls study was 200 diagnosed persons as pneumoconiosis, of whom 700 persons was the visitors in the outpatients departments of pneumoconiosis and 100 admissive pneumoconiosis patients. The serum copper and zinc are measured and compared. Results : The mean serum copper concentration of visitor group was significantly higher than that of control group, and that of stage V3 subgroup of visitor group was highest because of their advanced fibrosis. But, there was not the difference of serum copper concentration between patient and control group. We thought that the reason was poor nutritional and health status of the patient. The mean of serum zinc concentration of visitor and patient control was lower than that of control group. As the degree of pulmonary fibrosis was more severe from stage Vl, V2, V3 of visitor to stage Pl, P2, P3 of patient, the mean of serum zinc concentration was lower. The ratio of serum copper/zinc of visitor and patient was higher than that of control, and that of patient was higher than that of visitor. Those results showed that the ratio of serum copper/zlnc ratio more greatly expressed the degree of progression of pneumoconiosis than only copper or zinc concentration by adjustment of nutritional and health status of the patient. Conclusions : As above study results, the degree of pulmonary fibrosis of pneumoconiosis could be estimated by means of serum copper/zinc ratio.

정신분열병 증상을 동반한 진행성 핵상 마비 1례

박종익,조영래,홍진표,이민규,한오수,이명종 대한신경정신의학회 2001 신경정신의학 Vol.40 No.1

저자들은 환청과 망상을 주소로 정신과를 방문한 진행성 핵상 마비 환자를 진단하고 치료하였다. 진행성 핵상 마비는 보행 장해, 치매, 수직성 안구 운동의 장해가 특징적인 증상이며, 아직까지 특별한 치료법은 알려져 있지 않다. 정신과적 증상으로는 인지기능의 장해, 정동 및 행동의 변화, 수면 장해, 정신병적 증상 등이 있으며 정신분열병과 비슷한 증상을 보이는 경우는 극히 드물다고 한다. 본 증례에서는 파킨슨 증상과 정신병적 증상이 비슷한 시기에 발현된 진행성 핵상 마비의 예를 보고하면서 진단적 중요성을 강조하고자 한다. We have experienced a rare case of progressive supranuclear palsy with hallucination and delusion. The common manifestations of progressive supranuclear palsy are gait disturbance, mental change and sign of vertical ophthamoplegia but no efficacious therapy has been known. Neuropsychiatric symptom clusters include cognitive impairment, affective and behavioral changes, sleep disturbance, and psychotic symptoms. Though schizophrenia-like psychosis has been reported but this is certainly rare. Addressing a case of progressive supranuclear palsy, in whom parkisonian symptoms appeared with concurrent psychotic symptoms, we emphasize accurate diagnosis.

GIS를 이용한 양식어장 정보관리 시스템 구축

박성은,최우정,이원찬,구준호,정래홍,박종수 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.3

연안 양식어장의 정보 관리에 실용적인 지리정보시스템(GIS)을 적용함으로써 어업종사자와 연안 관리자에게 실현 가능한 관리방안을 제시하고 수산업 발전을 위한 유연한 의사결정의 기반을 마련하고자 하였다. 연안 양식어장의 효과적 관리는 경제적 실행 가능성과 운영비용에 영향을 미치며 양식 대상생물의 생산 및 사망률과도 관계가 있으므로 매우 중요하다. GIS는 양식어장 정보의 효율적인 관리도구로서 개인 및 공공분야에서 폭넓게 사용되고 있으며 해양수산 관련분야에서도 활발히 적용되고 있다 본 연구에서는 진해만을 대상으로 연안 양식장 자료의 3차원 가시화 모듈을 구축하였다. This paper illustrates some practical geographic information system (GIS) applications for aiding fishery managers and coastal area planners in analysing the likely control scheme of coastal farming areas, and in providing a flexible framework for decision making on fishery development and zoning issues. The effective management of marine farming operation is vitally important since it can greatly influence economic availability by determining capital outlay and by affecting running costs, rates of productions and mortality factors. GIS has been widely adopted elsewhere as a potent management tool in both the private and public sectors. GIS is now being extensively adopted in marine-associated activities. Here, we have used GeoMania v2. 5 GIS software and its 3D Analyst extension module to visualize marine farming areas data that were collected around the Jinhae bay.

3차원 의료기기용 초음파진단기 프로브 개발

박종수,김성래,남윤수 江原大學校 産業技術硏究所 2005 産業技術硏究 Vol.25 No.A

Three-dimensional ultrasonic probes being applied to the medical imaging can be grouped into three depending on the scanning methods, which are a mechanical type system, a free-hand system, and 2D phased arrays system. A mechanical type scanner uses a mechanically driven transducer to acquire series of 2D plane images. By integrating these images, a 3-D medical image can be constructed. A motor driving mechanism is a conventional choice for mechanically driving a transducer assembly which picks the raw ultrasonic images up. In this paper we attempt to design a 3D ultrasonic probe which has a operating mechanism of s tilting 3-D scanning. The motion of a transducer assembly of the ultrasonic probe is analytically modelled. We propose a selection procedure for the diameter of a wire rope driving the transducer assembly and the size of torsional spring which gives an initial tension to wire ropes.

Amylodextrin과 Acrylonitrile 및 Styrene의 Graft共重合

趙慶來,張貞戴,朴鍾範 新羅大學校 1991 論文集 Vol.31 No.1

Graft copolymerization of acrylonitrile(AN) and styrene(Sty)onto amylodextrin(AD) was carried out using ceric ammonium nitrate(CAN) as initiator under a variety of condition. The graft efficiency of PSty-AD increased by increasing CAN concentration from 0.001mol/1 to 0.0028mol/1, however, at higher CAN concentration(i.e., up to 0.004mol/1.) it decreased. In case of PAN-AD, the efficiency increased with increase in CAN concentration even at higher level. Increasing the AN concentration from 1% to 8% caused a significant enhancement in grafting. The same held true for raising the copolymerization temperature within the range of 25℃-50℃. The graft efficiency of PAN-AD increased by increasing AN concentration, while that of PSty-AD only increased by increasing Sty concentration from 0.5mol/1 to 3.0mol/1. The grafting reaction proceeded initially at a fast rate and decreased with time. The grafted polymers showed increased crystallinity and much lower water solubility as compared with AD. Furthermore the grafted polymers showed no reaction with iodine tincture

한국 제조기업의 공급자 관계유형에 대한 연구

김종래,박해천 조선대학교 생산기술연구소 2003 生産技術硏究 Vol.25 No.1

The purpose of this study is to empirically examine the types of supplier relationships of Korean manufacturing companies. This analysis is divided into three steps, (1) finding major factors of supplier relationships, (2) clustering similar groups in supplier relationships, (3) examining the characteristics of the groups The result of the analysis is as follows First, by the factor analysis, four factors are found - information & technology assistance, finance assistance, payment, communication. Second, by the cluster analysis with four factors, three groups are generated Three groups consist of traditional supplier relationships, semi-supportive supplier relationships, supportive supplier relationships The difference of group of semi-supportive supplier relationships and supportive supplier relationships is the factor of finance assistance. Third, by the statistical analysis, it is verified that supportive group recognizes the risk of external environment more highly, and is more delivery performance oriented. And the correlation between groups and types of manufacturing systems were found.

韓國産 미꾸리에 關한 育種·繁殖學的 硏究 : Ⅵ. Histological Changes of Pituitary Gland and Oocytes from March to May Ⅵ. 계절에 따른 암컷의 腦下垂體와 卵母細胞의 組織學的 變化

姜京來,盧淳昌,尹鍾萬,朴弘陽,李相鎬 건국대학교 동물자원연구센터 1993 動物資源硏究誌 Vol.18 No.-

1992년 3월부터 1992년 5월까지 자연적인 채광상태에서 溫度를 유지시킨 후 채취된 미꾸리 암컷의 腦下垂體, 肝 및 卵巢 組織의 번식주기에 일어나는 미세구조의 변화를 광학 및 투과형 전자현미경을 이용하여 살펴보고, 이것들의 相互 聯關性을 알기 위하여 본 연구를 실시하였다. 본 연구에서 얻어진 결과는 다음과 같다. 성숙된 개체의 뇌하수체는 수많은 작은 분비과립과 커다란 분비구 및 불규칙한 형태의 과립들이 관찰되었다. 핵소체가 핵막 주변에 위치헤 있는 후기 단계(LMO)의 난모세포가 난황이 축적되는 성숙초기 단계(EMO)의 난모세포로 변형되는 시기를 난황의 형성이 개시되는 시기로 본다. 난모세포가 성장함에 따라 핵소체의 크기와 난황과립의 수가 증가하게 된다. 난황과립은 결정상의 과립으로 난세포질에 치밀하지 않은 상태로 축적된다. 성숙초기(EMO) 및 말기단계(LMO)에 난소는 커지고 투명하며 과립형태로서 색깔이 연노란색을 나타낸다. 따라서 난 내부를 쉽게 관찰할 수 있다. 방사대(ZR)는 성숙초기단계(EMO)에 단층으로부터 입방형태로 변화된다. 과립막 세포와 난모세포로 부터 유래된 미세융모는 난황형성이 진행되는 동안에 성장하게 되며, 방사대의 pore canals의 구멍을 통해서 서로 연결되어 있다. 따라서 외부로부터 물질의 이동이 있게 된다. 난모세포가 완전하게 성숙되어 방사대가 단단해 지면 미세융모는 그 기능이 상실된다. This study was undertaken to understand the development stages of pituitary gland, liver and ovary of Korean loach(Misgurnus anguillicaudatus) under natural circumstances from March to May 1922. Expecially, the light microscopic and ultrastructural changes of ooplasm and follicular membranes of oocytes, were observed by light and transmission electron microscope during the reproductive cycle. In pituitary gland of mature individuals, there were observed a number of secretory granules,large globules, and irregular masses.The vitellogenic phase began as these late perinucleolus oocytes became transformed into early maturing oocytes through the accumulation of yolk. The size of the nucleoli and number of the yolk granules increased as the oocyte growed. Yolk granules were loosely deposited in the oocyte as crystalline granules. Due to the presence of early and late maturing oocytes, their ovaries were enlarged transparent, granular and yellowish in color. Zona radiata change a squamous into cuboid shape in EMO stage. Microvilli from the granulosa cells and from the oocyte grow and make contact with each other in the pore canals of the zona radiata during vitellogenesis, but are withdrawn as the zona radiata becomes more compact during oocyte maturation.