카드뮴 측적량과 붕어(Carassius auratus) 아가미 조직 변화의 상관성에 관한 연구

배희경,김은경,남성숙,문창규,전성환,나진균,박광식 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.1

Histopathological changes and cadmium accumulations in the gills were investigated in crucian carp (Carassius auratus) exposed to 0, 0.01, 0.1, 0.5 mg/l cadmium (Cd)concentrations for 25 days. After 25 days of exposure, cadmium accumulations increased in each of the different exposure concentrations. Histopathological changes in the gills of curcian carp exposed to cadmium included the acidification of mucous cell, the terminal clubbing of lamellae, the hyperplasia of epitherial cell and the curved of secondary lamellae. The similar histopathological changes were observed once the accumulations of cadmium reached the similar levels found in the present study with the different exposure schemes. Also the acidification of mucous cell in gills appeared when cadmium accumulations reached 5 ㎍/g and more. These results suggested that histopathological changes in the gills, an appearance of mucous cell acidification, be used to estimate the relation between toxic effect and cadmium accumulations in the gills.

경옥고 및 경옥고 가미방이 폐암에 미치는 영향

이은숙,서부일,이준우,배진숭 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : This research is to test anti-cancer effect of kyungohkgo (sample 1) and modified kyungohkgoes (sample 2 and sample 3) when they prescribed to mice that translate a 3LL lung cancer cell. A sample 1, 2, and 3 are prescribed for the 1st, 2nd and 3rd group, respectively. Methods : Inoculate mouse lung carcinoma cells to a BDFI mouse and did an experiment about tumor occurrence periods, body weight, tumor volume, survival rate, life prolongation. Results : The development time of tumor lump to the 3rd group is latest as 181.71±18.88 hours. That is, it means that a lung cancer of this group was induced latest. In tumor size, the 3rd group is also fewest by 1,536~9,375㎣. The tumor growth rate of the 3rd group appeared lowest by 610.35 percent. Only the 3rd group was appeared that has a control effect of tumor growth. Also, 3 mice of the 3rd group were survived for 30day after translating the lung cancer cells. The survival extension rate of the 3rd group was highest by 38.39 percent. Conclusion : In these experiments, it appears that the sample 3 prescribed by modified kyungohkgo has the highest anti-cancer effect. It is proved that the modified kyungohkgo affects the 3LL lung cancer cell by acting complexly.

부산시 일개구 지역주민의 위암선별검사 수검 및 반복수검 실태 및 관련요인조사

정인숙,배은숙,천동환,전진호,이화자,박남희 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

The importance of repeat screening for stomach cancer is well known to decrease deaths from stomach cancer. This study was aimed at assessing practice behaviors and to identify related factors in the aspects of demographic factors, health status and cancer risk recognition, attitude to cancer screening, health behaviors, and inhibiting or facilitating factors to stomach cancer screening in an urban area. Data was collected through self-administered questionnaires from 403 people aged 40 to 69 years from April 23th to May 15th, 2002. Practice behaviors were classified as :"ver"r "ver"and "peat"r "t repeat"rouped based on a recent 5 year screening history. The results were as follows: 1. Among the 403 subjects: "e ever group"as 23.8% and "e repeat group"as 4.0%. The rates of screening were 20.5% for men, 27.8% for those women, and 27.3% for aged 40-49, 24.5% for those aged 50-59, 19.0% for those aged 60-69. The rates of repeat screening were 4.0% for men, 4.1% for women, and 2.9% for those aged 40-49, 6.3% for aged 50-59, 2.5% for those aged 60-69. 2. The main factors associated with adherence to gastric cancer screening were education(post high school vs below : OR=2.44), previous cancer screening(yes vs no : OR=2.61), belief in personal health(no vs yes : OR=2.72), health status(unhealthy vs healthy : OR=3.40), possibility of cancer compared to others(low vs not low : OR=2.56), and regular exercise(yes vs no : OR=2.94). The main factor associated with adherence to gastric cancer repeat screening was other cancer screening (yes vs no : OR=6.33). Consequently, there is a need to change the recognition of the importance and necessity of stomach cancer screening in healthy conditions through health education, and to perform multiple screening tests each visit.

여성빈곤의 실태와 극복방안 : 도시 저소득층 여성을 중심으로 With Special Reference to Underprivileged Women in Urban Areas

이배용,박진숙,황은자,정현숙,이제진 이화여자대학교 한국여성연구원 1996 여성학논집 Vol.13 No.-

Since the 1960's, the rapid industrialization of Korea has been propelled full-scale by a handful of big business groups and effort- oriented trade, which has resulted in external and quantitative economic growth, but has also produced problems of poverty arising out of the unequal distribution of wealth. Industrialization led to impoverishment in rural areas and stimulated migration by the rural population to urban areas, who were marginalized, excluded from public sectors of labor market and led lives of poverty. In this context, a number of young Korean women were employed in the industrial sector as low waged and unskilled laborers to support their families. Women workers from poor families had to participate in economic activities from their youth in order to avoid "absolute poverty" and they grew up with economic, cultural, and educational limitations. After marriage, they still played crucial roles to maintain their poor families by taking charge of whole family subsistence, and/or trying to generate family income through part- time jobs. However, up to the present, academic concerns as well as governmental support for the underprivileged women have been limited. This study was started with this critical factor of women's rote in urban poor families in mind. It examines the women's conditions and how they can actively overcome their poverty, so as to lead qualitatively better lives, particularly through organizational activities. This paper, in the first place, surveys theories and research results on issues of poverty and various anti- poverty measures adopted by foreign countries such as U.K., USA, Germany, Japan, Taiwan and Singapore. Issues such as "feminization of poverty" and the "culture of poverty" are also discussed. Furthermore, existing research on poverty, including women's poverty in Korea, were examined to identify problems which have not been conceptualized so far. Genera1 living conditions of the poor were surveyed with emphasis on their unstable living conditions. Socio- economic and sexual discrimination were discussed in connection with the lives of underprivilged women. Alternatives were sought to solve the poverty problem. Women's organizations that have spontaneously formed in underprivileged areas and their communal economic activities were examined. The latter especially have turned out to be rewarding for those women who have only limited economic opportunities. It was not only helpful to them to generate income for their families, but also to realize the value of their labor, while having the pleasant experience of working together. Futhermore, through organizational activities, their communal consciousness and self-consciousness as women was promoted and their familial relationships were also altered for the better. Women could thus acquire self-confidence and become psychologically self-reliant members of their organization. These results show us tha4 women's organizations, especially those established in poor areas, are significant for the members, because they work as self-help groups preventing them from falling into pauperism in a situation where a relevant social welfare system is absent. Lastly, vocational traiillng programs and the rehabilitation funding system were examined and alternatives for re-vitalizing communal activities for women's organizations in poor communities were suggested as follows : Firstly, various communal economic activities, based on diverse aspects of women's lives, are needed. In doing so, Government should endeavor to construct a network between underprivileged women's organizations including their communal economic activity groups and "small and poor enterprises" which may employ them as well as provide workplaces for their communal activities. Also financial support by the Government, such as a rehabilitation fund which will be crucial for successfully implementing their small scale communal economic activities and/or loans in the long-term. Secondly, established vocational training programs should be reinforced. In order that vocational training programs may be functioned as an effective system of supporting the self-help groups of underprivileged women, more training programs should be developed and provided, based on an understanding of their lives and desires. In addition, for stimulating their positive/active participation in these programs, the following factors should be taken into account, i.e., educational/training programs should be held at welfare centers or women's centers located near their homes; development of programs for practical training and follow-up is needed; extension of child-care facilities for trainees; and group training programs for community women's organizations are also required. Thirdly, women living in underprivileged communities have psychological problems such as self-centeredness, heteronomy, and lack of communal consciousness, owing to their experionces in a distorted life, which sometimes hamper their communal economic activities. Accordingly, educational support to promote and encourage their communal consciousness and collective autonomy, as well as physical support, is essential. However, these inputs should be based on a deep understanding of the lives of underprivileged women, so that the policies are fruitful and rewarding. Therefore long-term plans, with the establishment of supportive agencies, involving community activists who share their lives with poor women over a long time, are required for solving these problems and eliminating women's poverty.

경옥고와 경옥고 가미방의 면역활성에 관한 연구

이은숙,서부일,이준우,배진숭 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : This study was conducted to investigate the immunological activities of Kyungohkgo and prescription of modified Kyungohkgo. Methods : Raw 264.7 macrophage treated with Kyungohkgo or other simuli enhanced production of the nitric oxide and TNF-α. Results : Among the sample 1. sample 2 and 3 of Kyungohkgo, sample 2 exerted more favorable influence on nitric oxide(NO) production than the sample 3. And production of NO and TNF-α were dependent on the concentration of Kyungohkgo. Conclusion : These results suggested that Kyungohkgo-activated macrophage induce the NO and TNF-α, and its containing in immunoregulatory components.

완전 포상기태 이후 발생한 지속성 융모질환의 치료경험 2례.

이진희,류은석,김윤숙,김종수,최승도,선우재근,배동한 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Persistent tumor develops in approximately 20% of patients with a complete mole, and chemotherapy is required to achieve remission. Following evacuation of hydatidiform mole, careful hCG monitoring is mandatory since it is the most reliable and sensitive method for the early detection of gestational trophoblastic disease. In carefully selected patients in whom the risk of developing gestational trophoblastic disease is significant or when the availability of hCG testing is suboptimal, chemoprophylaxis has been shown to decrease the risk of gestational trophoblastic tumor. We report here two cases of patient, 16-year-old and 45-year-old women who experienced unusual course after the evacuation of a complete mole and markedly elevated serum β-hCG levels. The patient developed persistent gestational trophoblastic disease and were successfully treated with EMA-CO and hysterectomy.

요하지통 환자에서 두 개의 캐눌라를 이용한 박동성 고주파 신경근 응고술의 임상 연구

김천숙,배재영,배덕구,강규식,안기량,권진형,김지은,유시현 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Dorsal root ganglion(DRG) block by the local anesthetics and steroids which has done classically in low back pain(LBP) patients with radiculopathy has high incidence of recurrence rate and side effects of steroids. Recently a new technique of pulsed radiofrequency thermocoagulation(P-RFTC) was introduced and substituted for it because of the benefits such as relatively low recurrence rate, low risk of nerve injury and comfort during the procedure. We experienced 15 patients who had LBP with radiculopathy and no or little response to epidural steroid injection. When we performed DR ganglionotomy by P- RFTC under the C-arm guide in these patients, we tried to approach the exact DR ganglion using tow cannulas - the one for obtaining patient's subjective symptoms and injection of contrast dye, the other for making a RF lesioning after identifying the impedance of sensory and motor stimulation. In conclusion, DR ganglionotomy by P- RFTC using two cannulas in LBP patients is an easy and safe procedure with satisfactory results.

서울시내 고등학교 위탁급식의 급식비와 투자비의 실태 및 위탁업체의 기대수준 비교 분석

양일선,배환미,김현아,신서영,조미나,박수연,차진아,이보숙 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.5

The purposes of this study were to a) find out the operational characteristics of the contract-managed highschool foodservice in Seoul, b) investigate the expected level of meal-price and facilities investment cost perceived by contract-managed highschool foodservice managers c) compare the present level and expected level of meal-price and facilities investment cost. From October 12 to November 13 in 2001, the questionnaires were mailed to 249 high schools which was managed by contract foodservice company with respondent rate 40.2%. Data were analyzed using SPSS Win(10.0) for descriptive analysis and one group paired t-test. The results of this study were as follows ; 1. The student enrollment of highschools run by contract-managed foodservice was 1,243 with 72.6% participation rate of school lunch program. The average meal-price was 2,138 won. The average annual period of school foodservice operation was 156.78 days per year. The average contracting period was about 3 years. 2. The average cost concerned in the facilities investment amounts 169,578,180 won at the initial investment and 25,204,092 won at the repairs and maintenance cost in the course of operation. 3. The present level of meal-price and facilities investment cost were respectively 2,136won/meal and 171,157,336.72 won. And expected level.of meal-price and amount of facilities investment cost were 2,418.75 won and 121,353,215.19 won. Comparing the present level with expected level of the meal-price and facilities investment cost, expected level of meal-price was significantly higher than the present level of meal-price(p<.001) and expected level of facilities investment cost was significantly lower than present level of facilities investment cost(p<.001).

각종 간 병변에 대한 양전자 방출 단층촬영(PET) 영상 소견 분석

손현배,한철주,김병일,김진,정숙향,김유철,이진오,최창운,임상무 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.4

목적: PET은 세포의 대사를 반영하는 기능적 영상기법으로서 각종 간 병변이 PET에 어떤 영상으로 나타나며, 간 종양의 진단 및 치료에 어떻게 활용될 수 있는지를 알아보고자 하였다. 대상과 방법: 간세포암 34예, 담관세포암 8예, 간 내 전이암 25예, 간 혈관종 6예, 간 농양 7예를 대상으로 PET 영상을 얻어 SUV 및 병변과 주변 조직의 SUV 비를 조사하였다. 각각의 질환에 대해 SUV, SUV 비의 평균치 및 SUV 비의 분포를 비교하였다. 결과: 담관 세포암과 전이암은 높은 SUV를 보이며, 거의 대부분 PET에서 선명하게 나타나며, 100%의 예민도를 보였다. 간세포암도 비교적 높은 SUV를 보이나 일부는 PET에서 뚜렷이 나타나지 않으며 59%의 예민도를 보였다. 혈관종은 PET에서 뚜렷이 나타나지 않는 반면, 간 농양은 뚜렷한 영상으로 나타나 100%의 예민도를 보였다. 결론: PET은 간에 발생 하는 각종 병변의 진단 및 감별에 제한적이기는 하나 활용 가능성이 있으며, PET에 선명한 영상을 보이는 일부 종양에 대해 병기 판정, 재발 발견, 치료 반응 평가 등의 목적에 활용될 가능성이 있는 것으로 기대된다. Background/Aims: [18F]FDG-PET is a functional imaging modality reflecting cellular glucose metabolism. In most malignant cells, accumulation and trapping of [18F]FDG allows the visualization of increased uptake compared with normal cells. The aim of this study was to assess the value of PET in differentiating benign from malignant hepatic lesions and to determine in which types of hepatic tumors PET can help evaluate stage, monitor response to therapy, and detect recurrence. Methods: Eighty patients with liver lesions were enrolled (hepatocellular carcinoma 34, cholangiocarcinoma 8, metastatic liver cancer 25, hemangioma 6, liver abscess 7). Liver metastases were 22 adenocarcinoma, 2 lymphoma, 2 squamous cell carcinoma. The PET images of these patients were analyzed. SUV and lesion-to-normal liver background SUV ratio were obtained and compared among the disease groups. Results: All liver metastases and all cholangiocarcinomas had increased uptake value, with SUV ratios greater than 2. Hepatocellular carcinoma had SUV ratios greater than 2 in 20 of 34 patients (59%). All hemangiomas had poor uptake, a SUV ratio of less than 2. All liver abscesses showed definite uptake. Conclusions: The PET technique using FDG static imaging was useful in differentiating malignant from benign lesions of the liver in limited situations. Limitations included false negative results in some patients with hepatocellular carcinoma. Liver abscesses raised problems in differential diagnosis from malignant liver tumors. The findings of this study suggest that the PET technique might be applied in tumor staging and the detection of recurrence, as well as monitoring responses to therapy for all adenocarcinomas and some hepatocelluar carcinomas.(Korean J Hepatol 2002;8:472-480)

위전절제시 단순공장간치술의 임상적 의의

노승무,배진선,정현용,이병석,조준식,신경숙,송규상,이태용 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.

Purpose: The aim of this study was to evaluate the short-term outcome of a jejunal interposition, by comparing it with a conventional Roux-en-Y gastrojejunostomy, after a total gastrectomy. Materials and Methods: For 28 patients (20 men and 8 women) with a gastric adenocarcinoma, who underwent an isoperistaltic simple jejunal interposition, weight, hemoglobin, hematocrit, serum protein and albumin, and cholesterol levels were checked before the operation and at 1 year and 2 years after the surgery. Also, endoscopy was performed to confirm reflux esophagitis. In this study, the data were collected between January 1993 and July 1999 at Chungnam National University Hospital, and the results were compared with those of the Roux-en-Y procedure. Results: The body weights at 1 year and 2 years after the surgery had returned to 86.0% and 87.6% of the recent original body weight in the jejunal interposition (Jl) group and to 90.8%, 87.0%, respectively in the Roux-en-Y (RY) group. The levels of hemoglobin (g/dl) were 13.3, 12.5, and 11.9 in the Jl group, and 13.8, 12.6, and 12.1 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum protein (g/dl) levels were 7.1, 7.2, and 7.5 in the Jl group and 7.1, 7.0, and 7.2 in the RY gropu at the time of the operation and at 1 year and 2 years after the surgery, respectively. The serum albumin (g/dl) levels were 4.2, 4.1, and 4.2 in the Jl group and 4.2, 4.2, and 4.2 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum cholesterol (mg/dl) levels were 186.5, 174, and 164 in the Jl group and 213.7, 171.1, and 141.0 in the RY group at the time of the operation and at 1 year and 2 years after the surgery, respectively. The endoscopic finding showed that reflux esophagitis occurred in 7.1% of the patients in the Jl group and in 3.5% in the RY group. Conclusion: We think that from the view point of quality of life, a jejunal interposition, as well as a Roux-en-Y procedure, is a useful reconstruction methods for a total gastrectomy. (J Korean Gastric Cancer Assoc 2001;1:210-214)