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      • SCISCIESCOPUS

        Facile preparation of a multifunctional fluorescent nanosensor for chemical and biological applications

        Wang, Jing,Guo, Wanping,Bae, Jae-Ho,Kim, Sun-Hee,Song, Jiale,Ha, Chang-Sik The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.47

        <P>To prepare a versatile solid-state fluorescent sensor for chemical and biological applications is still a challenge. In this report, we describe a multifunctional fluorescent nanosensor that is capable of highly sensitive and selective detecting of the heavy metal ion Hg<SUP>2+</SUP> in a range of pH from 4.0 to 6.6, sensitive probing of α-amino acids by a metal ion-mediated approach, turn-on sensing of the protein BSA under physiological conditions and <I>in vitro</I> monitoring of Hg<SUP>2+</SUP> within living cells. This all-round smart sensor <B>1</B> has been designed by functionalizing highly ordered mesoporous SBA-15 nanoparticles with 3-isocyanatopropyltriethoxysilane and dansylcadaverine, followed by the characterization of the pore structure, textural property, microscopic morphology, molecular composition of grafted organic fluorophore and the colorimetric property of <B>1</B>. The quenching fluorescence emission of <B>1</B> in the presence of Hg<SUP>2+</SUP> could be attributed to the photoinduced electron transfer (PET) from the exited dansyl moiety to the proximate mercuric ion. The successful sensing of α-amino acids has been realized by an indirect approach, in which the quenched fluorescence of <B>1</B> by Hg<SUP>2+</SUP> was recovered upon the addition of α-amino acids. The turn-on sensing of BSA under physiological conditions is based on the hydrophobic interaction between BSA and the naphthalene ring on the dansyl fluorophore of <B>1</B>. This interaction also makes <B>1</B> become an efficient adsorbent for storing and retaining BSA. Finally, <B>1</B> has been demonstrated to have application in living cells by detecting intracellular Hg<SUP>2+</SUP>.</P> <P>Graphic Abstract</P><P>A versatile solid-state fluorescent sensor has been designed and prepared for chemical and biological applications. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm33103a'> </P>

      • Construction Design and Theoretical Research on Cloud-based Intelligent Platform for Physical Fitness Test and Health Examination Data of College Students

        Wang Jiameng,Zhang Weiyu,Wen Tao,Sun Jiale,Zhou Fan,Ai Xianbin,Zhang Hui,Xiong Huayu,Xu Baichao 아시아건강운동학회 2022 Journal of Asian Society for Health & Exercise Vol.4 No.1

        PURPOSE : To build a cloud intelligent analysis platform for physical measurement data and physical examination data for college students, so as to enhance the physical health of college students and realize the deep integration of sports, education and medical treatment. METHODS : On this basis, a cloud-based intelligent early warning and screening analysis module for the physical fitness test level and the prevalence rate in college students can be established. Then, a cloud-based intelligent construction module for non-medical health intervention means and scientific physical education (PE) curriculum should be built, aiming to strengthen the corresponding physical fitness test indexes and improve weak health examination indexes, and further mitigate and prevent relevant diseases. RESULTS : Through the Internet of things technology, we can realize the co-platform link of physical examination instruments and physical examination instruments, process and analyze data in the same system, and realize the source combination of sports and medical treatment. CONCLUSIONS : The establishment of cloud intelligent college student physical examination and physical examination platform is the need of The Times, and is also one of the effective measures to realize Outline of the Healthy China 2030 Plan (the Outline).

      • KCI등재

        Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

        Dong Jiale,Wang Wenzhi,Zhou Wei,Zhang Siming,Li Meng,Li Ning,Pan Guoqing,Zhang Xianzuo,Bai Jiaxiang,Zhu Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

        Implant-associated infection (IAI) is increasingly emerging as a serious threat with the massive application of biomaterials. Bacteria attached to the surface of implants are often difficult to remove and exhibit high resistance to bactericides. In the quest for novel antimicrobial strategies, conventional antimicrobial materials often fail to exert their function because they tend to focus on direct bactericidal activity while neglecting the modulation of immune systems. The inflammatory response induced by host immune cells was thought to be a detrimental force impeding wound healing. However, the immune system has recently received increasing attention as a vital player in the host’s defense against infection. Anti-infective strategies based on the modulation of host immune defenses are emerging as a field of interest. This review explains the importance of the immune system in combating infections and describes current advanced immune-enhanced anti-infection strategies. First, the characteristics of traditional/conventional implant biomaterials and the reasons for the difficulty of bacterial clearance in IAI were reviewed. Second, the importance of immune cells in the battle against bacteria is elucidated. Then, we discuss how to design biomaterials that activate the defense function of immune cells to enhance the antimicrobial potential. Based on the key premise of restoring proper host-protective immunity, varying advanced immune-enhanced antimicrobial strategies were discussed. Finally, current issues and perspectives in this field were offered. This review will provide scientific guidance to enhance the development of advanced anti-infective biomaterials.

      • KCI등재

        Numerical Simulation of the Creep Behavior of Beishan Deep Granite Tunnel under the Coupling Thermal -Stress Field

        Jiawei Wang,Ju Wang,Zhichao Zhou,Peng Wu,Haoran Sun,Jiale Dou,Nan Li,Xianzhe Duan 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.4

        This study conducts a three-dimensional numerical simulation of the creep behavior of deep granite tunnels at 560 meters underground during the coupled thermal-stress process, with an aim to elucidate the effect of the temperature and stress fields on the creep behavior of these deep hard rock tunnels. A 100-h creep period was set, and the mechanical structure of the experimental chamber was accurately replicated at a 1:1 scale, considering the actual mechanical structure of the granite tunnels in the Beishan underground laboratory. The simulation results can demonstrate that: 1) The maximum stress at 90°C and 50°C are 2.86 and 1.91 times than that at 23°C, respectively, demonstrating significant strain accumulation in the deep granite tunnels at the surface. This phenomenon can primarily be attributed to the thermal stress resulted from the coupling between temperature and stress. 2) The maximum creep at 90°C and 50°C is 16 and 3.5 times than that at 23°C. Under the influence of thermal coupling, the creep increases significantly with increasing temperature, indicating that temperature is an important factor influencing creep in granite. 3) Compared with variations in the stress field, the temperature field emerges as the most critical factor influencing granite creep.

      • KCI등재

        Comparisons of Shuidouchi, Natto, and Cheonggukjang in Their Physicochemical Properties, and Antimutagenic and Anticancer Effects

        Xin Zhao,Jiale Song,Qiang Wang,Yu Qian,Gui-Jie Li,Liang Pang 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.4

        The comparing of shuidouchi, natto, and cheonggukjang were evaluated using physicochemical experiment, Ames test, and in vitro anticancer experiment. Cheonggukjang contained the highest amount of aroma components of amino and ammonia type nitrogens and the lowest amount of γ-glutamyltranspeptidase. Cheonggukjang showed the better sensory qualities than shuidouchi and natto. Three short-term fermented soybean foods were associated with high degree of antimutagenic activities. At a concentration of 2 mg/mL, the growth inhibitory rate of TCA8113 cells treated with cheonggukjang determined by a MTT assay was reduced by 78%; this rate of inhibition was higher than that achieved with shuidouchi (67%) and natto (55%). Cheonggukjang significantly induced apoptosis in cancer cells by upregulating Bax, caspase-3, and caspase-9, and downregulating Bcl-2 by RT-PCR and Western blotting. Our results demonstrated that cheonggukjang had the most potent in vitro anticancer effect, induced apoptosis as well as in terms of physico-chemical properties.

      • KCI등재

        Ethanol dry reforming over ordered mesoporous Co-Zn composite oxide for syngas production

        Feifei Li,Jiale Dong,Mingyue Wang,Xingtao Lin,Weijie Cai,Xianyun Liu 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7

        This work is mainly concerned with the synthesis of Co-Zn nanocomposites by employing MCM-41 silicaas hard template (CoZnO-HT) and its catalytic behavior toward to CO2 reforming with ethanol. The physicochemicalfeatures of the as-prepared catalysts were probed through various characterization techniques, including XRD, TEM,BET, H2-TPR, and XPS. Indeed, CoZnO-HT catalyst possessed a highly ordered mesostructure with similarity toMCM-41 template and a higher specific surface area (304m2/g) compared to the reference CoZnO-C sample (4.75m2/g) prepared by the conventional impregnation method. Consequently, CoZnO-HT exhibited good performance at lowtemperature, and full ethanol conversion could be achieved at 550 oC as well as the negligible formation of byproductacetone. In addition, this catalyst depicted good stability and no obvious deactivation was observed after 40 h time onstream tests under the stoichiometric feed ratio. Indeed, superior specific surface area and efficient mass transportwithin the mesopores might be critical factors assigned to better activity and stability for CoZnO-HT.

      • KCI등재

        Experimental Study on the Electro-osmotic Treatment of Frost Boiling Damage of Cold-Region Subgrade

        Deren Liu,Jiale Yang,Shuangyang Li,Xu Wang,Shuochang Xu 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.4

        In cold regions, the pore water of subgrade surface soil rises sharply because ice lenses thaw in spring-thawing seasons and cannot drain out in a short time, which leads to a high water content in the thawed layer of the cold-region subgrade. Frost boiling damage of subgrade occurs frequently under repeated traffic loads and seriously affects the normal operation of the road. Based on the advantages of rapid and effective electro-osmotic drainage, a horizontal stage electro-osmotic drainage method (HSEDM) was designed to treat the frost boiling damage of cold-region subgrade. To test the engineering effectiveness of the HSEDM, a model test was carried out, in which many key indexes, such as the current intensity, effective potential, electrode corrosion, water content, shear strength and surface settlement, were closely monitored. Through the controlled trial, it indicates that the pore water was mainly driven to move from the anode to the cathode and further drained out from the slope by electric field force. At the same time, the shear strength of the frost boiling subgrade increases significantly after electro-osmotic consolidation. The experimental results provide a theoretical basis for the engineering application of the HSEDM in the treatment of frost boiling damage of cold-region subgrade.

      • SCIESCOPUSKCI등재

        Radiated disturbance characteristics of SiC MOSFET module

        Huang, Huazhen,Wang, Ningyan,Wu, Jialing,Lu, Tiebing The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.2

        Wide band gap semiconductor device silicon carbide (SiC) metal oxide semiconductor field effect transistors (MOSFETs) have many advantages and are considered to be the most promising alternative to silicon (Si) insulated gate bipolar transistors (IGBTs) in low-/medium-voltage fields. However, a faster switching speed results in more serious electromagnetic disturbance problems in the application of SiC MOSFET. In this paper, an experiment system is established to measure the radiated disturbance of a single SiC MOSFET module operating at 9 kHz-300 MHz. The radiated electric fields of the SiC MOSFET module are mainly concentrated within 160 MHz. The switching voltage and radiated disturbance of the Si IGBT module are measured and compared with those of the SiC MOSFET module. The voltage of the SiC MOSFET has a faster change rate and a higher overshoot, which results in the radiated electric fields of SiC MOSFET module being 5-10 dB higher than those of the Si IGBT module below 8 MHz. The measurement results in the time-domain and frequency-domain correspond. A detailed model of a SiC MOSFET module is established and the radiated electric fields are calculated using the method of moments (MOM). The calculated results show the effectiveness of the model for radiated disturbance prediction. In this paper, the radiated electric fields of a SiC MOSFET module are measured and analyzed, and the calculation model can be used to further evaluate the radiated disturbance characteristics of SiC MOSFET and influencing factors.

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