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Experimental Study on the Electro-osmotic Treatment of Frost Boiling Damage of Cold-Region Subgrade
Deren Liu,Jiale Yang,Shuangyang Li,Xu Wang,Shuochang Xu 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.4
In cold regions, the pore water of subgrade surface soil rises sharply because ice lenses thaw in spring-thawing seasons and cannot drain out in a short time, which leads to a high water content in the thawed layer of the cold-region subgrade. Frost boiling damage of subgrade occurs frequently under repeated traffic loads and seriously affects the normal operation of the road. Based on the advantages of rapid and effective electro-osmotic drainage, a horizontal stage electro-osmotic drainage method (HSEDM) was designed to treat the frost boiling damage of cold-region subgrade. To test the engineering effectiveness of the HSEDM, a model test was carried out, in which many key indexes, such as the current intensity, effective potential, electrode corrosion, water content, shear strength and surface settlement, were closely monitored. Through the controlled trial, it indicates that the pore water was mainly driven to move from the anode to the cathode and further drained out from the slope by electric field force. At the same time, the shear strength of the frost boiling subgrade increases significantly after electro-osmotic consolidation. The experimental results provide a theoretical basis for the engineering application of the HSEDM in the treatment of frost boiling damage of cold-region subgrade.
You Hankun,Song Siyuan,Liu Deren,Ren Tongsen,Yin Song Jiang,Wu Peng,Mao Jun 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.1
To investigate the mechanism of Wenshen Xuanbi Decoction (WSXB) in treating osteoarthritis (OA) via network pharmacology, bioinformatics analysis, and experimental verification. The active components and prediction targets of WSXB were obtained from the TCMSP database and Swiss Target Prediction website, respectively. OA-related genes were retrieved from GeneCards and OMIM databases. Protein-protein interaction and functional enrichment analyses were performed, resulting in the construction of the Herb-Component-Target network. In addition, differential genes of OA were obtained from the GEO database to verify the potential mechanism of WSXB in OA treatment. Subsequently, potential active components were subjected to molecular verification with the hub targets. Finally, we selected the most crucial hub targets and pathways for experimental verification in vitro. The active components in the study included quercetin, linolenic acid, methyl linoleate, isobergapten, and beta-sitosterol. AKT1, tumor necrosis factor (TNF), interleukin (IL)- 6, GAPDH, and CTNNB1 were identified as the most crucial hub targets. Molecular docking revealed that the active components and hub targets exhibited strong binding energy. Experimental verification demonstrated that the mRNA and protein expression levels of IL-6, IL-17, and TNF in the WSXB group were lower than those in the KOA group (p < 0.05). WSXB exhibits a chondroprotective effect on OA and delays disease progression. The mechanism is potentially related to the suppression of IL-17 and TNF signaling pathways and the down-regulation of IL-6.