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        Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

        Dong Jiale,Wang Wenzhi,Zhou Wei,Zhang Siming,Li Meng,Li Ning,Pan Guoqing,Zhang Xianzuo,Bai Jiaxiang,Zhu Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

        Implant-associated infection (IAI) is increasingly emerging as a serious threat with the massive application of biomaterials. Bacteria attached to the surface of implants are often difficult to remove and exhibit high resistance to bactericides. In the quest for novel antimicrobial strategies, conventional antimicrobial materials often fail to exert their function because they tend to focus on direct bactericidal activity while neglecting the modulation of immune systems. The inflammatory response induced by host immune cells was thought to be a detrimental force impeding wound healing. However, the immune system has recently received increasing attention as a vital player in the host’s defense against infection. Anti-infective strategies based on the modulation of host immune defenses are emerging as a field of interest. This review explains the importance of the immune system in combating infections and describes current advanced immune-enhanced anti-infection strategies. First, the characteristics of traditional/conventional implant biomaterials and the reasons for the difficulty of bacterial clearance in IAI were reviewed. Second, the importance of immune cells in the battle against bacteria is elucidated. Then, we discuss how to design biomaterials that activate the defense function of immune cells to enhance the antimicrobial potential. Based on the key premise of restoring proper host-protective immunity, varying advanced immune-enhanced antimicrobial strategies were discussed. Finally, current issues and perspectives in this field were offered. This review will provide scientific guidance to enhance the development of advanced anti-infective biomaterials.

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        Ethanol dry reforming over ordered mesoporous Co-Zn composite oxide for syngas production

        Feifei Li,Jiale Dong,Mingyue Wang,Xingtao Lin,Weijie Cai,Xianyun Liu 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7

        This work is mainly concerned with the synthesis of Co-Zn nanocomposites by employing MCM-41 silicaas hard template (CoZnO-HT) and its catalytic behavior toward to CO2 reforming with ethanol. The physicochemicalfeatures of the as-prepared catalysts were probed through various characterization techniques, including XRD, TEM,BET, H2-TPR, and XPS. Indeed, CoZnO-HT catalyst possessed a highly ordered mesostructure with similarity toMCM-41 template and a higher specific surface area (304m2/g) compared to the reference CoZnO-C sample (4.75m2/g) prepared by the conventional impregnation method. Consequently, CoZnO-HT exhibited good performance at lowtemperature, and full ethanol conversion could be achieved at 550 oC as well as the negligible formation of byproductacetone. In addition, this catalyst depicted good stability and no obvious deactivation was observed after 40 h time onstream tests under the stoichiometric feed ratio. Indeed, superior specific surface area and efficient mass transportwithin the mesopores might be critical factors assigned to better activity and stability for CoZnO-HT.

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        One-Step Hydrothermal Deposition of Ag-Doped g-C3N4-TiO2 Nanocomposites on Cotton Fabric Surface with Enhanced Photocatalytic Activity

        Wenjun Li,Hui Zhang,Pei Chen,Jiale Yao,Xiangzhi Dong 한국섬유공학회 2023 Fibers and polymers Vol.24 No.2

        In this study, Ag-doped g-C3N4-TiO2 nanocomposite photocatalysts were deposited on the surface of cotton fabric by a simpleone-step hydrothermal method. The structure features of as-modified cotton fabric were examined by a series of characterizationtechniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction(XRD) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV–Vis diffuse reflectance spectroscopy (DRS) andphotoluminescence spectroscopy (PL). The experimental results showed that highly dispersed Ag nanoparticles were dopedinto g-C3N4-TiO2 nanocomposites which were evenly coated on the fabric surface. The introduction of Ag nanoparticles intog-C3N4-TiO2 composites could significantly improve the photodegradation rate of methyl orange (MO) dye under visiblelight irradiation. Importantly, the doping site of Ag nanoparticles had a significant influence on the photocatalytic activityof Ag-doped g-C3N4-TiO2 nanocomposites. Compared with the g-C3N4-TiO2 coated cotton fabric, the Ag-doped g-C3N4-TiO2 coated cotton fabric displayed excellent photocatalytic properties for the photodegradation of MO dyes because of thenarrowed band gap and the faster separation and transfer of photoinduced charge carriers. The substrate of cotton fabric hadlittle influence on the active radicals produced by the Ag-doped g-C3N4-TiO2 nanocomposites. In addition, the as-modifiedcotton fabric exhibited good reusability and stability after five recycles for the photodegradation of MO dyes.

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