A polymeric composite protective layer for stable Li metal anodes

Guo Suogang,Wang Li,Jin Yuhong,Piao Nan,Chen Zonghai,Tian Guangyu,Li Jiangang,Zhao Chenchen,He Xiangming 나노기술연구협의회 2020 Nano Convergence Vol.7 No.21

Lithium (Li) metal is a promising anode for high-performance secondary lithium batteries with high energy density due to its highest theoretical specific capacity and lowest electrochemical potential among anode materials. However, the dendritic growth and detrimental reactions with electrolyte during Li plating raise safety concerns and lead to premature failure. Herein, we report that a homogeneous nanocomposite protective layer, prepared by uniformly dispersing ­AlPO 4 nanoparticles into the vinylidene fluoride-co-hexafluoropropylene matrix, can effectively prevent dendrite growth and lead to superior cycling performance due to synergistic influence of homogeneous Li plating and electronic insulation of polymeric layer. The results reveal that the protected Li anode is able to sustain repeated Li plating/stripping for > 750 cycles under a high current density of 3 mA cm −2 and a renders a practical specific capacity of 2 mAh cm −2 . Moreover, full-cell Li-ion battery is constructed by using ­LiFePO 4 and protected Li as a cathode and anode, respectively, rendering a stable capacity after 400 charge/discharge cycles. The current work presents a promising approach to stabilize Li metal anodes for next-generation Li secondary batteries.

Recent Developments in the Effects of Different Dopants on the Structure and Property of Lithium Titanate Material

Xi-Yang Li,Qian-Lin Chen,Min Yang,Ya-Nan Li,Jing-Bo Ma 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.3

The lithium titanium spinel Li4Ti5O12 has attracted more and more attention as anode materials applied in lithium ion batteries. Li4Ti5O12 material has been found to be able to intercalate lithium ions without deformation of the lattice. However, compared with graphite and other anode materials, the low conductivity of Li4Ti5O12 restricts its charging and discharging rate. Doping is deemed to be a businesslike method to enhance ionic and electronic conductivity of Li4Ti5O12. This paper reviews the effects of Li4Ti5O12 with different doping ions on different crystal lattice states. And it has been found by a summary that the doping objective of doping ions at Li4Ti5O12 is also different. Moreover, the applications of ion doping in different fields of Li4Ti5O12 are prospected.

In-situ PECVD-enabled graphene-V₂O₃ hybrid host for lithium–sulfur batteries

Song, Yingze,Zhao, Wen,Wei, Nan,Zhang, Li,Ding, Feng,Liu, Zhongfan,Sun, Jingyu Elsevier 2018 Nano energy Vol.53 No.-

<P><B>Abstract</B></P> <P>Lithium–sulfur (Li–S) batteries have been regarded as promising candidates for current energy-storage technologies due to their remarkable advantages in energy density and theoretical capacity. However, one of the daunting challenges remained for advanced Li–S systems thus far deals with the synchronous suppression of polysulfide (LiPS) shuttle and acceleration of redox kinetics. Herein, a cooperative interface bridging adsorptive V<SUB>2</SUB>O<SUB>3</SUB> and conductive graphene is constructed <I>in-situ</I> by virtue of direct plasma-enhanced chemical vapor deposition (PECVD), resulting in the design of a novel V<SUB>2</SUB>O<SUB>3</SUB>-graphene hybrid host to synergize the LiPS entrapment and conversion. The redox kinetics and electrochemical performances of thus-derived cathodes were accordingly enhanced owing to the smooth adsorption-diffusion-conversion of LiPSs even at a sulfur mass loading of 3.7 mg cm<SUP>–2</SUP>. Such interfacial engineering offers us a valuable opportunity to gain insight into the comprehensive regulation of LiPS anchoring ability, electrical conductivity and ion diffusive capability in hybrid hosts on suppressing the LiPS shuttle and propelling the redox kinetics. Our devised PECVD route might pave a new route toward the facial and economic design of hetero-phased multi-functional hosts for high-performance Li–S systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Graphene-V<SUB>2</SUB>O<SUB>3</SUB> hybrid host was designed <I>in-situ</I> based on PECVD route. </LI> <LI> Thus-derived cathode showed a low capacity decay of merely 0.046% per cycle at 2 C after 1000 cycles. </LI> <LI> Cathodes with a relatively high sulfur mass loading (3.7 mg cm<SUP>–2</SUP>) were fabricated. </LI> <LI> The smooth adsorption-diffusion-conversion of polysulfides was thoroughly probed <I>via</I> experimental studies and DFT simulations. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

A Novel Molecular Grading Model: Combination of Ki67 and VEGF in Predicting Tumor Recurrence and Progression in Non-invasive Urothelial Bladder Cancer

Chen, Jun-Xing,Deng, Nan,Chen, Xu,Chen, Ling-Wu,Qiu, Shao-Peng,Li, Xiao-Fei,Li, Jia-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Purpose: To assess efficacy of Ki67 combined with VEGF as a molecular grading model to predict outcomes with non-muscle invasive bladder cancer (NMIBC). Materials: 72 NMIBC patients who underwent transurethral resection (TUR) followed by routine intravesical instillations were retrospectively analyzed in this study. Univariate and multivariate analyses were performed to confirm the prognostic values of the Ki67 labeling index (LI) and VEGF scoring for tumor recurrence and progression. Results: The novel molecular grading model for NMIBC contained three molecular grades including mG1 (Ki67 $LI{\leq}25%$, VEGF $scoring{\leq}8$), mG2 (Ki67 LI>25%, VEGF $scoring{\leq}8$; or Ki67 $LI{\leq}25%$, VEGF scoring > 8), and mG3 (Ki67 LI > 25%, VEGF scoring > 8), which can indicate favorable, intermediate and poor prognosis, respectively. Conclusions: The described novel molecular grading model utilizing Ki67 LI and VEGF scoring is helpful to effectively and accurately predict outcomes and optimize personal therapy.

Evidence for the medicinal value of Squama Manitis (pangolin scale): A systematic review

Xinyao Jin,Hui Zi Chua,Keyi Wang,Nan Li,Wenke Zheng,Wentai Pang,Fengwen Yang,Bo Pang,Mingyan Zhang,Junhua Zhang 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.1

Background: Squama Manitis (pangolin scale) has been used in traditional Chinese medicine for thousands of years. However, its efficacy has not been systematically reviewed. This review aims to fill the gap. Methods: We searched six electronic databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure Database (CNKI), WanFang Database and SinoMed from inception to May 1, 2020. Search terms included “pangolin”, “Squama Manitis”, “Manis crassicaudata”, “Manis javanica”, “Malayan pangolins”, “Manis pentadactyla”, “Ling Li”, “Chuan Shan Jia”, “Shan Jia”, “Pao Jia Zhu”, “Jia Pian” and “Pao Shan Jia”. The Cochrane Risk of Bias (RoB) assessment tool and Newcastle-Ottawa Scale (NOS) were used to evaluate the risk of bias of the included randomized controlled trials (RCTs) and case control studies (CCSs). Results: After screening, 15 articles that met the inclusion criteria were finally included. There were 4 randomized controlled trials, 1 case control study, 3 case series and 7 case reports. A total of 15 different diseases were reported in these studies, thus the data could not be merged to generate powerful results. Two RCTs suggested that Squama Manitis combined with herbal decoction or antibiotics could bring additional benifit for treating postpartum hypogalactia and mesenteric lymphadenitis. However, this result was not reliable due to low methodological quality and irrational outcomes. The other two RCTs generated negative results. All the non-RCTs did not add any valuable evidence to the efficacy of Squama Manitis beacause of small samples, incomplete records, non-standardized outcome detection. In general, currently available evidence cannot support the clinical use of Squama Manitis. Conclusion: There is no reliable evidence that Squama Manitis has special medicinal value. The removal of Squama Manitis from Pharmacopoeia is rational.

Late Paleoproterozoic ultrahigh-temperature metamorphism in the Korean Peninsula

Santosh, M.,Hu, Chao-Nan,Kim, Sung Won,Tang, Li,Kee, Weon-Seo Elsevier 2018 Precambrian Research Vol.308 No.-

<P><B>Abstract</B></P> <P>The Paleoproterozoic rock record from the Sino-Korean Peninsula was fundamental to the models on evolution of the Asian continental collage and its relationship with the amalgamation and disruption of Proterozoic supercontinents such as Columbia and Rodinia. In this study, we present results from a comprehensive investigation on the khondalites in the Hongseong area, along the western part of the Gyeonggi massif within the central Korean Peninsula involving petrography, phase equilibria forward modeling, and zircon U-Pb geochronology, REE geochemistry and Lu – Hf isotopes. The <I>P-T</I> pseudosections show that the peak mineral assemblage of garnet + sillimanite + quartz + plagioclase + K-feldspar + ilmenite in the khondalite is stable at 7.5–9.6 kbar and 895–990 °C, corresponding to ultra-high temperature (UHT) metamorphism. We also report the first finding of corundum and quartz inclusions within sillimanite enclosed in garnet porphyroblast further confirming UHT metamorphism. The interpreted <I>P-T</I> path involves decompression and exhumation along a clockwise trajectory as suggested by the retrograde textures and mineral phase equilibria modeling.</P> <P>The detrital zircon U – Pb data from the khondalite show multiple age peaks for the magmatic population suggesting Neoarchean – Paleoproterozoic provenance. Metamorphic zircons from the khondalites yield ages of 1931 ± 33 Ma, 1871 ± 11 Ma and 1866 ± 10 Ma. The spot ages range from 1923 Ma to 1832 Ma suggesting either a long-lived metamorphic event or two distinct thermal events. The REE patterns of the zircon grains also clearly distinguish the magmatic and metamorphic populations. The garnet + sillimanite assemblage is considered to represent the peak UHT assemblage and the cordierite + biotite represents the post-peak retrograde assemblage. The ca. 1923–1832 Ma ages obtained in our study from metamorphic zircon domains correlate well with similar ages reported for metamorphism associated with the amalgamation of crustal blocks within the North China Craton. Our study suggests that the Late Paleoproterozoic UHT metamorphism in the central Korean Peninsula might be part of a common event within the Sino-Korean Craton related to the tectonics of final assembly of cratonic blocks within the Columbia supercontinent. Although a substantial volume of the Paleoproterozoic basement of the Korean Peninsula was destroyed and recycled during the Neoproterozoic and Phanerozoic tectonic events, the preserved remnants provide insights into the contiguity of the basements of the Korean Peninsula and the North China Craton.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First precise documentation of ultrahigh-temperature metamorphism in Central Korean Peninsula. </LI> <LI> Discovery of corundum + quartz assemblage testifying to extreme thermal conditions. </LI> <LI> Metamorphic zircon grains define ages ranging from 1923 to 1823 Ma. </LI> <LI> Correlation with the North China Craton within the Sino-Korean continental collage. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Ecofriendly high-performance ionic soft actuators based on graphene-mediated cellulose acetate

Nan, Minghui,Wang, Fan,Kim, Seokjae,Li, Hao,Jin, Zhen,Bang, Doyeon,Kim, Chang-Sei,Park, Jong-Oh,Choi, Eunpyo Elsevier 2019 Sensors and actuators. B Chemical Vol.301 No.-

<P><B>Abstract</B></P> <P>Ionic-type artificial muscles with eco-friendly, biodegradable, and biocompatible functionalities have attracted attention for a wide range of potential applications in wearable electronics, soft haptic-feedback systems, and active biomedical devices. Here, we report on the development of an ecofriendly high-performance ionic soft actuator based on biofriendly cellulose acetate (CA), graphene nanopowders (GN), ionic liquid (IL) as a plasticizer, and biofriendly-flexible-nonmetallic conducting polymer poly(3,4-ethylene-dioxythiopene)-polystyrenesulfonate (PEDOT: PSS) as an electrode, thereby realizing a novel ecofriendly CA-IL-GN actuator with a large bending mechanical deformation and a fast response time. The proposed CA-IL-GN (0.2 wt%) nanocomposite membrane exhibited dramatic increments in specific capacitance (2.92 times) and Young’s modulus (2.38 times), thus leading to a 2.9 times larger bending deformation and a 4.8 times faster response than those of pure CA-IL actuator. Therefore, the developed ecofriendly high-performance CA-IL-GN actuator can be considered to be a promising candidate for human-friendly electronics, including artificial muscles, flexible haptic devices, soft wearable devices, and bio-medical devices, due to its cost-effectiveness, large bending mechanical actuation, fast response, and bio-friendly functionalities.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ecofriendly soft actuator based on cellulose acetate, graphene nanopowders, ionic liquid as plasticizer, and PEDOT:PSS as soft electrode. </LI> <LI> Proposed membrane exhibited increments in specific capacitance and Young’s modulus compare with a pure cellulose acetate actuator. </LI> <LI> Proposed actuator showed a 2.9 times larger bending deformation and a 4.8 times faster response than those of pure cellulose acetate actuator. </LI> </UL> </P>

Tumor-Derived Transforming Growth Factor-β is Critical for Tumor Progression and Evasion from Immune Surveillance

Li, Zheng,Zhang, Li-Juan,Zhang, Hong-Ru,Tian, Gao-Fei,Tian, Jun,Mao, Xiao-Li,Jia, Zheng-Hu,Meng, Zi-Yu,Zhao, Li-Qing,Yin, Zhi-Nan,Wu, Zhen-Zhou Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Tumors have evolved numerous mechanisms by which they can escape from immune surveillance. One of these is to produce immunosuppressive cytokines. Transforming growth factor-${\beta}$(TGF-${\beta}$) is a pleiotropic cytokine with a crucial function in mediating immune suppression, especially in the tumor microenvironment. TGF-${\beta}$ produced by T cells has been demonstrated as an important factor for suppressing antitumor immune responses, but the role of tumor-derived TGF-${\beta}$ in this process is poorly understood. In this study, we demonstrated that knockdown of tumor-derived TGF-${\beta}$ using shRNA resulted in dramatically reduced tumor size, slowing tumor formation, prolonging survival rate of tumor-bearing mice and inhibiting metastasis. We revealed possible underlying mechanisms as reducing the number of myeloid-derived suppressor cells (MDSC) and $CD4^+Foxp3^+$ Treg cells, and consequently enhanced IFN-${\gamma}$ production by CTLs. Knockdown of tumor-derived TGF-${\beta}$ also significantly reduced the conversion of na$\ddot{i}$ve $CD4^+$ T cells into Treg cells in vitro. Finally, we found that knockdown of TGF-${\beta}$ suppressed cell migration, but did not change the proliferation and apoptosis of tumor cells in vitro. In summary, our study provided evidence that tumor-derived TGF-${\beta}$ is a critical factor for tumor progression and evasion of immune surveillance, and blocking tumor-derived TGF-${\beta}$ may serve as a potential therapeutic approach for cancer.

Structural health monitoring of innovative civil engineering structures in Mainland China

Li, Hong-Nan,Li, Dong-Sheng,Ren, Liang,Yi, Ting-Hua,Jia, Zi-Guang,LI, Kun-Peng Techno-Press 2016 Structural monitoring and maintenance Vol.3 No.1

This paper describes the backgrounds, motivations and recent history of structural health monitoring (SHM) developments to various types of engineering structures. Extensive applications of SHM technologies in bridges, high-rise buildings, sport avenues, offshore platforms, underground structures, dams, etc. in mainland China are summarily categorized and listed in tables. Sensors used in implementations, their deployment, damage identification strategies if applicable, preliminary monitoring achievements and experience are presented in the lists. Finally, existing problems and promising research efforts in civil SHM are discussed, highlighting challenges and future trends.

Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

Yu, Li-Xiang,Zhou, Nan-Nan,Liu, Li-Yuan,Wang, Fei,Ma, Zhong-Bing,Li, Jie,Yu, Zhi-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95%CI: 1.21-1.70; G carriers vs A carriers, OR: 1.23, 95%CI: 1.11-1.36; dominant model, OR: 1.28, 95%CI: 1.10-1.49 and recessive model, OR: 1.31, 95%CI: 1.12-1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95%CI: 1.26-1.92; G carriers vs. A carriers OR: 1.30, 95%CI: 1.18-1.43; dominant model OR: 1.31, 95%CI: 1.08-1.60 and recessive model OR: 1.44, 95%CI: 1.26-1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.