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( Hye Hee Cha ),( So Yun Lim ),( Ji-soo Kwon ),( Ji Yeun Kim ),( Seongman Bae ),( Jiwon Jung ),( Sung-han Kim ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.2
Background/Aims: Data comparing the antibody responses of different coronavirus disease 2019 (COVID-19) vaccine platforms according to dose with natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-induced antibody responses are limited. Methods: Blood samples from adult patients with mild and severe COVID-19 and healthcare workers who received ChAdOx1 nCoV-19 vaccine (2nd dose at 12-week intervals) and BNT162b2 vaccine (2nd dose at 3-week intervals) were collected and compared by immunoglobulin G immune responses to SARS-CoV-2 specific spike protein using an in-house-developed enzyme-linked immunosorbent assay. Results: A total of 53 patients, including 12 and 41 with mild and severe COVID-19, respectively, were analyzed. In addition, a total of 73 healthcare workers, including 37 who received ChAdOx1 nCoV-19 and 36 who received BNT162b2, were enrolled. Antibody responses after the first and second doses of the ChAdOx1 nCoV-19 vaccine or the first dose of the BNT162b2 vaccine were similar to those in convalescent patients with mild COVID-19, but lower than those in convalescent patients with severe COVID-19, respectively. However, after the second dose of the BNT162b2 vaccine, the antibody response was comparable to that in convalescent patients with severe COVID-19. Conclusions: Our data suggest that the second dose of mRNA vaccination may be more beneficial in terms of long-term immunity and prevention of SARS-CoV-2 variant infection than a single dose of COVID-19 vaccination or homologous second challenge ChAdOx1 nCoV-19.
급성 신우신염이 선행된 Escherichia coli 농흉 1예
차치운,조준형,김미진,오윤정,연재우,이성규,오미정,채지영,김수연 대한감염학회 2009 감염과 화학요법 Vol.41 No.5
We experienced a case of acute pyelonephritis which progressed to Escherichia coli bacteremia and later complicated by empyema in a 65-year-old female. She was successfully treated with intravenous antibiotic therapy and percutaneous drainage of empyema.
Potassium alum과 비우식성 감미료의 병용이 Streptococcus mutans의 성장에 미치는 영향
김윤정,차정단,김지영,김강주,이흥수 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.3
Traditionally, Koreans have used potassium alum by mouth rinse when they suffered from stomatitis. This study was carried out to investigate the combined effect of potassium alum with aspartame, sorbitol and xylitol on the growth of Streptococcus mutans (S. mutans). The relative growth ratio of S. mutans JC-2 cultured at different concentrations of potassium alum and different concentrations of aspartame, sorbitol and xylitol was examined. The combined effect of different concentrations of potassium alum with 0.5% and 10.0% of aspartame, sorbitol and xylitol was examined. The lowest minimum inhibitory concentration of potassium alum was 5.0mg/ml against S. mutans JC-2. The relative growth ratio of potassium alum on S. mum JC-2 was affected at the concentration of 2.0mg/ml. The growth of S. mutans JC-2 decreased at the concentration of 10.0% of aspartame and sorbitol. Also, a combination of potassium alum and sugar substitutes was more effective against S. mum than the use of one sugar substitute alone. The inhibitory effect of potassium alum and sugar substitutes on S. mutans may be an important mechanism of caries prevention by potassium alum.
류지구,최혁환,차영호,김정헌,조경연 釜慶大學校 1997 釜慶大學校 論文集 Vol.2 No.2
The wide spread of multimedia sysrem deands a large viewing display device which can inform a message to many peoples in open area. This paper is about the design and simulating of a large viewing digital multi-wision control ASIC(Application Specific Integrated Circuit). In this paper. the digital multi-vision ASIC has one channel of imput cideo signal wihich is compliance with CCIR-656 specification and four channels of output video signal which are compliance with CCIR-601 specificarion. It has 2 operating mode. The one is the pass-thro;ugh mode. input vido signal goes to output video signal without any change, and the another one is the expension mode, input video signal is expended by from 2 to 16 times into output video signal. In expension mode. awindow could be programmed and only the input video signal in the window is expended. The 0.6 micron CMOS sEA OF Gate is used to design the ASIC in amount of about 23,000 gates, and it is simulated at 48MHz.
Cha, Ji-Yun,Jeon, Yong-Deok,Xin, Mingjie,Kim, Do-Kuk,Lee, Hoon-Yeon,Kim, Bo-Ram,Hwang, Sung-Woo,Kim, Dae-Ki,Jin, Jong-Sik,Lee, Young-Mi Informa UK (TaylorFrancis) 2017 Bioscience, Biotechnology, and Biochemistry Vol.81 No.11
<P>The aim of this study is to examine the anti-inflammatory effect of Euphorbia supina (ES) ethanol extract in dextran sulfate sodium (DSS)-induced experimental colitis model. ES was per orally administered at different doses of 4 or 20 mg/kg body weight with 5% DSS in drinking water for 7 days. Twenty mg/kg of ES administration regulated body weight decrease, recovered colon length shortening, and increased disease activity index score and myeloperoxidase level in DSS-induced colitis. Histological features showed that 20 mg/kg of ES administration suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Furthermore, ES suppressed the expressions of COX-2, iNOS, NF-kB, IkBa, pIkBa in colon tissue. These findings demonstrated a possible effect of amelioration of ulcerative colitis and could be clinically applied.</P>
Cha, Ji Young,Jung, Ji Yun,Jung, Jae Yup,Lee, Jong Rok,Cho, Il Je,Ku, Sae Kwang,Byun, Sung Hui,Ahn, Yong-Tae,Lee, Chul Won,Kim, Sang Chan,An, Won G. Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Pyungwi-san (PWS) is a traditional basic herbal formula. We investigated the effects of PWS on induction of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), pro-inflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-<I><I>α</I></I> (TNF-<I><I>α</I></I>)) and nuclear factor-kappa B (NF-<I><I>κ</I></I>B) as well as mitogen-activated protein kinases (MAPKs) in lipopolysaccharide-(LPS-) induced Raw 264.7 cells and on paw edema in rats. Treatment with PWS (0.5, 0.75, and 1 mg/mL) resulted in inhibited levels of expression of LPS-induced COX-2, iNOS, NF-<I><I>κ</I></I>B, and MAPKs as well as production of prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>), nitric oxide (NO), IL-6, and TNF-<I><I>α</I></I> induced by LPS. Our results demonstrate that PWS possesses anti-inflammatory activities via decreasing production of pro-inflammatory mediators through suppression of the signaling pathways of NF-<I><I>κ</I></I>B and MAPKs in LPS-induced macrophage cells. More importantly, results of the carrageenan-(CA-) induced paw edema demonstrate an anti-edema effect of PWS. In addition, it is considered that PWS also inhibits the acute edematous inflammations through suppression of mast cell degranulations and inflammatory mediators, including COX-2, iNOS and TNF-<I><I>α</I></I>. Thus, our findings may provide scientific evidence to explain the anti-inflammatory properties of PWS <I>in vitro</I> and <I>in vivo</I>.</P>
차지윤(Ji-Yun Cha),노영식(Young-Sik Noh),변지웅(Ji-Woong Byun),변영철(Yung-Cheol Byun) 한국멀티미디어학회 2008 한국멀티미디어학회 학술발표논문집 Vol.2008 No.2
현재 RFID 기술은 유통, 물류, 이력관리 뿐만 아니라 교통, 방범, 텔레매틱스, u헬스, 등의 다양한 분야에서 서비스를 실현하고 있다. 이에 따라 RFID에 관한 연구와 표준화 작업이 진행되고 있으며, 특히 RFID 리더에서 수집된 데이터들을 효율적으로 관리, 사용하기 위해서 RFID 미들웨어에 대한 요구사항이 증대되고 있다. 본 논문에서는 기존의 ALE 기반 RFID 미들웨어에서 다양한 기능을 확장 할 수 있는 프레임워크를 제안한다. 제안하는 프레임워크는 여러 종류의 태그 데이터를 처리 할 수 있으며, 이기종 다수의 리더들을 동시에 제어하기 위해서 다양한 프로토콜 및 통신방식을 정의한 인터페이스를 제공하여 미들웨어의 기능을 동적으로 확장 할 수 있다.
Lee, Jung-Woo,Cha, Jeong-Ho,Shin, Sun-Hee,Kim, Yun-Jeong,Lee, Seul-Ki,Cha, Hye-Jin,Kim, Ji-Hae,Ahn, Ji-Hyun,Kim, Hye-Young,Pak, Kyung-Ah,Yoon, Ji-Sung,Park, Seo-Young,Park, Choon-keun The Korean Society of Developmental Biology 2016 발생과 생식 Vol.20 No.3
Most of the commercial devices for vitrification are directly immersed into the warming solution (WS) for increasing of warming rate. However, the previous modified cut standard straw (MCS) which has reported is difficult to immerse into the WS. The aim of this study was to investigate whether the long cut straw (LCS) could be useful as a stable tool for vitrified-warmed human blastocysts. A total of 138 vitrified-warmed cycles were performed between November 2013 and November 2014 (exclusion criteria: women ${\geq}38$ years old, poor responder, surgical retrieval sperm, and severe male factor). The artificial shrinkage was conducted using 29-gauge needles. Ethylene glycol and dimethyl sulfoxide (7.5% and 15% (v/v)) were used as cryoprotectants. Freezing and warming were conducted using the LCS tool. The cap of LCS was removed using the forceps in the liquid nitrogen ($LN_2$) and then directly immersed into the first WS for 1 min at $37^{\circ}C$ (1 M sucrose). Only re-expanded blastocysts were transferred after it was cultured in sequential media for 18-20 h. A total of 294 blastocysts were warmed, and all were recovered (100%). Two hundred eighty-five embryos were survived (96.9%). The vitrified-warmed blastocysts of all patients were transferred without any cancellation. We were able to achieve a reasonable implantation (24.2%), following by clinical pregnancy (36.2%), which then continued to ongoing pregnancy (36.2%), and live birth (31.2%). Using LCS is achieved the acceptable rates of survival, pregnancy and live birth. Therefore, the LCS could be considered as a stable and simple tool for human embryo vitrificaton.