Comparison of antibody responses after the 1st and 2nd doses of COVID-19 vaccine with those of patients with mild or severe COVID-19

( Hye Hee Cha ),( So Yun Lim ),( Ji-soo Kwon ),( Ji Yeun Kim ),( Seongman Bae ),( Jiwon Jung ),( Sung-han Kim ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.2

Background/Aims: Data comparing the antibody responses of different coronavirus disease 2019 (COVID-19) vaccine platforms according to dose with natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-induced antibody responses are limited. Methods: Blood samples from adult patients with mild and severe COVID-19 and healthcare workers who received ChAdOx1 nCoV-19 vaccine (2nd dose at 12-week intervals) and BNT162b2 vaccine (2nd dose at 3-week intervals) were collected and compared by immunoglobulin G immune responses to SARS-CoV-2 specific spike protein using an in-house-developed enzyme-linked immunosorbent assay. Results: A total of 53 patients, including 12 and 41 with mild and severe COVID-19, respectively, were analyzed. In addition, a total of 73 healthcare workers, including 37 who received ChAdOx1 nCoV-19 and 36 who received BNT162b2, were enrolled. Antibody responses after the first and second doses of the ChAdOx1 nCoV-19 vaccine or the first dose of the BNT162b2 vaccine were similar to those in convalescent patients with mild COVID-19, but lower than those in convalescent patients with severe COVID-19, respectively. However, after the second dose of the BNT162b2 vaccine, the antibody response was comparable to that in convalescent patients with severe COVID-19. Conclusions: Our data suggest that the second dose of mRNA vaccination may be more beneficial in terms of long-term immunity and prevention of SARS-CoV-2 variant infection than a single dose of COVID-19 vaccination or homologous second challenge ChAdOx1 nCoV-19.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

夫婦의 結婚實在相異性에 대한 事例硏究 : 幼兒期 ·學童期 家族을 중심으로 Case of the Families with Preschoolchildren & Schoolchildren

차명희,박혜인 啓明大學校 生活科學硏究所 1994 科學論集 Vol.20 No.-

This study is intended to identify the dichotomized structure of both sexes in the marriage life of husband and wife. This study used, as a qualitative method, a deep interview on the discrepancy between a dyad about their marriage realities. 20 couples were interviewed by the ethnomethodology. And the main results are as follows. In terms of marriage processes, husbands showed an active tendency while wives a passive one. This seems attributable to the effects of socialization. And in terms of role performance, roles were divided into public and private between dyads in the middle class, while couples together performed public roles in the lower class, but did not do private ones together. Consequently, couples were revealed to sympathize only half of each other's understanding and sympathy, and each of them recognized in a way that marriage realities between a couple are different. However, the origins of these discrepancy are a lot related to a society with the double standard, a structural division of role, and to discriminatory social areas, there should be alternatives for the realities in this respect.

7차 초등학교 과학 교과서의 삽화에 나타난 성역할 고정관념 분석

노태희,차정호,왕혜남 한국초등과학교육학회 2004 초등과학교육 Vol.23 No.1

이 연구는 제7차 교육과정기의 과학 교과서와 실험관찰 교과서에 제시된 삽화를 성역할 고정관념 측면에서 분석하고 6차 교육과정기의 과학 교과서와 비교하였다. 교재에 나타난 삽화에서 성별에 따른 등장인물의 빈도를 세고, 활동 유형을 분석하였다. 연구 결과는 다음과 같다. 1) 과학 교과서의 전체 삽화 수는 6차에 비해 7차에서 2배 정도 증가하였다. 2) 아동의 경우 학습활동에서는 성에 관계없이 등장 빈도가 대체적으로 균형을 이루었지만, 학습의 활동에서는 남학생의 등장 빈도가 여학생보다 더 높았다. 3) 행동 특성에서는 남녀 학생 모두 적극적으로 묘사되었고, 소극적으로 묘사되는 여학생의 비율은 6차 과학 교과서에 비해 감소하였다. 4) 성인의 경우에는 남성의 등장 빈도가 여성보다 높게 나타났다. 5) 가사 활동을 하는 모습에서는 여성의 등장 빈도가 40%로 높게 나타난 반면, 남성은 드물게 나타났다. The illustrations in elementary science textbooks and experimental workbooks based on the 7th national curriculum were analyzed for gender-role stereotyping, and compared with those of the 6th curriculum. The frequencies of men and women who appeared on text illustrations were counted and the types of roles assigned to males and females were investigated. The results were as follows. 1) The 7th national curriculum textbooks contained double the number of illustrations in the textbooks based on the 6th curriculum. 2) Boys and girls were illustrated in 'learning activities' with equal frequency, but boys were more frequently represented than girls in illustrations of 'other' activities. 3) Both boys and girls were generally depicted in 'active' processes and the ratio of 'passive girl' illustrations decreased as compared with the 6th national curriculum. 4) Male adults were more frequently represented than female adults in both textbooks and experimental workbooks. 5) 40% of female adults were illustrated doing housework, while male adults were rarely illustrated in such a role.

중학생의 역사 드라마 시청이 역사의식에 미치는 영향

장희흥,차경호,구혜진 大邱大學校 師範大學 附設 敎育硏究所 2010 學校敎育硏究 Vol.5 No.2

This study is aimed at proposing the specific plans to use history drama lessons through the study on the relations between reality, fascination and involvement that are sub-variables of history drama viewing and middles school students’ historical consciousness, and to raise their historical consciousness by using history drama lessons. In order to accomplish such a goal, the study selected respective 250 middle school students in Daegue and Gumi, Gyeongsangbuk-do as its subjects, and the surveyed and analyzed findings are obtained as follows. First, it is the result obtained by dividing the subjects’ general characteristics. Fascination and involvement among reality, fascination, and involvement that were sub-variables had a difference in the division by sex. Fascination was shown to be higher in female students while involvement was higher in male students. In addition, as to the region, history drama viewing had no difference in middle school students of Daegue and Gyeongsangbuk-do. Historical consciousness was higher in middle school students of Daegue that those of Gyeongsangbuk-do, while regarding the grade there was no difference in history drama viewing and historical consciousness. Second, it was the result regarding how reality, fascination, and involvement that were sub-variables of history dram viewing affected historical consciousness. With regards to types of history dram viewing, fascination, reality, and involvement significantly affected historical consciousness in order. According to the gender, male students’ reality, involvement, and fascination gave a significant effect on historical consciousness while female students’ involvement didn’t affect historical consciousness, and fascination and reality gave an effect on historical consciousness in order. As to the grade, the first graders’ reality, fascination, and involvement were not related to historical consciousness while the second graders’ reality and fascination except for involvement affected in order. Besides, the third graders’ fascination only affected historical consciousness. Regarding the region, fascination and reality of middle school students in Daegu affected historical consciousness in order while fascination, involvement, and reality of middle school students in Gyeongsangbuk-do influenced historical consciousness. Like this, there was a little difference in the gender, grade, and region, but reality, fascination, and involvement that were sub-variables related to history drama viewing affected historical consciousness, and the higher sub-variables related to history drama viewing were, the higher historical consciousness was. Due to the fact that history dramas had a fictional element, there was a discussion on educational efficiency. However, this study verified the fact that history dramas can be educationally used, instead of deciding whether history drams were true or not. Based on the findings of the study, the effective utilization methods of history dramas in history lessons are suggested as follows. First, the study of historical figures using history dramas is possible. Students can understand properties of characters through re-enactment and empathy, and approach various figures that don’t appear in textbooks. Second, they can raise critical view that is able to divide false and fact of history dramas and use it to the fact learning. Third, it is possible to learn historical terms. By learning unfamiliar and difficult historical terms in advance, they can increase interest in history lessons. Fourth, storytelling of historical materials is possible. Students can make their own new interpretation by constructing various historical materials in a way of history dramas. Fifth, they can use a decoration making of history dramas, a visiting of the set, and a clipping of TV screen capture in various manufacturing studies as materials. Sixth, they can have a mock trial and a role-playing lesson regarding behaviors decisions of history drama figures. Seventh, they can study the public life history through history dramas. 이 논문은 중학생의 역사 드라마 시청이 역사의식에 미치는 영향에 대한 것이다. 역사 드라마 시청과 관련된 하위변인인 현실감, 심취도, 관여도는 성별, 학년, 지역에 따른 차이는 있지만, 역사의식에 분명 히 영향을 미치고 있다. 영향력의 크기는 심취도, 현실감, 관여도 순으로 나타났다. 그렇기에 역사 드라 마 시청과 관련한 역사 수업은 중학생의 역사의식 향상에 도움을 줄 수 있을 것으로 보인다. 역사 드라마를 시청하려는 의도와 시청하는 동안의 관여도 정도는 남학생의 경우 역사의식에 유의한 영향을 미쳤지만, 여학생의 경우 유의한 영향을 미치지 않는 것으로 나왔다. 학년별로 결과를 살펴보면 모든 학년에서 관여도는 역사의식에 통계적으로 유의한 영향을 주지 않는 것으로 나타났고, 제일 고학 년인 3학년에서 심취도만이 영향을 주는 것으로 보아 역사 드라마를 시청함에 있어 역사적 사실과 허구를 구별하는 능력이 아래 학년보다 발달하여 현실감의 영향을 덜 받은 것으로 보인다. 역사의식은 대구광역시 중학생이 경상북도 중학생보다 다소 높다. 그리고 실제 사극의 선호도는 퓨전 이나 판타지를 선호하지만 실제 전통사극이 역사의식에 더 높은 영향을 미쳤다. 이것은 현장 교사의 경 험담과 일치한다.

관상정맥동과의 연결이 없는 좌상대정맥의 CT 소견 : 1예 보고 case report

백상현,박재성,이혜경,홍현숙,김대호,조준희,박성진,차장규 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A persistent left superior vena cava (PLSVC) is the most common thoracic venous anomaly. It is a persistent remnant of a vessel that is present as a counterpart of normal right-sided superior vena cava(SVC) in early embryological development but normally disappears later. Its diagnosis can be confirmed by many noninvasive and invasive tests, or it is incidentally diagnosed at insertion into the left subclavian or jugular vein or thoracic surgery. If it is not associated with other congenital cardiac anomalies, it is usually asymptomatic and hemodynamically insignificant. We describe the chest radiograph and CT findings of bilateral SVC with drainage to left superior intercostal vein, hemiazygos, azygos vein and right SVC, and no connection of coronary sinus.

Identification of classifier genes for hepatotoxicity prediction in non steroidal anti inflammatory drugs

Cha, Hye-Jin,Ko, Moon-Jung,Ahn, Soo-Mi,Ahn, Joon-Ik,Shin, Hee-Jung,Jeong, Ho-Sang,Kim, Hye-Soo,Choi, Sun-Ok,Kim, Eun-Jung The Korean Society of Toxicogenomics and Toxicopro 2010 Molecular & cellular toxicology Vol.6 No.3

Toxicogenomics has the potential to be used for the regulatory decision making to predict toxicity in developing new drugs. We have identified the classifiers for hepatotoxicity prediction in nonsteroidal anti inflammatory drugs (NSAIDs) through analyzing differential gene expression profiles of hepatotoxic and nonhepatotoxic compounds using HepG2 cell. $100\;{\mu}M$ of 8 hepatotoxic and 8 nonhepatotoxic NSAIDs were treated to HepG2 cell and the analysis of gene expression changes after 24 hallowed a set of genes to be identified differentiating hepatotoxicants from nonhepatotoxicants by statistical method. The hepatotoxicity prediction model was built using the selected 77 genes. These genes and pathways, commonly regulated by hepatotoxicants, may be indicative of the early characterization of hepatotoxicity and possibly predictive of later hepatotoxicity onset. 4 test compounds including hepatotoxic and nonhepatotoxic NSAIDs were used for validating the prediction model and the accuracy was 100%. Given that the specificity and sensitivity showed 100%, these are the most precise classifiers identified until now.

Sulfatase 1 mediates the attenuation of Ang II-induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats

Cha, Hye Ju,Kim, Hye Young,Kim, Hee Sun Elsevier 2018 Cytokine Vol.110 No.-

<P><B>Abstract</B></P> <P>Extracellular sulfatases, sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling and carcinogenesis. Chemokine CCL5 inhibits Ang II-induced hypertensive mediators via angiotensin II (Ang II) type 2 receptor (AT<SUB>2</SUB> R) pathway in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR). In this study, we investigated the effect of Sulfs on anti-hypertensive effects of CCL5 in SHR VSMCs. CCL5 attenuated Ang II-induced inhibition of sulfatase activity in SHR VSMCs. Inhibition of Ang II-induced 12-lipoxygenase (12-LO) and endothelin-1 (ET-1) expression by CCL5 was reduced in Sulf1 small interfering RNA (siRNA)-transfected SHR VSMCs. In addition, attenuation of Ang II-induced dimethylarginine dimethylaminohydrolase-1 (DDAH-1) inhibition by CCL5 was reduced in Sulf1 siRNA-transfected SHR VSMCs. Downregulation of Sulf2 did not affect inhibitory effects of CCL5 on Ang II-induced 12-LO and ET-1 expression and Ang II-induced inhibition of DDAH-1 expression in SHR VSMCs. Downregulation of Sulf1 abrogated the expression of CCL5-induced AT<SUB>2</SUB> R messenger RNA (mRNA) and synergistic effect of CCL5 on Ang II-induced AT<SUB>2</SUB> R expression in SHR VSMCs. These findings suggest that Sulf1 is a potential up-regulatory factor in anti-hypertensive actions of CCL5 via AT<SUB>2</SUB> R pathway on Ang II-induced hypertensive effects in SHR VSMCs.</P>

Association of the Folate Metabolism-related Gene Polymorphisms in Spontaneously Aborted Embryos with Abnormal Chromosomal Integrity

Hye Mi Park,Hye Jin Kim,Seung Joo Shin,Sun Hee Cha,Dong Hee Choi,Jung Jae Ko,Do Yeun Oh,Nam Keun Kim 한국유전학회 2007 Genes & Genomics Vol.29 No.3

The major reason for early spontaneous abortion is believed to be chromosomal abnormality. But the genetic etiologies are still largely unknown in aborted embryos with abnormal chromosomal integrity. MTHFR and TS proteins are key enzymes that modulate plasma levels of folate and homocysteine. We studied 25 spontaneously aborted embryos with abnormal chromosomal integrity at <20 weeks of gestational age, 317 adult controls and 100 child controls. Genotypes of MTHFR and TSER genes were analyzed by PCR-RFLP. The statistical analysis was performed by GraphPad Prism 4.0. The AC+CC genotype of MTHFR 1298A>C polymorphism was significantly different between abnormal chromosomal integrity group in spontaneously aborted embryos and child control. The two control groups and case group also exhibited significant differences in the combined MTHFR 1298/TSER genotype. In the present study, we found a relationship between folate metabolism-related gene polymorphisms and risk of spontaneously aborted embryos with abnormal chromosomal integrity in a Korean population.

CCL5 Inhibits Elevation of Blood Pressure and Expression of Hypertensive Mediators in Developing Hypertension State Spontaneously Hypertensive Rats

Hye Young Kim,Hye Ju Cha,Jin Hee Choi,Young Jin Kang,So Young Park,Hee Sun Kim 대한미생물학회 2015 Journal of Bacteriology and Virology Vol.45 No.2