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서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
정신분열병환자의 뇌량에 대한 신경병리적 고찰 : 확산텐서영상(Diffusion Tensor Image)기법의 적용
이경진,신용욱,하태현,이종민,김인영,김선일,문원진,정은철,박해정,오정은,박지영,강경훈,권기원,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4
Objectives : Diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue. It is particularly useful for evaluating white matter abnormalities. In this paper, we investigated the neuropathology of the corpus callosum in patients with schizophrenia through the new methods, diffusion tensor imaging. Methods : Diffuse tensor imaging was performed in 19 schizophrenic patients and 26 healthy controls. One complementary measure, fractional anisotropy (FA), which is considered to be sensitive indices of axonal integrity, was obtained from regions of interest in the five areas of the corpus callosum. Neuropsychological measurement also underwent for measurement of frontal lobe function in two groups. Results : There were no significant differences of FA in the DTI measures for either the schizophrenic patients compared with controls. FA was significantly decreased in women compared with men. Neuropsychological measurements such as Wisconsin card sorting test were correlated with FA of patients with schizophrenia. Conclusion : FA measures revealed no differences between schizophrenia and controls. The findings suggest that the structural integrity of white matter in patient with schizophrenia was not disrupted. The results are discussed in relation to previous studies reporting positive and negative findings. It is concluded that further studies using DTI in larger samples, improved and standardized methods of data acquisition and analysis are needed.
Ji Soon Sin,Su Youn Yim,Yeon Kyung Lee,Chul Kyu Kim,Byung Guk Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Chang Jun Bae,Jong-Min Woo,Sang Seop Kim,Mi Kyong Jang,Jung Sik Cho,Sung Man Kim,Chung Yeol Lee,K 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
Selenium and selenoprotein are tightly associated with the protective and antioxidant effects against damage induced by various metal ions in the kidney. Many effects of these kidney damage and stress are mediated by the mitogen-activated protein kinase signaling pathways. To investigate whether selenium treatment and selenoprotein M overexpression would impact on the mitogen-activated protein kinase pathway in the kidney, we detected the phosphorylation level of major components involving p38 kinase, c-jun N-terminal kinase and extracellular signaling-regulated kinase in the transgenic rat overexpressing human selenoprotein M gene. At first, western blot analysis showed that transgenic rats used in this study had the highly expression level of selenoprotein M in the kidney tissue, respectively. The phosphorylation level of p38 kinase was slightly increased in the wild-type rats of selenium-treated group, while did not change in the transgenic rats. Also, the phosphorylation level of c-jun N-terminal kinase was very similar with the change patterns of p38 kinase. Especially, extracellular signaling-regulated kinase was significantly inhibited in the selenium-treatment group. Furthermore, this inhibition rate of extracellular signaling-regulated kinase was stimulated by selenium M overexpression in the transgenic rats. These results suggest that the overexpression of selenoprotein M could effectively influenced the kidney cell proliferation, differentiation and apoptosis through the inhibition of extracellular signaling-regulated kinase in the kidney tissue of transgenic rat.
Preparation of Phosphine-Amido Hafnium and Zirconium Complexes for Olefin Polymerization
Jun, Sung Hae,Park, Ji Hae,Lee, Chun Sun,Park, Seong Yeon,Go, Min Jeong,Lee, Junseong,Lee, Bun Yeoul American Chemical Society 2013 Organometallics Vol.32 No.24
<P>Aniline (<I>N</I>-R-C<SUB>6</SUB>H<SUB>5</SUB>NH) and 1,2,3,4-tetrahydroquinoline (2-R-C<SUB>9</SUB>H<SUB>9</SUB>NH) derivatives were ortho-lithiated via conversion of the respective −NH groups to −N(COOLi), followed by treatment with <I>t</I>BuLi. The resulting ortho-lithiated compounds were transformed to <I>ortho</I>-Ph<SUB>2</SUB>P-substituted derivatives on treatment with Ph<SUB>2</SUB>P(OPh). Further reaction of the resulting compounds with M(CH<SUB>2</SUB>Ph)<SUB>4</SUB> (M = Zr, Hf) afforded a series of Hf and Zr complexes: (2-R-8-Ph<SUB>2</SUB>PC<SUB>9</SUB>H<SUB>9</SUB>N)Hf(CH<SUB>2</SUB>Ph)<SUB>3</SUB> (<B>8</B>, R = H; <B>9</B>, R = Me; <B>10</B>, R = <I>i</I>Pr; <B>11</B>, R = <I>n</I>Bu), (N-R-2-Ph<SUB>2</SUB>PC<SUB>6</SUB>H<SUB>4</SUB>N)Hf(CH<SUB>2</SUB>Ph)<SUB>3</SUB> (<B>12</B>, R = Me; <B>13</B>, R = Et; <B>14</B>, R = <I>i</I>Pr), (2-R-8-Ph<SUB>2</SUB>PC<SUB>9</SUB>H<SUB>9</SUB>N)Zr(CH<SUB>2</SUB>Ph)<SUB>3</SUB> (<B>15</B>, R = H; <B>16</B>, R = Me; <B>17</B>, R = <I>i</I>Pr; <B>18</B>, R = <I>n</I>Bu), and (N-R-2-Ph<SUB>2</SUB>PC<SUB>6</SUB>H<SUB>4</SUB>N)Zr(CH<SUB>2</SUB>Ph)<SUB>3</SUB> (<B>19</B>, R = Me; <B>20</B>, R = Et)]. X-ray crystallographic studies of <B>9</B>, <B>14</B>, <B>16</B>, and <B>19</B> revealed a distorted trigonal-bipyramidal structure with two benzyl moieties in equatorial positions and the remaining benzyl ligand occupying an apical position; in solution, however, three benzyl ligands became scrambled, as evidenced by a single set of benzyl signals in the corresponding <SUP>1</SUP>H NMR spectra. The complexes showed comparable activities (17–48 × 10<SUP>6</SUP> g/mol-M·h) to the Ti-based constrained geometry catalyst (CGC) (36 × 10<SUP>6</SUP> g/mol-Ti·h) in ethylene/1-octene copolymerization, despite their inferior 1-octene incorporation capabilities (3–8 mol % versus 17 mol %). Compound <B>15</B> showed a moderate 1-octene incorporation capability (7.7 mol %), whereas the others showed low 1-octene incorporations (2–4 mol %). Compounds <B>9</B> and <B>16</B> provided high-molecular-weight polymers with <I>M</I><SUB>w</SUB> > 200 000 even at high reaction temperatures of 100–130 °C.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orgnd7/2013/orgnd7.2013.32.issue-24/om400899g/production/images/medium/om-2013-00899g_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/om400899g'>ACS Electronic Supporting Info</A></P>
Ethyl pyruvate is renoprotective against ischemia-reperfusion injury under hyperglycemia
Jun, Ji Hae,Song, Jong Wook,Shin, Eun-Jung,Kwak, Young-Lan,Choi, Nakcheol,Shim, Jae-Kwang C.V. Mosby 2018 Journal of thoracic and cardiovascular surgery Vol.155 No.4
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Hyperglycemia (HG) is common in cardiovascular surgeries due to diabetes, inflammation, and the neuroendocrine stress response. HG aggravates renal ischemia-reperfusion (I/R) injury through an increased inflammatory response, and blunts the protective effect of various measures. Ethyl pyruvate (EP) provides anti-inflammatory effects against I/R injury via inhibition of high-mobility group box 1 protein (HMGB1) release. This study aimed to determine the renoprotective effect of EP against I/R injury under HG.</P> <P><B>Methods</B></P> <P>Sprague–Dawley rats were randomly assigned at random to 8 groups: normoglycemia (NG)-sham, NG-I/R-control, NG-EP-I/R (pretreatment), NG-I/R-EP (posttreatment), HG-sham, HG-I/R-control, HG-EP-I/R, and HG-I/R-EP. Renal I/R was induced by 45 minutes of ischemia (clamping of renal arteries), followed by 24 hours of reperfusion. EP (50 mg/kg) was administered intraperitoneally at 1 h before ischemia (pretreatment) or on reperfusion (posttreatment).</P> <P><B>Results</B></P> <P>I/R injury under HG significantly aggravated the degree of renal tubular apoptosis and damage compared with the NG groups, which could be attenuated by both pretreatment and posttreatment of EP. I/R-induced increases in HMGB1 and Toll-like receptors (TLRs), activation of NF-kB, and resultant alterations in interleukin-1β, tumor necrosis factor-α, proapoptotic Bax, and antiapoptotic Bcl-2 were all favorably modulated by EP treatment in both the NG and HG groups compared with their corresponding control groups.</P> <P><B>Conclusions</B></P> <P>Despite aggravation of renal I/R injury by HG through amplified inflammation, EP administration showed similar suppression of the HMGB1-TLR-NF-kB pathway in the HG and NG groups. EP retained anti-inflammatory, antiapoptotic, and renoprotective effects in the HG groups, whether administered before ischemia or on reperfusion.</P>
Ji Hae Jun,Jung Hyun Kwon,Kyeong Ho Chung 한국원예학회 2007 Horticulture, Environment, and Biotechnology Vol.48 No.4
S-genotypes of Japanese plums (Prunus salicina Lindl.) were determined by polymerase chain reaction (PCR) and cross-pollination tests. Three sets of consensus primers designed from Prunus S-RNases were used to amplify fragments containing the first and the second S-RNase intron, respectively. When the results obtained from the three PCRs were combined, 12 S-genotypes, corresponding to our results and 32 new S-genotypes were found in the 44 cultivars used. Several cultivars had the same S-genotypes. Cross-pollination tests revealed that there was cross-incompatibility between the cultivars with the same S-genotypes. These results might be very useful for growers for effective pollination and for breeders using these in cross breeding programs.
Identification of RAPD and AFLP Markers Linked to the Fruit Acidity Gene D in Peach (Prunus persica)
Ji Hae Jun,Kyeong Ho Chung,Sang Bouk Jeong,Hee Jae Lee 한국원예학회 2005 Horticulture, Environment, and Biotechnology Vol.46 No.1
The fruit acidity is a very important characteristic to select promising seedlings in peach breeding programs. Bulked segregant analysis (BSA) with randomly amplified polymorphic DNA (RAPD) analysis was performed to detect markers linked to D gene using F₁ seedlings of low acid ‘Yumyeong’ × low acid ‘Baekhyang’. One RAPD marker coupled to D allele, designated as UBC423₂₁??, was identified from 578 decamer primers examined. In addition, BSA with amplified fragment length polymorphism (AFLP) analysis of this progeny was performed to detect markers tightly linked to D gene. One AFLP marker, EAA/MCAC₃₃?, was identified through the 168 primer combinations tested. The co-segregation of two markers and D/d locus was verified in the 96 individuals of the F₁ progeny of ‘Yumyeong’ × ‘Baekhyang’. The markers UBC4232100 and EAA/MCAC₃₃? were found to be located at 22.1 and 1.1 cM, respectively, on the same side of the D/d locus. The tightly linked marker, EAA/MCAC₃₃?, was attempted to be converted to a sequence characterized amplified region (SCAR) marker. However, this marker could not be converted to SCAR marker. Although polymorphic SCAR could not be developed in the present study, the AFLP marker EAA/MCAC₃₃? could be useful for discriminating seedlings with high fruit acidity from peach seedlings at early developmental stage of the trees.