중심성 전정병변: 해부학 및 영상소견

문원진 대한평형의학회 2010 Research in Vestibular Science Vol.9 No.-

Vertigo, one of the most common complaints in medicine, is caused by asymmetric involvement of vestibular system. While peripheral vestibular lesion involves the semicircular canals, the otoliths, and the vestibular nerve, central vestibular lesion affects the vesibular nuclear complex (medial, lateral, superior and inferior), vestibulocerebellum, brain stem, spinal cord and vestibular cortex. Cerebrovascular disorders related to the vertebrobasilar arteries, migraine, multiple sclerosis, tumors of the posterior fossa as well as neurodegenerative disorders are the underlying etiologies of central vesibular lesions. This lectures reviews anatomy of central vestibular structures and imaging findings of some central vestibular disorders, with emphasis on magnetic resonance imaging (MRI).

만성 간질환에서의 T1-201 경직장 문맥 신티그라피 : T1-201 섭취 지표의 평가 Assessment of Tl-201 Uptake Indices

문원진,최윤영,조석신,이민호 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.1

Purpose: Heart to liver ratio on T1-201 per rectal scintigraphy (shunt index) is known to be useful in the assessment of portal systemic shunt. We assessed T1-201 uptake pattern and early liver/heart uptake rate of T1-201 and correlated with shunt index in patients with chronic active hepatitis (CAH) and liver cirrhosis (LC). Materials and Methods: Fifty eight patients with biopsy-proven chronic liver disease (35 with CAH, 23 with LC) underwent T1-201 per rectum scintigraphy after instillation of 18.5 MBq of T1-201 into the upper rectum. We evaluated hepatic uptake (type 1: homogeneous, 2: inhomogeneous segmental, 3: inhomogeneous nonsegmental) and extrahepatic uptake of spleen, heart and kidney (grade 0: no uptake, 1: less than liver, 2: equal to liver, 3: greater than liver). We measured the early liver/heart uptake rate (the slope of the liver to heart uptake ratio for 10 min) and shunt index (heart to liver uptake ratio). T1-201 uptake pattern and early liver/heart uptake rate of T1-201 was correlated with the pathologic diagnosis and shunt index. Results: Hepatic uptake patterns of type 1 and 2 were dominant in CAH (CAH: 27/35, LC: 8/23), and type 3 in LC (CAH: 8/35, LC: 15/23) (p<0.005). The grades of extrahepatic uptake were higher in LC than in CAH (spleen: p<0.001, other soft tissue: p<0.005). The early liver/heart uptake rate of CAH (0.110±0.111) was significantly higher than that of LC (0.014±0.090) (p<0.001). The sensitivity and specificity of the early liver/heart uptake rate were 77.7% and 67.7% in differentiating LC from CAH. There was negative correlation between early liver/heart uptake rate and shunt index (r=-0.3347, p<0.01). Conclusion: Hepatic and extrahepatic uptake pattern and early liver/heart uptake rate on T1-201 per rectum scintigraphy are useful in the assessment of portal systemic shunt in patients with chronic liver disease.

Fe-Si-Mn-P강판의 초기조직변화가 잔류오스테나이트 형성 및 인장성질에 미치는 영향

문원진,강창용,김한군,김기돈,성장현 ( Won Jin Moon,Chang Yong Kang,Han Goon Kim,Ki Don Kim,Jang Hyun Sung ) 한국열처리공학회 1997 熱處理工學會誌 Vol.10 No.1

This study has been conducted to investigate the effects of initial structure on the microstructure and tensile properties of high strength trip steel sheet. The initial structure before austempering remarkably influenced the second phase. The specimen with normalized initial structure showed mainly bainitic ferrite and retained austenite, while the as rolled specimen and spherodized specimen showed martensite plus retained austenite and martensite plus bainitic ferrite with small retained austenite, respectively. Two type of retained austenite, film type and granual type were observed in all specimens. The as rolled specimen appeared the highest contents of retained austenite owing to the compressive stress by cold rolling. The contents of retained austenite increased with increasing intercritical annealing temperature and austempering time. Tensile strength showed the highest in the as rolled specimen, while the highest elongation were obtained in the normalized specimen. The maximum T.S.×El. Value showed in normalized initial structure and increased with increasing intercritical annealing and austempering time. The highest Value of T.S.×El. obtained at austempering temperature of 400℃ and retained austenite of 12%.

Diffusion-Weighted Imaging with Sensitivity Encoding (SENSE) for Detecting Cranial Bone Marrow Metastases: Comparison with T1-Weighted Images

문원진,Min Hee Lee,정은철 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.3

Objective: This study was designed to determine whether diffusion-weighted imaging (DWI) with sensitivity encoding (SENSE) could detect bone marrow involvement in patients with cranial bone marrow (CBM) metastases. DWI results obtained were compared with T1-weighted imaging (T1WI) findings. Materials and Methods: DWI with sensitivity encoding (SENSE; b value = 1,000) was performed consecutively in 13 patients with CBM metastases diagnosed pathologically and radiologically. CBM lesions were dichotomized according to the involved site, i.e., skull base or calvarium. Two radiologists qualitatively evaluated the relative conspicuousness of CBM lesions and image qualities in B0 and in isotropic DWI and in T1WI. According to region of interest analysis of normal and pathologic marrow for these three sequences, absolute signal difference percentages (SD%) were calculated to quantitatively analyze lesion contrast. Results: All 20 lesions in 13 patients with CBM metastases revealed abnormal DWI signals in areas corresponding to T1WI abnormalities. Both skull base and calvarial lesions provided better lesion conspicuousness than T1WI and B0 images. Although the image quality of DWI was less satisfactory than that of T1WI, relatively good image qualities were obtained. Quantitatively, B0 images (SD%, 82.1 7.9%) showed better lesion contrast than isotropic DWI (SD%, 71.4 13.7%) and T1WI (SD%, 65.7 9.3%) images. Conclusion: For scan times of less than 30 seconds, DWI with SENSE was able to detect bone marrow involvement, and was superior to T1WI in terms of lesion conspicuity. DWI with SENSE may be helpful for the detection of cranial bone/bone marrow metastases when used in conjunction with conventional MR sequences.

A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson’s Disease Dementia, Alzheimer’s Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging

문원진,박주연,Won-Sung Yun,전지영,문연실,Heejin Kim,곽기창,Jong-Min Lee,한설희 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.5

Objective: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted highresolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson’s disease dementia (PDD), Alzheimer’s disease (AD) and age-matched controls. Materials and Methods: This retrospective study enrolled 10 patients with PDD, 18 patients with AD, and 13 age-matched healthy elderly controls. MR imaging was performed at 3 tesla. To measure the T1 hyperintense area of SN, we obtained an axial thin section high-resolution T1-weighted fast spin echo sequence. The volumes of interest for the T1 hyperintense SN were drawn onto heavily T1-weighted FSE sequences through midbrain level, using the MIPAV software. The measurement differences were tested using the Kruskal-Wallis test followed by a post hoc comparison. Results: A comparison of the three groups showed significant differences in terms of volume of T1 hyperintensity (p < 0.001, Bonferroni corrected). The volume of T1 hyperintensity was significantly lower in PDD than in AD and normal controls (p < 0.005, Bonferroni corrected). However, the volume of T1 hyperintensity was not different between AD and normal controls (p = 0.136, Bonferroni corrected). Conclusion: The volumetric measurement of the T1 hyperintensity of SN can be an imaging marker for evaluating neuromelanin loss in neurodegenerative diseases and a differential in PDD and AD cases.

냉각제어된 Fe-Si-Mn-P 고장력 강판의 미세조직 및 기계적성질

문원진,김익수,강창용,성장현,김기도 ( Won Jin Moon,Ik Su Kim,Chang yong Kang,Jang Hyun Sung ) 한국열처리공학회 1997 熱處理工學會誌 Vol.10 No.2

Microstructure and mechanical properties of Fe-Si-Mn-P high strength steel sheet have been investigated by controlling the cooling rate. Bainite and ferrite were obtatined by annealing in the ferrite pluse austenite region, and ferrite and austenite were obtatined after annealing in the fully austenite region. Ferrite and pearlite were obtained when the cooling rate was controlled from the annealing temperature above 760℃ and bainite showed with increasing cooling rate, however below 760℃ ferrite and bainite were obtained. Tensile strengths and hardness nearly unchanged with increasing cooling rate after control the cooling rate from the temperature above 760℃, while tensile strengths increased and elongation decreased with increasing cooling rate when the cooling rate was controlled from the tempeature below 760℃. Without regard to annealing temperature, tensile strength increased and elongation decreased with increasing cooling rate. Tensile strengths and elongation values heat treated in the ferrite plus austenite region were higher than those in the fully austenite region. Retained austenite and strength-elongation balance showed the maximum value at 780℃ and decreased with increasing annealing temperature. Strength-elongation balance value was controlled by the retained austenite.

Fluid-Attenuated Inversion Recovery Hypointensity of the Pulvinar Nucleus of Patients with Alzheimer Disease: Its Possible Association with Iron Accumulation as Evidenced by the T2* Map

문원진,김희진,노홍기,최진우,한설희 대한영상의학회 2012 Korean Journal of Radiology Vol.13 No.6

Objective: We hypothesized that prominent pulvinar hypointensity in brain MRI represents the disease process due to iron accumulation in Alzheimer disease (AD). We aimed to determine whether or not the pulvinar signal intensity (SI) on the fluid-attenuated inversion recovery (FLAIR) sequences at 3.0T MRI differs between AD patients and normal subjects, and also whether the pulvinar SI is correlated with the T2* map, an imaging marker for tissue iron, and a cognitive scale. Materials and Methods: Twenty one consecutive patients with AD and 21 age-matched control subjects were prospectively included in this study. The pulvinar SI was assessed on the FLAIR image. We measured the relative SI ratio of the pulvinar to the corpus callosum. The T2* values were calculated from the T2* relaxometry map. The differences between the two groups were analyzed, by using a Student t test. The correlation between the measurements was assessed by the Pearson’s correlation test. Results: As compared to the normal white matter, the FLAIR signal intensity of the pulvinar nucleus was significantly more hypointense in the AD patients than in the control subjects (p < 0.01). The pulvinar T2* was shorter in the AD patients than in the control subjects (51.5 ± 4.95 ms vs. 56.5 ± 5.49 ms, respectively, p = 0.003). The pulvinar SI ratio was strongly correlated with the pulvinar T2* (r = 0.745, p < 0.001). When controlling for age, only the pulvinar-to-CC SI ratio was positively correlated with that of the Mini-Mental State Examination (MMSE) score (r = 0.303, p < 0.050). Conversely, the pulvinar T2* was not correlated with the MMSE score (r = 0.277, p = 0.080). Conclusion: The FLAIR hypointensity of the pulvinar nucleus represents an abnormal iron accumulation in AD and may be used as an adjunctive finding for evaluating AD.

Ultrasonography and the Ultrasound-Based Management of Thyroid Nodules: Consensus Statement and Recommendations

문원진,백정환,정소령,김동욱,김은경,김지영,곽진영,이정현,이준형,이영흔,나동규,박정선,박선원 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.1

The detection of thyroid nodules has become more common with the widespread use of ultrasonography (US). US is the mainstay for detecting and making the differential diagnosis of thyroid nodules as well as for providing guidance for a biopsy. The Task Force on Thyroid Nodules of the Korean Society of Thyroid Radiology has developed recommendations for the US diagnosis and US-based management of thyroid nodules. The review and recommendations in this report have been based on a comprehensive analysis of the current literature, the results of multicenter studies and from the consensus of experts.

Soft Tissue Sarcoma of the Head and Neck

문원진 대한두경부종양학회 2007 대한두경부종양학회 학술대회 논문집 Vol.2007 No.1

고실 경화증 : 방사선학적 소견과 수술소견의 비교

문원진,박동우,이승로,성진용,송순영,함창곡,김용수,박충기,태경,Moon, Won-Jin,Park, Dong-Woo,Lee, Seung-Ro,Seong, Jin-Yong,Song, Soon-Young,Hahm, Chang-Kok,Kim, Yong-Soo,Park, Choong-Ki,Tae, Kyung 대한영상의학회 1998 대한영상의학회지 Vol.38 No.2

Purpose: Tympanosclerosis is a common problem causing conductive hearing loss accompanied by chronic otitismedia. The purpose of this study was to evaluate the CT findings of tympanosclerosis, and correlate them with thesurgical findings. Materials and Methods: The CT scans of 17 patients with surgically-proven tympanosclerosis andthose of a control group of 34 patients with nontympanosclerotic chronic otitis media were reviewed. According totheir location, they were assigned to one of three groups; tympanic membrane, epitympanum, or ossicles. Results:Tympanosclerosis was found during surgery to be located in the tympanic membrane (n=11), the epitympanum (n=6), oraround the ossicles(n=8). Calcification of the tympanic membrane, ossicular thickening, narrowing of theepitympanum and calcification of the tympanic cavity occurred to a significant extent, and were more often afeature of tympanosclerosis than of nontympanosclerotic chronic otitis media (p<0.05). As an indicater of tympanicmembrane involvement, sensitivity and specificity of calcification of the tympanic membrane were 73% and 83%,respectively. As an indicator of ossicular involvement, the corresponding figures for ossicular thickening were50% and 93% ; as an indicator of involvement of the tympanic cavity (especially the epitympanum) the figures fornarrowing of the epitympanum and calcification of the tympanic cavity were 50% and 50% (respective sensitivities),and 89% and 93%(respective specificities). Conclusion: Tympanosclerosis usually appears on CT as ossicularthickening, narrowing of the epitympanum, calcification of the tympanic membrane and/or tympanic cavity. CT isvery helpful in evaluating ossicular involvement and determining the appropriate surgical treatment oftympanosclerosis.