갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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Na-K-ATPase 活性度에 對한 Cyclophosphamide의 影響

柳志明,金光鎭 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1

The sodium and postassium ion-stimulated adenosine triphoshatase(Na-K-ATPase) is the membrane-embedded enzyme responsible for the active transport of sodium and potassium ions through the cell membrane. And this enzyme is an electrogenic pump, transporting 3Na^+ for 2K^+, and is specifically inhibited by the cardiac glycoside, ouabain. Cyelophosphamide to be be used in chemotherapy of neoplastic disease, is generally useful in the treatment of lymphomas, acute lymphocytic leukemia in children, and some solid tumors. This study was attempted to investigate the effects of cyclophorphamide on Na-K-ATPase activity in the red cell ghosts of the rabbits. The results are summarized as follows. 1. Na-K-ATPase activity was significantly inhibited by cyclophosphamide at dose of 20.Omg/ml. 2. Ginseng water extract was significantly decreased the inhibited degree of Na-K-ATPase activity by cyclophosphamide. 3. Mg-ATPase had not any effect under the presence of cyclophosphamide with Ginseng extract or not. From the above results, it suggested that cyclophosphamide inhibited directly Na-K-ATPase activity and ginseng water extract enhanced the inhibited the enzymatic activity.

중학교 가정과 '인간발달과 가족관계' 영역의 교육자료 (CD-Rom) 개발 및 현장 적용 연구 : 실천적 추론 수업을 중심으로

유태명,장혜경,유지연,김주연,김항아,김효순 한국 가정과 교육 학회 2000 한국가정과교육학회지 Vol.12 No.3

The purpose of this study is to develop lesson plans. teaching guide, and teaching materials applying practical reasoning teaching model in the area of 'human development and family relationship' in middle school home economics. The practical reasoning teaching model consists of five factors: Desired results, Awareness of context. Alternative approaches, Consequences of action, and Action. This study based on practical reasoning has following process: Curriculum development, Developing lesson plan. teaching material, and teaching guide. Experimental teaching and evaluation, Feedback, Production of CD-Rom. Teaching guide includes lesson Plan. workbook, multimedia materials and teaching resources, Especially teaching guide in CD-Rom can be used effectively in the actual teaching. In the classroom, this teaching model accomplished active and interesting Participation of teachers and students. It is proposed that practical reasoning teaching model should be applied to other areas of home economics. In addition, various teaching materials based on Practical reasoning need to be developed.

토양환경지도 자료를 이용한 콩밭 토양의 화학성 비교

박지숙,이민진,정재원,김미혜,이서연,지윤미,한준호,김유학,공명석,한광현,노희명 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

It is important to interpret the soil chemical properties in order to effectively manage the farmland. This study was conducted to investigate the soil chemical properties of upland soybean field according to the soil series at 32 upland fields located in the parts of Gangwon-do. Soil sampling sites were selected by using the National Statistics DB and KSIS DB that is a soil environment information system provided by the Rural Development Administration. Soil samples were collected from 0~15 cm of top soil before seeding or transplanting, air-dried, passed through a 2 mm sieve, and analyzed for soil pH, EC, organic matter, available phosphorus (P2O5), exchangeable potassium, exchangeable calcium and exchangeable magnesium. The average chemical properties have exceeded the each nutrient optimum range level of RDA, except the organic matter in experimental soil 2015. And despite application of conventional fertilization, each soil series nutrient contents were change respectively. The results of this study suggest that conventional fertilization should be applied based on the analysis about the amount of accumulated nutrient contents in the soil.

십우도(十牛圖) 단계를 활용한 미술치료프로그램이 중년여성의 영성에 미치는 효과

유지명 서울여자대학교 여성연구소 2014 여성연구논총 Vol.29 No.-

The purpose of this study is to validate the effect of art therapy programs using the stages of Shipwoodo on spirituality of middle aged women. Thus, this study presented the research question on the effects of art therapy program using stage of Shipwoodo based on theories of Shipwoodo, art therapy, spirituality on spirituality and tree test representing in-depth self image of middle aged women. The subjects were middle aged women who were recruited through announcements on the homepage of a child development center in A city. Eight subjects who answered only the survey were assigned to a control group and six subjects who wanted to participate in the program were assigned to a test group .Pre-tests of spirituality and the tree test were performed. A total of 14 sessions of the art therapy program using the stages of Shipwoodo were given to a test group. Any treatment was given to a control group. In order to examine the effects on research question after treatment, post-tests were performed with spirituality and tree test. Mixed ANOVA was performed to validate the effectiveness of the program by using SPSS v12.0 statistical package program. As the results of this study, spirituality was significantly increased in a test group experiencing art therapy using the stages of Shipwoodo than those in a control group. In the tree test, internal resources and core emotions, maturity of personality, ability to cope with reality and major desires could be identified. According to results of the tree test, contents analyzed based on sub-factors of spirituality in terms of representation of essential parts of a tree, balance, size, writing pressure and quality of lines, attitude of the picture and contents of picture were positively changed. Thus, it was found that the practical experience representing self-image, life and the process of re-awareness, opening the self, exchanging the information and communicating with others within a group using art with concept, understanding the structure of actions of mind and process of changes in self-awareness was effective on improvements on spirituality. On the other hand, the total score for spirituality was significantly improved in a test group compared with that in the pre-test, but among sub-factors of spirituality, the awareness was not significantly changed. Since awareness of spirituality is to recognize and experience the important internal and external incidents occurring in self environment, there are limitations to achieve significant change through a short-term program. This study is significant, since it shared the tendency and context of recent counseling and psychotherapy studies and developments in the therapy model appropriate for Oriental culture and emotion and it presented the program appropriate for developmental characteristics of middle aged women in art therapy as the measure to establish the internal environment appropriate to get over psychological crisis and pursue true happiness in the process of development of middle aged women.

가상환경을 위한 효율적인 3차원 협동 저작 기법

최명아,차지은,유지현,엄성용 서울여자대학교 컴퓨터과학연구소 2003 정보기술논문지 Vol.1 No.-

In this paper, we propose a new 3-dimensional cooperative authoring tool the environments. In this method, we clearly define the roles of authors Involved In the cooperation and extend the functionality of the each client system, and thus reducing the overload in server systems and/or the network bottleneck than existing client-server models, while minimizing the locking delays of the existing pessimistic locking mechanism. In addition, we use scene-graphs of Java 3D to represent the rapidly changing scenes vividly 본 논문에서는 새로운 3차원 협동 저작 기법에 대해 설명한다. 이 방법에서는 협동 저작에 참여하는 작업자에 대한 명확한 역할 구분과 클라이언트의 기능 확장을 통해, 기존의 클라이언트-서버 구조가 갖는 서버 부담 및 네트워킹 병목 현상을 완화하는 한편, 기존의 '비관적 잠금 기법'에서 발생하는 작업 공유에 따른 불필요한 대기 시간을 줄인다. 또한 자바 3D의 '장면 그래프'를 이용하여 장면을 표현함으로써 실시간 장면 정보의 변화를 빠르고 쉽게 반영하였다.

중학교 가정교과의 열린교육 활성화를 위한 수업 모듈 및 웹 기반 교육자료 개발

신상옥,유태명,한규정,윤지현,홍정숙,김유정,양정혜 한국 가정과 교육 학회 2000 한국가정과교육학회지 Vol.12 No.3

This study is about open and secondary level Home Economics Education which is applicable to field and which includes the characteristics, purpose and problems of each open education. secondary education and home economics education. Based on the ideology of open education, this study will identify the meaning of openness in terms of Home Economics Education reconstructing meaning. purpose, characteristics, curriculum paradigm and curriculum. The instructional model and module which use web, will be Presented as the results of the reconstruction works. The open instructional module in Home Economics Education, which will be operated on the web, is consisted of 1)setting the orientation of curriculum development, 2)instructional model development. 3)rebuilding the Home Economics Education curriculum 4)development of instructional modules and web-based materials and 5)construction of the web-site . Six instructional module begin with critical/emancipatory curriculum Paradigm in open Home Economics Education. use module as a unit of class management instead of 1 class. facilitates nest-type integration which is applied from open education keeping the nature of Home Economics Education. and focus on practical problem and problem solving through reconceptualization with dialectical perspective on individual, family and society. The practical problem solving model has four steps : Identifying practical problems. Understanding the contexts of Problem, Searching for solutions and examining its consequences . Action and evaluation . The web-site has to be developed based on the six instructional module includes those issues : self-identification for reinforcing autonomy and self-esteem. living with famity. living with friends, autonomous living. healthy living, and understanding sexuality.

정신분열병의 유전적 고위험군에서 인지, 정서 및 사회기능 연구

이경진,위휘,유소영,이애라,송지연,하태현,홍경수,김명선,권준수 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : Vulnerability marker in biological relatives of schizophrenia may be very useful in identifying the propensity for the development of schizophrenia. This study suggests that the relatives at risk for genetically developing schizophrenia have impairments in several domains of cognition, social function and affective function as a vulnerability marker. Methods : A neurocognitive function test, a social function test and an affective function test were administered to fifteen healthy relatives from families with two or more patients with schizophrenia (geneticallly high risk subjects). Fifteen healthy controls matched for age and gender were recruited in this study. Results : Compared to the control subject, the genetic high risk subjects performed significantly more poorly in the selective attention and recall memory of neurocognitive function. The high dsk subjects also had lower scores in independence-performance and independence-competence of the social function test and emotion control of the affective function test. Conclusion : Selective attention, recall memory, independence-performance, independence-competence and emotion control ability may be a valuable marker for genetic study of schizophrenia.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

Two Cases of Norovirus Gastroenteritis Associated with Severe Neurologic Complications

Myung Ji Yoo(Myung Ji Yoo),Dong Jun Ha(Dong Jun Ha),Dong Hyun Kim(Dong Hyun Kim),Young Se Kwon(Young Se Kwon) 대한소아신경학회 2022 대한소아신경학회지 Vol.31 No.1