동진강 수계 농업용수 수질평가

한수곤,최정식,문영훈,엄미정,김갑철 한국환경농학회 2000 한국환경농학회지 Vol.19 No.2

동진강 수계의 수질현황을 파악하기 1994∼1998년 까지 4∼9월에 월 1회에 걸쳐 5개년간 조사한 결과를 요약하면 다음과 같다. 월별로는 빗물에 의한 희석효과로 7, 8월에 수질이 가장 양호하였으며, 4월이 다소 불량하였으나 수도생육 피해 한계농도에는 미치지 못하는 수준이었다. 지점별 수질현황은 생활하수 유입지인 정읍천과 지천의 폭이 좁은 원평천의 무기성분 함량이 높았으며 동진천 상류지역에서 가장 양호하였다. 연도별 현황은 '94년 이후 '95년까지는 수질이 악화되는 경향을 보였으나 '95년 이후로는 각 성분 함량이 낮았지는 등 점점 양호해지고 있으며 COD함량으로 볼 때 특히, 정읍천의 수질이 개선되고 있음을 알 수 있었다. 양이온과 음이온의 총당량온 4월에 가장 높았고 7, 8월에 가장 낮았으며 양이온/음이온의 당량비는 5월에 높았고 7월이 가장 낮았으며 지점에 따라서는 총당량은 정읍천, 원평천, 동진천 하류, 중류, 상류의 순위였으며 양이온/음이온 총당량 비율은 원평천이 상대적으로 작은 수치를 보였지만 지역간 큰 차이는 보이지 않았다. 수질 중 각 성분 상호간의 상관관계를 보면, 대개의 성분 상호간에 유의성이 높게 나타났으나, NO₄^--N는 대개의 성분과 유의성이 없었고, PO₄^(3-)-P도 COD, NH₄^+-N, NO₃^--N, SO₄^(2-)과는 유의성을 보이지 않았다. This study was conducted to monitor the irrigation water qualities along Dong-Jin river watershed. The water quality was surveyed at 6 sites from April to september during 1994∼1998. And the results were as follows : In July and August, water quality was better than that of any other months due to dilution with rainwater. Whereas, it became worse in April but it involved lower contents than limitted contents affected to the crop damage. Content of inorganic components was higher at Jeong-up and Won-pyeong stream. The reason for it that Jeong-up stream was deteriorated with sewage water from Jeong-up city, and Won-pyeong stream has narrow width. Water quality in upstream of Dong-Jin river, was evaluated best conditions in all sampling sites. For investigated period, water quality got worse from 1994 to 1995 but it was getting better to 1998 after 1995, especially at Jeong-up stream. The total equivalent of cation and anion was the highest at April through all months and at Jeong-up stream in sampling sites. Equivalent ratio of cation to anions(∑C/∑A) was higher at May than any other months and lower at Won-pyeong streams than any other sites. The value of most inorganic components was highly correlated with those of other components. But the value of NO₃^--N was not correlated with that of most components, and PO₄^(3-)-P was not correlated with COD, NH₄^+-N, NO₃^--N, SO₄^(2-_.

G-CSF로 체내 증폭된 골수를 이용한 동종 조혈모세포이식

이종욱,김정아,민창기,김희제,엄현석,박수정,서정곤,김동욱,홍영선,민우성,김춘추,김동집 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.2

연구배경: 이식시 주입되는 골수세포수는 생착 속도 및 생존율과 밀접한 관계가 있으나, 임상적으로 환자의 체중이 공여자에 비해 지나치게 많을 때 단위 체중당 환자에게 주입되는 세포의 양이 적어 문제가 될 수 있다. 방법: 저자들은 가톨릭 조혈모세포이식 센터에서 동종 골수이식을 시행한 환자들 중 환자의 체중이 공여자에 비해 10kg이상 많은 경우 골수 채취 전에 공여자에게 3일간 피하로 G-CSF(10ug/kg/day)를 투여하여 골수를 체내(in vivo) 증폭시킨 후 골수이식을 시행한 25예의 환자를 대상으로 고식적인 방법으로 골수이식을 시행한 위험인자가 일치되는 대조군과 비교하여 이식된 세포수, 혈구의 회복속도 및 이식편대 숙주반응(GVHD)의 발생율, 그리고 생존율 등을 비교 분석하였다. 결과: 단기간의 G-CSF 투여로 증폭된 골수의 총 유핵세포수, 단핵구수는 대조군에 비해 3-5배, CD34 + 세포수는 6배 증폭되었으며, 두 군간에 세포의 면역표현형(CD4, CD5, CD7, CD8, CD20)의 차이는 없었다. 중성 백혈구 수가 0.5×10^(9)/L 이상 회복되는 시기는 두 군간의 차이가 없었으나(15.5일 vs 16일; p=0.131), 혈소판 수가 30×10^(9)/L 이상으로 회복되는 시기는 G-CSF 투여군에서 의의있게 단축되었다(20일 vs 26일; p=0.013). 두 군간 급성 및 만성 GVHD의 발생률과 정도의 차이는 없었으며, 이식 후 재발 및 생존율의 차이도 없었다. 결론: 이식전 공여자에게 단기간 G-CSF를 주사하여 생체내에서 골수 조혈모세포를 증폭시킨 후 이식하는 방법은 공여자와 환자의 심각한 체중 차이로 인해 단위체중당 이식되는 조혈모세포양이 부족한 환자들에게 안전하고 유용한 방법일 뿐만 아니라 GVHD의 증가 없이 빠른 혈구회복을 기대할 수 있는 이식기법이라고 생각한다. 향후 증폭된 골수 조혈모세포의 특성 연구 및 이의 효용성을 확인하기 위한 전향적인 연구가 필요하리라고 생각된다. Background: Sufficient stem cell doses are necessary to overcome engraftment failure in allogeneic bone marrow transplantation(BMT). Cell doses harvested may depend on body weight (BW) difference between donor and recipient. In practice, it is important to achieve large number of stem cells from donor who were lower BW than that of recipient. Methods: We have tried to inject G-CSF(10ug/kg/day) subcutaneously for 3 days to the allogeneic donor with lower BW than recipient before harvest to increase BM inoculum. BM was infused into patients without any manipulation on day 5. A total 25 patients were enrolled; 12 AML, 6 ALL, 5 SAA and 2 CML(expansion group). We compared the expansion group with 25 historical control patients, matched for diagnosis and clinical characteristics, who underwent unprimed BMT. Results: Recipient BW is not different between the expansion and control group. However, allogeneic donors in the control group weigh heavier than those in the expansion group. The yield of TNC, MNC, and CD34^(+) cells from G-CSFprimed BM was significantly higher than that from unprimed BM. There was no difference in immunophenotyping analysis(CD4, CD5, CD7, CD8, CD20) between two groups. The median time reaching to absolute neutrophil count more than 0.5×10^(9)/L was not different(15.5 vs 16 days: p=0.131), but time to platelet recovery more than 30×10^(9)/L was significantly shorter for the patients who received G-CSF-primed BM (20 vs 26 days: p=0.013). There was no difference in the incidence of acute and chronic GVHD, relapse rate and overall survival between the two groups with a median follow-up of 13 months. Conclusion: These data suggest that the short-term administration of G-CSF to an allogeneic donor prior to BM harvest seems to be a feasible method to achieve an adequate number of cell doses for patients who weigh higher than donors. Randomized, prospective study is needed to evaluate the efficacy of allogeneic BMT using in vivo expansion of BM by G-CSF.

高麗 前期의 救恤 政策에 관한 硏究

金玎坤 진주교육대학교 1979 論文集 Vol.19 No.1

This study is an attempt to discover some aspects of the relief policy of the early Koryo period as a part of the study of the entire history of the Korean relief policy. The main sources of information here are from Koryosa (the History of Koryo), and Koryosa-jeolyo (the Concise History of Koryo). The relief policy in Korea has based on the belief of Heaven's Repremand, Confucianism, Buddhism, Taoism, the thought of Five Elements, Geomancy, etc. It seems remarkable that the thought of Five Elements and Geomancy were the thoughts behind the welfare policy in theearly Koryo period. The policy was generally put into practice directly in response to natural calamities, famine, disease, war, extortion, major national functions, affairs about the royal household, and such things. Among natural disasters damage from drought was most common cause for implementation of the policy. In this respect, it was the same as had been during the Three Kingdoms and the United Silla period. During the early Koryo period, however, there were frequent invasions of the Kiltan and the Jurchen, and the relief policy was mainly for the purpose of helping soldiers, especially the people who lived near the border, and the bereaved families of the war dead. The government authorities took care to save people from the extortion by some corrupt local officials. The policy was sometimes enacted by the direction of the King, and sometimes by the request of Jungseo-seong, Munhaseong, Sangseo-seong, Samsa, Gamchang-sa, Anchal-sa, Do-byongma-sa, Yusa, etc. Through the policy, they helped people in need by providing grain, cloth, food, medcine, medical treatment, and so forth, or by exemption from taxation, compulsory labor, and punishment. People were helped by such a variety of food as salt, soy, gruel, vegetable, etc. The exemption of taxation and labor was determined according to the degree of calamity, and the duration of the exemption varied between half a year and three years. The procedure of giving an account of the calamity to the Governments authorities was very systematic. It was not until King Seongjong in the early Koryo period that they began to help poor patients by providing medcine or medical trearment. It can be observed that the relief policy was arranged to become more concrete, varied, systematic, and consistent in the early Koryo period than it had been in Three Kingdoms and in the United Silla Period. The administrators made clear the applications of talc policy: they exempted the duty of labor and grain depending on the degree of the calamity, helped patients with medcine or medical treatment, provided food, exempted debt. They adapted the policy according to the needs of the seasons. The fact that Heuck-chang in the King Taejo period, Eui-chang and Sangpyong-chang in the King Seongjong period, and Guje-dogam and Hyemin-guk in the King Yejong period were all launched in the early Koryo period will provide evidence of the organization and formalization of the policy. All of these facts mean that during the early Koryo period the relief policy changed to be more effective one in helping people in need more quick1y and consistently and without failure than the relief policies of the previous ages.

기니픽에서 Magnesium의 혈관 이완과 혈압 하강 효과

김정곤,강형섭,김진상 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.2

The present study evaluated the effects of various agents on magnesium sulfate (Mg^(2+))-induced relaxation in aorta and blood pressure lowering in anesthetized guinea pigs. Mg^(2+) inhibited phenylephrine (PE)- or 40 mM KC1-induced sustained contraction of endothelium-intact (+E) guinea pig aortic rings in concentration-dependent manner. In preparations preconstricted with PE or KC1, Mg^(2+)-induced concentration-dependent relaxations. In preparations preconstricted with PE or KCl, Mg^(2+)-induced relaxations were not affected by the removal of endothelium (-E) and by the pretreatment of aortic rings with NO synthase (NOS) inhibitors (L-NAME and LNNA), guanylate cyclase inhibitors (methylene blue and ODQ, adenylate cyclase inhibitor (MDL), K^(+) channel blockers (glibenclamide and tetrabutylammonium), nifedipine or ryanodine. However, Mg^(2+)-induced relaxations were inhibited by Na^(+)-Mg^(2+) exchange inhibitor (imipramine) or removal (or attenuation) of extracellular Ca^(2+) in +E aortic rings. PE-induced contraction was not inhibited by nifedipine. In addition, Mg^(2+)-induced relaxations were inhibited by phospholipase C inhibitor (NCDC) or inositol monophosphatase inhibitor (lithium), but not by protein kinase C inhibitor (staurosporine). In vi패 infusion of Mg^(2+), directly into the femoral veins of guinea pigs, elicited sustained decrease in arterial blood pressure. The Mg^(2+)-lowered blood pressure was attenuated by intravenous administration of imipramine or lithium, but not by methylene blue, indomethacin, tetrabutylammonium nifedipine, LNNA, L-NAME or saponin (as an endothelium removal agent). These results suggest that endothelium independent vasorelaxant effect of Mg^(2+) on aortic ring appear to play important roles on the antihypertensive action in guinea pig, most likely via the inhibitory action of Mg^(2+) on the intracellular C^(2+) involve in PLC-IP pathway and influx (through the Na^(+)-Mg^(2+) exchanger) into the cell in guinea pig aorta.

지역자원의 효과적 활용과 컨텐츠화를 위한 서산시 축제의 특화·발전 방안 연구

김신원,노희곤,김정주 경희대학교 부설 디자인연구원 2008 예술· 디자인학연구 Vol.11 No.1

The purpose of this paper was to analyze the current situation and problems of festivals through a case study of local festivals in the city of Seosan, Korea. It also examined ways to develop festivals. According to the analysis of festivals in Seosan, an economic ripple stemming from the festivals influenced the development of the city, through gradual improvement in various fields. However, some problems were found in event planning, execution and in satisfaction of festivals. To resolve these problems, suggestions to improve festivals were examined. This research compared and analyzed the performance of local festivals held in different areas up to present. In addition, through analyzing problems, this research suggests factors for festivals to create a higher cultural standard for Seosan citizens. The research also contributes to the culture of festivals in all of Korea.

응급실에서 시행된 기관내 삽관의 현황

김병철,강보승,송형곤,이정훈,송근정,정연권 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Background : The purpose of this study was to analyze the endotracheal intubation cases performed in the emergency department. Methods : We investigated retrospectively 326 cases of endotracheal intubation performed in the emergency department of a tertiary care center form April 1, 1998 to March 31, 1999. We focused on operators, medications used, its success rate and immediate complications, and the relationship between its success rate and medications. Results : Of 326 consecutive intubations, 193 patients(59.2%) were done by emergency medicine residents or attending physician. While 320 patients(98.2%) were successfully intubated, 6 patients could not be intubated and 2 patients underwent tracheostomy. Of 50 cases of intubations(15.3%) attempted with paralyzing agents, 48 cases were done with succinylcholine and 46 cases underwent by emergency physicians. Intubations with neuromuscular paralysis resulted in high success rates at the first attempt. Of 55 immediate adverse events were encountered in 47 patients(desaturation=17, bronchial intubation=15, hypotension=8, bradycardia=4, cardiac arrest=2, others=5). Conclusion : At this institution, paralyzing agents were used infrequently, but almost all of them were used by emergency physicians.

정신장애 환자의 심리사회적 문제사정 도구개발

김창곤,유수현,이혜원,채정호 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

Objeetives : There have been no consistent reliable and valid tool for examining the psychosocial problems for the patients with mental disorders in Korea. The purpose of the present study is to develop a scale that examine the psychosocial problems for the patients with mental disorders and to test its reliability and validity. Methods : To identify the psychosocial problems for 1,100 patients with mental disorders were selected in university hospitals and professional training institutes. And the items of the psychosocial problems were taken from them and divided them into individual and environmental categories. The representative items were established among these items of psychosocial problems and a questionnaire for a pilot study was made based on the representative items. The pilot study was done for 306 patients with mental disorders using the questionnaire to investigate reliability of the questionnaire. After the pilot study items and format of the questionnaire were revised and complemented. The revised questionnaire was given to 600 patients with mental disorders to test its validity and reliability and new scale for psychosocial problems was developed. Results : At the pilot study, which was performed with 1,100 patients, 3,200 items of psychosocial problems of 205 types were selected. Among these items 78 representative psychosocial problems items were withdrawn. Fifty-eight psychosocial problem items were finally set for the questionnaire after discussing them with the expert groups and examining its content reliability. Forty-seven psychosocial problems items were finally selected and given to 306 subjects at the pilot study. At the main study in which 600 subjects were tested inner-reliability. Correlation between items and scale was relevant and correlation coefficient between test and retest was high. The finally developed psychosocial problems testing scales were consisted of 46 testing items into 9 areas. Conclusion : The Psychosocial Problems Assessment Scale, which were developed at this study is proved to be valid and reliable and it will be able to be used to examine overall psychosocial problems for the patients with mental disorders in Korea.

불소방출성 콤포짓트 레진계 수복재의 특성

김상훈,백병주,김재곤,양연미,박정렬 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

본 연구에서는 구강 환경과 유사한 조건에서 불소방출성을 보이는 콤포짓트 레진계 수복재의 내구성과 불소방출성을 조사하기 위해 4종의 콤포머와 1종의 불소방출성 콤포짓트 레진을 실험재료로 선택하고 5℃와 55℃ 수중에서의 열순환 처리 후의 인장강도, 열순환 처리 후 칫솔에 대한 작용력 1.5N으로 100,000회 칫솔질을 시행하였을 때의 표면조도 및 불소치약 칫솔질 후 37℃ 수중에서의 불소이온 용출 양상을 조사한 결과 다음과 같은 결론을 얻었다. 1. 인장강도는 TC(Tetric^(ⓡ) Ceram)군에서 32.3 MPa, CF(Compoglass F)군에서 16.8 MPa이고, TC군과 DF(Dyract^(ⓡ) flow)군 및 CF군에서 유의한 차이를 보였다(P<0.05). 2. 칫솔질 마모시험 후의 표면조도 Ra는 TC군에서 0.287, FT(F2000)군에서 1.516이고, FT군과 나머지 시험군 사이에 유의한 차이를 보였다(P<0.05). 3. 칫솔질 마모시험 후의 표면에서는 필러의 돌출과 탈락 양상이 관찰되었다. 4. 불소치약 Perio Alpine Herb로 칫솔질 한 후 콤포머는 초기에 높은 용출을 보인 후 시간이 경과하면서 용출량이 감소하는 양상을 보였지만, 불소방출성 콤포짓트 레진의 TC군에서는 초기단계부터 낮으면서도 지속적인 용출을 보였다. 5. 불소치약 Perio Alpine Herb로 칫솔질 한 후 1시간이 경과하였을 때의 불소이온 용출량은 CF군에서 2.064μg/cm², TC군에서 0.1119μg/cm²이고, CF군의 용출량이 나머지 시험군에 비해 유의하게 높은 값을 보였다(P<0.05). The objectives of this study were to examine the properties of fluoride-releasing resin composite restorative materials. Four commercially available compomer materials (Compoglass F: CF, Dyract^(ⓡ) AP: DA. Dyract^(ⓡ) flow:DF, F2000: FT) and one fluoride-releasing composite resin (Tetric^(ⓡ) Ceram: TC) were selected as experimental materials. Rectangular-shaped tensile test specimens were fabricated in a teflon mold giving 5 mm in gauge length and 2 mm in thickness. Disk-shaped specimens were fabricated in the split teflon mold with diameter of 15mm and thickness of 1 mm. After curing for an hour, specimens were immersed in deionized water at 37℃±1℃ for 30 days. All specimens were thermocycled for 10,000 cycles with 15 seconds of dwelling time in each 5℃ and 55℃ water baths. Toothbrush abrasion test was conducted under a load of 1.5 N and the abraded surfaces were examined with surface roughness tester (SV-3000, Mitutoyo Co, Japan) and SEM (JSM-5800, JEOL, Japan). Fluoride recharging was done by toothbrushing for 3 min. using a fluoride toothpaste (Perio Alpine Herb, LG Household & Health Care, Korea). The results obtained were summarized as follows; 1. The highest tensile strength value of 32.3 MPa was observed in TC group and the lowest value of 16.8 MPa was observed in CF group. The tensile strength of TC group was significantly higher than those of CF and DF groups (P<0.05). 2. The lowest Ra value of 0.287 was observed in TC group and the highest value of 1.516 was observed in FT group. The Ra value of FT group was significantly higher than other groups (P<0.05). 3. The abraded surfaces revealed the increase of surface roughness due to the protrusion and missing of filler particles. 4. The release of fluoride of compomers after tooth brushing by Perio Alpine Herb was initially large and then followed by small and continuously. But it remains small and constant in fluoride-releasing composite resin of TC. 5. The highest value of fluoride release after toothbrushing by Perio Alpine Herb was 2.064 μg/cm² in CF group and the lowest value was 0.119μg/cm² in TC group. The amount of fluoride release of CF group was significantly higher than other groups (P<0.05).

Cariostat를 이용한 아동의 우식활성에 관한 임상적 연구

김재곤,이영수,양정숙,양연미,백병주 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.3

The purpose of the study was to determine the ability of the caries activity test, 'Car-iostat'to identify preschool children with dental caries, The subjects of this study were 76 children of 3 to 5 years of age. Oral examination was carried out to out to assess the caries experience using a mirror and explorer. In all subjects buccal plaque samples were obtained, incubated. and scored as the manufacturer's instructions for the cariostat test. statistical analyses were used with the Crosstabulation. The test group exhibited mean dft index 5.21, while 27.63% of subjects were caries free and had no restorations. The sensitivity of the Cariostat test was found to be 98.8% while the specifioity was found to be 19.05% The results showed that caries activity measured by visual reading was highly significant to the Cariostat score and dft index(P<0.001). the Cariostat method has indicated the future possible occurrence of caries. The use of this method is meant to require in the caries prevention program.

상아질 접착제의 전단결합강도와 미세누출에 관한 연구

김정호,조영곤,문주훈 大韓齒科保存學會 1997 Restorative Dentistry & Endodontics Vol.22 No.2

New bonding agent systems have been supplied which operators can simply apply to conditioned tooth surfaces. The purpose of this study was to evaluate the shear bond strengths and the microleakages of three bonding agents and composite resins to dentin. Seventy-five extracted human maxillary and mandibular molar teeth were used in this study. For the shear bond strength test, the entire occlusal dentin surfaces of thirty teeth were exposed with Diamond Wheel Saw and smoothed with Lapping and Polishing Machine (South Bay Technology Co., U.S.A.). For the microleakage test, Class V cavities were prepared in the buccal surfaces of fourty-five teeth. They were randomly assigned into 3 groups according to dentin bonding agents (Scotchbond^TM Multi-Purpose plus, ONE-STEP^TM and Prime & Bond^TM) and composite resins (Z-100, Aelitefil^TM and TPH Spectrum^TM) to be used. Bonding agents and composite resins were bonded to exposed dentin surfaces of the tooth crown and to Class V cavities on the buccal surfaces respectively according o manufacturer's directions. The shear bond strengths were measured by universal testing machine(U^TM AGS-100, Japan). In addition, the degree of microleakage at the occlusal and gingival margin was examined by 2% methylene blue and stereomicroscope(Olymous SZH 10, Japan). The results were as follows: 1. The shear bond strength to dentin was the highest value in SBMP-Plus group(16.68±7.38MPa) and the lowest value in Prime & Bond group(11.61±5.82MPa), but there was no significant difference of shear bond strength among three groups. 2. The degree of microleakage at both occlusal and gingival margin was showed the lowest in SBMP-Plus group and the highest in ONE-STEP group. 3. At both occlusal and gingival margin, there was significant difference of microleakage between SBMP-Plus and ONE-STEP/Prime & Bond groups(p<0.05), but no significant difference of microleakage between ONE-STEP and Prim & Bond group(p>0.05).