청피에 함유된 복강 파크로파지의 탐식작용 억제 성분

은재순,김대근,소준노,지옥표 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The phagocytic activity of murine peritoneal macrophage was determined by lucigenin chemiluminescence and engulfment of fluorescein-conjugated E. coli particles. The activity-guided fractionation upon the methylenechloride fraction of Aurantii immaturi pericarpium led to the isolation of a flavonoid, isosinensetin, as a suppressive component of phagocytosis, lsosinensetin suppressed the lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles and enhanced the production of nitric oxide in murine peritoneal macrophage.

전이성 뇌종양에 대한 방사선치료시 예후인자에 관한 연구

김재성,박승호,조문준 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

To evaluate the effect of radiation therapy and prognostic factors in metastatic brain tumor, we analyzed the 29 patients diagnosed as brain metastases and treated with radiation therapy, retrospectively. We evaluated the symptom palliation effect and mean survival time of patients treated with radiation therapy by means of prognostic factors such as initial performance status, primary site, extracranial metastasis, radiation dose etc. Conclusively, we confirmed the good symptomatic response rate but poor survival time of these patients. Also, this study revealed that prognostic factors of metastatic brain tumor treated with radiation therapy were initial preformance status, age and radiation dose but sex, use of steroid, primary site and extracranial metastasis were not. To increase the survival time of the patients with brain metastases, further study for adequate radiation dose/fractionation schedule, combination with chemotherapy and surgical resection, and stereotactic radiotherapy will be needed.

자궁경부암의 수술후 방사선치료 성적

김재성,김준상,조문준 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

In order to assess the role of postoperative radiotherapy and prognostic factors, 50 patients who were treated with radiotherapy after surgery for clinical early-stage carcinoma of the cervix were reviewed. All patients received external pelvic radiotherapy alone(dose range 4,500 cGy-6,480 cGy, median 5,040 cGy). The 5 year overall survival, disease free survival and locoregional control rates were 93%, 87% and 90%, respectively. Clinical stage was found to he a statistically significant prognostic factor on univariate analysis (p=0.003) but clinical stage and pathological pararnetrial invasion on multivariate analysis (p=0.016, 0.041). Grade Ⅰ and Ⅱ complication rate was 4% in all patients. In conclusion, postoperative radiotherapy should be used in patients treated with radical hysterectomy with unfavorable pathological findings and clinical stage IIB patients is recommended to be treated by radical radiotherapy rather than surgery due to their poor prognosis shown in this study.

보존적 치료 및 수술적 치료에 의한 상위 경추 골절 및 탈구의 안정성

이준규,안재성,양준영,이장익 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

In general, hangman's fracture, odontoid Type III fractures, and most miscellaneous axis fractures are effectively managed with nonoperative methods (typically, the halo vest with its rigid external immobilization). Halo apparatus is a reliable instrument for the management of cervical spine injury, including that of odontoid fractures and other C1-2 injuries. Surgical fusion is the usual alternative to the halo device. Posterior wiring with or without fusion using autogenous iliac bone graft is probably the most common surgical treatment of cervical spine fracture and dislocation. The purpose of this study was to compare with stability of each others and to estimate the atlanto-dental interval and space for available in patients who were received conservative treatment and operative treatment due to upper cervical spine fracture and/or dislocation. 25 patients who were recieved conservative and operative management due to fracture and/or dislocation of the upper cervical spine (Cl and C2) during 1990. Jan. to 1997. May. were defined as a patient group. 12 patients were received conservative treatment. 13 patients were received operative treatment. In patient group who were received conservative treatment, the average of ADI and SAC was within normal range. In patient group who were received operative treatment, the average of ADI and SAC was within normal range. The patient group with the ADI and SAC of normal range were stable with good bone union at the last follow-up examination. Also the patient group was received fusion as their initial treatment for injuries incurred 1 month to 8 month prior to hospitalization were stable with good bone union.

강직성 척추염에 대한 연구 : 척추 골절을 중심으로 Focused in Spine Fractures

이준규,안재성,김형성 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

In ankylosing Spondylitis, ankylosis of some or all segments of the spine, segmentally or diffusely can be affected. Because all the ligaments become ossified in the involved area, a fracture that occur through this involved segment traverses both bone and ligaments, producing an extremely unstable situation similar to a shearing type of fracture. As the disease enters a chronic phase, the pathologic changes lead to a rigid, brittle, and osteoporotic spine. Mild trauma can lead to fractures that are difficult to diagnose, cause a high incidence of neurologic deficits, and present treatment problems. Patients known to have ankylosing spondylitis should be counseled regarding the possibility of a fracture, and if pain persists after an injury, they should be thoroughly investigated radiologically to rule out a potentially serious problem. Reduction of the displacement and stabilization is best achieved with posterior instrumentation, and laminectomy is not indicated. From March, 1990 to October, 1996, 11 cases of the ankylosing spondylitis in the department of orthopaedic surgery at Chungnam National University Hospital were managed nonoperatively with good healing and one case is operatively treated by anterior interbody fusion for cervical lesion, posterior instrumentation for thoracolumbar lesion.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

사군자탕이 항암제를 투여한 마우스의 면역세포에 미치는 영향

殷載淳,金大根,柳東和,權鎭,洪鍾星,蘇俊魯,全焄,吳贊鎬 우석대학교 의약품개발연구소 1997 藥學硏究誌 Vol.2 No.-

The purpose of this research was to investigate effects of Sa-Kunja-Tang(SKT) on immune cells of antitumor drugs administered mice. The apoptosis and T lymphocytes subpopulation were tested using a flow cytometry, and the proliferation was tested using a MTT assay. The administration of etoposide. vincristine or doxorubicin increased the apoptosis of T-lymphocytes, but the action of doxorubicin was decreased by the administration of SKT. The administration of etoposide or vincristine decreased helper T and cytotoxic T cells population of T lymphocytes, but the action of vincristine was recovered by the administration of SCT. The administration of etoposide, vincristine or doxorubicin decreased the proliferation of T-lymphocytes, but the action of doxorubicin was increased by the administration of SKT. These results suggest that SKT has a regulative function of T-lymphocytes in anti-tumor drugs administered mice.

수모세포종의 수술후 치료에 대한 임상적 고찰

김재성,김준상,조문준 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

Although craniospinal irradiation has been employed in children with medulloblastoma for the past 40 years, many issues concerning its use have been raised and examined, and some continue to be debated. Careful radiation technique includes adequate irradiation of the neuraxis with special attention to the cribriform plate region and the inferior portion of the frontal and temporal lobes. Conventional-dose craniospinal radiation therapy, in combination with chemotherapy, is currently recommended for patients with high-risk medulloblastoma. The appropriate dose of radiation to the craniospinal axis when this modality is combined with chemotherapy for low-risk medulloblastoma remains to be defined. Long-term results of hyperfractionated radiation therapy re likewise awaited.

특화거리 조성의 변천과정에서 나타난 Network의 중요성에 관한 연구

손재룡,최준호,이용준,이상호,이경회 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

Recently, the Specified streets are designated in the many cities. The specified street is formed naturally by gathering the same type of shops in the same street. The purpose of the specified street is to enhance and to make more lively the characteristics of the street. These specified street has the network consisted of elements, namely shop owner, the authorities, the consumers, etc. In the beginning, we examined how specific streets are made and composed in Seoul and Inchun: the street of the culture, the rodeo, and the furniture. As it turned out, the formation of the network organization in the specific streets showed that how much it is important that it impacted managing. The members of network work together for improvement of the street by negotiation and cooperation. In that process, the street scenery is also improved. This network promotes the spontaneous participation of the members of the affair. In the result of that, the effect of the network is a core which is one of the factors managing and improving specific street. A continuous examination of the more study would strengthen the importance of the network in changing specific street construction.

방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고

조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.