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국내 자생 Rumex속 식물의 Anthraquinone 함량분석
김대근,박영서,홍민욱,임종필 한국생약학회 2011 생약학회지 Vol.42 No.4
Rumex species (Polygonaceae) is widely distributed in Korea and its little sprout has been used as wild greens. The roots of Rumex sp. are used as a substitute for Rhei Rhizoma in Korea for its antipyretic and laxative properties. For the purpose of researching the value of Rumex sp. plants as natural resources, pattern recognition for the analysis of those plants was conducted using HPLC method. Two anthraquinone compounds, chrysophanol and emodin, were isolated from Rumex crispus to use standards. Chrysophanol and emodin from R. crispus were detected at retention time of 14.96 and 12.21 min, respectively. These compounds were detected from Rhei Rhizoma and all Rumex sp. plants. The content of chrysophanol of R. conglomeratus was higher than any other Rumex sp. plants. The amount of emodin was much higher from R. crispus than any other Rumex sp. The HPLC patterns of Rumex sp. are similar to that of Rhei Rhizoma, so they have something valuable as natural resources.
김대근,김상진,문홍상,박성열,김용태,최홍용,이춘용,박해영 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.5
Purpose: We aimed to investigate the significance of early detection of transition zone prostate cancer by transurethral resection of prostate (TURP) in benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS) in whom prostate cancer was suspected despite a negative transrectal ultrasonography (TRUS) biopsy result. Materials and Methods: From January 2006 to January 2009, a total of 165 patients who underwent TURP were evaluated. The prostate cancer detection rate was compared between patients who underwent TRUS biopsy before TURP (group A) and those who did not (group B). All charts were evaluated retrospectively, including prostate-specific antigen (PSA), digital rectal examination (DRE), TURP results (including resection volume and pathology report), TRUS, and TRUS biopsy results. Group A was subdivided into group A1, who were diagnosed with prostate cancer after TURP, and group A2, who were diagnosed with BPH after TURP. Results: The cancer detection rate showed no significant difference between groups A and B (8.9% vs. 7.5%, p>0.05). The mean PSA levels in groups A1 and A2 were 15.5±14.0 ng/ml and 9.1±5.1 ng/ml, respectively (p>0.05). In group A1, 40% had an abnormal DRE, compared with 6.7% in group A2 (p<0.05). After TURP, the mean percentage of resected prostatic chips of the prostate cancer group and BPH group were 33.9% and 18.6%, respectively (p=0.001). A positive correlation was found between the detection rate of prostate cancer and PSA (p=0.01). Conclusions: BPH patients in whom prostate cancer is suspected and who have lower urinary tract symptoms (LUTS) with a previously negative TRUS biopsy result can undergo TURP, which results in immediate improvement in bladder outlet obstruction and early diagnosis of clinically significant transition zone prostate cancer.
Initial Experience with Robotic-Assisted Laparoscopic Partial Cystectomy in Urachal Diseases
김대근,이재원,박성열,김용태,박해영,이춘용 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.5
Purpose: In this study, we report our initial experience with robot-assisted laparoscopic partial cystectomy (RLPC) in urachal diseases. Materials and Methods: Two men and two women with a mean age of 51.5±9.3 years underwent RLPC between June 2009 and December 2009. In each case, a single surgeon using the da Vinci-S robotic system (Intuitive Surgical, Sunnyvale, CA, USA) used a transperitoneal approach with a 0° robotic camera. After careful observation of the intravesical portion of the mass, the mass was excised by use of monopolar scissors circumferentially. The bladder was closed in two layers with watertight running sutures made with 2-0 Vicryl. Results: The mean operative time was 198 minutes (range, 130-260 minutes), the mean console time was 111 minutes (range, 70-150 minutes), and the mean estimated blood loss was 155 ml. The urethral catheter was removed on postoperative day 7 after a normal cystogram, and the surgical drain was removed on postoperative day 2.5 (range, 2-3 days). The mean hospital stay was 6 days (range, 4-7 days). There were no major complications. The pathology report revealed that one patient had a urachal cystadenoma, two patients had a urachal cyst, and one patient had a patent urachus. Conclusions: Our initial experience with RLPC for benign urachal disease is that it is a safe and feasible treatment modality. However, more cases are required to confirm the efficacy of RLPC.
김대근 한국생약학회 2016 생약학회지 Vol.47 No.4
Three tetrastilbene compounds were isolated from the aerial parts of Carex dimorpholepis Steudel (Cyperaceae) through repeated column chromatography. Their chemical structures were elucidated as kobophenol A (1), cis-miyabenol A (2), and kobophenol B (3), respectively, by spectroscopic analysis. These compounds were isolated for the first time from this plant.