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Performance Improvement of Near Earth Space Survey (NESS) Wide-Field Telescope (NESS-2) Optics
Yu, Sung-Yeol,Yi, Hyun-Su,Lee, Jae-Hyeob,Yim, Hong-Suh,Choi, Young-Jun,Yang, Ho-Soon,Lee, Yun-Woo,Moon, Hong-Kyu,Byun, Yong-Ik,Han, Won-Yong 한국우주과학회 2010 Journal of Astronomy and Space Sciences Vol.27 No.2
( Sung Won Lee ),( Hae Lim Lee ),( Jung Hyun Kwon ),( Jun Suh Lee ),( Young Chul Yoon ),( Yu Ri Shin ),( Hye Ji Kim ),( Eun Chung ),( Young Woon Kim ),( Jeong Won Jang ),( Soon Woo Nam ),( Nam Ik Han 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Intraoperative radiofrequency ablation (RFA) is one of the treatment options for hepatocellular carcinoma (HCC) patients with relatively poor liver function to undergo surgical resection or when percutaneous approach for RFA is not feasible due to the difficult location of the tumor. The aim of this study is to investigate the clinical outcomes of intraoperative RFA compared to surgical resection. Methods: A total of 76 consecutive patients who received either intraoperative RFA (n=23) or surgical resection (n=53) with curative intent at the Incheon St Mary``s hospital from June 2012 to September 2015 were enrolled. Disease free survival and overall survival rates were analyzed. Results: The median follow-up period was 20.1 months (range, 0.9-41.5). The mean baseline Model for End-Stage Liver Disease (MELD) score was higher in the RFA group compared to the resection group (11.5±4.7 vs. 7.8±1.5, p=0.001). The resection group consisted of larger tumors with the median diameter of 2.7cm (range, 1-16) compared to 2cm (range, 1-5) of the RFA group (p=0.002). However, there was no difference in the number of tumors and the tumor stage between the two groups. The disease free survival rates at 6 and 12 months were 81.6%, 74.8% in the RFA group and 92.2%, 86.2% in the resection group, respectively (p=0.256). The overall survival rates at one year were 91.3% in the RFA group and 94.3% in the resection group, respectively (p=0.635). In the RFA group, 5 patients (21.7%) received liver transplantation (LT) after median interval of 10.9 months (range, 9.2~26.4) since the intraoperative RFA. Conclusions: The patients who received intraoperative RFA presented with relatively poor liver function but the disease free survival and overall survival rates were non-inferior compared to the patients who underwent resection. Therefore, intraoperative RFA may be considered as a useful option for patients ineligible to percutaneous RFA and surgical resection, or as a bridge therapy before liver transplantation.
( Ik Sung Choi ),( Kil Jong Yu ),( Dae Hyeon Cho ),( Ji Enu Oh ),( Chang Wook Jeong ),( Kwang Min Kim ),( Hyoun Soo Lee ),( Jung Won Lee ),( Dong Kyu Lee ),( Byung Soo Kwan ),( Sang Goon Shim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: A direct-acting antiviral (DAA) drug is in the spotlight for the treatment of patients with chronic hepatitis C. The combination of sofosbuvir and ribavirin is more effective than the peg IFN and ribavirin in patients with genotype 2 HCV. The aim of this study was to evaluate the treatment efficacy and safety for GT2 HCV patients treated with sofosbuvir and ribavirin in a single center. Methods: The study was performed retrograde from May 2016 to December 2017 in GT2 HCV patients treated with sofosbuvir (400mg) plus ribavirin (800-1200mg; based on body weight) treatment. The primary endpoint was sustained virologic response at 12 weeks (SVR12). The secondary endpoint was the occurrence of side effects during treatment. Results: A total of 95 patients with GT2 HCV infection were enrolled, of which 92 were genotype 2a (96.8%) and 3 were 2b (3.2%). 2 patients were follow up loss, 1 patient discontinued treatment voluntarily. SVR12 was confirmed in 91 of 92 patients (98.91%). 1 patient with failed treatment were combined LC and HCC, HCV RNA was not detected at 4 weeks and 8 weeks after initiation of treatment, but HCV RNA detected at 12 weeks. Liver cirrhosis was diagnosed on the imaging studies or clinical manifestations and 24 patients were included (CTP-A; n=23, C; n=1). SVR12 with cirrhotic patients was 95.83%. The average HCR RNA titer was 2.46x10<sup>6</sup> IU/ml. Hemoglobin decrease (Mean ± SD; 2.95±1.19 g/dl) occurred in 21 patients during treatment and ribavirin dose reduction was required. Conclusions: This study was performed on a small group of patients compared with other studies, but showed that treatment with sofosbuvir and ribavirin was highly effective in patients with GT2 HCV infection. In aspect of safety, there was no serious side effects about treatment although hemoglobin decrease.
Sang-Ik Oh,Ha-Young Kim,Jae-Won Byun,Myungju Chae,Jong Ho Kim,Yu-Ran Lee,Bun Seung Jo,Ji-Sun Yoon,Jong Wan Kim 한국예방수의학회(구 한국수의공중보건학회) 2017 예방수의학회지 Vol.42 No.1
The seroprevalence of major infectious abortion agents was investigated in native Korean goats from Jeonnam province using ELISA. A total of 98 blood samples were collected from goats. Overall, 48 (49.0%), 11 (11.2%), and 1 (1.0%) serum samples tested positive for C. burnetii, T. gondii, and C. abortus, respectively, while none of the samples were positive for B. abortus or N. caninum. Moreover, a PCR assay conducted to detect C. burnetii antigens in goats with a history of abortion revealed 18 (38.3%) of 47 goats were C. burnetii positive by both the ELISA and PCR assay.
Yu-Jung Won,Lae Hyung Kang,Sung Geun Lee,Seung Won Park,Jae Ik Han,Soon-YoungPaik 한국미생물학회 2019 The journal of microbiology Vol.57 No.10
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne emerging infectious disease caused by the SFTS virus (SFTSV) and is a threat to public health due to its high fatality rate. However, details on tick-to-human transmission of SFTSV are limited. In this study, we determined the wholegenome sequence of a South Korean SFTSV strain (CUKJJ01), compared it to those of other recent human SFTSV isolates, and identified the genetic variations and relationships among the SFTSV strains. The genome of CUK-JJ01 was consistent with the genome of other members of the genus Phlebovirus, including the large (L), medium (M), and small (S) segments of 6368, 3378, and 1744 nucleotides, respectively. Based on amino acid sequences of the M and S segments, which are used to distinguish the six SFTSV genotypes, CUK-JJ01 was classified as genotype B. Segment analysis revealed that the L, M, and S segments were 97.49%, 97.18%, and 97.94% similar to those of KAJNH2/2013/ Korea, ZJZHSH-FDE/2012/China, and KADGH/2013/Korea, respectively. Currently, only few studies on SFTSV have been conducted in Korean population and most were limited to serological analysis. Although the present study has limitations in terms of number of sample analyzed, the findings may serve as basis to understand the transmission and spread of SFTSV, as well as for the development of diagnostic and detection methods for viral recombinants by comparing the whole genome sequence of SFTSV isolates from South Korea and that of foreign isolates.
Sung Woo Kim,Min Soo Kim,Yeonhui Yu,Chan-Lan Kim,Ik Soo Jeon,Chongdae Kim 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
This study examined factors affecting the analysis of motility of chicken semen. The viability of spermatozoa was estimated using varying dilution ratios and supplementation with BSA or fatty acid free (FAF)-BSA as protein sources in semen diluent. Fresh semen was examined after preparing dilutions in BPSE of 1/8, 1/16 and 1/32 at 25℃. The motility of incubated semen at each dilution was observed at 3 min (89.9%, 69.9 % and 53.2%), 30 min (86.7%, 71.4% and 51.7%), 1 h (89.5%, 74.0% and 53.5%) and 3 h (78.5%, 66.5% and 45.7%), respectively. The addition of BSA or FAF-BSA to BPSE diluent significantly increased the viability of semen in 1/32 dilution with results of 53.2% (control), 84.8% (BSA) and 92.9% (FAF-BSA) (p<0.05). This phenomenon was also observed in the dilution of frozen semen, where FAF-BSA treatment increased the viability of thawed semen from 17.6% to 34.0% in a 1/8 dilution (p<0.05). When the protein sources were used in the dilution, the survival rates of diluted chicken semen were also increased with time lapse. These results show that FAF-BSA may act to protect chicken semen and is suitable as a basic component of chicken semen diluent for the method of analyzing rooster semen after freezing.
Differential Benefit of Statin 2ndary Prevention of AMI according to level of TG and HDL cholesterol
( Sang Woo Jeong ),( Wan Kim ),( Sun Ho Hwang ),( Won Yu Kang ),( Sang Cheol Cho ),( Kyung Hwan Kim ),( Gyu Ik Lee ),( Young Eun Jo ),( Myung Ho Jeong ),( Young Keum Ahn ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: The benefit of statin in acute myocardial infarction (MI) was well established. However, there were few studies about the differential efficacy of statin according to the baseline level of triglyceride and high-density lipoprotein (HDL)-cholesterol. Objective: To address the efficacy of statin in secondary prevention of MI according to the level of triglyceride and HDL-cholesterol on admission. Methods: The 36580 acute MI patients were enrolled from November 2005 to August 2012. Total patients were divided according to level of triglyceride and HDL cholesterol on admission and evaluated the efficacy of statin in patients with no lipid component of metabolic syndrome (Group A; n=15,461) (HDL cholesterol ≥40 mg/dL & triglyceride <150 mg/dL) and both components of metabolic syndrome (Group B; n=4,399)(HDL<0.001). However, the efficacy of statin was not prominent in Group B (HR=0.987; 95% CI; 0.708-1.376; p=0.939). After propensity matching, the survival analysis revealed that statin therapy reduced the risk of MACE in group A (HR=0.752, 95% CI; 0.609-0.929, p=0.008). This result was mainly due to reduction of cardiac death (HR=0.628, 95% CI; 0.420-0.938, p=0.023). Multivariate analysis revealed that use of statin contributed independently to improvement of clinical outcome in only Group A (HR=0.692, CI; 0.543-0.882, p=0.003). Conclusions: The long-term benefit ofstatin was not prominent in acute MI patients with lipid profiles of metabolic syndrome. Therefore, different lipid-lowering strategy is necessary in patients with low HDL and high triglyceride.