관상동맥 질환에서 SDF-1α의 농도

김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.

環境要因이 在來種 煙草의 精油成分 發現에 미치는 影響

정형진 안동대학교 기초과학연구소 1990 基礎科學 硏究論文集 Vol.1 No.1

The content of volatile acids such as 2.3-methylbutanoic acid and 3-methylpentanoic acid known as the major components influencing on tobacco aroma similar in both Hyangcho, a local variety, and Xanthi Basma, an oriental variety. Hyangcho contained 4.14 and 3.40mg/100g of 2.3-methyl butanoic acid and 3-methylpentanoic acid, respectively. However, these components of Hyangcho was about 80% of KA 101 and Izmir, the oriental varieties. In addition, volatile neutural compounds such as benzyl alcohol, 2-phenylethyl alcohol, solanone, β-damascene and ionone were also higher in Hyangcho than those of other local varieties. The early transplanting increased the volatile acid contents such as 2.3-methylbutanoic, 3-methylpentanoic acid and solanone etc. Volatile organic acids such as 3-methylpentanoic acids decreased under high soil moisture content.

유한요소법과 경계요소법의 결합을 이용한 2차원접촉문제의 해석

정진형,우호길 충남대학교 공업교육연구소 1997 論文集 Vol.20 No.1

The coupled finite element method and boundary element method is applied to 2 dimensional elastic contact problem. Coupling the FEM and BEM is achieved by using the non-symmetric method which is a boundary element-like approach. In order to verify the method, the problems of simple cantilever beam and infinite plate with a circular hole are analysed. The results obtained the proposed method are compared with other numerical and analytic solutions, they are coincided well.

방사선 치료 중인 암환자의 정신병리, 자아존중감 및 삶의 질

정찬영,양종철,신일선,최영,윤진상,이무석,이형영,나병식 한국정신신체의학회 2002 정신신체의학 Vol.10 No.2

관류 심장과 심장 세포에서 Insulin에 의한 Mg^(2+) 유리 조절

정창우,강형섭,김진상 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.3

It is well known that β-adrenergic stimulation increases the intracelluar cAMP concentration through activation of adenylate cyclase (AC) and evokes marked Mg^(2+) release in the heart, liver, and kidney. The goal of this study was to investigate the effect of insulin on isoproterenol (ISO), norepinephrine (NE), forskolin (FOS), cAMP, or dimaprit (DMP) induced Mg^(2+) efflux from the perfused rat or guinea pig heart and isolated myocytes. We hypothesized that insulin would regulate Mg^(2+) efflux induced by AC activators and cAMP analogues because insulin activates phosphodiesterase (PDE) in the hearts. The Mg^(2+) content in the perfusate was significantly higher in the presence than in the absence of insulin. The addition of ISO, NE, FOS, or cAMP to perfused rat or guinea pig heart and isolated myocytes induced a marked Mg^(2+) efflux. These effluxes were inhibited by insulin. The Mg^(2+) efflux could also be induced by DMP, a histamine H2-receptor agonist, in the perfused guinea pig heart and isolatd myocytes. This effect was also inhibited by insulin. In rat heart and myocytes, the histamine H2-receptor agonist had no effect on Mg^(2+) efflux. In conclusion, these data suggest that insulin regulates Mg^(2+) homeostasis and the inhibitory effect of insulin on adrenoceptor-stimulation or AC activation induced Mg^(2+) efflux may occur through a regulation of cAMP pathway in rat and guinea pig hearts.

이성분 양이온성 계면활성제 혼합용액의 임계미셀농도에 대한 연구 1. CTAB와 다른 양이온성 계면활성제 CTB 및 DTAB 혼합용액

김진형,오세웅,고정수 木浦大學校基礎科學硏究所 1999 基礎科學硏究誌 Vol.17 No.-

The critical micelle concentration (??) in a micellar state of the mixed surfactant systems of cetyltrimethylammonium bromide (CTAB) with cetylpyridinium bromide(CPB) and dodecyltrimethylammonium bromide (DTAB) were determined at 25℃ as a function of the overall mole fraction of CTAB by the use of surface tension method. CMC values of pure CTAB, CPB, and DTAB were 9.95×10-4 M, ?? M, and ?? M, respectively. Interaction parameterβ value of CPB-CTAB mixture was evaluated as -1.3. In case of DTAB-CTAB mixture, constancy in β value was not obtained over all composition of the mixture.

Ti-6Al-4V 합금의 표면개질에 의한 calcium phosphate의 형성

박은진,김도균,김교한,고 융부,김형일,정용수 대한치과기재학회 2000 대한치과재료학회지 Vol.27 No.1

The purpose of this study os to investigate the formation of calcium phosphate on Ti-6Al-4V surface on aqueous solutions containing phosphate and calcium ions. The surface of Ti-6Al-4V specimens were treated in phosphate buffered solutions for 3 days followed by immersion in calcium phosphate buffered solutions for 10 days. These solutions have different concentration and pH(pH 5.8, 7.0, 8.0) one another. Then, the specimens treated with P and Ca ions and control group without surface treatment were immersed in Hanks' balanced solution for 30 days to make sure the effectiveness of this surface treatment. All specimens were characterized using scanning electron microscopy(SEM), X-ray diffractometry(XRD) and Fourier transform infrared spectrophotometry(FT-IR). The amount of crystallized particles formed on the specimens by surface treatment was significantly increased in all experimental conditions as compared with that immersed only in Hanks' solution. Dense granular shaped precipitates were observed on the surface and these particles were recognized as calcium phosphate similar to HA(hydroxyapatite) or TCP(tri-calcium phosphate).

전기장이 걸린 양자우물 구조의 바닥상태 특성

황형준,권태진,최정우 慶熙大學校 材料科學技術硏究所 1999 材料科學技術硏究論集 Vol.12 No.-

We estimate the ground state energy and wavefunction in the biased quantum well structure by using the periodic boundary condition. In this calculation, we assumed that the probability of finding the particle has maximum value at the ground state energy and the amplitude of the wavefunction should not depend on a period. The obtained energy value was in good agreement with the result predicted by the complex energy method.

7두의 개에서 배설성 요로조영술을 통한 신장 기능 평가

최윤정,이기자,최형준,이용진,박성준,송근호,정성목,최호정,이영원 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

Excretory urography is a type of contrast study used to verify and localize upper urinary tract disease. It is an inexpensive and easy way to visualize of anatomic and functional status of the kidney and has been used as a primary imaging modality for the evaluation of urinary tract abnormalities. We describe urological signs of 7 dogs who examined with excretory urography and ultrasonography. Six cases were referred to veterinary medical teaching hospital. Chungnam national university (VMTH, CNU) to evaluate renal function after the treatment for renal failure and one case was referred showing hematuria. In case 1, 2 and 4, blood test and urinalysis was normal and the results of excretory urography presented that renal function were normal range. In case 3, the results of urinalysis, ultrasonography, and excretory urography except blood test presented abnormal kidney and hydronephrosis was diagnosed. In case 5 and 6, blood test, urinalysis, ultrasonography and excretory urography indicated renal failure. In case 7, blood test, urinalysis and ultrasonography presented partially abnormal signs, however, the results of excretory urography was normal range.

Wegener 씨 육아종 증례보고 1예 : A Case Report

정선관,임형근,정은택,노병석,김창근,원종진 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2

Wegener's granulomatosis is characterized by necrotizing and granulomatous disease which involves upper, lower respiratory tract and kidney. The basic pathophysiologic mechanism of Wegener's granulomatosis is still unknown. We report a case of Wegener's granulomatosis which involved lung and pleura and was diagnosed by clinical symptoms, radiologic findings and anti-neutrophilic cytoplasmic autoantibodies.