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허지혜,김형욱,김영대,이영호,김남수,설인준,김상우 인제대학교 2006 仁濟醫學 Vol.27 No.-
Objective : We analyzed and investigated clinical manifestations, laboratory tests, and inhibitor development of hemophilia that had not been thoroughly studied. Methods : We retrospectively reviewed 96 patients with hemophilia who were registered in the Hanyang University hospital from Jan, 1984 to Dec, 2003, Results : The total patients, whose median age at onset was 46.0 months, in clude 84 cases of type A (87.5%) and 12 cases of type B (12.5%). The most common chief complaint was a traumatic hemorrhage. The family histories of hemophilia were revealed in 41 cases (42.7%). The median activated partial thromboplastin time (aPTT) was 66.7 seconds. The number of severe cases was 39 (40.6%). Inhibitors were present in 13 cases (13.5%) and seven cases (53.8%) were high responders. aPTT and factor levels showed reverse correlation (r=-0.467). aPTT is more prolonged in group without family history than the group with family history (P=0.037). Conclusion : In this study, the diagnosis of hemophilia are made at the lower age and the serological positivity of the HCV is decreased. Activated partial thromboplastin time and factor levels shows reverse correlation. Activated partial thromboplastin time is more prolonged in group without family history compared with group with family history. The frequencies of family history are lower than those of other developed countries, because of concealing the family history of hemophilia. The prevalence of the development of inhibitors increased compared with those of previous studies in Korea, but was lower than those of other countries. Further studies would be necessary to decrease the inhibitor development.
김홍태,박봉훈,천동욱,김형표,정재호 대한척추외과학회 1995 대한척추외과학회지 Vol.2 No.1
A lumbar fusion may influence biomechanically on the remained unfused segments to take over the lost motions. The adjacent segments to fusion particulatly will experience an additional motional stress following a fusion, and then various late complications can occur. Moreover, the amount of this stress may differ according to the levels and extents of the fusions. The aim of this study is to evalu- ate this motional stress in different levels of fusion. A retrospective review of flexion and extension lateral radiograghs was undertaken for 142 consec- utive patients who had undergone various fusions in the lumbar region. Included in this study were the patients who had performed active daily livings after surgery and followed for minimum of two years. They were 60 males and 82 females, having mean age of 46.7(range 14-72). There were three posterior fusions, 123 lateral fusions, and 16 interbody fusions. The extent of fusions were one seg- ment in 71, two segments in 53, three segments in 16, and four segments in two patients. The follow- up period was 53 months in average(range 2-15 years). The intervertebral angles were measured on the flexion/extension lateral radiographs, and then the calculated intervertebral angular motions at follow-up periods were compared with those of preoperative values. The average increases of angular motion at the adjacent segments to fusions were 2.3˚at L1-2 seg- ment(ranging 0˚to 5˚increase),2.5˚at L2-3 segment(ranging 1˚decrease to 8˚increase), 2.9˚at L3-4 segment (ranging 3˚decrease to 12˚increase), 6.7˚at L4-5 segment(ranging 2˚to 18˚ increase), and 1.5˚at L5-S1 segment(ranging 5˚decrease to 7˚increase). The average increases of the above and below adjacent segments to fusions were 3.3˚(ranging 3˚decrease to 18˚increase) and 1.7˚(ranging 5˚decrease to 12˚increase) respectively. There were no significant differences in the changes of angular motion according to the extents of fusion and during these follow-up periods. In conclusion, the angular motions at the adjacent segment to fusions increased most signficantly at L4-5 segment regardless of the fusion sites whether it is below or above a fusion. Excluding the L4-5 segment, the angular motions at the above adjacent segments to fusion increased significantly compared to those at the below adjacent segments. The late complications at adjacent segments to lumbar fusions are expected to appear preferably at these segments.
금속-반도체-금속 광검출기 내부 이종접합 경계면에서의 캐리어 포획에 의한 검출 효율 감소에 관한 모델링
金炯奭,徐鍾旭 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.2
암전류를 줄이기 위해서 사용한 wide-bandgap 반도체 덮개층이 금속-반도체-금속 광검출기(MSMPD)의 검출 효율 감소에 미치는 영향을 정량적으로 분석하기 위하여 MSMPD내부 이종접합 경계면에서의 캐리어 포획 현상을 연구하였다. 이종접합 경계면에서의 전위 우물을 infinite Airy well로 가정하고 양자역학적인 면을 고려하여 우물내에서 수치 해석적 반복법을 이용해서 Schrodinger 방정식과 Poisson 방정식의 self-consistent 해를 구하였다. AlGaAs 덮개층에 의해 이종접합 경계면에서 많은 캐리어가 포획됨을 알 수 있었다. 경사층에 대해서는 고려하지 않았는데, 실험 결과에 의하면 경사층을 사용함으로써 이종접합 경계면에서의 캐리어 포획량을 감소시켜서 검출 효율을 증대시킬수 있다.
水泳一스트레스에 의한 血裝 Corticosterone 증가에 미치는 水溫, Clonidine 및 Bromazepam의 영향
金炯健,申炅浩,金庚旭,全普權,千然淑 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.2
Recently, many reports suggested that warm water swim-stress induces an opioid-analgesia, while cold water swim-stress produces a nonopioid form of analgesia. And Hong et. al. reported that the increase of plasma corticosterone (p-CS) in response to swim-stress at 20℃(20-SS) was significantly attenuated by swim-stress at 4℃ (4-SS) was affected by CL but markedly suppressed by BA. In this paper, the influences of CL-500㎍/㎏ and BA-5㎎/㎏ on the change of p-CS in response to 20-SS or 4-SS were studied in male mice comparing with those of morphine and naloxone. The 20-SS induced increase of p-CS was significantly inhibited by CL and BA, respectively, while the 4-SS induced increase was not affected by CL but markedly inhibited by BA. And the 20-SS or 4-SS induced increase of p-CS was slightly inhibited by naloxone,2mg/kg but not affected by morphine, 2㎎/㎏. The increase of p-SS in response to three times repeated 20-SS or 4-SS with one hour interval was little affected by B-pretreatment, but CL-pretreatment slightly attenuated the 4-SS induced increase of p-CS and significantly inhibited the 20-SS induced increase. The increase of p-CS induced by the repeated SS was little affected by the treatment of BA 30 minutes before the last SS, but the such treatment of CL slightly attenuated the p-CS increase induced by the repeated 20-SS but significantly enhanced the p-CS increase by the repeated the repeated 4-SS. And during the experiment of repeated 4-SS, 55.6% of mice pretreated with BA were drowned. The results demonstrate that there are some pharmacological differences between the mechanisms of hypothalamo-adenohypophysial responses to 20-SS and 4-SS, respectively.
Capacitated Minimum Spanning Tree 문제를 위한 쌍대기반 해법
김형욱,노형봉,지원철 한국경영과학회 1989 한국경영과학회 학술대회논문집 Vol.- No.1
We develop a dual-based procedure for solving the capacitated minimum spanning tree problem (CMSTP). Dual ascent procedure generates a good feasible solution to the dual of the linear programming relaxation of CMSTP. A feasible primal solution to CMSTP can then be constructed based on this solution. The procedure can be used either as a stand-alone heuristic or, else, it can be incorporated into a branch and bound algorithm. A numerical result is given with quite favorable results.