측사위경두개방사선사진(Oblique Transcranial Radiograph)을 이용한 하악전돌증환자의 하악지 시상골절단술후 하악과두위치변화 분석

권대근,이상한,장현중 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.1

This study was intended to evaluate condyle position and the relationship of condyle position change and post surgical relapse following the sagittal split ramus osteotomy for mandible setback in 25 patients by paired t-test and multiple regression analysis. We used oblique transcranial and cephalometric radiographs taken before operation, immediate after operation, and at least 6 months post operatively. 1. In oblique transcranial view, posterior joint space was decreased immediate after operation and increased 6 months after operation. To compare the measurement before and 6 months after operation, there was no statistically significant change in over all joint spaces(P>0.05). 2. The joint spaces changed under the 0.2mm were 30%, 0.2mm to 1.0mm were 60.7%, above 1.0mm were 9.3%. This result reveals that condyle position was relatively reproduced to pre-operative state. 3. Statistically, the amount of mandible set back didn't influence the post operative relapse(P>0.05). 4. Statistically, the amount of mandible set back didn't influence the condylar displacement(P>0.05), and the amount of joint space change didn't influence the post operative relapse.(P>0.05) The changes in joint space is in the standard tracing error or within the adaptive capacity of the individual, it was too small to influence the stability of surgery.

영상 처리 기법을 이용한 OMR 답안지 판독

권갑현,서정상 동양대학교 1999 동양대학교 논문집 Vol.5 No.1

In this paper, a method for scoring OMR exam sheets using image processing techniques is suggested. In many schools, the special-purpose OMR card reader is used to score OMR exam sheets, but it is very expensive and foreign-made as well. Jn this method, a PC and a digital camera are used, so it is relatively low-priced. In addition, the intermediate images produced in this procedure can be stored easily in the computer storage media. Therefore, the necessary store space can be significantly reduced, and the specific card image can be easily retrieved.

정상교합자의 치열궁 형태

권용철,성정옥,권오원,성재현 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.1

This study was designed to investigate dental arch shapes buccally and lingually at Bracket Level of Koreans. This involved studying 63 inviduals (37 males, 26 females) with normal occlusion ranging in age from 17 to 24 yesrs old. The landmarks were digitized and measurements and statistical analysis were performed by NEC 9801 V-M computer. The Results were as Follows: Bicanine width, Bipremolar width and Bimolar width were larger in males than in females. Buccal and lingual arch form and coordination form were obtained by NEC 9801 V-M computer. The parabolic equations which represents buccal and lingual arch form were obtained.

흰 쥐에서 Olanzapine의 장간 재순환을 설명하기 위한 약동학적 모델

백현문,채정우,권광일 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract - Olanzapine is an atypical antipsychotic drug that is widely used for the treatment of schizophrenia and acute bipolar disorder. It had been reported that olanzapine was shown enterohepatic recirculation in rat and human. But pharmacokinetic model for enterohepatic recirculation of olanzapine had not been developed yet. In this study, we developed pharmacokinetic model for enterohepatic recirculation of olanzapine. 30mg/kg of olanzapine was administered to rats (n=7) by oral and plasma concentration of olanzapine was determined by HPLC-MS/MS(API2000). Noncompartmental analysis was done by WinNonlin and pharamcokinetic model was developed by NONMEM ver 7.2. Enterohepatic recirculation model was developed with two compartment including gall bladder compartment with mtime option and evaluation was done by visual predictive check(VPC) and bootstrap. As a result of VPC and bootstrap, our model was robust and parameter values were reliable. In conclusion, pharmacokinetic model for enterohepatic recirculation of olanzapine was successfully developed and evaluated. The model was appropriate to predict the plasma concentration of olanzapine in rat and may be useful to develop human model in further study.

청소년의 진로의식성숙과 일의 가치에 관한 연구

권소희,안현주,정혜원 경주대학교 창의력개발연구소 2000 創意力開發硏究 Vol.- No.4

The purpose of this study was to examine the relationship between the career maturity level of adolescent students and work values and to provide basic materials that can be some help to the career guidance and counseling. To achieve this purpose, research problems were as follows; First, this study was to analyze the relationship between the career maturity level and the work values. Second, this study was to investigate the most important predictive variables which influence on the career maturity. The samples consisted of 600 students (300 boys and 300 girls) from 7th grade, 9th grade and 11th grade students in Taegu, Korea. Students were administered the Career Maturity Inventory (CMI) by Crites(1973), and Work Value Inventory (WVI) by Super(1975). The CMI and WVI are self-report written instruments. For the statistical analysis, Pearson's coefficient correlation and stepwise multiple regression by SAS program have been applied. The results of this study were as follows; First, the correlation between the career maturity and intrinsic work values such as altruism, intellectual stimulation showed statistically significant positive correlation at P<.05 level. 7th graders have positive correlation at P<.01 level in achievement, altruism, intellectual stimulation and independence, and 11th graders in activity, esthetics, intellectual stimulation and independence. 9th graders have negative correlation in intrinsic and extrinsic values. Second, there were no influencing predictive variables of work values, grade and gender on the career maturity level, but there were statistically significant relationships at P<.05 level. Variables affecting career maturity were showed as the following order: intrinsic work values, extrinsic work values, gender and grade.

개에 있어서 耳根部의 Lidocaine 水針에 의한 全身 無痛覺의 誘發

권현주,유건주,이상은,이정연,송근호,김명철,정성목,박성준,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Twelve clinically healthy mongrel dogs were used to clarify the possibility of general analgesia induction by lidocaine aquapuncture to auricular root area in the present study. The experimental animals were devided into control (6 heads) and experimental groups (6 heads), respectively. Physiological salines (3 ml/kg) were injected into both auricular root areas in control group. Lidocaine hydrochlorides (3 ml/kg) were injected into both auricular root areas in experimental group. Superficial pain, the changes of vital signs and blood leukocytes, and PCV were examined on pre, 5 min., 15 min., 30 min, and 60 min. after injection in control and experimental groups, respectively. Analgesia was not detected at all in control group, however, all experimental animals were recumbent and analgesia was generally detected in the auricles, noses, dorsal parts, ventral areas, limbs and tails from 5 to 30 minutes after injection with lidocaine hydrochloride into auricular root areas in experimental group. As for the change of vital signs, body temperature showed decreasing tendency from 5 minutes after lidocaine injection in experimental group. Heart rates and respiration rates were increased on 5 minutes after lidocaine injection and then they showed decreasing tendency in experimental group. No significant difference were found among groups. As for the changes of hematological findings, the numbers of blood leukocytes were increased till 15 minutes after lidocaine injection and then they showed decreasing tendency. PCV values were increased on 5 minutes after lidocaine injection, and then they showed decreasing tendency. However, no significant differences were observed among groups. Considering the above findings, it was thought that general analgesia was possible by aquapuncture with lidocaine hydrochloride into auricular root areas and lidocaine aquapuncture didn’t affect so much to the changes of vital signs and blood.

지방간에서 발생한 폐 지방색전증의 병리학적 및 임상적 의의에 대한 연구

권태정,강현욱 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

Fat embolism is the presence of fat globules in the peripheral circutation and in the lung, brain, kidney, pearl, and so on -not in the fine emulsion of a metabolic lipemia but in globules large enough to obstruct arterioles and capillaries. The fat droplets can deride from fractures of long bone due to disruption of the fatty marrow from extensive bruising of the soft tissue, and from fat tissue in burns. Fat embolism has also been reported in patients suffering from various diseases including alcoholism, fatty liver, diabetes mellitus and pancreatitis. We investigated 19 autopsies with fatty liver of varying degrees to establish a correlation between fatty change of limier and pulmonary fat embolism. Among 19 cases, 3 cases with moderate to severe fatty change of elver, and 1 case with submassive hepatic necrosis and mild fatty change showed Grade II pulmonary fat embolism. In histologic section with Sudan III stain, the arteries and capillaries of lung were occupied and distended by round, oval, or staghorn fat globules. The alveoli may contain edema fluid and blood Although the pulmonary fat embolism occuring in the presented cases didn't cause death on its own, one should be aware that a life-threatening mobilization of fat into the lungs and ever into the systemic circulation is possible In fatty fiver and submassive hepatic necrosis.

몇 가지 항진균제가 Aspergillus fumigatus에 의한 대식세포의 Cytokine 생산에 미치는 영향

권은영,박철민,박선희,최수미,이동건,유진홍,신완식,최정현 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

배경 : 현재 임상에서 사용되는 서로 다른 계열의 항진균제가 면역세포인 폐 대식세포(alveolar macrophage)에서의 cytokine 생산과 nuclear factor- κB (NF- κB)활성에 미치는 영향을 시험관내에서 파악하고 그 의미를 추론해 보고자 하였다. 재료 및 방법 : AmB, MF, ITZ 등 세 가지 항진균제가 쥐의 폐 대식세포인 RAW264.7 세포의 생존에 미치는 영향과, 이들 항진균제의 전처치가 Aspergillus fumigatus conidia 자극에 의한 RAW264.7 세포에서의 TNF-α, IL-10 생산, NF-κB 활성에 미치는 영향, 그리고 GMCSF와의 상승 작용 등을 WST-1, ELISA, western blot assay를 이용해 통해 측정하였다. 결과 : AmB, MF, ITZ 모두 농도 의존적으로 RAW264.7 세포의 생존을 감소시켰다. A. fumigatus conidia 자극으로 RAW264.7 세포에서 TNF-α 생산이 증가하였으며, 세포 생존에 영향을 미치지 않는 농도의 AmB를 전처치하고 conidia로 자극한 경우 TNP-α 생산에는 차이를 보이지 않았으나, MF와 ITZ을 전처치한 경우에는 TNF-α 생산이 감소하였다. GM-CSF는 AmB 전처치 및 A. fumigatus conidia 자극에 의한 TNF-α 생산에 상승 효과를 보였으나, MF, ITZ은 GM-CSF에 의한 상승 효과를 보이지 않았다. IL-10은 AmB에 의해 생산량이 증가하였으며 GM-CSF와 동시 투여시 IL-10 생산이 유의하게 상승하였다. MF와 ITZ 역시 RAW264.7 세포에서 IL-10 생산을 유도하였으나 AmB에 비해 상승폭이 적었으며 GM-CSF와의 상승 효과는 관찰되지 않았다. A. fumigatus conidia는 NF- κB를 활성화하였으며 항진균제와 GM-CSF 등 약제 처치에 따른 NF-κB의 활성 정도는 분비된TNF-α와 IL-10의 생산 정도와 상관관계를 보였다. 결론 : AmB, MF, ITZ 등 본 연구에 사용된 항진균제는 시험관내에서 A. fumigatus conida로 자극하는 RAW264.7 세포에 전처치함으로써 염증성 cytokine인 TNF-α의 생산을 감소시키고 항염증성 cytokine인 IL-10의 생산을 증가시키는 면역 조절 효과를 나타낼 수 있음이 관찰되었다. 추후 약제간의 면역조절 기능 차이가 항진균효과에 미치는 영향 및 약제에 따른 면역 조절 경로 등에 대한 연구가 필요할 것으로 사료된다. Background : We wanted to evaluate the immunomodulatory effect of three antifungal agents, amphotericin B (AmB), micafungin (MF), itraconazole (ITZ), in the aspect of cytokine production and expression of nuclear factor-κB (NF-κB) in the Aspergillus fumigatus conidia treated-RAW264.7 cells, a murine alveolar macrophage cell line. Materials and Methods : We evaluated cytotoxic effect of antifungal agents using commercial cell proliferation assay. Tumor necrosis factor (TNF)-α and interleukin (IL)-10 production according to stimulation (control, A. fumigatus conidia only, conidia + antifungal drug, conidia + antifungal drug + GM-CSF) was evaluated and compared each using commercial ELISA method. NF-κB activation was evaluated by western blot analysis. Results : AmB, MF, ITZ showed dose-dependent cytotoxic effect on the tested cells. Stimulation of cells by A. fumigatus conidia induced TNF-α production. Pretreatment of AmB at concentration not affecting cellular survival did not change the production of TNF-α compared to conidia treated cells, but pretreament of MF or ITZ showed reduced amount of TNF-α production compared to conidia treated cells. AmB also showed synergistic effect on TNF-α production when simultaneously treated with GM-CSF. IL-10 production was markedly increased when the cells were treated with AmB with conidia. MF and ITZ induced less increase of IL-10 production than AmB. AmB also showed synergistic effect on the production of IL-10 when treated with GM-CSF simultaneously. A. fumigatus conidia enhanced expression of NF-κB. The degree of NF-κB expression was associated with the amount of TNF-α and IL-10 produced. Conclusion : The antifungal agents we used in this experiment showed that decreased TNF-α production and increased IL-10 production from the RAW264.7 cells stimulated by A. fumigatus conidia after pretreatment of antifungal agents. But more studies, such as the association between immunomodulatory effect, antifungal activity and difference of signal pathway of cellular activation according to drugs should be performed.

Streptococcus mutans 로 부터 분리된 mutan의 화학적 특성

권현정,한만덕 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.1

Streptococcus mutans produces water-soluble and water-insoluble α-glucan from sucrose by multiple glucosyltransferase (GTFs). Mutan, primarily water-insoluble α-glucan plays an important role in the development of dental plaque. The study was conducted to investigate the chemical properties of mutan purified from crude extracellular polysaccharide of S. mutans. In batch culture of S. mutans, the percent yield(%) of crude extracellular polysaccharide was calculated as 0.026%. Total carbohydrate and protein contents of crude polysaccharide showed 67.3 and 24.3%, respectively. The contents of hexosamine from extracellular polysaccharide extract were found to be 2.4%. Sugar composition analysis showed that mutan obtained from purification of crude polysaccharide is mainly composed of glucose with a slight amount of galactose. In an infrared absorption spectrum of the mutan, the absorption peak in the range of 700 ∼ 900 cm^(-1) indicated that the mutan contained α-1,3-glucan. The ^(13)C NMR spectrum analysis shows that mutan has a high similarity with the α-1,3 linked glucan.

사회교육 무용 프로그램이 정신건강에 미치는 영향에 대한 연구

권의준,윤현정 목원대학교 자연과학연구소 2000 自然科學 硏究論文集 Vol.9 No.1

본 연구는 구청 문화원에서 주관하는 사회교육 프로그램 중 중년 여성들이 무용 프로그램에 참가후 신체적 정신적 건강 측면에서 효과를 검증하고자 하였다. 본 연구의 목적을 달성하기 위해서 서울특별시 소재 3개 구청의 문화원과 경기도 고양시 관내 3개의 문화원의 프로그램 참가자 138명이 본 연구에 참여 하였으며 이들이 정신건강차원에서 여러 발생 요인들을 공변량 분석을 통해 분석한 결과 프로그램 참여자가 비참여자에 비해 정신적 건강에 대한 치료효과가 있음을 입증하고 있다.