참지식 부직포여과 활성슬러지 시스템의 가정 오수처리 적용 타당성 조사 연구

임태진,서규태,이택순,문병현 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

An experimental study was conducted to investigate the applicability of non-woven fabric filter as an alternative separation material in membrane combined activated sludge process. The most advantage of the fabric filtration activated sludge system is the low operation and maintenance cost resulting from the ready available material and gravity filteration. The system was consisted of two reactors, anoxic and aerobic one with working volume of 0.28㎥ and 0.47㎥, respectively. The non-woven fabric filter module was immersed in the aerobic compartment for separation of activated sludge by gravity filtration. Although the system showed high potential to treat domestic wastewater the initial leakage of bio-solid from the reactor and reduction of permeate flux were main problems of the system. The initial flux of 0.4㎥/㎡/day reduced to 0.2㎥/㎡/day in 12 days operation at 133㎝ water head. During the stable operation period, average SS concentration of effluent was 1.8㎎/L showing 96.4% removal. Organic removal efficiency was 98.3% as COD_Cr and 91.6% as BOD with the effluent concentration, 14.4㎎/L and 1.5㎎/L, respectively. T-N removal efficiency was 60% at C/N ratio 4.5.

생체내 심근허혈-재관류 모델에서 멜라토닌의 재관류 부정맥에 대한 심근보호작용에 관한 연구

조규종,김원,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Recently, a few studies demonstrated that melatonin reduced the severity of myocardial reperfusion injuries, such as reperfusion arrhythmias. However, it is uncertain whether the melatonin reduces reperfusion arrhythmias in thus anesthetized animals because results were obtained using isolated hearts. Thus, to see whether melatonin reduces reperfusion arrhythmias in anesthetized animals, we examined the effect of melatonin on the incidence of reperfusion arrhythmias in an anesthetized-cat model of regional ischemia. Method: Adult mongrel male cats(n=30, 2.9∼4.2 kg) were anesthetized under positive-pressure artificial ventilation with room air. The animals of the control group(n=15) were subjected to 20-minute left anterior descending coronary artery(LAD) occlusion followed by abrupt reperfusion. The animals in experimental group(n=15) were divided into two. Group I(n=6) was pretreated with melatonin, 1 mg/kg, before occluding the LAD. Group II(n=9) was pretreated with melatonin, 10 mg/kg. The animals in experimental group were subjected to ischemia/reperfusion insult following drug treatment: melatonin was applied intra-peritoneally for 3 minutes just before LAD coronary artery ligation. The Fisher's exact test was used to compare the data from different animal groups. p<0.05 was considered significant. Results: The incidence of ventricular fibrillation(VF) during the reperfusion phase in group II(pretreated with melatonin, 10 mg) was significantly smaller than that in the control group(p-value = 0.0029). However, no statistically significant difference of VF incidence was found between group I(pretreated with melatonin, 1 mg) and the control group. Conclusion: Employing an anesthetized-cat model of regional cardiac ischemia, we investigated the dose-dependant effects of melatonin on reperfusion-induced arrhythmia. The cats pretreated with 10 mg/kg of melatonin before ischemia had a significantly reduced incidence of lethal reperfusion-induced arrhythmia, but there was no difference between the cats pretreated with 1 mg/kg of melatonin before ischemia and the control group.

사업장 근로자의 건강위험 평가도구 개발

정규철,이용애,홍윤철,조희숙,박혜숙,임현술,하은희 이화여자대학교 환경문제연구소 1998 이화환경연구 Vol.2 No.-

Health Risk Appraisal(HRA) is usually defined as a process by which we expect of individual's chances of acquiring specific diseases within a defined period of time. The concept of worksite as an area of health maintenance and promotion is newly developing. Our movement for health promotion of employees has been increasingly known in the worksite. The aim of this study is to develop health risk appraisal tools about health promotion at the worksite for employees. We performed this study by two steps: one step was to develop a HRA questionnaire of worksites in Korea, another was to evaluate the reliability of the questionnaire. For developing HRA questionnaire, we reviewed scientific examples at first, and then weighted the score by delphi. To evaluate the reliability of developed questionnaire, we carried out survey by test-retest method. A total of 131 employees completed HRA questionnaire on two times. The results are as follows. The total score of health risk in unhealthy workers was higher than that of healthy workers. The range of test-retest reliability of responses to the questionnaire was 0.57-0.94. Therefore it seems that this questionnaire was very suitable to assess the health behavior of workers. In conclusion, the developed HRA questionnaire can be used as a tool for evaluating health behavior and for providing health counseling materials.

천안지역 대학생의 흡연군과 비흡연군간의 충동성,우울 및 불안정도 비교 연구

강영규,김현우,백기청,이경규,임명호 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구에서는 근래에 와서 건강을 위협하는 중요한 변인으로 강조되고 있는 흡연이 어떤 심리적 요인과 관련이 있는지 검증하고자 하였다. 여러 가지 심리적 변인 중 아마도 흡연과 가장 관련이 높을 것으로 생각되는 우울, 불안 그리고 충동성 정도가 흡연자와 비흡연자 간 뿐 아니라, 같은 흡연자라 할지라도 성별에 따른 차이가 있는지 검증하고자 하였다. 이러한 연구는 흡연을 예방하고 치료하는 데 있어 다른 물질중독의 경우와 마찬가지로 우울, 불안 및 충동성 등의 심리적 요인의 고려가 중요한 변인으로 간주되어야할 지를 알 수 있는 지표가 될 수 있을 것이다. 방 법 : 이 연구는 크게 BIS-11의 신뢰도 검증을 위한 예비연구와, 흡연과 정신건강과의 관계를 알아보기 위한 본 연구로 대별될 수 있다. 예비연구의 대상으로는 BIS-11을 한글로 번역하고 그 신뢰도를 측정하기 위해 일반인 187명을 대상으로 한 설문작업이 이루어졌으며 이중 30명에 대해서는 1주일 간격의 검사-재검사의 과정을 거쳤다. 본 연구의 연구대상으로는 천안 소재의 대학생 총 550명을 대상으로 하였다. 본 연구에 사용된 설문지는 ① 사회인구학적인 변인에 대한 문항들 ② Barrat 충동척도 임시 번안판 ③ Beck의 우울증 척도 한글판(Beck Depression Inventory : BDI한글판) ④ 상태-특성 불안척도 한글판(State-Trait Anxiety Inventory) 중 특성불안 척도 이렇게 총 4개의 부분으로 구성되었다. 통계분석은 SPSS Win 9.0을 이용하였으며 주로 이원변량분석법(Two-Way ANOVA)과 independent T-test 등을 이용해 분석하였다. 결 과 : 흡연군이 비흡연군에 비해서 'Barrat 충동척도 임시 번안판' 총 점수, 그 하위 3개요인 중 즉흥성(제 2 요인), Beck의 우울증 척도 점수 그리고 이들을 합한 '불안-우울-충동성 표준종합점수합'이 유의미하게 놓았다. 또한 여성이 남성에 비해 특성불안 점수, BIS-11 총점수, 그 하위 3개요인 중 즉흥성(제 2 요인), 운동성(제 3 요인), Beck의 우울증 척도 점수 그리고 이들을 합한 '불안-우울-충동성 표준화 점수의 합'이 유의미하게 높았다. 또 성별 및 흡연여부의 상호작용효과가 있는 변수로는 'Barrat 충동척도 임시 번안판' 총점수, 그 하위 3개 요인 중 즉흥성(제 2 요인), 운동성(제 3 요인), Beck의 우울증 척도 점수 그리고 이들을 합한 '불안-우울-충동성 표준화 점수의 합'이 있었다. 이러한 상호작용 효과를 검증하기 위하여 남성 흡연-비흡연군, 여성 흡연-비흡연군을 비교한 결과 남성의 경우 흡연군과 비흡연군 사이에 이들 모든 척도에서 통계적으로 유의미한 차이가 없었으나, 여성의 경우 흡연군이 비흡연군에 비해 이들 모든 영역에서 유의미하게 높은 점수를 보였다. 결 론 : 이상의 연구결과는 그것이 원인이지 결과인지는 알 수 없으나 흡연자가 대체로 우울, 불안, 충동성 등의 심리적 영역에서 문제가 있으며 특히 여성 흡연자의 경우 그 정도가 심해 흡연의 예방 및 치료에 있어 단순히 신체적 문제만을 부각시킬 것이 아니라 이러한 심리적 요인을 고려해야 함을 시사한다 하겠다. Objective : The study aims to determine whether smokers are more likely to have depression, anxiety and impulsiveness than nonsmokers. In addition, the difference between male and female smokers in terms of psychiatric symptoms are also to be looked at, particularly considered that there is still social stigma against female smokers in Korea. Ultimately, conclusions of the report can decide whether the psychiatric factors should be regarded important in treating smokers and prevention of smoking. Methods : The study is composed of two parts, a preliminary study to check confidence level of BIS-11 and the main study to examine relations between smoking and mental health. For the preliminary study, BIS-11 was translated into Korean to check its confidence level by interviewing 187 people, among whom 30 respondents had gone through an examination and a reexamination with one-week interval. Respondents of the main study were total 550 college students in Cheonan area. The questionaires were categorized into five parts ; 1) sociodemographic variants 2) temporary Korean version of Barrat Impulsiveness Scale(Version 11 : BIS-11) 3) Korean version of Beck Depression Inventory 4) trait anxiety scale from Korean verison of State-Trait Anxiety Inventory. SPSS Win9.0 has been run to analyze the outcome mainly using Two-Way ANOVA and independent T-test. Results : Difference between genders/smokers and nonmokers : The overall score of BIS-11, one of its three subcategories : impromptuness, Beck Depression, and the combined score for multi scales were significantly higher among smokers. Female smokers showed significantly higher scores than male smokers in trait anxiety, overall BIS-11, and two of its three subcategories(indiscretion and motor), Beck Depression and the combined score for multi scales. Overall BIS-11, two of its three subcategories(indiscretion and motor), Beck Depression and the combined score for multi scales were meaningful variants in comparison between male smokers/nonsmokers. While there was no significant difference between smokers and nonsmokers among men, significant difference was identified among women who showed higher scores across all variants. Conclusion : Although it is not sure whether it is the result or the cause of smoking it is confirmed that smokers have problems in psychiatric areas such as depression, anxiety, and inpromptuness, particularly among female smokers to greater degree. Therefore, it strongly implies that psychiatric aspects should be considered in preventing and treating severe smoking problems of female smokers along with physical ill effects.

사업장 근로자의 건강위험 평가도구 개발

홍윤철,임현술,하은희,정규철,조희숙,박혜숙,이용애 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

Health Risk Appraisal(HRA) is usually defined as a process by which we expect of individual's chances of death or acquiring specific diseases within a defined period of time. The concept of worksite as an area of health maintenance and promotion is newly developing. Our movement for health promotion of employees has been increasingly known in the worksite. The aim of this study is to develop health risk appraisal tools about health promotion at the worksite for employees. We performed this study by two steps; one step was to develop a HRA questionnaire of worksites in Korea, another was to evaluate the reliability of the questionnaire. For developing HRA questionnaire, we reviewed scientific examples at first, and then weighted the score by delphi. To evaluate the reliability of developed questionnaire, we carried out survey by test-retest method. A total of 131 employees completed HRA questionnaire on two times. The results are as follows. The total score of health risk in unhealthy workers was higher than that of healthy workers. The range of test-retest reliability of responses to the questionnaire was 0.57-0.94. Therefore it seems that this questionnaire was very suitable to assess the health behavior of workers. In conclusion, the developed HRA questionnaire can be used as a tool for evaluating health behavior and for providing health counseling materials.

도플러지수를 이용한 급성 심근경색증의 진단에 있어 노인 환자의 특징

김원,조규종,오세현,이영수,이은주,홍진숙,김영득,현석천,임경수 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.4

동종 골수이식 후 만성 이식편대숙주질환과 동반되어 신증후군으로 발현된 IgA 신병증 1예

정철권,김현수,박준성,정성현,조도연,최진혁,남동기,임호영,김명성,신규태,임현이,김효철 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.2

동종 골수이식 후 발생하는 신기능부전은 원인이 다양하여 감별에 어려움이 있다. 만성 GVHD는 흉선의 기능저하에 따른 면역관용의 실패로 발생되는 자가면역현상에 의해 발생되는 것으로 알려져 있으며 드물게 신장을 침범하여 신증후군을 일으키기도 한다. CaA의 용량을 줄이거나 투약중지 후 발생한 만성 GVHD에 동반된 신증후군의 경우 조기에 신조직검사를 시행하여 감별진단하고 CsA의 용량을 증량하거나 재투약하여 좋은 치료 결과를 보일 것으로 기대된다. 저자들은 문헌고찰을 통해 동종 골수이식 후 발생된 신증후군이 유사한 임상양상을 보이며 발생기전에 만성 GVHD와 자가면역현상이 연관되어 있음을 확인하였으며 동종 골수이식 후 신증후군의 임상양상을 보이는 환자에서 병리조직학적으로 lgA 신병증을 진단하고 이러한 lgA 신병증이 발생기전에 만성 GVHD와 자가 면역현상이 연관되어 있을 가능성을 최초로 확인하였으며 CsA를 이용하여 성공적으로 치료한 경험을 하였기에 보고하는 바이다. Renal insufficiency is occasionally encountered in allogeneic bone marrow transplantation and its cause is difficult to ascertain. Chronic graft-versus-host disease (GVHD) related to thymic dysfunction is immune-mediated and involves autoreactivity of T-lymphocytes derived from donor marrow to recipient's major histocompatibility complex(MHC) minor antigens. The clinical mainifestations of chronic GVHD are similar to those of autoimmune disease but kidney involvement is rare. Few cases of nephrotic syndrome with membranous nephropathy or minimal change nephrotic syndrome have been reported to be associated with chronic GVHD in allogeneic bone marrow transplant recipient especially after cyclosporine A(CsA) withdrawal, and these cases have responded well to CsA. Therefore, it is prudent to differentiate the cause of post-transplant renal insufficiency using renal biopsy and to start CsA in a case of nephrotic syndrome associated with chronic GVHD as early as possible. We report a case who had a massive proteinuria during the post-allogeneic marrow transplantation period. The cause of nephrotic syndrome was diagnosed as IgA nephropathy by renal biopsy. The patient was successfully treated with reintroduction of CsA.

국균세포벽을 모델로 한 새로운 고정화담체의 개발

유은정,김종덕,송상호,임현수,최명락,정규화 여수대학교 1997 論文集 Vol.11 No.2

The purpose of this investigation was to develop a new carrier using chitin and glucan as the model for Aspergillus oryzae cell wall. In case of the ratio of chitin and glucan(3/1), the activity of the immobilized protease had higher than that of model(chitin/glucan=1/3) and carriers were formed gel. In case of soluble chitin and glucan treated with calcium carbonate, there were a 1.8-fold increase in activity of immobilized protease compared with untreated chitin. The scanning electron microscope image showed that a pore size of this carrier had a homogenized pore size and a smooth surface.

특발성 자발성 신장 파열 1예

윤재철,김원,조규종,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Primary aldosteronism is a syndrome characterized by hypertension, hypokalemia, suppressed plasma renin activity, and elevated serum aldosterone levels. Conn first described it 1955 in association with adrenal cortical adenoma(Conn's syndrome). Today, it can be divided into at least six distinctive sub-groups. The diagnosis of primary aldosteronism is usually suspected when the patient presents with poorly controlled hypertension with hypokalemia. The main issues in the evaluation of primary aldosteronism are to differentiate an adenoma from hyperplasia and to localize the adenoma. Basic hormonal studies and computed tomographic(CT) scanning can be used effectively for that differentiation. An adenoma is one of a few potentially curable forms of hypertension, and it is best treated by removing the adrenal tumor. We experienced a case of a typical adrenal adenoma. The patient was a 37-year-old male who had experienced in both his legs over a period of several days a weakness due to hypokalemia. He was diagnosed using basic hormonal studies and adrenal CT scanning. After, he received laparoscopic adrenalectomy and was discharged with improved condition.

양 하지의 근력저하를 주소로 응급실로 내원한 원발성 알도스테로증 1예

안력,김원,조규종,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

A primary central nervous system lymphoma(PCNSL) is defined as a lymphoma limited to the cranial-spinal axis without systemic involvement. PCNSLs were formerly very rare, only 0.5∼ 1.2% of all intracranial neoplasms, and were usually associated with acquired immuno-deficiency syndrome(AIDS) and other immune-compromised states. Recently, there has been a clear rise in the incidence of this disease among normal individuals. We describe a 77-year-old female with hyponatremia who presented with a confused mental state. Computed tomography(CT) of the brain demonstrated a suprasellar mass with enhancement. We evaluated the basic hormonal studies and the magnetic resonance imaging(MRI). A ventricular biopsy was done, and the result was a diffuse, large, B-cell-type malignant lymphoma. She presented panhypopituitarism and partial central diabetes insipidus. She received chemotheraphy and was discharged in an improved condition. We report a case of panhypopituitarism due to PCNSL and give a review of the literature.