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Rifampicin에 의한 것으로 추정되는 위막성 대장염1예
김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2
Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.
Seung‑Hyeon Lee,Seung‑Han Choi,In‑Seung Lee,Yumi Kim,Eun‑Jin An,Hyeung‑Jin Jang 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.2
Backgrounds Exposure to a toxic stress environment leads to excessive inflammatory reactions and induces allergic asthma resulting in airway hyper-responsiveness. We investigated whether Rosa laevigata Michx. (RL) exhibits anti-inflammatory effects related allergic asthma in both an in vitro and in vivo studies. Methods To investigate the preventive effect of RL, A549 cells were pretreated with non-toxic doses of RL (500, 1000 μg/ mL) and induced by epidermal growth factor (EGF) (10 ng/mL). First, we evaluated cytotoxicity via a MTT assay. The inhibitory effects of NF-κB activity and COX-2 expression were confirmed by a western blot assay. In the in vivo study, BALB/c mice were challenged with regard to ovalbumin via an intraperitoneal injection of RL (50, 100 mg/kg) and were killed to collect bronchoalveolar lavage fluid, lung tissues and blood serum. The number of inflammatory cells, the secretion of IgE and related cytokines were monitored by ELISA and multiplex assays. Results RL significantly suppressed NF-κB activity and COX-2 expression levels in EGF-induced A549 cells. In a chronic inflammation mice model, pretreatment of RL attenuated allergic airway inflammation by reducing inflammatory cells, the secretion of IgE and related cytokines in a dose-dependent manner. Conclusions The results of this study present the possibility of RL as a therapeutic agent for allergic asthma patients via the suppression of IgE and related cytokines.
Autophagy 매개체인 LC3로 인한 Aβ 신경 독성의 증가
이승아;이현정;김도희;김옥현 박지애;김대진;정윤희;김경용;김성수;이원복 중앙대학교 의과대학 의과학연구소 2012 中央醫大誌 Vol.37 No.1/2
Autophagy is a highly regulated cellular mechanism that results in the bulk degradation process and which seems to be implicated in a variety of physiological and pathological conditions relevant to Alzheimer's disease (AD). Also, it has been suggested that the large part of autophagy is mediated by Light Chains 3 (LC3). Despite research suggesting an association between AD and autophagy, many issues remain to be addressed. To determine the relevance between autophagy and AD, we evaluated amyloid beta (Aβ) toxicity either in SH-SY5Y cells transfected with only EGFP or the cells exogeneously transfected with EGFP-LC3, mediating autophagy easily by overexpressed LC3. Without treatment of Aβ, the cell viabilities were quietly similar in both kinds of cells. The cell viability was decreased significantly in LC3 overexpressed cells. Consistently, more increased oxidative stress was detected in LC3 overexpressed cells. These results suggest that autophagy enhanced Aβ toxicity by way of increasing oxidative stress at least in part. This study will be of help to understand the role of autophagy in neurodegenerative diseases.
OpenGL에 기반한 전자부품 3D 그래픽 툴의 설계 및 구현
김승구,조현준,형대진,박경환 東亞大學校附設 情報技術硏究所 2005 情報技術硏究所論文誌 Vol.13 No.1
Up to the present, we have used general 3D modelling tool for 3 dimensions visualization of electronic parts. If we use general 3D modelling tool, we are consumed many time and effort because it is not optimized modelling of electronic parts. Therefore we need technical 3D modelling tool for electronic parts. In this paper, in order to solve this problem, we develop the graphic tool that model and visualize the electronic parts as 3 dimensions.
위에 발생한 유암종 (Carcinoid Tumor) : 1예 보고
김남재,김진희,이경태,서광식,정현용,이승민,김석현,이병석,이헌영 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.3
A carcinoid tumor of the stomach is uncommon, has no clinical symptoms, and is regarded as a benign. It is also incidentally found in most cases. 48-year-old woman with gastric carcinoid tumor was admitted. She had suffered from a anorexia and a dry mouth for 4-months. A gastroscopy revealed a polypoid mass on the greater curvature of the mid-body of the stomach which was subsequently thought to be an adenocarcinoma. An endoscopic mucosectomy revealed however, that it was a carcinoid tumor. A case of carcinoid tumor of the stomach is here by presented with a brief literature review.
自然과 調和를 이룬 光山區의 文化觀光資源 開發 推進方向
김승현 조선대학교 지역사회발전연구원 2003 地域發展硏究 Vol.8 No.1
Gwangsan-gu is called the hidden place for Gwangju with its beautiful scenery. We must develop this inherited natural resources for the rest place of residents and the cultural sightseeing points with pro-environmental plans. Especially, Mt Udoong. Mt youngjun and Hwangyong river must be developed for the rest place of domestic and foreign tourists, preservation of the local history and the cultural resources. It will contribute to the enhancement of the life quality of residents and the personal income. By doing so, Gwangsan will take a firm root as a central city in the Korean South-west zone, coexisting cities and rural districts.
Mo¨nckeberg 중막 석회화로 인해 초기자궁내막암이 진행성 자궁내막암으로 판독되었던 1례
김승만,배철성,김동훈,김정란,이현경,윤혜원 동국대학교 경주대학 1997 東國論集 Vol.16 No.1
Mo¨nckeberg 중막 석회화는 크거나 중간크기의 근육성 동맥(large and medium-sized muscular arteries)의 중막(media)에 노화와 관련되어 퇴행성 과정인 윤상석회화가 특징적으로 나타나는 동맥경화증의 일종으로, 근본적으로 폐쇄성 죽상경화증(occlusive atherosclerosis)과는 다른 과정으로 동맥의 관강(lumen)을 막는 경우는 드물어 상대적으로 임상적 의의는 적거나 거의 없다. 저자들은 Mo¨nckeberg 중막 석회화때문에 초음파 및 컴퓨터 단층촬영에 의한 병기결정에 혼란을 초래하였던 초기 자궁내막암 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The Mo¨nckeberg medial calcification is aging change rather than disease entity. The Mo¨nckeberg medial calcification involve muscular arteries of limb, head, and genital track and cause fibrosis change associated with hyalinization and fine basophilic staining, suggesting early calcification with little or no clinical significance but is demonstrable on roentgenograms as regular and diffuse radiopaque shadow under intima. We experienced one case of mis-staging of early endometrial cancer due to the Mo¨nckeberg medial calcification therefore, we report this case with a brief review of the literature of the Mo¨nckeberg medial calcification.