혈액암환자에서 조혈모세포 이식 후 따르는 헤르페스 바이러스 감영 양상

이호섭,탁희상,신성훈,김양수,남성진,김혜수,박진희,정수현,김성빈,김예나 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

배경 : 헤르페스바이러스과에는 단순포진 바이러스(HERPES SIMPLEX VIRUS, HSV), 수두대상포진 바이러스 (VARICELLA-ZOSTER VIRUS, VZV), 엡스타인-바 바이러스 (EPSTEIN-BARR VIRUS, EBV), 그리고 거대세포 바이러스 (CYTOMEGALOVIRUS, CMV) 등이 있다. 헤르페스바이러스 감염은 혈액암환자에서 조혈모세포 이식 환자에서 전파 (dissemination), 이차감염, 세균 중복 감염의 심각한 합병증을 일으킬 수 있다. 하지만 항암약물치료를 받는 림파종 환자에서 항 바이러스 약제의 사용 용량과 기간에 대한 concensus는 없다. 헤르페스바이러스 감염에 대한 발생율과 위험인자를 후향성으로 분석하였다. 방법 : 고신대학교 복음 병원에서 1995년 6월부터 2009 년 2월 사이에 새롭게 진단되어 조혈모세포 이식을 받은 전체 58명의 환자들이 후향적으로 현 연구에 등록했다. 헤르페스 바이러스 감염은 임상적 진단, 혈청학적 검사 또는 병리학적 진단에 기초하여 확진한다. 환자들의 특성은 다음과 같다: 평균 연령은 44세 (범위 19-62세)였고 남녀비는 30:28이었다. 등록된 질환은 백혈병 (n=9, 15.5%), 림프종 (n=30, 51.7%), 다발성 골수종 (n=12, 20.7%), 재생불량성 빈혈 (n=6, 10.3%) 그리고 골수이형성증후군 (n=1, 1.7%)이 포함되었다. 결과는 chi-squre test나 independent samples T test를 사용하여 분석되었다. Multivariate analysises에 대해 logistic regression test를 사용하였다. 결과 : 15명의 환자들 (25.9%)에서 조혈모세포 이식후 헤르페스 바이러스 감염이 발생하였다. 조혈모세포 이식 5년간 누적 발생율은 53.9%였다. Univariate analyses에서 헤르페스 바이러스 감염에 대한 유의한 위험 인자는 없었다. 하지만 조혈모세포 이식후 생존 기간(40.18 ± 30.14 months vs 20.06 ± 26.67 months, p=0.018)은 헤르페스 바이러스 감염의 낮은 발병율과 유의한 관련성이 있었다. 이식 편대 숙주질환 (GVHD)의 존재 (37.5% in developed GVHD vs 0% in no GVHD, p=0.200), 동종조혈 모세포 이식에서 면역억제요법의 기간 (15.98 ± 14.02 months vs 6.78 ± 3.67 months, p = 0.374)은 헤르페스 바이러스 감염에 대한 위험인자가 아니었다. 결론 : 조혈모세포 이식 후 생존 기간은 어사이클로비어 예방을 받은 혈액암 환자에서 헤르페스 바이러스 감염의 낮은 발병율과 연관성이 있는 것으로 보인다. 저용량의 어사이클로비어 예방은 헤르페스 바이러스 감염의 고위험군인 조혈모세포 이식을 받은 혈액암 환자에 필요하리라 생각된다. Background : Herpesviridae family includes herpes simplex virus, varicella zoster virus, Epstein-Barr virus, and cytomegalovirus, etc. Herpesviridae viral infection (HVI) can lead to serious complications including dissemination, secondary infection, bacterial superinfection in patients with hematologic malignancy following hematopoietic stem cell transplantation (HSCT). But there was no consensus on the dose and duration of antiviral agents prophylaxis in patients undergoing chemotherapy. We retrospectively analyzed the incidence and the risk factors for HVI. Method : A total of 58 patients who newly diagnosed and received HSCT with prophylaxis of acyclovir at the Kosin University Gospel Hospital, Busan, Korea between June 1995 and February 2009 were enrolled retrospectively in the current study. HVI was confirmed based on clinical diagnosis, serologic test or pathologic diagnosis. The characteristics of the patients were as follows: the median age was 44 years (range 19-62 years) with a female-to-male ratio of 30:28. The enrolled diseases included leukemia (n=9, 15.5%), lymphoma (n=30, 51.7%), multiple myeloma (n=12, 20.7%), aplastic anemia (n=6, 10.3%) and myelodysplastic syndrome (n=1, 1.7%). The results were analyzed using a chi-square test and independent samples T test. For the multivariate analysis, we used logistic regression test. Results : Fifteen patients (25.9%) developed HVI after HSCT. The cumulative incidence of HVI was 53.8% at 5 years after HSCT. In univariate analysis, there was no significant risk factor for HVI. The presence of graft-versus-host disease (GVHD) (37.5% in developed GVHD vs. 0% in no GVHD, p=0.200), duration of immunosuppressive therapy (IST) in allo-SCT (15.98 ± 14.02 months vs. 6.78 ± 3.67 months, p = 0.374) were not risk factors for HVI. Conclusion : The incidence of HVI was similar to that in historical other studies. There was no risk factor associated with development of HVI. Most of the HVI occurred within the first 24 months after transplantation. So long term use of antiviral prophylaxis may be needed to prevention of HVI after HSCT.

제1급 부정교합 환자에서 치료전후 PAR 지수와 두부방사선 계측치의 변화

김현혜,김종철 전남대학교 치과대학 1998 전남치대논문집 Vol.10 No.1

The purpose of this study was to evaluate the relation between the treatment duration and cephalometric measurements and the PAR index in Class Ⅰ malocclusion patients. In 100 Class Ⅰ malocclusion patients, PAR score and cephalometric measurements were taken and analyzed from study model and cephalometric radiographs. The results of this study were obtained as follows; 1. Excellent correlation was exhibited within and between examiners in measuring the PAR score. 2. Treatment duration was correlated with extraction and pre PAR index. 3. ANB, FMA, FMIA and IMPA exhibited positive correlation between pre PAR index and pretreatment cephalometric measurements. 4. 1_ to FP exhibited positive correlation between post PAR index and posttreatment cephalometric measurements, and 1￣ to FP exhibited negative correlation. 5. 1_ to SN, IIA and 1￣ to exhibited positive correlation between % PAR reduction and the change of cephalometric measurements and FMA, FMIA, WITS and UL exhibited negative correlation.

푸드뱅크 기탁식품의 안전성 확보를 위한 HACCP 제도 적용

김철재,박현신,배현주,이지해,양일선,강혜승 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.3

The purpose of this study was to analyze the problems arising from the actual conditions of the Foodbank, and to implement the HACCP system as a solution in terms of increasing the safety of donated food within the Foodbank. In order to apply HACCP system, the entire Foodbank working process such as preparation, collection, transportation, division, and distribution was considered and analyzed to decide the application point for CCPs. Donated foods mainly consisted of processed foods, raw materials, lunch boxes, and cooked foods from mass catering establishments, which dominated over the others in terms of quantity. Cooked foods were divided into three groups based on menu-types and processing methods. Temperature, pH, and aw were measured on cooked foods, and Total Plate Count, Coliforms, E. coli, Salmonella spp., Staphylococcus aureus, Listeria monocytogenes, and E. coli O157:H7 were conducted in order to apply a HACCP plan. Form these experiments, temperature, pH, and aw of donated food were likely contributed to microbial growth. Donated foods before HACCP implementation showed high numbers in terms of total plate count and Coliforms, both well over the acceptable standard levels. By setting the CCPs on maintenance of donated food below 10℃ and using a 75 ℃ reheating method, microbiological hazard levels were able to be controlled and lowered. From these results, it is concluded that in order to guarantee food safety, foods donated to the Foodbank must not only maintain a reasonable level of initial microbiological growth, but also must be handled properly through time and temperature controls within the Foodbank system. Furthermore, in terms of implementing the HACCP plan within the Foodbank management structure, basic food safety and sanitation measures, such as reheating facilities and various cold chain systmes such as refrigerated vehicle for food transportation are importantly needed. The training and education of Foodbank personnel and management in areas such as awareness of hygiene and safe food handling and practice are also required and necessary.

서울 단일 지역의 Helicobacter pylori 1차 제균율과 2차 제균율의 변화

김미연,심기남,김혜인,강현주,류민선,안소영,정혜경,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Objectives: To investigate the rate of first-line eradication and the rate of second-line eradication of Helicobacter pylori (H. pylori) from 2001 to 2010 in a single institute in Seoul. Methods: Among the 2,717 patients who received H. pylori eradication treatment from 2001 to 2010 at Ewha Womans University Mokdong Hospital, the medical records of 1,466 patients who satisfied the condition of execution of upper gastrointestinal endoscopy, positive H. pylori eradication results at 6~8 weeks after eradication therapy were reviewed retrospectively. Then the first-line and second-line eradication rates and the eradication rates according to endoscopy findings were also compared. Results: The first-line eradication rate was 77% H. pylori eradication rate for the last 5 years was continuously increasing and no sign of decline was observed even for the whole 10 years. The rates of eradication related to endoscopic findings showed statistical significance (P<0.001) of 79.8% and 70.1% each for peptic ulcer and non-ulcerative gastric diseases, respectively. Conclusion: In this study, no decrease in tendency of first-line eradication rate could be found. In addition, the patients with the non-ulcerative gastric disease seemed to show significantly lower eradication rate. This finding suggests eradication treatment may be affected by the category of gastric diseases, and careful considerations should be taken assessing the effects and needs for the H. pylori eradication treatment.

제1급 부정교합 환자에서 치료전후 PAR지수와 두부방사선계측치의 변화

김현혜,이기헌,김종철 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.2

제 I급 부정교합 환자에서 PAR 지수가 교정치료기간 및 측모두부방사선 계측 항목과 관계 가 있는지를 규명하고자 100명의 교정 환자의 치료 전후 석고모형에서 PAR지수를 구하고, 측모두부방사선사진에서 12개의 계측치를 측정하여 분석한 후 다음과 같은 결과를 얻었다. 1. 치료 기간은 발치 여부 및 치료전 PAR 지수와 상관관계를 보였다. 2. ANB, FMA, FMIA,IMPA는 치료전 PAR 지수와 치료전 측모두부방사선 계측치에서 순 상관관계를 보였다. 3. 1 to EP는 치료후 PAR지수와 치료후 측모두부방사선 계측치에서 순상관관계를 보였고 1 to EP는 역상관관계를 보였다. 4. 1 to SN, IIA, 1 to FP는 % PAR와 치료전후 측모두부방사선 계측치의 변화량과의 관 계에서 순상관관계를 보였고, FMA, FMIA, WITS, UL은 역상관관계를 보였다. 이상의 결과는 석고모형상의 치아관계에서 측정한 PAR 지수가 측모두부방사선 계측치 중 상하 전치와 관련된 항목과 연관이 있으며, 제 I급 구치관계를 보이는 환자중 ANB 값이 크고 hyperdivergent한 안모를 갖는 경우 치료전 PAR 지수가 큰 경향을 나타냄을 시사하였다. The purpose of this study was to evaluate the relation between the treatment duration and cephalometric measurements and the PAR index in Class I malocclusion patients. In 100 Class I malocclusion patients. PAR score and cephalometric measurements were taken from study model cephalometric radiographs and analyzed statistically. The results of this study were obtained as follows: 1. Treatment duration was correlated with extraction and pre PAR index. 2. ANB, F MA, FMIA and IMPA exhibited positive correlation between pre PAR index pretreatment cephalometric measurements. 3. 1 to FP exhibited positive correlation between post PAR index and posttreatment cephalometric measurements and 1 to FP exhibited negative correlation. 4. 1 to S N, IIA and 1 to FP exhibited positive correlation between % PAR reduction and the change of cephalometric measurements and FMA, FMIA, WITS and UL exhibited negative correlation. The results of this study indicate that PAR index taken from study model related with items concerned with upper and lower incisors, and there are the tendency that pretreatment PAR index are larger in the patients with large ANB value and hyperdivergent face.

강자성공명장치 제작과 MgFe₂O₄단결정에 대한 S,K-band에서의 강자성공명 연구

김기현,이혜정,김영호 명지대학교 자연과학연구소 1995 자연과학논문집 Vol.12 No.-

S,C,X, K,Q-band(2 ~34GHz)의 전자기파영역에서 강자성공명실험 할 수 있는 강자성공명장치를 제작하였다. 실험온도 범위는 4K~300K이다.자체 제작한 이 장치를 시험하기 위해 표준시료 DPPH를 사용하였으며, 공명신호를 관찰한 결과 강자성공명장치는 잘 제작되었음을 확인하였다.그리고 본 장치를 이용하여 MgFe?O? 단결성 시료에 대한 자기적 특성을 조사하였다. 상온에서 (100) 결정면의 각 결정방향과 [100],[110]방향에서의 온도(77 K~300K)에 따른 공명흡수선을 관찰하였다.그 결과 (100)결정면에 대한 상온에서의 이방성상수(K?)는 K-band 와 S-band에서 각각 -2.9x10?erg/cm 과 -2.8x10?erg/㎤의 값을 얻었으며, g인자는 각각 2.02와 2.01의 값을 나타냈다. 이들 결과와 이미 보고된 연구결과 [9,10,11]를 비교함으로써 자체 제작한 강자성공명장치의 특성을 보이고자 한다. We have manufactured FMR equipment over wide range(2 ~34GHz) at temperature range 4K~300K.In order to test FMR equipment, resonance signal has been measured using the standard sample DPPH.The observed signal shows very good resolution. As a result , We noticed that FMR equipment has been manufactured well.FMR studies of MgFe204 single crystal have been performed at S(3.6GHz).K(23.89GHz)-band. The resonance lines have been observed for the each orientatior of (100) plane at room temperature and for the [100],[110] orientation at tempeature range 77K ~300K.The values of the magnetic anisotropy constant K?and the spectroscopic splitting g factor have been calculated from the ferromagnetic resonance curve,-2.9x10?erg/㎤,2.02 at 23.89GHz and -2.8x10?erg/㎤,2.01 at 3.6GHz. As these results compared to others [9,10,11] we have shown the characteristic of home-made FMR equipment.

Resilon을 이용한 근관충전 시 수종의 치면처리제에 따른 미세누출 평가

오종현,박세희,신혜진,조경모,김진우 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.2

이 실험의 목적은 Resilon으로 근관충전된 치아에서 자가산부식전처리제에 따른 치근단 미세누출을 평가하고자 함이다. 70개의 단근치를 사응하였고 .04 Taper ProFile을 사용하여 ISO #40까지 근관성형 하였다. 치아는 근관충전 재료와 자가산부식 전처리제에 따라서 15개씩 4개의 실험군과 5개씩 2개의 대조군으로 나누었다. 실험 치아는 치아 장축에 평행하게 잘라내어 염색액의 최대 침투 길이를 측정하였다. 통계분석은 One-way ANOVA test로 분석하였으며 Scheffe test로 사후검정 하였다. 실험결과 자가산부식전처리제를 사용한 2, 3, 4군 사이에서는 통계적으로 유의한 차이를 나타내지 않았다. 그러나 1군과 4군 사이에서는 통계적으로 유의한 차이가 나타났으며 (p < 0.05), 1군에서 가장 적은 치근단 미세누출을 나타냈다. 이 실험 결과에 따르면 Resilon으로 근관충전을 한 치아는 gutta percha와 AH26^(ⓡ)으로 근관충전할 치아와 비교했을 때 더 좋은 치근단 밀폐를 나타내지 않는다는 결론을 얻었으며, Resilon을 사용하여 근관충전을 한 경우에 자가산부식 전처리제의 차이에 따른 치근단 밀폐효과의 차이를 보이지 않는다는 결론을 얻었다. The purpose of this study was to compare the apical microleakage in root canal filled with Resilon by several self-etching primers and methacrylate-based root canal sealer. Seventy single-rooted human teeth were used in this study. The canals were instrumented by a crown-down manner with Gate-Glidden drills and .04 Taper Profile to ISO #40. The teeth were randomly divided into four experimental groups of 15 teeth each according to root canal filling material and self-etching primers and two control groups (positive and negative) of 5 teeth each as follows: group 1 - gutta percha and AH26^(ⓡ) sealer; group 2 - Resilon, RealSeal™ primer and RealSeal™ sealer; group 3 - Resilon, Clearfil SE Bond^(ⓡ) primer and RealSeal™ sealer group 4 - Resilon, AdheSe^(ⓡ) primer and RealSeal™ sealer. Apical leakage was measured by a maximum length of linear dye penetration of roots sectioned longitudinally by diamond disk. Statistical analysis was performed using the One-way ANOVA followed by Scheffe' s test. There were no statistical differences in the mean apical dye penetration among the groups 2, 3 and 4 of self-etching primers. And group 1, 2 and 3 had also no statistical difference in apical dye penetration. But, there was statistical difference between group 1 and 4 (p < 0.05). The group 1 showed the least dye penetration. According to the results of this study, Resilon with self-etching primer was not sealed root canal better than gutta precha with AH26^(ⓡ) at sealing root canals. And there was no significant difference in apical leakage among the three self-etching primers.

폐주변부 병변 진단 시 기관지솔질에 의한 출혈이 병소확인에 주는 유용성 연구

김예나,정수현,김혜수,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background : Diagnosis of peripheral pulmonary lesion by conventional bronchoscopy is still challenging. The sheathed bronchial brush has been used to collect samples from the visible endobronchial lesion. Recently developed endobronchial ultrsonography (EBUS). can obtain image of peripheral pulmonary lesion at bronchus suspected by bleeding sign of sheathed brush. This study evaluated availibility of detected lesions by bleeding after bronchial brushing in pheripehal pulmonary lesions before transbronchial lung biopsy Methods : Between August 2006 and November 2008, 50 patients(38 men and 12 women, median age, 65 yrs) whose peripheral pulmonary lesions could not be detected with flexible bronchoscopy were included in this study. Among 50 patients, 40 cases were malignant lesion(non-small cell carcinoma 35, small cell carcinoma 5), and 10 cases were benign lesions(inflammatory disease 7, others 3) Results : Of the 50 patients, lesions detected bleeding after bronchial brushing was 34 cases(68%) and lesions detected by EBUS was 33 cases(66%). Sensitivity was 90.0-95.4%, Specificity was 83.3-80%, Positive predictive value(PPV) was 83.3-95.4% and Negative predictive value(NPV) was 80-90.9%. Diagnostic rates in visualized lesion by EBUS and otal peripheral lesions were 75%(25/33), 58%(29/50) respectively. There was no significant complication related with bronchial brushing. Conclusions : Bleeding sign by bronchial brushing was safe and effective method to predict location of peripheral pulmonary lesion with sufficient diagnostic yield

무안군 초등학교 급식실태 평가 : Ⅱ. 학생 및 학부모의 급식에 대한 만족도 조사 Ⅱ. Children's and Their Parents' Satisfaction for School Lunch Program

박해정,김현아,김영옥 목포대학교 생활과학연구소 1999 생활과학논집 Vol.2 No.-

The purpose of this study was to assess satisfaction of elementary school children and their parents with the school lunch program(SLP). 430(209 male, 221 female) 5th and 6th grade elementary school children and their parents participated. Most joyful mealtime for children was lunch because of eating with friends. Many children leftover their meals because they didn't prefer food served by SLP. Children also thought the taste of meals delivered from home was better than that of meals served by SLP. Many schools provide tap water(14.0%) and underground water(25.6%) , and there were many children who had ever found some foreign subjects in food, plates, or spoons. Mother wanted the school lunch program to be continued and claimed the quality of nutrition of SLP should be improved. In conclusion, unless the children prefer the food served by SLP or adjust to the general aspects of SLP, SLP can't accomplish its purposes. Therefore, the menu for the SLP should be selected with consideration of children's preference and it is necessary to prepare the way to solve the problems concerning general aspects of SLP.

KS H ISO 1242 표준의 평가 : 라반딘 정유의 산값 측정

전혜림,이은지,장혜진,손현화,김건,김남선,전명숙,이동선 서울여자대학교 2010 자연과학연구논문집 Vol.22 No.-

The acid value (AV) as well as the ester value of essential oil is an important index to evaluate quality of essential oil. The official standard analytical method of KS H ISO 1242 dealing with “Essential oils - Determination of acid value” was assessed experimentally using two lavandin essential oils obtained in France as an example. One French lavandin oil sample showed the results of AV= 0.9 by both indicator method and potentiometry. Another sample showed AV = 1.9 by indicator method and AV = 1.6 by potentiometry. Latter lavandin oil sample exhibited significantly higher acid value than maximum value of 1 described in the standard. This result suggests that latter lavandin oil was contaminated, because this oil was contained in an orange juice bottle. Results of this study proved that KS H ISO 1242 could be used as a suitable scientific standard for the determination of acid value of essential oils.