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( Hye Yeon Chon ),( Jae Seung Lee ),( Hye Won Lee ),( Ho Soo Chun ),( Beom Kyung Kim ),( Won Young Tak ),( Jun Yong Park ),( Young-oh Kweon ),( Do Young Kim ),( Sang Hoon Ahn ),( Se Young Jang ),( Soo 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Recently, CAGE-B and SAGE-B models were used to assess the risk of developing hepatocellular carcinoma (HCC) in Caucasian patients with chronic hepatitis B (CHB) under sustained antiviral therapy (AVT). We checked the predictive performance of these models in Asian patients with CHB. Methods: We reviewed 737 treatment-naïve patients with CHB who started entecavir between 2006 and 2011, and who were followed up for more than 5 years without HCC development within 5 years of AVT. The predictive performance of CAGE-B and SAGE-B scores were calculated using area under the receiver operating curves (AUROCs). Results: A total of 338 (45.9%) patients had liver cirrhosis at the start of AVT. And liver stiffness value at 5 years of AVT was 8.8 kPa. CAGE-B and SAGE-B scores at 5 years of AVT were 7.5 and 6.5, respectively. After 5 years of AVT, 66 (9.0%) patients developed HCC. The AUROC of CAGE-B and SAGE-B scores were 0.775 and 0.770 at 7 years and 0.805 and 0.793 at 10 years of AVT, respectively. The cumulative incidence rate of HCC was significantly higher in the high-risk group according to CAGE-B and SAGE-B-based risk stratification than in those of medium and low-risk groups (all P<0.05). The SAGE-B score showed a higher likelihood ratio (χ2) (55.2 vs. 52.0) and linear trend (χ2) (53.3 vs. 47.5) than the CAGE-B score, whereas the SAGE-B score showed lower akaike information criteria (50.4 vs. 63.7) than the CAGE-B score. Conclusions: Both SAGE-B and CAGE-B showed acceptable predictive performance in predicting HCC after 5 years of AVT in Asian patients with CHB.
( Se Young Jang ),( Soo Young Park ),( Hye Won Lee ),( Yeon-kyung Choi ),( Keun-gyu Park ),( Ghil Suk Yoon ),( Won Young Tak ),( Young Oh Kweon ),( Keun Hur ),( Won Kee Lee ) 대한소화기학회 2016 Gut and Liver Vol.10 No.6
Background/Aims: Periostin is an extracellular matrix protein and is known to be related to the metastatic potential and prognosis of cancer. However, few studies have investigated the expression level of periostin and its association with prognoses in hepatocellular carcinoma. Therefore, we analyzed periostin overexpression in hepatocellular carcinoma and its implication for prognoses. Methods: We evaluated 149 patients who underwent surgical resection between 2006 and 2010. Tissue microarrays were constructed from hepatocellular carcinoma tissue and adjacent nontumor tissue, and immunohistochemistry was performed. Results: A high periostin level was observed more frequently in cases of multiple tumors (odds ratio [OR], 2.826; 95% confidence interval [CI], 1.224 to 6.527; p=0.013), positive microvascular invasion (OR, 2.974; 95% CI, 1.431 to 6.181; p=0.003), and advanced stage disease (OR, 3.032; 95% CI, 1.424 to 6.452; p=0.003). Patients with high periostin expression had significantly (p=0.002) lower overall survival rates than those with low periostin expression (90.3%, 66.1%, and 56.2% vs 97.7%, 85.1%, and 77.5% at 1, 3, and 5 years). Conclusions: We found that a combination of periostin overexpression and microvascular invasion in hepatocellular carcinoma was correlated with a poor prognosis and can be a good prognostic marker for hepatocellular carcinoma. (Gut Liver 2016;10:948-954)
Size Dependence of the Photo- and Cathodo-luminescence of Y<sub>2</sub>O<sub>2</sub>S:Eu Phosphors
Sung, Hye-Jin,Ko, Ki-Young,Kim, Hyun Soo,Kweon, Seok-Soon,Park, Jong-Yun,Do, Young-Rak,Huh, Young-Duk Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.6
$Y_2O_2S$:Eu phosphors were synthesized via solid-state reactions. $Y_2O_2S$:Eu phosphor particles of various sizes were obtained by varying the firing temperature and firing time. The photoluminescence properties of these $Y_2O_2S$:Eu phosphors were examined. In addition, the cathodoluminescence properties of the $Y_2O_2S$:Eu phosphors were examined for applied voltages of 3-8 kV. The relationship between the luminescence intensity and particle size of the$Y_2O_2S$:Eu phosphors was investigated. The photoluminescence and cathodoluminescence of the $Y_2O_2S$:Eu phosphors are affected differently by variations in particle size.
Jang Won Young,정우진,장병국,황재석,이헌주,Hwang Moon Joo,Kweon Young Oh,Tak Won Young,Park Soo Young,Lee Su Hyun,Lee Chang Hyeong,Kim Byung Seok,Kim Si Hye,Suh Jeong Ill,Park Jun Gi 대한의학회 2020 Journal of Korean medical science Vol.35 No.29
Background: Liver cirrhosis has become a heavy burden not only for patients, but also for our society. However, little is known about the recent changes in clinical outcomes and characteristics of patients with cirrhosis-related complications in Korea. Therefore, we aimed to evaluate changes in characteristics of patients with liver cirrhosis in Daegu-Gyeongbuk province in Korea over the past 15 years. Methods: We retrospectively reviewed the medical records of 15,716 liver cirrhotic patients from 5 university hospitals in Daegu-Gyeongbuk province from 2000 to 2014. The Korean Standard Classification of Diseases-6 code associated with cirrhosis was investigated through medical records and classified according to the year of first visit. Results: A total of 15,716 patients was diagnosed with cirrhosis. A number of patients newly diagnosed with cirrhosis has decreased each year. In 2000, patients were most likely to be diagnosed with hepatitis B virus (HBV) cirrhosis, followed by alcoholic cirrhosis. There was a significant decrease in HBV (P < 0.001), but alcohol, hepatitis C virus (HCV), and non- alcoholic fatty liver disease (NAFLD) showed a significant increase during the study period (alcohol, P = 0.036; HCV, P = 0.001; NAFLD, P = 0.001). At the time of initial diagnosis, the ratio of Child-Turcotte-Pugh (CTP) class A gradually increased from 23.1% to 32.9% (P < 0.001). The most common cause of liver-related hospitalization in 2000 was hepatocellular carcinoma (HCC) (25.5%); in 2014, gastrointestinal bleeding with esophageal and gastric varices (21.4%) was the most common cause. Cases of hospitalization with liver-related complication represented 76.4% of all cases in 2000 but 70.9% in 2014. Incidence rate of HCC has recently increased. In addition, HCC-free survival was significantly lower in CTP class A than in classes B and C. Finally, there was significant difference in HCC occurrence according to causes (P < 0.001). HBV and HCV cirrhosis had lower HCC-free survival than alcoholic and NAFLD cirrhosis. Conclusion: In recent years, the overall number of cirrhosis patients has decreased. This study confirmed the recent trend in decrease of cirrhosis, especially of cirrhosis due to HBV, and the increase of HCV, alcoholic and NAFLD cirrhosis. Targeted screening for at-risk patients will facilitate early detection of liver diseases allowing effective intervention and may have decreased the development of cirrhosis and its complications.
영양표시정착화사업(Ⅲ) : 영양표시제도 개선방안 연구 Study for Better Nutrition Labeling System in Korea
김대병,박혜경,박건상,장재희,이혜영,구용의,최윤주,김보영,권우정,정해랑,장영애,조양희,이현정 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-
본 연군는 우리나라의 가공식품 영양표시제도를 종합적으로 평가하고 현행 영양표시기준에서 미비한 전들을 도출하여 연구 ·검토함으로써 영양표시기준개선안 및 선진화론 영양표시제도가 피기 위한 항후 정책방안을 Tf시하고자 하였다. 주요국의 영양표시 관련법령 및 규정과 국네기준과의 비교 ·겅토를 통하여 현행 영양표시기준의 미비점을 도출하였고, 도출된 문제점을 토대로 영양소의 정의, 영양소 표시 항목, 영양소 표시방법, 열량 및 영양성분 계산방법, 영양소 함량 강조표시 등에 대한 개선안을 계시하였다. 또한 시판 가공식품의 영양표시 현황 조사 및, 산업체의 영양표시 업무실태를 파악하고 의견을 숙렴하기 위한 산업체 대상 설문조사를 실시하였으며, 각 조사결과를 토대로 영양표시제도의 선진화를 위하여 향후 필요학 사업파 앞으로 발전방향을 제시하엿다 The purpose of this study was to examine the situation of nutrition labelling system in order to identify the problems and propose a strategic framework for improvement of the system. We reviewed the foreign and domestic acts and regulations for nutrition labelling, suggested draft of the revised nutrition labelling regulation, analysed the food labels carrying nutrient information and claims and response of food manufacturers to the nutrition labeling system. And we developed the strategy and the further studies for improvement of nutrition labelling system.
( Yu Rim Lee ),( Kyunghwa Kim ),( Se Young Jang ),( Won Young Tak ),( Young Oh Kweon ),( Bina Jung ),( Gyoun Eun Kang ),( Sang Kyung Seo ),( Jung Gil Park ),( Hye Won Lee ),( Young Seok Han ),( Jae Mi 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Long interspersed nuclear element-1 (LINE-1) hypomethylation, representing global DNA methylation level, is associated with prognosis via activation of oncogenic functions of genes. This experiment was performed to evaluate prognostic implication of LINE-1 methylation in patients with hepatocellular carcinoma (HCC) and the possible mechanisms related to oncogene activation. Methods: Ninety-six HCC patients between October 2014 and September 2015 at Kyungpook National University Hospital, Daegu, South Korea were enrolled for this prospective study. Quantitative pyrosequencing was performed to quantify the methylation level of for CpG sites in the LINE-1 promotor. The expression of CD133 and ST18 were measured by immunohistochemistry and their correlation with LINE-1 methylation levels were analyzed. Results: LINE-1 was significantly hypomethylated in tumor tissues compared with nontumor tissues (64.0 ±11.6% vs. 75.6 ±4.0%, respectively, P<0.0001). In this study population, LINE-1 hypomethylation group had a large proportion of female gender, smaller tumor size, and nonexistence of ascites (P< 0.05). Contrary to previous reports, LINE-1 hypomethylation was not an independent risk factor for overall survival and disease progression (all P >0.05). A total of 81 (84.4%) patients had demethylation of LINE-1 (ΔMI<0), and 15 (15.6%) patients had hypermethylation of LINE-1 (ΔMI≥0). HCC with demethylation of LINE-1 (ΔMI<0) had higher CD 133 expression than HCC with hypermethylation of LINE-1 (ΔMI≥0) (P=0.011). Moreover, when patients divided into two groups based on the mean value of tumor line-1 methylation, ST18 showed borderline significance in distinguishing the LINE-1 hypomethylation group than the other (P=0.053). Conclusions: LINE-1 demethylation is associated with expression of CD133 and ST18 in Hepatocellular carcinoma. In this study, LINE-1 hypomethylation was not related to overall survival and disease progression, this is probably due to the enrollment of HCC patients with various tumor stages and liver function.
Yoon, Jun Sik,Lee, Yu Rim,Kweon, Young-Oh,Tak, Won Young,Jang, Se Young,Park, Soo Young,Hur, Keun,Park, Jung Gil,Lee, Hye Won,Chun, Jae Min,Han, Young Seok,Lee, Won Kee Wolters Kluwer Health, Inc. All rights reserved. 2018 European journal of gastroenterology & hepatology Vol.30 No.10
<P>BackgroundTo compare the clinical value of acoustic radiation force impulse (ARFI) elastography and transient elastography (TE) for hepatocellular carcinoma (HCC) recurrence prediction after radiofrequency ablation (RFA) and to investigate other predictors of HCC recurrence.Patients and methodsBetween 2011 and 2016, 130 patients with HCC who underwent ARFI elastography and TE within 6 months before curative RFA were prospectively enrolled. Independent predictors of HCC recurrence were analyzed separately using ARFI elastography and TE. ARFI elastography and TE accuracy to predict HCC recurrence was determined by receiver operating characteristic curve analysis.ResultsOf all included patients (91 men; mean age, 63.5 years; range: 43-84 years), 51 (42.5%) experienced HCC recurrence during the follow-up period (median, 21.9 months). In multivariable analysis using ARFI velocity, serum albumin and ARFI velocity [hazard ratios: 2.873; 95% confidence interval (CI): 1.806-4.571; P<0.001] were independent predictors of recurrence, and in multivariable analysis using TE value, serum albumin and TE value (hazard ratios: 1.028; 95% CI: 1.013-1.043; P<0.001) were independent predictors of recurrence. The area under the receiver operating characteristic curve of ARFI elastography (0.821; 95% CI: 0.747-0.895) was not statistically different from that of TE (0.793; 95% CI: 0.712-0.874) for predicting HCC recurrence (P=0.827). The optimal ARFI velocity and TE cutoff values were 1.6m/s and 14kPa, respectively.ConclusionARFI elastography and TE yield comparable predictors of HCC recurrence after RFA.</P>