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      • KCI등재

        족저압력분포 측정장비를 이용한 골프 스윙시 족저압 분석

        이동기,이중숙,이범진,이훈식,김용재,박승범,주종필 한국운동역학회 2005 한국운동역학회지 Vol.15 No.1

        D. K. LEE, J. S. LEE, B. J. LEE, H. S. LEE, Y. J. KIM, S. B. PARK, J. P. JOO. PIantar foot pressure analysis during golf swing motion using plantar foot pressure measurement system. Korean Journal of Sport Biomechanics, Vol. 15, No. 1, pp. 75-89, 2005. In this study, weight carrying pattern analysis and comparison method of four foot region were suggested. We used three types of club(driver, iron7, pitching wedge). This analysis method can compare between top class golfer and beginner. And the comparison data can be used to correct the swing pose of trainee. If motion analysis system, which can measure the swing speed and instantaneous acceleration at the point of hitting a ball, is combined with this plantar foot force analysis method, new design development of golf shoes to increase comfort and ball flight distance will be available. 1. Address acting, forces concentrated in rare foot regions and lateral foot of right foot. Back swing top acting, relatively high force occurred in medial forefoot region of left foot and forefoot region of right foot. Impact acting, high force value observed in the lateral rarefoot region of left foot and medial forefoot region of right foot. Finish acting, force concentration observed on the lateral region and rarefoot region of left foot. 2. Forces were increased in address of right foot with clubs length increased. All clubs, back swing top acting, high force value observed in the lateral forefoot region of right foot. All clubs, in impact, high force value observed in the lateral rarefoot region of left foot and medial forefoot region of right foot. Finish acting, force concentration observed on the rarefoot region in driver and lateral foot region in iron on left foot. 3. Right foot forces distribution were increased in address, back swing top and left foot force distribution were increased in impact, finnish

      • SCOPUSKCI등재

        In vivo transduction of ETV2 improves cardiac function and induces vascular regeneration following myocardial infarction

        Lee, Sunghun,Lee, Dong Hun,Park, Bong-Woo,Kim, Riyoun,Hoang, Anh Duc,Woo, Sang-Keun,Xiong, Wenjun,Lee, Yong Jin,Ban, Kiwon,Park, Hun-Jun Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.2

        <▼1><P>Vascular regeneration in ischemic hearts has been considered a target for new therapeutic strategies. It has been reported that ETV2 is essential for vascular development, injury-induced neovascularization and direct cell reprogramming of non-endothelial cells into endothelial cells. Thus, the objective of this study was to explore the therapeutic potential of ETV2 in murine models of myocardial infarction in vivo. Direct myocardial delivery of lentiviral ETV2 into rodents undergoing myocardial infarction dramatically upregulated the expression of markers for angiogenesis as well as anti-fibrosis and anti-inflammatory factors in vivo. Consistent with these findings, echocardiography showed significantly improved cardiac function in hearts with induced myocardial infarction upon ETV2 injection compared to that in the control virus-injected group as determined by enhanced ejection fraction and fractional shortening. In addition, ETV2-injected hearts were protected against massive fibrosis with a remarkable increase in capillary density. Interestingly, major fractions of capillaries were stained positive for ETV2. In addition, ECs infected with ETV2 showed enhanced proliferation, suggesting a direct role of ETV2 in vascular regeneration in diseased hearts. Furthermore, culture media from ETV2-overexpressing cardiac fibroblasts promoted endothelial cell migration based on scratch assay. Importantly, intramyocardial injection of the adeno-associated virus form of ETV2 into rat hearts with induced myocardial infarction designed for clinical applicability consistently resulted in significant augmentation of cardiac function. We provide compelling evidence that ETV2 has a robust effect on vascular regeneration and enhanced cardiac repair after myocardial infarction, highlighting a potential therapeutic function of ETV2 as an efficient means to treat failing hearts.</P></▼1><▼2><P><B>Cardiovascular disease: New hope for healing the heart</B></P><P>A gene therapy strategy that stimulates cardiovascular repair could improve recovery for heart attack patients. Heart attacks inflict severe damage on the heart and blood vessels, tissues with limited capacity for self-repair. Researchers led by Kiwon Ban of the City University of Hong Kong and Hun-Jun Park of the Catholic University of Korea, Seoul, have now demonstrated that a gene responsible for cardiovascular development can also efficiently stimulate heart repair. They used viruses to deliver the gene into a mouse model of heart attack, and showed that treated heart tissues exhibited strong recovery relative to untreated controls. The treatment reduced scar tissue formation and promoted proliferation of the cells lining blood vessels and blood vessel formation, measurably improving heart function. This approach could lay the groundwork for treating a common potentially fatal event.</P></▼2>

      • 서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

        김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

        In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

      • 소아ㆍ청소년기에 발병한 탈모증의 정신의학적 특성

        이길홍,이헌재,이창훈 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

        연구목적: 소아 청소년기에 조기 발병한 탈모증과 성인기에 발병한 탈모증 환자들의 개인적 특성이나 탈모 양상, 정신의학적특성, 동반신체질환 및 치료 방법에 관한 비교 분석을 통해 조기 발병탈모증의 치료 및 예방지침을 수립하기 위해 본 연구를 시도하였다. 방법: 1998년 1월부터 1999년 6월까지 중앙대학교 용산병언 피부과에 내원하여 정신과로 의뢰된 탈모증 환자 93명(남 40명, 여 53명) 중에서 소아 청소년기에 발병한 31명(남 14명, 여 17명)을 연구대상 집단으로 선정하였고, 성인기에 발병한 탈모증 환자 62명(남 26명, 여 36명)을 대조군으로 선정하여 양군간의 임상 양상의 차이를 비교 분석하였다. 수집된 자료는 SPSSWIN 9.0V 프로그램을 통해 자료 처리를 하였고, 집단간의 차이는 교차 분석 및 t-검정을 통해 비교 분석 하였다. 결과: 1) 조기에 발병할수록 가을에 출생하고, 환자나 부모의 사회 경제 수준의 높으며, 형제수가 적다. 2) 조기에 발병할수록 전신성 탈모가 많고, 탈모 과거력이 있으며, 3회이상 재발하고, 탈모 정도가 심하며, 탈모기간이 2년 이상 장기간이고, 첫 탈모부위가 두정부이며, 탈모부위가 두군데 이상이고, 치료를 해도 변화가 없거나 악화되고, 치료를 자의 중단하거나 효과가 없어 중단한 경우가 많다. 3) 조기에 발병할수록 가정내 적응이나 인간관계에서 적응상의 어려움을 겪으며, 입시 부담이나 학교생활에서의 변화로 인해 학교 스트레스를 경험한 비율이 높다. 4) 조기에 발병할수록 불안장애가 많고, 불안증상과 우울증상을 많이 호소하며, 인격장애가 있을 때 탈모가 촉진되고, 특히 히스테리성인격이나 의존성인격을 지닐수록 조기에 탈모가 발생한다. 5) 조기에 발병할수록 지루성피부염등 동반 피부질환이 많고, 정신과약물인 alprazolam을 복용하고 있으며, polytar나 tretinoin을 처방한 비율이 높다. 결론: 일차 진료의사인 피부과 의사들은 공존하는 정신장애에 대해 깊은 관심을 갖고, 청소년기 이전부터 조기에 탈모증의 공동 치료 계획을 세워야 한다. Objectives: There have been growing interests about alopecia occured during childhood and adolescence in clinical practice. The purpose of this paper is to explore the clinical characteristics of early onset alopecia in order to establish effective psychiatric intervention strategy. Method: The subjects were 31 early onset alopecia patients(14 males, 17 females) and 62 late onset control patients(26 males, 36 females). These patients had visited psychiatric outpatient clinic consulted from the department of dermatology, Yongsan hopital, Chung Ang University, Seoul, Korea, from January 1998 to june 1999. The sociodemographic data, clinical pattern of alopecia, psychiatic characteristics, comorbid physical illnesses and treatment variables were assesed. The data was statistically analyzed using chi-squre test and t-test through SPSSWIN 9.0V. Results: 1) Early onset alopecia patients were more likly born in autum, had fewer siblings, and showed higher economical level of both patient and their parents than late onset patients. 2) Early onset alopecia patients were more likely to show diffuse hair loss, had more experienced past history of alopecia, more frequently had recurrence more than 3 times, were more severely damaged, had longer duration of hair loss had more loss of hairs on the vertex area at onset of alopecia, had more loss of hairs more than 2 areas, and had poorer prognosis such as no change or exacerbation in spite of treatment, spontaneous withdrawal of tratment and lack of efficacy to treatment than late onset patients. 3) Early onset alopecia patients were poorer in their adjustment in family life, or interpersonal relations, and more suffered from school stress such as changes of school life or test stress related with school entrance examination than late onset patients. 4) Early onset alopecia patients were more likely to show erious psychopathlology such as increased rate of the anxiety disorders, of anxiety symptoms or depressive symptoms, and of personality disorders including the hitrionic or the passive traits than late onset patients. 5) Early onset alopecia patients were more likely showed dermatits including seborrheic dermatits, and more significantly responding to the tratment with anti-anxiety drug, such as alprazolam, and dermatological therapies including polytar or tretinin than late onset patients. Conclusions: These findings suggest that dermatologists, as primary care physicians, are in unique position to recognize psychiatric comorbidity and to execute earlier intervention, in collaboration with psychiatrists, of early onset alopecia patients.

      • CHARACTERISTICS OF FIRE PROTECTIVE COATING THE TERNARY SOLUBLE SILICATE

        Lee,Nae-Woo,Choi,Jae-Wook,Kim,Jeong-Hun 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-

        The fire protective coating can reduce certain damages in case of fire, also conserve energy by thermal insulation and prevent corrosion and errosion in normal daily life by means of blocking thermal transfer, that were generally made of organic, inorganic and metallic materials as adiabatic coating. In case of inorganic material such as soluble silicate, it produces less toxic substances which are exposed to Ore, and have a plenty of raw material. Also inorganic thermal insulator is good in heat resistance. To develope such a excellent inorganic thermal insulator, the study of fire protective coating using the alkali silicate is necessary The principle of intumescence for alkali silicate is from rapid evolution of water in the coating material, the quantity of water in it is of course influenced on the degree of intumescence. The phenomenon of intumescence in ternary silicate is increased as the radius of ion is bigger, and this is caused by evolution of so many kinds of water. The individual degree of intumescence is ordered like this ; <TEX>$K^+$</TEX> > <TEX>$Na^+$</TEX> > <TEX>$Li^+$</TEX> . The best protection effect is similarity found to intumescence of ternary silicate. The result of X-ray diffraction analysis indicates that <TEX>$KHSi_2O_5$</TEX> is an important ingredient in K-silicate.

      • KCI등재

        평행봉 2회전 뒤돌아 무릎 구부려 내리기 동작의 운동학적 분석

        이종훈,이용식 한국운동역학회 2004 한국운동역학회지 Vol.14 No.1

        J. H. LEE, Y. S. LEE. Kinematic Analysis of Double Backward Somersault on the Parallel Bars. Korean Journal of Sport Biomechanics, Vol. 14, No. 1, pp. 27-40, 2004. The purpose of this study was to provide basic data for improving athletic performances by analyzing the kinematic variables of the Double Backward Somersault on the Parallel Bars through the 3D motion analysis. The subjects in this study were 5 male gymnasts who were ranked as national athletes. The results are as follows. 1. A total time(Mean Time) of performance showed 2.72±0.82 sec. and flight time to landing after releasing was o.87sec.(mean). In order to perform better stable flying movement, the flight time should be increased. 2. In the change of velocity of the center of mass, when the increasing ascension velocity of the upper point was high, the position in the top point was high on releasing. 3. In the position variable of the center of mass, the mean of upper-bottom position in horizontal posture was 242.1±6.5cm, 232.8±6.4cm in releasing, and 265.0±5.6cm in the highest point. This result is explained that the position of center of mass can be raised by using elastic power when wrist raised the bar in the releasing movement. 4. The angle of shoulder joint was 271.1±14.0. Such a big angle influences a negative effect on the releasing velocity, because trunk is not a position in the enough vertical direction. 5. The ankle of hip joint in hand-standing was 191.1±5.9, 118.8±5.3 in releasing, and 122.3±5.3 in taking on. Therefore, the result suggests that trunk should be straightly raised in taking on.

      • SCOPUSKCI등재

        김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

        이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

        표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

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