NK/T 세포 림프종 환자에서 시행된 비골수제거성 조혈모세포이식

정준원,김진석,장준호,서형찬,이승태,김현옥,양우익,민유홍,한지숙,고윤웅 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

저자 등은 맹장, 충수돌기 및 흉막을 침범한 고위험군 NK/T 세포 림프종 환자에서 비골수제거 조혈모세포이식을 시행한 후 이식연관 합병증 없이 무병생존하였기에 보고하는 바이다. NK/T cell lymphoma is a rare type of non-Hodgkin"s lymphomas. It has the histological features of angiocentric lymphoma characterized by prominent angio-invasion by tumor cells, and commonly presents in nasal and paranasal structures. Non-nasal form of NK/T cell lymphoma involves skin, gastrointestinal tract, or liver. With conventional chemotherapy and/or radiotherapy, NK/T cell lymphoma shows poor response rate and seldom results in long term survival. Especially, non-nasal form has more aggressive clinical manifestations and grave outcome than nasal form. We report a case of NK/T cell lymphoma presenting with small bowel perforation and malignant pleural effusion due to lymphoma infiltration, transplanted with allogeneic peripheral blood stem cells from HLA identical sibling donor after fludarabine-based nonmyeloablative chemotherapy. After transplantation, the patient achieved an enduring tri-lineage hematological complete response without any evidence of relapse for 10 months.

디지탈 信號의 周波數 變移變調

康俊吉,洪義錫 光云大學校 1974 論文集 Vol.3 No.-

디지탈 통신 혹은 아날로그신호의 디지탈 메모리등을 위한 주파수 변조에 관한 시스템을 구성하였다. 본래는 양자화된 음성신호의 디지탈녹음을 위한 것으로서 디코딩을 행하였을때 본래의 아날로그 신호에 가까운 결과를 가져왔다. In the transmission or recording system for digital signals, some modulation techniques are used. High level and low level are shifted on frequencies of 50 KHz and 35 KHz respectively, and transmited to communication channel or to memory system. All system designed for these purposes showed in good results.

순비기나무 (Vitex rotundifolia L. f.) 삽수 종류 및 생장조정제 처리에 따른 발근율

Jeong Yeob Kim,Yoon Ki Hong,Song Hee Ahn,Jung Seob Moon,Eun Seok Park,Hee June Kim 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05

Background : This study was conducted to developed the propagation method by cutting for mass cultivation of Vitex roundifolia. We were pitched the cutting two times and treated plant growth regulators to enhance the rooting percentage. Vitex roundifolia is live in beach sandy soil south of Hwanghae-Do and Gangwon-Do. Vitex roundifolia have been used to bath foam. It is good for aromatic plant. It has 0.8% essential oil content in leaf and flower. Major components of essential oil were alpha-Pinene, Sabinene, beta-Pinen, 1,8-cineole, d-Limone. Despite the superior usability, it had not yet been made by the artificial cultivation Methods and Results : We were pitched the cutting of a first-year branch on June 5, which was greenwood cutting and July 17, which was semi-hardwood cutting at Kwangseung-ri beach, Gochanggun, Jeonbuk. The length of cutting was 10cm. It had 3~4 nodes, we stuck a cutting remain 2 nodes above ground on ordinary raise seedling soil. Rooting percentage was measured at 60 days after stuck a cutting. Rooting percentage was higher greenwoody cutting(95%) than semi-hardwood cutting(57.6%). In green wood cutting, there was no significance with plant growth, but chemical injury was occurred in IBA 5,000ppm. In semi-hardwood cutting, there was significance with plant growth regulators. The rooting percentages of all the treat were higher than control(no treatment). Rooting percentage was the highest in NAA 5,000ppm treated. Conclusion : Greenwood cutting method was more proper to propagation for Vitex roundifolia than semi-hardwood cutting. The optimum time to cutting for Vitex roundifolia propagation was the early in June. If miss a time to propagation Rooting percent was elevated by plant growth regulator.

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

Effects of repeated education of inhaler device handling by advanced practice nurse in teaching Korean chronic obstructive pulmonary disease patients

( June Hong Ahn ),( Kwan Ho Lee ),( Jin Hong Chung ),( Kyeong-cheol Shin ),( Eun Young Choi ),( Hyun Jung Jin ),( Jong Geol Jang ),( Kyung Soo Hong ),( Young Seok Lee ),( Euna Lee ),( Mi Jeong Nam ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0

Objectives: The effects of inhaler education in chronic obstructive pulmonary disease (COPD) patients remain unclear. The objective of this study was to evaluate techniques and adherence in using inhaler devices and to investigate the effects of repeated education using inhaler device handling in COPD patients. Methods: We prospectively enrolled COPD patients who used their particular inhaler device for more than 1 month and evaluated the efficacy of repeated education for COPD. The educational intervention was 6-month education program of three visits, during which subjects were tested their inhaler technique and adherence, taught about inhaler technique face-to-face by advanced practice nurse. Inhaler technique, adherence, mMRC, COPD assessment tests (CAT), EuroQol-5D (EQ-5D), patient health questionnaire (PHQ-9), and feeling of satisfaction with inhaler questionnaire (FSI-10) were compared before and after education. Results: A total of 261 COPD patients performing a total of 308 inhaler devices were included in the study. 244 (93.5%) were men and the mean age was 69.8 ± 7.7. At least one errors were observed in 267 (86.7%) and at least one critical inhaler errors were observed in 43.2% (133/308). Education significantly decreased in percentage of incorrect techniques, incorrect critical techniques and poor adherence (86.7% vs 39.3%, p<0.001; 43.2% vs 8.8%, p<0.001; 2.3% vs 0.4%, p=0.009, respectively). FSI-10 for inhaler was significantly improved after education (44.4 ± 4.7 vs 47.7 ± 4.1, p<0.001). mMRC, CAT, EQ-5D and PHQ-9 were not significantly improved after education. Conclusions: Repeated face-to-face inhaler device handling education by advanced practice nurse significantly improved the inhaler technique, adherence and feeling of satisfaction with inhaler.

High-Speed Signaling in SDARM Bus Interface Channels : Review

Hong June Park,Young Soo Sohn,Jin Seok Park,Seung Jun Bae,Seok Woo Choi 대한전자공학회 2001 Journal of semiconductor technology and science Vol.1 No.1

Comparison of prognosis and specific features related to mortality according to tumor size in small sized breast cancer with extensive lymph node involvement

Hong-Seok Han,Jai Min Ryu,Hyun-June Paik,Sungmin Park,Ha Woo Yi,Suyeon Bae,Sekyung Lee,Kil Won Ho,Jeong Eon Lee,Seok Jin Nam,Seok Won Kim 대한외과학회 2016 대한외과학회 학술대회 초록집 Vol.2016 No.5

Critical inhaler handling error is an independent risk factor of frequent exacerbation of chronic obstructive pulmonary disease

( June Hong Ahn ),( Kwan Ho Lee ),( Jin Hong Chung ),( Kyeong-cheol Shin ),( Eun Young Choi ),( Hyun Jung Jin ),( Jong Geol Jang ),( Kyung Soo Hong ),( Young Seok Lee ),( Euna Lee ),( Mi Jeong Nam ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Acute exacerbations are significant event of morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. “Frequent exacerbator” phenotypes are considered as a distinct subgroup. The objective of this study was to evaluate risk factors associated with frequent exacerbations of COPD in Korean tertiary university hospital patients. Methods: The study was designed as a cross sectional, case-control study. We prospectively enrolled 261 COPD patients at Yeungnam University Hospital from January 2018 to November 2018. Subjects were tested their inhaler technique at study entry. Frequency of moderate to severe COPD exacerbations were reviewed retrospectively via electronic medical records during 12 months prior to study entry. “Frequent exacerbations” were defined as ≥2 moderate to severe exacerbations in the last 12 months. Multivariate logistic regression was performed to identify the risk factors of frequent exacerbations. Results: Among 261 COPD patients enrolled, 65 (24.9%) patients were “frequent exacerbator”. Frequent exacerbators had lower forced expiratory volume in 1 s (FEV1), lower forced vital capacity (FVC), higher mMRC, longer duration of inhaler usage, lower body mass index (BMI), higher critical inhaler handling error (<0.05). In multivariate analysis, longer duration of inhaler usage (odds ratio [OR], 1.09; 95% confidence interval [CI], 1.00-1.19; p=0.041), lower BMI (OR, 0.91, 95% CI, 0.83-0.99; p=0.032), critical inhaler handling error (OR, 1.92, 95% CI, 1.06-3.48; p=0.032), low FVC (OR, 0.97, 95% CI, 0.95-0.99; p=0.005) were associated with frequent exacerbations. Conclusions: Our data revealed that longer duration of inhaler usage, lower BMI, critical inhaler handling error and low FVC are independent risk factors of frequent exacerbations in COPD patients. Careful monitoring and education in inhaler use devices, especially in “frequent exacerbators” are important part of COPD treatment.

Evaluating inhaler device handling technique and risk factors for critical inhaler errors in Korean chronic obstructive pulmonary disease patients: single center study of 261 patients

( June Hong Ahn ),( Kwan Ho Lee ),( Jin Hong Chung ),( Kyeong-cheol Shin ),( Eun Young Choi ),( Hyun Jung Jin ),( Jong Geol Jang ),( Kyung Soo Hong ),( Young Seok Lee ),( Euna Lee ),( Mi Jeong Nam ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: The objective of this study was to evaluate inhaler device handling techniques and risk factors associated with critical inhaler errors among patients with chronic obstructive pulmonary disease (COPD) in Korea. Methods: We assessed the handling of 308 devices used for continuous treatment of COPD in 261 patients. We enrolled 143 subjects who used dry power inhaler (DPI), 145 who used soft mist inhaler (SMI) and 20 who used pressured metered-dose inhaler (pMDI) for COPD treatment at Yeungnam University Hospital and visually tested inhaler device handling technique. Results: A total of 308 devices were evaluated. At least one errors were observed in 267 (86.7%). At least one critical inhaler errors were observed in 39.2% (56/143), 45.5% (66/145) and 55.0% (11/20) of inhalation assessment test with DPI, SMI and pMDI. Among DPI, critical errors were respectively observed in 60.0%, 41.0%, 27.8%, 12.5% and 44.4% of inhalation assessment test with Turbuhaler (n=20), Breezhaler (n=61), Ellipta (n=36), Diskus (n=8), and Genuair (n=18). In multivariate analysis, female sex (odds ratio [OR], 10.75; 95% confidence interval [CI], 2.30-50.30; p=0.003), higher inhaler puff burden (OR, 1.58, 95% CI, 1.24-2.02; p<0.001), higher mMRC (OR, 1.46, 95% CI, 1.05-2.03; p=0.025), lower feeling of satisfaction with inhaler (OR, 0.94, 95% CI, 0.88-0.99; p=0.032), and frequent exacerbation in previous one year (OR, 1.94, 95% CI, 1.03-3.66; p=0.040) were associated with critical inhaler errors.Conclusions: Among Korean COPD patients in tertiary hospital settings, inhaler device handling errors are common problem. Careful monitoring and training in inhaler use devices, especially in female, higher inhaler puff burden, higher mMRC, lower feeling of satisfaction with inhaler and frequent exacerbation COPD patients are important part of COPD management.

Sarcopenia is an independent risk factor for NAFLD in COPD: nationwide surveys (Korean National Health and Nutrition Examination Survey 2008-2011)

( June Hong Ahn ),( Kwan Ho Lee ),( Jin Hong Chung ),( Kyeong-cheol Shin ),( Eun Young Choi ),( Hyun Jung Jin ),( Jong Geol Jang ),( Kyung Soo Hong ),( Young Seok Lee ),( Euna Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in chronic obstructive pulmonary disease (COPD) and is independently associated with cardiometabolic comorbidities and systemic inflammation. Although several factors are associated with NAFLD, influence of sarcopenia on NAFLD has not been fully determined in COPD. We explored whether sarcopenia is associated with NAFLD in COPD population. Methods: Data from the Korean National Health and Nutrition Examination Surveys 2008-2011 were analyzed. The subjects were defined as having NAFLD when they had scores higher than 36 in a hepatic steatosis index (HSI) value, which was a previously validated NAFLD prediction score. The sarcopenia index [=total appendicular skeletal muscle mass (kg)/body mass index (kg/m2) x100] measured by dual-energy X-ray absorptiometry was used to diagnose sarcopenia with cut points of 0.789 for men and 0.512 in women. Results: Using the HSI, NAFLD was identified in 124 (14.6%) of 850 COPD subjects. Among the entire of 850 subjects, the prevalence of sarcopenia in subjects without NAFLD, with NAFLD were 18.0% and 34.7%, respectively (p<0.001). In univariate analysis, NAFLD was significantly associated with young age, male, high body mass index (BMI), sarcopenia, metabolic syndrome, hypertension, diabetes mellitus (DM) and decreased forced vital capacity (FVC) in COPD population. Multivariate logistic analysis adjusted for the age, sex, metabolic syndrome, hypertension, DM, and FVC demonstrated that sarcopenia (odds ratio =1.95; 95% confidence interval, 1.11-3.46, p value=0.0219) was associated with NAFLD in COPD subjects. Conclusions: Sarcopenia is associated with increased risk of NAFLD, independent of age, sex, lung function and metabolic factors. Pulmonologist should be aware of possible liver comorbidities in sarcopenic COPD patients.