Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.

BEZ235 (PIK3/mTOR inhibitor) Overcomes Pazopanib Resistance in Patient-Derived Refractory Soft Tissue Sarcoma Cells

Kim, Hee Kyung,Kim, Sun Young,Lee, Su Jin,Kang, Mihyeon,Kim, Seung Tae,Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Lee, Dong Woo,Park, Woong Yang,Kim, Sung Joo,Park, Se Hoon,Lee, Jeeyun Neoplasia Press 2016 Translational oncology Vol.9 No.3

<P><I>BACKGROUND:</I> Although pazopanib treatment has become the standard chemotherapy in salvage setting for metastatic sarcoma patients, most patients progress after pazopanib treatment in 4 to 6 months. After failure to pazopanib, patients have limited options for treatment. Therefore, subsequent therapy in patients who failed to pazopanib is urgently needed and the use of patient derived cells or patient derived tumors for accompanying testing with various pharmacological inhibitors could offer additional treatment options for these patients. <I>METHODS:</I> Patient derived tumor cells were collected from ascites at the time of progression to pazopanib and a 13-drug panel was tested for drug sensitivity. We confirmed the results using <I>in vitro</I> cell viability assay and immunoblot assay. We also performed the genomic profiling of PDX model. <I>RESULTS:</I> The growth of patient derived tumor cells was significantly reduced by exposure to 1.0 μM AZD2014 compared with control (control versus AZD2014, mean growth = 100.0% vs 16.04%, difference = 83.96%, 95% CI = 70.01% to 97.92%, <I>P</I> = .0435). Similarly, 1.0 μM BEZ235 profoundly inhibited tumor cell growth <I>in vitro</I> when compared to control (control versus BEZ235, mean growth = 100.0% vs 7.308%, difference = 92.69%, 95% CI = 78.87% to 106.5%, <I>P</I> < .0001). Despite the presence of CDK4 amplification in the patient-derived tumor cells, LEE011 did not considerably inhibit cell proliferation when compared with control (control vs LEE011, mean growth = 100.0% vs 80.23%, difference = 19.77%, 95% CI = 1.828% to 37.72%, <I>P</I> = .0377). The immunoblot analysis showed that BEZ235 treatment decreased pAKT, pmTOR and pERK whereas AZD2014 decreased only pmTOR. <I>CONCLUSION:</I> Taken together, upregulation of mTOR/AKT pathway in sarcoma patient derived cells was considerably inhibited by the treatment of AZD2014 and BEZ235 with downregulation of AKT pathway (greater extent for BEZ235). These molecules may be considered as treatment option in STS patient who have failed to pazopanib in the context of clinical trials.</P>

찰옥수수연구 XVIII 시설하우스에서 2기작 찰옥수수 교잡종의 주요 생육특성 비교

나웅현,복태규,고혁수,백승우,조양희,이희봉 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

The major characteristics of the developed corn hybrids were compared at each different planting time; 1st time(April 28) and 2nd time(August 20), respectively. Among traits surveyed, stem height showed highly at 1st time than 2nd, while ear height, stem diameter and ear length were similar at two times. Sugar content of the used hybrids showed highly at 2nd planting time than 1st. Pericarp thickness was also high at 2nd planting time. Especially, among hybrids CNU99 was the highest in stem height and ear length, CNU11 and CNU56 were high in sugar content, and CNU51 and CNU124 were thiner than other hybrids in pericarp thickness. Accordingly, these hybrids will be planted and recognized in 2nd yield trial for superior corn hybrid selection.

대기중의 오존이 느티나무에 미치는 영향

이웅상,윤명희 명지대학교 자연과학연구소 1995 자연과학논문집 Vol.12 No.-

대기중의 오존이 느티나무(Zelkova serrata Nakai)에 미치는 영향을 open-top chamber를 이용하여 관찰하였다. 2개월동안 대기중의 오존에 노출시킨 식물의 광합성율과 엽록소함량은 activated charcoal로 filter한 chamber의 식물에 비해 각각 60%정도 낮았다. 증산율과 stomatal conductance 도 non-filtered chamber 내의 식물이 charcoal-filtered chamber내의 식물에 비해 40%정도 감소되었다. 그러나 오존에 의한 가시피해는 관찰되지 않았다. Effects of ambient ozone on Zelkova serrata were observed by using open-top chambers. Net photo synthesis rate and total chlorophyll content were about 60% decreased in non-filtered chamber plants compared with charcoal-filtered chamber plants were also 40% lower compared with charcoal -filtered chamber plants. However, no visible symptoms of ozone were observed.

鹽浴浸炭 後 高周波表面硬化處理된 軟綱의 磨耗特性에 관한 硏究

李相允,金凞雄,李準範 東亞大學校 1984 東亞論叢 Vol.21 No.3

This study has been performed to investigate into the improvement of wear resistance and hardness characteristics of mild steel heat treated by a combined technique, bath carbonizing and then induction surface hardening treatment, under various experimental conditions. The results obtained from the experiment are summarized as follows. (1) Optical micrographs have shown that at a given condition of output power microstructures generally vary as changes in the rate of travel during induction hardening and that martensitic transformation occurs for the travel rate of 0.33㎜/sec. (2) It has been found that for a given output power and the rate of travel as the carbonizing time increases the surface hardness and effective case depth are increased. (3) At the given output power and carbonizing time the surface hardness and effective case depth have been found to increase as the rate of travel decreases. (4) Wear test has shown that the weight loss of mild steel specimens treated by this combined heat treatment decreases as the rate of travel decreases at the given output power and carbonizing time, and that as the carbonizing time increases the weight loss of these mild steel specimens decreases at the given output power and rate of travel.

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

차트 파싱을 이용한 한국어 구문 분석에 관한 연구

이웅재,정희연,김희연,김혜주 서울여자대학교 자연과학연구소 2001 자연과학연구논문집 Vol.13 No.-

In order to understand natural language, we have to follow the process "Input → Lexical Analysis → Syntactic Analysis → Semantic Analysis". Among those, "syntactic analysis" plays the most important role since it is able to be applied to various fields such as natural language query systems, natural language interface systems, text summary systems, and machine translation systems. It is also important to analyze a sentence containing ambiguity. In this paper, we propose an algorithm to parse the Korean language using chart. It is implemented using Prolog programming language.

금속재료의 기계적 물성과 피로한도의 상관 관계

윤웅기 ; 조백희 ; 이성호 김천대학교 2000 김천대학교 논문집 Vol.21 No.-

The dynamic fatigue-life equation is applied to the uniaxial tensile test. On this study, we show that the fatigue limit values can be extracted from the tensile testing data. Consequently, those experi-ments can be correlated and the fatigue limit can be found by the tensile test. The theory is verified by comparing the theoretical fatigue limit from tensile test to experimental fatigue limit from fatigue test. The results can be used to find the reliable fatigue limit by tensile test.

쥐노래미 Hexagrammos otakii 난의 부화에 미치는 수온의 영향 및 자치어의 성장과 생존에 미치는 수온과 먹이의 영향

강희웅,정의영,이창훈,이정열 한국어류학회 2002 韓國魚類學會誌 Vol.14 No.2

쥐노래미 Hexagrammos otakii의 부호조건 및 자치어의 성장 및 생존에 미치는 영향을 조사하기 위하여 수온에 따른 부화 소요시간 및 부화율, 자치어의 성장과 생존에 미치는 수온과 먹이조건을 조사하였다. 쥐노래미 수정란의 수온별 부화 소요시간은 수온이 높을수록 짧았다. 부화율은 12℃에서 가장 높았으나, 반면 수온이 14℃ 이상으로 상승하면 급격히 감소되었으며 18.0℃이상에서는 비정상 기형 개체들이 출현하였다. 부화 후 70일 경과 후 수온별 자치어의 초기 성장과 생존율(%)은 수온이 높은 조건(16℃)일수록 낮은 수온조건보다 성장이 빨랐던(P<0.01) 반면, 생존율은 낮은 수온(10℃)조건에서 높게 나타났다. 70일간 먹이공급계열이 따른 자치어 사육실험에서 최적 성장과 높은 생존 조건은 윤충류(Brachionus plicatilis, 부화 후 1~10일) + Artemia nauplii(부화 후 10~20일) + 배합사료(부화 후 15~70일)를 공급한 실험군으로 나타났다. 자치어의 빠른 성장과 생존율을 높이기 위해서는 되도록 일찍 배합사료에 먹이붙임을 하는 것이 바람직하다고 판단된다. To obtain optimal rearing conditions for seedling production of the greenling Hexagrammos otakii, the effects of seawater temperature on hatching of egg, and seawater temperature and feeding regime on growth and survival of hatched larvae were studied. The hatching time of fertilized eggs of H. otakii decreased with increasing seawater temperature. Total length of hatched larvae was in the range of 7.21~8.16㎜. The highest hatching rate was found at 12℃. As seawater temperature increased higher than 14℃, the hatching rate sharply decreased. Abnormal larvae were found at 18.0℃. Seawater temperature affected significantly the growth and survival of H. otakii larvae(P<0.001). After rearing larvae for 70 days after hatching, we found the growth rate highest when seawater temperature was highest(16℃), whereas survival was highest when seawater temperature was lowest(10℃). Feeding regime also affected significantly the growth and survival of H. otakii larvae(P<0.001). The most efficient feeding regime was under the conditions of feeding rotifer(Brachionus plicatilis) during days 1~10 after hatching+ Artemia nauplii during days 10~20 after hatching+commercial feeds during days 15~70 after hatching. To ensure rapid growth and higher survival of H. otakii larvae, commercial feeds should be provided as early as possible.

공동주택 바닥충격음 차폐성능평가 실태에 관한 연구

윤웅기 ; 이성호 ; 조백희 김천대학교 2002 김천대학교 논문집 Vol.23 No.-

Now, Resident in apartment is over 50% in our country.