일 대학병원 주차장 유료화에 따른 주차장 이용실태 조사

김정희,박진숙,주찬웅,최기철 한국의료QA학회 1997 한국의료질향상학회지 Vol.4 No.1

Background : As parking problem caused by increasing owner-driver and patients concentration to a general hospital is becoming one of the dissatisfactions in medical care. It is time that a general hospital should solve the parking problem in a desirable way. The purpose of this survey is to let the clients understand the basic motivation of the pay parking and develop the better parking system. Methods : Clients of a tertiary care hospital in Chon-ju were surveyed by means of a questionnaire. All in all, 193, subjects answered the questionnaire. Results : In relation to the previous experiences, 39.6% of the subjects experienced inconvenience with confuse parking lot and the shortage of parking space. Under the were more than those who didn't 62.7% of the subjects answered that the y could find the parking lot easily. 33.2% of the subjects mentioned that it was not easy to drive in the parking area ; The reasons were pointed out the shortage of space, disordered parking, and insufficient guide, 12.8% of the subjects satisfied with the current administering system of parking lot. The outpatients were more affirmative than the admitted patients about the charging system. As for the parking fee, 64% of the subjects answered that it is expensive, and 89.5% of the subjects answered that it is expensive, and 89.5% of the subjects thought imposing of parking fee is irrational. Conclusion : To say as a whole, th basic purpose of the charging system are more of less accepted. However, the management details like parking facilities and payment method are dissatisfactory, so it is necessary to improve the management system. It is also noted that the inpatients showed more negative attitude than the outpatients with the charging system. To secure a more convenient parking, the parking system should be considered in relation to the information service, kind guidance, improve facilities, personnel cooperation, fix outpatient scheduling system. etc.

균류 분화과정의 유전적 조절기작

박범찬,이환희,박윤희,박희문 충남대학교 생물공학연구소 2003 생물공학연구지 Vol.9 No.1

Fungi are well suited for studying mechanism controlling development and cell differentiation in multicellular eukaryotes. The asexual and sexual reproductive cycles are tightly coordinated during the life cycle of Aspergillus nidulans. The asexual (mitotic) reproductive cycle involves the formation of a number of differentiated cell types. Successful formation of multicellular reproductive structures and spores (conidia) requires the establishment of spatiotemporal gradients in essential transcriptional regulators, such as brlA, abaA and wetA. Altered gene expression is coordinated with critical changes in the movement of nuclei and the regulation of the cell division cycle. Therefore, it has been proposed to define a central regulatory pathway. Several early regulatory genes involved in signal transduction pathway controlling asexual sporulation are also required for activating the central pathway. Sexual (meiotic) reproduction is more complex, requiring the differentiation of several specialized tissue types. Although technical difficulties have limited efforts to study the genetics of sexual fruiting-body formation directly, some recent progress has been made. With the recent availability of mutants blocked in sexual development, understanding the genetic interactions between genes that function primarily in determining sexual sporulation will be achieved in the near future.

PHV年齡에서 본 體格 ·體力의 發育 ·發達 速度曲線에 관한 연구

朴哲浩,朴贊熙,朴俊東,朴相甲,辛尙根 東亞大學校附設스포츠科學硏究所 1992 스포츠科學硏究論文集 Vol.10 No.-

The purpose of this study was to examine the timing and sequence of growth and development velocity curves of some physique and physical fitness aligned on age at peak height velocity. The study design, the subjects, and the method used in cross-sectional investigation reported by Ministry of Physical Education and Youth of Korea(1989). According to the reported by Ministry of Physical Education and Youth, the subjects participated in goverment study were 7 through 50 over years of age who belonged to typical primary, junior and senior high school, college and adult, and about 550 males and 550 females in each age. Thus, the total sample size were 6,316 males and 6,316 females. Grand total was 12,632. For physique measured, 2 body linearity items ; body height and sitting height, 5 body bulk items ; body weight, chest girth and 3 site skinfold thickness items were selected. For physical fitness measured, 8 items such as grip strength, sit-ups, 10m shuttle run, standing long jump, 50m dash, long distance run, eyeclosed foot balance and trunk flexion were selected. Measurements were actually worked out in April through July, 1989. The mean and the standard deviation were computed for each itesm, each age, and each sex, respectively. The growth and development velocity magnitudes of some physique and physical fitness in this study were calculated by personal computer. The conclusion obtained as follows. 1. Ages at PHV occurred earlier about 3years than males on the average. 2. Maximal annual increments (PV) in body weight, chest girth and sitting height appeared to coincide with PHV in males, but, to about 1 and 2 years after PHV in females. 3. Two occurrence of peak velocity gained in the chest girth for males and 3 site skinfold for females. In contrast, peak velocity of triceps skinfold was not appeared in males. 4. Peak velocities of grip strength and trunk flexion occurred about 1 to 2 years after PHV in both sexes. Peak velocities of 50m dash and long distance run occurred about 1 to 2 years after PHV in males. 5. Peak velocities of sit-ups, standing long jump and eyeclosed foot balance occurred about 1 to 2 years before PHV in both sexes, respectively. 6. Peak velocity of 10m shuttle run was not occurred in both sexes, peak velocity of 50m dash was not occurred in females. 7. Generally, peak velocities of physique and physical fitness occurred earlier about 1 to 3 years in females than in males.

間歇的 運動에 의한 脫水 및 水分攝取의 生理的 效果

朴哲浩,朴吉俊,李相于,金永明,朴贊熙,玄松子,呂南會,朴相甲,金榮俊 東亞大學校附設스포츠科學硏究所 1989 스포츠科學硏究論文集 Vol.7 No.-

This study aims at revealing the physiological responses of dehydration (DH) and rehydration (RH) in intermittent exercises at the work intensity of 70% HR max. First, with general student public, three times of exercise (each for 20 minutes) at the given work intensity were taken, with a break for 25 minutes respectively. Their heart rate, rectal temperature and plasma electrolyte concentration both DH and RH were measured. Second, in two groups of athletes and non-athletes, 9 rounds of exercise (for 100 minutes) and 8 breaks (for 60 minutes) were taken, with RH forced 10 times to compensate for the subjects' water loss. Their change in sweat loss and plasma electrolyte concentration as well as the IVDP(Intensive Voluntary dehydration Phenomenon) were experimented. The summary of this research follows. 1) Mean heart rate and rectal temperature in intermittent exercises were higher at DH than at RH, growing up at the increasing level of DH. 2) RH saw no change in the plasma concentration of Na+, K+ and Cl-, while DH observed a significant increase. 3) HCO₃made a significant decrease at DH before growing up. 4) Mg++ had no change, while Ca++ increased significantly at RH and DH. 5) Lactate showed an increase with significance at RH and DH, especially greater at DH. 6) Osmotic pressure increased meaningfully at DH. 7) Anion gap increased significantly at DH and RH. 8) On the other hand, when the forced RH was held, the group of athletes had greater sweat loss per body surface area than that of non-athletes. 9) The athletes' plasma concentration of Na+ and Cl- revealed a clear decrease. 10) There was seen no significant change in the plasma concentration of K+, Mg++ and Ca++ in both groups. 11) The IVDP occurred at the RH of 2.3ℓfor athletes and more than 2.5ℓfor no-athletes.

폐결핵 환자 혈청에서 수용성 Interleukin 2 수용체 및 Adenosine Deaminase 활성도에 관한 연구

고정희,박성규,백상현,박찬권,박병수,안진영,최우석,박정규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Interleukin-2 (IL-2) induces T cell proliferation in an autocrine manner and provides a means by which antigen triggered T cells can be clonally expanded in vitro. During the following activation, the activity of IL-2 is mediated by specific high affinity IL-2 binding membrane receptors which are expressed shortly after activation. In this process, a 42 KD-fragment (soluble IL-2R) is continuously cleaved off and circulates as a soluble marker of T lymphocyte activation. Elevated level of soluble IL-2R has been identified in the serum of patients with malignant autoimmune and allergic disorders, systemic parasitic infection, undergoing graft versus host disease, acute or chronic lymphocytic leukemia and HIV-infection. ADA (adenosine deaminase) completes the process of differentiation of T cell and is essential for progression of T cell maturation. Therefore level of ADA is to correlated with magnitude of T cell immune response. The fact that expression of sIL-2R and ADA activity increases in peripheral blood T-lymphocytes of patients with active pulmonary tuberculosis suggests that T cell activation might have a major role in the pathogenesis of pulmonary tuberculosis. In order to evaluate the T cell immune response in pulmonary tuberculosis, we measured the serum concentration of sIL-2R and ADA activity in 17 patients with current pulmonary tuberculosis, 10 chronic inactive pulmonary tuberculosis, 10 as normal controls. (1) Current pulmonary tuberculosis had significantly higher levels of sIL-2R (237.24±95.47)when compared with those of inactive tuberculosis (78.6±11.06). and the control (68.17±15.4) group. (2) ADA activity in current pulmonary tuberculosis was significantly increased (34.41±20.63) when compared with those of inactive tuberculosis (24.7±14.36) and control (17.65± 5.94) group. (3) There was good correlation between sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group. (4) sIL-2R concentration and ADA activity was decreased significantly 6 months after anti-tuberculosis drug medication. In conclusion, sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group was increased when compared with those of inactive pulmonary tuberculosis and the control group. By the way, T cell mediated immune response was enhanced in current pulmonary tuberculosis, but in inactive chronic pulmonary tuberculosis who had treated by antituberculosis drug medication, the concentration of sIL-2R and ADA activity was nearly normal.

고속주축 모니터링용 광파이버 변위센서의 파이버 특성에 따른 센서 성능 연구

박찬규,신우철,배완성,홍준희,이동주 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

To make high speed spindle system work properly, sensors with outstanding resolution and dynamic characteristics are essential. An optical fiber displacement sensor is based on simple principles. Electrical signal responds to the optical flux change due to the displacement change between a target and a sensor probe. In this paper, the performance of optical fiber displacement sensor has been investigated according to properties of optical fiber. Firstly, optical loss has been measured before and after polishing optical fiber endface. Secondly, allowance of optical fiber bending has been tested. thirdly sensitivity and linear range of the sensor has been found out according to the shape of cross section of optical fiber.

인천광역시 고등학교 특수학급 졸업생의 직업실태 분석

박희찬,정경숙 국립특수교육원 2004 특수교육연구 Vol.11 No.2

이 연구는 인천광역시 고등학교 특수학급 졸업생(2000년-2003년도)을 대상으로 취업실태와 직무, 취업관련 경로, 직업특성을 조사·분석하고 개선방안을 모색하는 데 목적이 있었다. 이를 위하여 선행연구를 검토한 후 학교용 조사지와 졸업생용 조사지의 두 종류를 개발하였다. 연구결과 첫째, 취업실태 면에서는 취업 68.9%, 미취업 22.2%, 교육·훈련 6.7%로 높은 취업률을 보였으며, 직무는 부품조립·생산제조 67.8%, 제과·제빵 14.5%, 서비스업 11.3%, 기타 6.5%로 나타났다. 둘째, 취업관련 경로 면에서는 한 번의 경로를 가진 졸업생이 70%로 가장 높았다. 셋째, 직업특성 면에서는 취업알선, 고용유형, 근무시간, 급여, 취업기간, 취업만족, 상호작용 대상을 조사·분석하였다. 취업실태조사 결과는 인천광역시 고등학교 특수학급을 졸업한 장애학생들의 취업률이 전국의 2003년 고등학교 특수학급 졸업생 취업률 40%보다 훨씬 그 비율이 높음을 보여 주었다. 이는 인천광역시 고등학교 특수학급 졸업생이 전국의 고등학교 특수학급 졸업생들보다, 평균적으로 볼 때, 직업인으로서 사회통합에 보다 근접하고 있음을 보여준다. 이 연구에서는 또한 지역사회 기반의 다양한 전환교육 실천 프로그램 모색, 전환교육 실천을 위한 전담교사의 필요성, 전환 모델 개발, 다른 시 도의 고등학교 특수학급 졸업생의 취업실태 조사 필요성 등이 제안되었다. The study investigated the occupational status, job duties, tracks related to employment, and job characteristics of graduates of high school special classes in Inchon City. To collect data, a telephone survey was implemented using two types of questionnaire, one for special education teachers, the other for graduates' family. The results of the study was as follows: First, among the 90 graduates, employment rate was 68.9%, unemployment rate was 22.2%, and training and education rate was 6.7%. Second, regarding the tracks related to employment, 70% of the graduates had one track, 27.8% of them had two tracks, and 2.2% of them had three tracks. Third, the characteristics of jobs, employment types, working hours, average monthly wage, the degree of job satisfaction, interaction with the people were also surveyed. The results of the study suggested for the development of various transition education practice programs in community based, the application of the survey in other cities and provinces, the importance of the qualified vocational special education teachers, and the expansion of the transition education focusing on adult community lives.

短距離選手의 全力疾走時 身體動作에 관한 映像分析

朴贊熙 東亞大學校 1982 東亞論叢 Vol.19 No.1

The new method of researches in body motion based on the principle of vital dynamics has brought about the betterment of the record in short-distance race. For this thesis, the researcher took pictures of body motion of four of the state male amateurs on the actice list, when running a 100-meter race, and acquired the following data. 1. The duration of keeping themselves above the ground of the above mentioned runners when running at full sprint was 0. 138 second, and that of touching on the ground, 0.111 second, thus the time gap being 0.0027 second. 2. The number of steps per second of the examinees during sprinting was 4.44 to 4.77, while that of the world-record holders is 5.43. 3. Only runner 'Suh' showed 6 degrees backward angle in his upper body motion, the others having no tendency to backward motion at all. It is interesting to note that the average world-record holders tend to keep backward at the angle of 7 to 8 degrees. 4. The angle of the runners' legs when touching the ground kept at 67 to 68 degrees, and their speed at full sprint was 10.03 to 10.57 meters per second. Whereas the world-record holders run as 11.11 to 11.62 meters per second. 5. Theoretically, the angle of arm motion in full should bo 90 degrees for ward and 120 degrees backward, but in the case of the runners under examination, their arm motions fell far less.

NCHS와 韓國의 發育 Chart를 基準한 남녀 다운症兒와 精神遲滯兒의 體格發育樣相

朴贊熙,辛尙根,朴英權 東亞大學校 附設 스포츠科學硏究所 1994 스포츠科學硏究論文集 Vol.12 No.-

The purpose of the present study was to examine on the growth pattern of body height and weight from NCHS and Korean growth chart in down's syndrome and mentally retarded children from 7 through 17 years of age. The study design, the subjects and the method were used by the longitudinal data. The subject groups participated in this study were males down's syndrome group(n=16), female down's syndrome group(n=16), male mentally retarded group(n=21), female mentally retareded group(n=14), male normal group(n=90), and female normal group(n=97). Total subjects size was 254. All subjects lived in pusan city, Korea. The data of body height and weight in this study were plotted relative to National Center for Health statistics(1982) and Korean(1975) reference growth charts for stature and weight of American and Korean boys and girls from 2 through 18 years of age, respectively. The conclusion were as follows : 1. In the body height growth chart of NCHS, males and females with down's syndrome were grown within the ranges of 10th P(percentile)∼5th P under, males and females with mentally retardation were grown within the ranges of 10th P∼5th P, respectively. 2. In the body weight growth chart of NCHS, males with down's syndrome were grown within the ranges of 75th P∼25th P, females with down's syndrome were grown within the ranges of 25th P∼50th P, males with mentally retardation were grown within the ranges of 25th P∼10th P, females with mentally retardation were grown within the ranges of 25th P∼50th P, and normal males and females were grown within the ranges of 25th P, respectively. 3. In the body height growth chart of Korean, males with down's syndrome were grown within the ranges of 25th P∼3th P under, females with down's syndrome were grown within the ranges of 10th P∼3th P under, males with mentally retardation were grown within the ranges of 25th P∼10th P, females with mentally retardation were grown within the range of 25th P, and males and females were grown within the ranges of 25th P∼75th P, respectively. 4. In the body weight growth chart of Korean, males with down's syndrome were grown within the ranges of 97th P∼75th P, females with down's syndrome were grown within the ranges of 50th P∼90th P, males with mentally retardation were grown within the ranges of 50th P∼25th P, females with mentally retardation were grown within the ranges of 25th P∼75th p, normal males were grown within the ranges of 25th P∼75th P, and normal females were grown within the ranges of 25th P∼50th P, respectively.

의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics

박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.