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이환희,조효선 한국미생물·생명공학회 2019 한국미생물·생명공학회지 Vol.47 No.1
Apigenin, a common natural product that is found in many plants and vegetables, has been reported to have many biological activities, including antioxidative, anti-inflammatory, and anticancer effects. The triple- negative breast carcinoma cell line MDA-MB-231 is known to be highly invasive and resistant to chemotherapy. In this study, we investigated the anticancer effect of apigenin on human MDA-MB-231 cells. First, the cytotoxicity of apigenin toward MDA-MB-231 cells was analyzed by MTT assay. Then, the cell cycle and apoptotic effects of apigenin were examined, and the molecular mechanism underlying its anticancer activity was explored. Apigenin inhibited the growth of the cells in a dose-dependent manner, correlating with the cell cycle arrest at the G2-M phase as well as an increase of early apoptosis. The cell-cycle inhibitory effect was highly associated with the increased expression of p21 and decreased expression of CDK6, cyclin D1, and cyclin B1. The induction of apoptosis by apigenin was associated with the upregulated expression of cleaved PARP and cleaved caspase-3, -7, and -9.
이환희,양재원 한국건강심리학회 2018 한국심리학회지 건강 Vol.23 No.2
The present study examined the effect of social anxiety on perception of Duchenne smile by applying a signal detection theory. Two hundred and thirty one undergraduate students completed measures of social anxiety and depression. Based on total social anxiety scores, subjects who were in the upper 20% were selected to be in the high social anxiety group, and those who were in lower 20% were selected to be in the low social anxiety group. In the experiment, 34 subjects (19 subjects in the high social anxiety group and 15 subjects in the low social anxiety group) participated. After 20 videos of smiling individuals (10 Duchenne smiles and 10 non-Duchenne smiles) were presented, participants were asked to discriminate whether the smile was genuine(Duchenne) or fake(non-Duchenne). Then, to control the effect of the attractiveness of the smiling individuals on the perceptions of the Duchenne smile, the attractiveness of each individual was measured. The results showed a significant difference in response bias between the high social anxiety group and the low social anxiety group. However, the difference between the groups was not significant when the levels of depression symptoms were controlled. The results suggest that people with high social anxiety tend to judge Duchenne smiles as fake smiles, though it does not seem to be a feature unique feature to individuals with social anxiety. 본 연구에서는 미소를 지각하는 데 사회불안이 미치는 영향을 신호탐지이론을 적용하여 알아보고자 하였다. 231명의 대학생을 대상으로 사회불안과 우울을 측정하였고, 사회불안 점수를 토대로 상·하위 20%를 고사회·저사회불안 집단으로 분류하였다. 이 중 총 34명(고사회불안 19명, 저사회불안 15명)의 피험자가 실험에 참가하였다. 실험 자극은 중립적 표정의 인물이 미소를 보이고 다시 중립적 표정으로 돌아오는 약 4초간의 영상이었다. 뒤상느(진짜)/논뒤상느(거짓) 미소 각 10개씩 총 20개의 얼굴 영상이 자극으로 제시되었다. 참가자들은 이 영상을 보고 그 인물의 미소가 진짜 미소인지 혹은 거짓 미소인지를 평정하였다. 실험 결과, 고사회불안집단이 저사회불안집단에 비해 뒤상느 미소를 거짓 미소로 판단하는 반응 편향이 있는 것으로 나타났다. 그러나 함께 측정한 우울을 공변인으로 통제할 경우 반응 편향의 유의성은 사라졌다. 이는 사회불안이 높은 사람들이 뒤상느 미소를 거짓 미소라고 판단하는 경향이 높음을 시사한다. 그러나, 그것이 사회불안 특정적인 것이라기보다는 우울과 공유하는 특성일 가능성이 시사된다.