강원도 화천군 수달(Lutra lutra) 서식지의 식생 구조

서형수 ( Hyung Soo Seo ),신영섭 ( Young Seob Shin ),이경은 ( Kyung Eun Lee ),김윤미 ( Yoon Mi Kim ),전미나 ( Mina Jeon ),남택우 ( Taek Woo Nam ),한성용 ( Sung Yong Han ),정연숙 ( Yeonsook Choung ) 한국하천호수학회 2014 생태와 환경 Vol.47 No.special

In order to determine whether vegetation would be one of the factors for the selection of otter home range, vegetation structure and other potential factors were studied in Hwacheon, Korea. Thirteen sites, otter’s activity found and not found, were investigated in North Han River and connected tributary streams of Hwacheon-gun. Three types of vegetation were classified by cluster analysis, which is short grass, tall grass and shrub type. Vegetation zone of each channel is composed of either one type, or mosaic of tall grass and shrub type. Short grass type is common in Lake Paro and upper North Han-river where water level is highly variable throughout a year. Therefore, annual species such as Persicaria nodosa, Fimbristylis dichotomam and Chenopodium ficifolium are the most dominant. Shrub type is common at the downstream sites of Jichon stream and along mainstream of North Han River down Lake Paro. A shrub species, Salix koreensis, is the most common. Tall grass type is dominant occupying the most vegetation zone of the tributary channels. Phragmites japonica is absolutely dominant. Due to its dense cover, a few plant species are co-existed. Otter activity was found in all three vegetation types and no marked activity was found at some sites of tall grass type. There is no difference in species composition and physiognomy between tall grass sites with and without otter activity, while it shows significant difference in fish availability between two groups. Overall we found that home range of otters in the region is along the mainstream and downstream of tributary streams with high fish availability in all vegetation types and in various human activity levels.

혈압점(血壓點)에 윤제(潤劑)의 주입이 고혈압에 미치는 영향

위종성,한재섭,박희수,박재영,Owi, Jong-Sung,Han, Jai-Seop,Park, Hee-Soo,Park, Jai-Young 대한약침학회 2002 Journal of pharmacopuncture Vol.5 No.1

Objective: This study was designed to evaluate the possibility of Hypertension by moistening Herbal-acupuncture at Blood Pressure Point(HN136). Methods: We reviewed 14 patients of Hypertension. They were hospitalized at oriental medical hospital of Sang-Ji university for 2002. 1. 2. - 2002. 5. 2. First, we divided into two groups; Group Ⅰ was administrated by moistening Herbal-acupuncture at Blood Pressure Point(HN136), and was not given any western medicine about Hypertension during the period of experiment. Group Ⅱ was administrated by moistening Herbal-acupuncture at Blood Pressure Point(HN136), and given western medicine about Hypertension during the period of experiment. we observed the change of systolic and diastolic for 2 weeks, and compared Group Ⅰ with Group Ⅱ . Results: The results obtained as follows: 1. The figure of systolic in Group Ⅰ was decreased, but there was no signification. There was a significant decrease in Group Ⅱ (p<0.05) 2. The figure of diastolic in Group Ⅰ was decreased, but there was no signification. There was a significant decrease in Group Ⅱ (p<0.05) 3. Group Ⅱ was more effective than Group Ⅰ in the results. Conclusion: The results suggest that moistening Herbal-acupuncture at Blood Pressure Point(HN136) was effective treatment of Hypertension. So further research is needed continuously.

한강수계의 고회수율 UF 막여과 정수처리 공정의 적용

이태국 ( Tae Kuk Lee ),김지훈 ( Ji Hoon Kim ),김동수 ( Dong Soo Kim ),홍성호 ( Sung Ho Hong ),박민구 ( Min Koo Park ),박정은 ( Jung Eun Park ),한명애 ( Myung Ae Han ),김병훈 ( Byung Hoon Kim ),김형수 ( Hyung Soo Kim ) 한국물환경학회 ( 구 한국수질보전학회 ) 2008 공동 추계학술발표회 Vol.2008 No.-

류마티스 관절염에 대한 한약의 면역학적 연구동향

최도영,이재동,백용현,이송실,유명철,한정수,양형인,박상도,유미현,박은경,박동석,Choi, Do-young,Lee, Jae-dong,Back, Yong-hyeon,Lee, Song-shil,Yoo, Myung-chul,Han, Chung-soo,Yang, Hyung-in,Park, Sang-do,Ryu, Mi-hyun,Park, Eun-kyung,Park, 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4

Objective : Rheumatoid arthritis is an autoimmune disease that pathogenesis is not fully understood and one of the most intractable musculoskeletal diseases. The concern in the immunopathogenesis of rheumatoid arthritis has been increased since 1980's and many immunotherapeutic agents including disease-modifying antirheumatic drugs (DMARDs) were developed and became the mainstay of treatment of rheumatoid arthritis. However, the cure of the disease has hardly been achieved. In oriental medicine, rheumatoid arthritis is related to Bi-Zheng(痺證), that presents pain, swelling, andlor loss of joint function as major clinical manifestations, and also known to be deeply involved in suppression of immune function related to weakness of Jung-Ki(正氣). The herbal medicine, empirically used, could be a potential resource of development of new immunotherapeutic agents for rheumatoid arthritis. Methods : We developed a search strategy using terms to include "rheumatoid arthritis and herbal medicine" combined with "Chinese medicine" and/or "Oriental medicine". The search was focused on experimental studies of herbal medicine (January 1999 to May 2004), which is known to have effects on immune function of patients with rheumatoid arthritis. Computerized search used Internet databases including KISS and RISS4U (Korea), CNKI (China), MOMJ (Main Oriental Medicine Journal, Japan), and PubMed. The articles were selected from journals of universities or major research institutes. Results : The literature search for experimental studies on effects of herbal medicine on immunity of rheumatoid arthritis retrieved a total of 21 articles (Korea; 8, China ; 12, Japan ; 1). Of 21 articles, 10 were related to single-drug formula, 2 to drug interaction, and 9 to multi-drug formula. Single-drug formula was mainly used for aqua-acupuncture and researches on active components. Studies of drug interaction emphasized harmony of Ki-Hyul(氣血) and balance of Han-Yeul(寒熱). Multi-drug regimen was mainly found among formulas for Bo-Ki-Hyul(補氣血) and Bo-Sin(補腎). Conclusion : Studies on rheumatoid arthritis were performed both in vitro and in vivo in vitro study, LPS-stimulated splenocytes and synoviocytes were treated with herbal medicine, resulting in proliferation and activation of immune cells and suppression of cytokine activities in vivo study CIA animal model demonstrated that herbal medicine decreased antibody production and improved function of immune cells. In cellular and molecular study herbal medicine showed profound effects on the level of mRNA expression of certain cytokines related to immune function. This study revealed that herbal medicine has significant immune modulatory action and could be used for recovery of immune dysfunction of rheumatoid arthritis patients.

Environmental Management in Industry

Han, Sang Wook,Kim, Ik Soo,Terence P. CURRAN 한국환경정책학회 1995 環境政策 Vol.3 No.1

환경문제를 야기시키는 원인은 인간 그 자체에 있으며, 경제주체별로는 개인, 기업, 정부로 볼 수 있다. 시시각각 변화하고 강화되여가는 국제환경질서에 대처하기 위해서는 기업과 정부가 협조적인 관계를 유지하면서 각각의 역할을 하여야하는 바, 기업은 사회공헌책임주의에 입각하여 환경친화책인 기업경영을 도입, 실천해야 하며, 정부는 이를 지원, 촉진하기 위한 정책을 펼쳐야 할 것이다. 이 논문은 지구차원에서의 환경문제, 미국과 한국의 최근 환경정책 그리고 기업에서의 환경경영도입의 중요성과 환경경영이 모든 조직기능에서 통합 고려되어야 하는 필요성올 논의하였으며, 기업의 환경경영을 위한 환경성과지표, 환경심사, 전과정분석 등의 요소들을 검토하였다. 끝으로 3M, Body Shop, Baxter International 둥 3개 기업에 있어서의 환경경영의 사례를 동해 환경경영에 의한 기업이익을 엿볼 수 있었다.

Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media

Han, Seung Beom,Kim, Jong-Hyun,Kang, Jin Han,Ma, Sang Hyuk,Kim, Chun Soo,Kim, Kyung-Hyo,Kim, Hwang Min,Choi, Young Youn Elsevier 2017 Journal of infection and chemotherapy Vol.23 No.3

<P>Conclusion: S. pneumoniae serotype 19A, serogroups 11 and 15 were the major nasopharyngeal-colonizing bacteria in Korean children with AOM after the introduction of PCV7. These relatively prevalent serotype/serogroups showed lower antibiotic susceptibility rates. (C) 2016 Published by Elsevier Ltd on behalf of Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.</P>

Effects of Particle Size and Gelatinization of Job's Tears Powder on the Instant Properties

Han, Sung-Hee,Park, Soo-Jea,Lee, Seog-Won,Rhee, Chul The Korean Society of Food Science and Nutrition 2010 Preventive Nutrition and Food Science Vol.15 No.1

The effects of particle sizes (small, medium and large sizes) and gelatinization treatment on the changes of the instant properties of Job's tears powder were investigated. The degree of gelatinization on the different particle size samples of Job's tears powder was the highest in the small particle size, and it also showed an increasing trend regardless of pregelatinizing whether it is or not as the particle size decreased from large particle size to small particle size. The water solubility index of the pregelatinized samples was high compared to that of ungelatinized samples regardless of particle size and temperatures. The water absorption and swelling power increased as particle size and temperature were increased. The dispersibility and sinkability of ungelatinized sample was increased as particle size and temperature were increased and it also showed lower value regardless of particle size and temperature. However, the dispersibility and sinkability of pregelatinized samples were shown to have the opposite result, such that the smallest particle size of pregelatinized sample had the lowest sinkability (11.3%). The turbidity of the pregelatinized small particle size was the highest by a factor of 1.08.

Point Mutations in the Split PLC-γ1 PH Domain Modulate Phosphoinositide Binding

( Sung Kuk Kim ),( Sung Mo Wee ),( Jong Soo Chang ),( Taeg Kyu Kwon ),( Do Sik Min ),( Young Han Lee ),( Pann Ghill Suh ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.6

A number of signaling molecules contain small pleckstrin homology (PH) domains capable of binding phosphoinositides or proteins. Phospholipase C (PLC)-γ1 has two putative PH domains, an NH₂-terminal (PH1) and a split PH domain (nPH₂ and cPH₂). We previously reported that the split PH domain of PLC-γ1 binds to phosphatidγ1inositol 4-phosphate (PI(4)P) and phosphatidγ1inositol 4,5-bisphosphate (PI(4,5)P₂) (Chang et al., 2002). To identify the amino acid residues responsible for binding with PI(4)P and PI(4,5)P₂, we used site-directed mutagenesis to replace each amino acid in the variable loop-1 (VL-l) region of the PLC-γ1 nPH₂ domain with alanine (a neutral amino acid). The phosphoinositide-binding affinity of these mutant molecules was analyzed by Dot-blot assay followed by ECL detection. We found that two PLC-γ1 nPH2 domain mutants, P500A and HSO3A, showed reduced affinities for phosphoinositide binding. Furthermore, these mutant PLC-γ1 molecules showed reduced PI(4,5)P₂ hydrolysis. Using green fluorescent protein (GFP) fusion protein system, we showed that both PH₁ and nPH₂ domains are responsible for membrane-targeted translocation of PLC-γ1 upon serum stimulation. Together, our data reveal that the amino acid residues Pro^(500) and His^(503) are critical for binding of PLC-γ1 to one of its substrates, PI(4,5 )P₂ in the membrane.

The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling

Sung Ryul Lee,Su Jin Noh,Julius Ryan Pronto,Yu Jeong Jeong,Hyoung Kyu Kim,In Sung Song,Zhelong Xu,Hyog Young Kwon,Se Chan Kang,Eun-Hwa Sohn,Kyung Soo Ko,Byoung Doo Rhee,Nari Kim,Jin Han 대한생리학회-대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.5

Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc (Zn²⁺) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc’s critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and complexity of Zn²⁺ activity has been presumed to parallel the degree of calcium’s participation in cellular processes. Whole body and cellular Zn²⁺ levels are largely regulated by metallothioneins (MTs), Zn²⁺ importers (ZIPs), and Zn²⁺ transporters (ZnTs). Numerous proteins involved in signaling pathways, mitochondrial metabolism, and ion channels that play a pivotal role in controlling cardiac contractility are common targets of Zn²⁺. However, these regulatory actions of Zn²⁺ are not limited to the function of the heart, but also extend to numerous other organ systems, such as the central nervous system, immune system, cardiovascular tissue, and secretory glands, such as the pancreas, prostate, and mammary glands. In this review, the regulation of cellular Zn²⁺ levels, Zn²⁺-mediated signal transduction, impacts of Zn²⁺ on ion channels and mitochondrial metabolism, and finally, the implications of Zn²⁺ in health and disease development were outlined to help widen the current understanding of the versatile and complex roles of Zn²⁺.

Diagnosis of BVD MD in breeding Holstein cow by RT-PCR

Sung-hyo Lee,Soo-chol Han,Jong-o Lee,Yea-baek Yoon,Hee-jong Song,Hyo-seok Chai 대한수의학회 1997 대한수의학회 학술대회발표집 Vol.1997 No.-