갱년기 여성의 호르몬 대치 요법에 대한 수용율

이임순,장진영,이정재,이순곤,이권해,이해혁,김승형 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose: We have evaluated the compliance of hormone replacement therapy. Method: There are 185 climacteric women who are divided into three groups (Group I, Group II, Group III). Group I is given conjugated equine estrogen(CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate(MPA, 5mg, day 1-12). Group II is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group III is given only conjugated equine estrogen(CEE, 0.625mg, day 1-30). Results: 1) The compliance rate of hormone replacement therapy during three months is 77.9% including each Group I : 77.7%, Group Ⅱ : 76.1%, Group Ⅲ :80.4%. 2) The compliance rate of hormone replacement therapy during six months is 60.7% including each Group Ⅰ:52.9%, Group Ⅱ: 56.4%, Group Ⅲ: 79.5%. 3) The compliance rate of hormone replacement therapy during nine months is 49.7% including each Group Ⅰ: 45.5%, Group Ⅱ:41.7%, Group Ⅲ: 64.3%. 4) The compliance rate of hormone replacement therapy during a year is 44.4% including each Group Ⅰ: 40.2%, Group Ⅱ:35.3%, Group Ⅲ: 59.5%. Conclusion : It is vital that we maximize compliance if patients are to receive the full benefits from hormone replacement therapy. We think that physicians who prescribe hormone replacement therapy for climacteric women should enough explain the purpose, risks, and side effect of treatment for maximizing compliance of hormone replacement therapy.

폐경기 여성에서 1년간 호르몬 대치 요법이 혈청 지질에 미치는 영향

이해혁,남계현,김승형,이임순,이권해,최승도 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Cardiovascular disease is one of the most common cause of death in postmenopausal women. After the onset of menopause, the risk of cardiovascular disease is increased. Several risk factors of cardiovascular disease are well known to us. Among the risk factors, the changes of lipid profiles are roles for cardiovascular disease. Estrogen appears to protect the development of cardiovascular disease, by several mechanism. Especially the protective effect is believed to be mediated by the changes of lipid profiles. Decreased high-density lipoprotein (HDL)-cholesterol and increased low density lipoprotein (LDL)-cholesterol are important factors for development of cardiovascular disease. The purpose of this study was to evaluate the effect of hormone replacement therapy on the lipid profiles to include total cholesterol (TC), high density lipoprotein(HDL)-cholesterol, low density lipoprotein(LDL)-cholesterol, and triglycerides. We measured lipid profiles in 31 postmenopausal women and gave each conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 5mg, day 1-12) for 12months. The levels of serum TC, LDL-cholesterol, and triglycerides were decreased significantly (p<0.05) and HDL-cholesterol was increased significantly (p<0.05) after 12months of hormone replacement therapy. These data suggest that hormone replacement therapy appears to protect agianst the development of cardiovascular disease by the changes of lipid profiles.

플라즈마 소결 PZT 세라믹스의 유전특성

이형직,송두규,권혁병,정해경,윤상옥,이형복,이홍림 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

소결첨가제나 바인더를 넣지않고 만든 무첨가 PZT 분말 성형체를 플라즈마 소결-로 열처리 후의 미세조직의 변화, PbO의 거동 그리고 이에 따른 유전특성을 로소결한 경우와 비교하여 다음과 같은 결과를 얻었다. 플라즈마 소결-로 열처리로 만든 PZT 시편이 로 소결 시편과 비교하여 입성장이 크게 일어나지 않은 미세조직을 나타내었으며, 또한 균일한 Pb, Zr, Ti 성분분포를 보였다. 유전특성에 있어서는 1kHz에서 20%정도의 유전율의 향상을 얻을 수 있었으며 유전소실 또한 40%정도 낮출 수 있었다. 상기의 결과는 DC 플라즈마 소결법의 특징인 소결초기의 급속가열 효과와 PbO의 증발 억제 효과에 의한 것으로 고려된다. PZT powder compacts without additives and binder were processed by plasma sintering-furnace annealing. Microstructures, PbO behaviour and dielectric properties were investigated, and compared to the specimen obtained by furnace sintering. The specimen prepared by plasma sintering-furnace annealing showed more not only fine microstructures but also homogeneous pb, Zr, Ti composition distribution, and revealed 20% higher dielectric constant as well as 40% lower dielectric loss (measured at 1kHz). Above results might be considered to be caused by rapid heating effects, high temperature sintering effects and preventing effects of PbO evaporation characterized by dc plasma sintering.

비만세포주에서 Histamine 유리에 관한 연구

김형룡,국윤아,신민,이홍수,원진숙,김형민,이영미,정헌택,이혜숙,안녕형 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

개발산출물의 신뢰성 측정을 위한 메트릭스의 제안과 평가

이하용,황석형,양해술 한국정보처리학회 1998 한국정보처리학회 추계 학술발표논문집 Vol.4 No.1

소프트웨어는 갈수록 대규모화, 다기능화되는 방향으로 발전하고 있다. 더불어 소프트웨어에 관한 사용자의 요구 수준도 높아지고 있으며 특히 소프트웨어의 품질에 대한 요구는 지속적으로 높아지고 있다. 이러한 사용자의 요구를 만족시킬 수 있는 방안들이 다양한 관점에서 연구되고 있다. 그중에서도 소프트웨어의 품질평가를 통해 그 결과를 개발자에게 피드백함으로써 소프트웨어의 품질을 향상시키려는 관점에서 품질평가 체계 및 방법론에 대한 연구가 활발히 진행되고 있다. 본 논문에서는 소프트웨어의 품질에 관한 국제표준인 ISO/IEC 9126의 품질특성 중 신뢰성에 대한 품질특성, 부특성, 내부특성의 체계에 따른 메트릭스와 품질측정표를 개발함으로써 관련 내부특성의 품질평가를 통해 신뢰성에 대한 평가 결과를 산출할 수 있는 체계를 확립하고 개발산출물에 대해 평가한 결과를 제시하였다. α,ω-Bis[Co₂(CO)6{μ-η²:η²-C(R)≡C}]oligothiophene derivatives (6-10), in which two dicobalt hexacarbonyl acetylides are π-conjugated onto both terminals of the oligothiophene, were prepared by the reaction of the α,ω-bis(alkynyl)oligothiophenes (1-5) with Co₂(CO)8. The molecular structures of new compounds were identified by spectroscopic methods and elemental analysis. In cyclic voltammetry of the clusters 6-10, two oligothiophene-based oxidation processes (one for 7) occur between - 0.2 and 1.5 V, and the one reductive process of the metal cluster moieties occurs between 0.0 and - 1.6 V, which is not present for the oligothiophenes (1-5). The silence of the expected electronic communication of the clusters 6-10 may be attributed to the reduction process followed by fast chemical reactions at ambient temperature. The clusters 6-10 commonly exhibit three characteristic bands: a moderately intense, high-energy band, strong medium-energy band and weak-low energy band. The high-energy bands are attributed to the a π-π localized excitation. The medium- and low-energy bands may be ascribed to the metal-to-ligand (d□-π□) charge-transfer transitions of the cluster moiety.

부분구속 접합된 철골보의 신뢰성 해석에 관한 연구

이치형,김해수 동의공업대학 2001 論文集 Vol.27 No.1

The reliability of partially restrained connections is dependent on the variability in the moment-rotation characteristics. In this study, the moment-rotation relation is adopted by power model considering three parameters. Probability distribution functions of three parameters reliability indices are calculated by structural reliability analysis. Limit state equation on the moment-rotation relation of partially restrained connections of steel beam in non-sway steel frame is presented. In order to provide target reliability index by changing coefficient of variance of random variable, advanced first-order second moment method is applied. The results by this method are compared with those by Monte-Carlo method.

화상 처리 기술을 이용한 공기 가압식 인젝터의 분무 특성 분석

이기형,정해영 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

본 연구에서는 공기 가압식 인젝터의 분무 특성과 보조 공기압에 따른 분무 특성에 의한 영향을 분석하였다. 분무 분리각, 분무 도달력, 분무 도달거리, 자우터 평균 입경 등의 분무 특성은 인젝터와 최상의 엔진 성능을 실현하기 위해 필요한 흡기 포트의 최적 설계에 매우 중요한 인자이다. 이러한 분무 특성을 파악하기 위해 거시 분무 구조를 가시화하고, 분무 미립화 과정은 그림자 촬영법과 디지털 화상 처리법을 이용하여 정량화하였다. 실험을 통하여 공기 가압식 인젝터와 공기 보조 어댑터를 설계시 필요한 유용한 설계 인자를 파악할 수 있었으며 본 논문에 상세한 내용을 기술하였다. An experimental study is carried out to analyze spray characteristics for air-shrouded injector and to see the effects of air shrouding pressure differential on the spray characteristics. The spray characteristics including spray angle, targeting capability, penetration, and SMD(Sauter Mean Diameter) are very important for injector and intake port design to achieve best engine performance. The global spray structure are visualized and spray atomization processes were quantified using shadow graphy method and image processing algorithm. Effective spray characteristics to design air-shrouded injector is derived from this experimentation and described in more detail in this thesis.

치매 및 경도인지장애에 대한 인지선별검사 4종의 타당도 비교

이강수,정해관,오병훈,홍창형 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.2

Objectives The authors have evaluated the validity of four currently used screening tools of cognitive function in Korea for dementia and mild cognitive impairment in a community elderly population. Methods We screened 5,085 non-randomly sampled elderly over age 60 in the Gwangju city, Gyeonggi Province. Among those, 927 persons were examined further for evidence of dementia and mild cognitive impairment (MCI). A baseline questionnaire on sociodemographic characteristics and four major screening tests (K-MMSE, MMSE-K, MMSE-KC, and K-HDS) were administered. For the evaluation of validity, we have analyzed the ROC curve and calculated the sensitivity and specificity of each test at its optimal cutoff points. Results ROC analysis of the 3 MMSEs and K-HDS has shown that area under the curve (AUC) was between 0.897 and 0.923 for dementia. Sensitivity and specificity were 0.768 and 0.870, respectively, when the cutoff line was set at 17/18 in K-MMSE. The other two MMSEs had optimal cutoff lines at 16/17 with sensitivity of 0.768 and specificity more than 0.90. K-HDS had its optimal cutoff line at 18/19 with higher sensitivity (0.874) and lower specificity (0.755). Compared with dementia, the four screening tests showed poor validity on MCI, Sensitivity and specificity was in the range of 0.733-0.756 and 0.840-0.855, respectively. Conclusion The validity of the screening tools which are currently being used in Korea to screen for MCI was not significantly different among tests. Because of the difference in the population norm and z-score estimation, use of the common norm is advisable.

부산지역 모 공단 및 인근지역 사업체의 산업보건 실태에 관한 조사연구

이동영,손혜숙,이채언,박형종,김대환,엄상화,최성용,유병철 인제대학교 1993 仁濟醫學 Vol.14 No.4

부산지역 공단 및 인근지역 사업체의 산업보건실태를 파악하기 위하여 205개 사업체의 보건담당자를 대상으로 1990년도의 보건실태에 관한 설문조사를 하였다. 조사내용을 일반사항, 보건관리실태에 관한 사항, 작업장 유해환경 및 보호구 지급사항, 건강관련 사항 및 근무조건에 관한 사항 등으로 대별하여 분석ㆍ관찰하였다. In order to obtain the fundamental data for developing more effective and acceptable programs of public health manegement in an industrial complex, 205 health manager in the plants answered the questionaire of the status of industrial health during 1990. The questionaire consisted of general charateristics, health care status, environmental problems, health problems, and others. 72.4% of 205 plants had less than 100 workers. Fabricated metal manufacture was 32.4%. Although Footwear manufacture was 6.4%, the percentage of workers was 33.1% of total workers. The percentage(56.2) of retired women was higher than that(38.2) of men. 51.9% of total plants has recieving group health care services. 85.4% of plants was exposed to noise, 66.5% was exposed to dust. Ear plug and mask were given to prevent noise and dust in 69.2% and 68.6%, respectively. Among 22,299 workers, 618(2.8%) were diagnosed as suspected non-occupatinal disease. 85.9% of them worked on continuously and had their disease treated. The cases suspected for occupational disease was 100 workers. 82.5% of them changed their post. 45% had the compensation for their occuaptional disease. The rate of working: accidents was 2.3%.

고기능 전력변환 이중데드비트 전류 제어기

이진섭,정해덕,백형래 조선대학교 에너지.자원신기술연구소 2000 에너지·자원신기술연구소 논문지 Vol.22 No.1

This paper describes a new digital control system based on the model state equations and a prediction method of the load current for PLW inverter with DC link. A new technique used dead beat theory to obtain a sinusoidal PWM inverter output voltage with LC filter has been presented. The dead schemes possess one sample delay in theses controlled signal which can compensate by prediction of the reference wave of the load current at next sample time. Load current prediction which has quick response is applied to compensate the random and high frequency components. This proposed control inherently is verified vary good sinusoidal output wave synthesis of voltage and current, providing accurate phase positioning for various load and excellent transient response. The experimental implementation of the system uses a real time TMS320C31 DSP(Digita1 Signal Processor)based digital controller.