항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

삼상 순환 유동층 생물반응기에서 열전달 계수

강태규,송평섭,최길수,조용준,강용,최호석,김상돈 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.5

직경이 0.102m이고 높이가 1.0m인 기체-액체 순환 및 삼상 순환유동층 생물반응기의 상승관에서 열전달 특성을 고찰하였다. 기체 및 액체의 유속 그리고 생물막 담체의 체류량이 상승관 내부의 수직 열원과 반응기 사이의 열전달 계수에 미치는 영향을 결정하였다. 기체-액체 순환 반응기에서 열전달 계수는 기체의 유속이 증가함에 따라 증가하였으나 액체 유속의 증가에 따라서는 약간 증가하였다. 삼상 순환유동층 생물반응기에서 열전달 계수는 기체의 유속과 유동 생물막 매체의 체류량이 증가함에 따라 증가하였으나 액체의 유속이 증가함에 따라서는 약간 증가하였다. 본 연구의 실험 범위에서 이들 열전달 계수는 실험 조작 변수의 상관식으로 잘 나타낼 수 있었다. Heat transfer characteristics have been investigated in the riser of gas-liquid circulation and three-phase circulating fluidized-bed bioreactors whose diameter and height are 0.102m and 1.0m, respectively. Effects of gas and liquid velocities and holdup of fluidized biofilm media on the heat transfer coefficient between the immersed vertical heater and the bed have been determined. The heat transfer coefficient in the gas-liquid circulation reactor increases with increasing gas velocity, but increases only slightly with increasing liquid velocity. The h(heat transfer coefficient) value in the three-phase circulating fluidized-bed bioreactor also increases with increasing gas velocity or holdup of fluidized biofilm media, but it increases only slightly with liquid velocity. The value of heat transfer coefficient has been well correlated in terms of operating variables.

할로아세틸시코닌 유도체의 합성 및 항암성 평가 : Synthesis and Evaluation of Antitumor Activity

鄭相國,金光洙,송규용,조훈,안병준 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

The secondary hydroxy group at side chain of shikonin structure was selectively acylated with various haloacetic acids in presence of dicyclohexylcarbodiimide and 4-dimethylaminopyridine to produce haloacetylshikonin derivatives. The cytotoxicity of monohaloacetylshikonin derivatives against L1210 cells increased in the following order: monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖) nonobromoacetylshikonin (ED_50, 0.158㎍/㎖)>monoiodoacetylshikonin (ED_50, 0.173 ㎍/㎖). Introduction of larger halogen atoms decreased the cytotoxic activity, presumably due to steric hinderance. The cytotoxicity of chloroacetylshikonin derivatives was dependent on the number of chlorine atom, thus increasing in the following order : trichloroacetylshikonin (0.032 ㎍/㎖)>dichloroacetylshikonin (0.059 ㎍/㎖)> monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖). Thus, the electron-withdrawing effect seems to be important for the cytotoxicity of chloracetylshikonin derivatives. Consistent with the above, dichloracetylshikonin (T/C, 182%) and trifluoroacetylshikonin (195%) showed higher T/C values than monochloroacetyl-(T/C, 122%), monobromoacetyl-(T/C, 154%) and monoiodoacetylshikonin (T/C, 117%) derivatives. Haloacetylshikonin derivatives showing lower cytotoxic activities against L1210 cells exhibited lower T/C values. It seems that there is a relationship between the cytotoxicity of haloacetylshikonin and their antitumor activity.

지지행거를 갖는 배관계의 구조해석

류봉조,임경빈,이규섭,송영봉,공용식,오부진 한밭대학교 생산기반기술연구소 2002 생산기반기술연구소 논문집 Vol.2 No.1

The paper deals with stress and deflection analyses for newly developed PP-pipe structures of LG-Caltex company. In order to calculate the values of stress and deflection, the elements of pipes and its hanger supports are discretized. Through the numerical simulations using commercial FEM code, stresses and deflections of pipes with two or more hanger supports are obtained, and the stability of pipes are checked. Finally, optimal numbers of hanger supports satisfying allowable bending stress is proposed.

희귀 진세노사이드 Rg6, Rg4, Rk3 및 Rh4의 효능 연구

정규진, 이지현, 조수현, 송규용 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

The research on the efficacy of rare ginsenosides in comparison to that of major ginsenosides has not been performed systematìcally and is insufficient, Therefore, with based on the literature survey, the efficacy of the rare ginsenosides, such as Rg6, Rg4, Rk3, and Rh4, is reviewed, and the direction for further research is presented. Sìnce ginsenosides Rg6, Rg4, Rk3, and Rh4 show very diverse and strong activities in various disease models, such as antioxidant activity, anticancer activity, immunity enhancing activity, antì-microbial activity, etc., it can be strong potential candidates as new materials derived from natural materials for pharmaceuticals, cosmetics. and food industry. However, most research is limited to the in-vitro efficacy. Therefore, to systematically investigate the in-vivo effìcacy of individual ginsenosides is required for the application of the ingredients. To do that, it is essential to establish standardized mass production and iso-lation method for individual rare ginsenosides

제2형 당뇨병 환자에서 체내 총항산화능 측정의 의의

윤여일,윤석기,김선규,김용현,남일송,차건영,황의원,김영선 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: The diabetic patients are at significantly increased risk of developing vascular disease. It's etiology may involve oxidative damage by free radiacals and protection againse such damage can be offered by antioxidants. We investigated that oxidative stress as assessed by measurement of total antioxidant status may play a role in development of diabetes mellitus. Method: We measured total antioxiant status using merchandised kit, glycated hemeglobin(HbA1c) in 46 type 2 diabetes mellitus patients and 50 healthy matched control subjects. Result: The total antioxidant status(TAS) was 2.10(±0.04) mmol/L in uncontrolled type 2 DM patients, 2.60(±0.03) in controlled type 2 DM patients and 2.70(±0.16) in healthy control subjects. TAS was significantly lower(P<0.05) in uncontrolled type 2 DM patients, but no significant association between in controlled type 2 DM patients and healthy control subjects. The TAS was 2.00(±0.17) mmol/L in complicated type 2 DM patients and 2.10(±0.29) uncomplicated type 2 DM patients. There was no significant associations between complicated type 2 DM patients and uncomplicated type 2 DM patients. Conclusion: Poor glycemic control is associated with reduced TAS in type 2 DM patients. TAS was thought indirect index that predict glycemic control of type 2 DM patients.

Naphthazarin Derivatives (Ⅶ): Antitumor Action against ICR Mice Bearing Ascitic S-180 Cells

Song, Gyu-Yong,Kim, Yong,You, Young-Jae,Gho, Hoon,Ahn, Byung-Zun The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.1

Various analogues of 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) such as 2- or 6-(1-hydro-xyiminoalkyl)-DMNQs were prepared and evaluated for the antitumor action. (1-Hydroxyiminoalkyl)-DMNQ derivatives expressed greater antitumor action than (1 -hydroxyalkyl)- or acyl-DMNQ derivatives. Moreover, 6-(1-hydroxyiminoalkyl)-DMNQ derivatives expressed higher anti-tumor action than 2-sudstituted ones, suggestive of a steric effect. Some of 6-(1-propyloxyalkyl)-DMNQ derivatives with an alkyl group of butyl to octyl moiety showed T/C values of > 400 %.

Synthesis of Dibenzoylmethanes as Intermediates for Flavone Synthesis by a Modified Baker-Venkataraman Rearrangement

Song, Gyu-Yong,Ahn, Byung-Zun The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.6

1-Polyoxyphenyl-3-(2, 6-dioxyphenyl)propane-1, 3-diones have been synthesized as intermediates for flavone synthesis by condensation of 2-(2, 6-dioxybenzoyloxy)polyoxyacetophenone in the presence of phae transfer catalyst. The average yields of 1-polyoxyphenyl-3-phenylpropane-1, 3-diones, 1-polyoxyphenyl-3(2-benzyloxyphenyl)propane-1, 3-diones and 1-polyoxy-3-(2, 6-dibenzyloxyphenyl)propane-1, 3-dions were 79%, 74% and 71% respectively. The bulkiness of the benzyloxy groups or methyoxy gorups exerted steric hindrance and reduced the yield. Nevertheless, the yield were higher than the previously reported ones.

Study on Change of Human's Psychological and Physical response in Train

Yong Soo Song,Jong Hyun Baek,Yong Gyu Kim,Tae Kyun Ko 대한인간공학회 2011 대한인간공학회 학술대회논문집 Vol.2011 No.5

Objective: The purpose of this study is to investigate changes of Psychological and physical responses in train. Train drivers use their forearm 4hours/day for normal operation. The frist, the method for measuring the driver's physical response is to investigate changes in the R-R interval of a train driver operating the MasCon by using ECG(electrocardiogram) measurement technique. Accordingly, four different ECG signals of deltoid, biceps brachii, brachioradialis, flexor carpi ulnaris muscle of upper extremity have been measured and analyzed. The raw ECG Signals have been converted into median frequency using spectrum analysis. As the result, 80% of 10 subjects(real train drivers) showed that median frequency value of all R-R intervals has been reduced after 30 minutes of train operation. This results demonstrated that operating MasCon for 30 minutes could induce EEG fatigue. The second, the method for measuring the driver's psychological response is to investigate changes of GSR(Galvanic Skin Response) at the same time. As the result, GSR value significantly increased over time. this means that driver's emotional awakening is increased. This is likely to cause mental stress.

Antitumor and Anti-metastatic Effect of Mineral Powder

Gyu Yong Song,Ki Whan Bae,Chang-Seon Myung,Wen Yi Jin,Yong Jin Park,Mi Young Yun,Dong Hee Kim 한의병리학회 2005 대한동의병리학회 학술대회논문집 Vol.2005 No.8