Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

효율적인 군 전직지원체제 정립 방안

정철영,고재관,황원채,윤희철,박가열,김재호,이성식,김동승,표성일,이건남,양안나,최수정,김은석 한국직업능력개발원 2008 직업능력개발연구 Vol.11 No.1

이 연구의 목적은 제대군인에 대한 효율적인 전직지원을 위해서 현행 전직지원 프로세스에 대한 개선 안과 이에 따른 국방부, 국가보훈처 등 제대군인 전직지원관련 기관 간의 역할분담 및 연계방안에 대해서 제안하는 것이다. 연구는 크게 세 가지 과정을 거쳤다. 첫째, 국내 군 전직지원 실태를 분석하여 문제점과 시사점을 도출하였다. 둘째, 이러한 문제점과 시사점, 군 전직지원 선행연구를 종합하여 효율적인 군 전직지원 프로세스 안을 제시하였다. 셋째, 구축한 군 전직지원 프로세스 안에 따라 주요 군 전직지원 관련 기관인 국방부, 국가보훈처의 역할 분담 안을 제안하였다. This study aims to suggest an improvement plan for the support process of effective occupation change for discharged soldiers and then role assignments among related institutions for supporting discharged soldiers such as Ministry of Defense, Ministry of Patriots and Veterans Affairs, Ministry of Labor and the cooperation plan among the institutions. The study was made in three steps. First, after analyzing currents support facts and status for discharged soldiers, it induced its problems and implications. Second, integrating the findings of previous studies related to support plan on occupation changes for the discharged soldiers, Problems and implications mentioned above, it constructed effective occupation change process for discharged soldiers. Then, according to the established process, it suggested role assignments such as Ministry of Defense, Ministry of Patriots and Veterans Affairs, Ministry of Labor.

유치원 일반교실의 색채계획에 관한 연구

이청웅,정가영,김무오 朝鮮大學校 建設技術硏究所 2006 建設技術硏究 Vol.26 No.1

A kindergarten requires an approach to meet the nature and sense of children who is main users. This study selected 33 private kindergartens which were within a housing site development zone in Gwangju since the 1990's, had single use. and was constructed in the last five years. Also the image assessment according to types of color scheme was made. Then the factors which affected preference by type were analyzed and the basic of color scheme in a kindergarten classroom was provided. The following results were obtained. First, types of color scheme in a classroom included identity 12.1%, similarity 51.5%, and novelty 36.4% in harmony, but on contrast and achromatic color. Secondly, the assessment of preference according to each type was mostly positive. The highest preference was found in similarity harmony of warm color(e .g. YR, Y) and bright, clear, nice and strong images were high in assessment. The lowest preference was found in identity harmony of cold color(e.g. GY). This color system had on clear image assessment, except manly of strong. In particular, warm color showed higher preference than cold color in similarity, novelty, and identity harmony. Thirdly, the factors affecting the preference of color scheme in a classroom most were 'stable-unstable', 'clean-dirty', 'nice-not nice', and 'vital-dull'.

가로환경요소에 따른 고층집합주택의 외관색채계획에 관한 연구

이청웅,김무오,정가영 朝鮮大學校 建設技術硏究所 2006 建設技術硏究 Vol.26 No.1

This study examined types and color conditions of street views through relationship of high-storied apartment house to environment components which has great visual influence on urban street view and requires harmony with street environment as background factor and conducted positive experiment with high-storied apartment houses located at housing site development districts in Gwangju Metropolitan City since 1990s in order to set applicable color ranges in designing colors of high-storied apartment houses which became background of street view by types. Consequently, in image changes of four factors of main colors in classified street types, P. RP. Rand YR colors showed high average values in naturalness, harmony and unity and GY, G, BG and B colors showed dichotomy with low average value, but image of personality showed generally low average value. RP. Rand YR colors showed higher adaptability and GY, G and BG colors showed lower adaptability. It was confirmed that according to adaptability of main colors used in high-storied apartment houses by street types, there was difference of appropriate color range in environment components and color design of high-storied apartment houses by street types.

Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice

Ga-young Jung,Sae-Bom Won,Juhae Kim,Sookyoung Jeon,Anna Han,Young Hye Kwon 한국독성학회 2013 Toxicological Research Vol.29 No.1

Betaine supplementation has been shown to alleviate altered glucose and lipid metabolism in mice fed a high-fat diet or a high-sucrose diet. We investigated the beneficial effects of betaine in diabetic db/db mice. Alleviation of endoplasmic reticulum (ER) and oxidative stress was also examined in the livers and brains of db/db mice fed a betaine-supplemented diet. Male C57BL/KsJ-db/db mice were fed with or without 1% betaine for 5 wk (referred to as the db/db-betaine group and the db/db group, respectively). Lean non-diabetic db/+ mice were used as the control group. Betaine supplementation significantly alleviated hyperinsulinemia in db/db mice. Betaine reduced hepatic expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha, a major transcription factor involved in gluconeogenesis. Lower serum triglyceride concentrations were also observed in the db/db-betaine group compared to the db/db group. Betaine supplementation induced hepatic peroxisome proliferator-activated receptor alpha and carnitine palmitoyltransferase 1a mRNA levels, and reduced acetyl-CoA carboxylase activity. Mice fed a betaine-supplemented diet had increased total glutathione concentrations and catalase activity, and reduced lipid peroxidation levels in the liver. Furthermore, betaine also reduced ER stress in liver and brain. c-Jun N-terminal kinase activity and tau hyperphosphorylation levels were lower in db/db mice fed a betaine-supplemented diet, compared to db/db mice. Our findings suggest that betaine improves hyperlipidemia and tau hyperphosphorylation in db/db mice with insulin resistance by alleviating ER and oxidative stress.

Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice

Jung, Ga-Young,Won, Sae-Bom,Kim, Juhae,Jeon, Sookyoung,Han, Anna,Kwon, Young Hye Korean Society of ToxicologyKorea Environmental Mu 2013 Toxicological Research Vol.29 No.1

Betaine supplementation has been shown to alleviate altered glucose and lipid metabolism in mice fed a high-fat diet or a high-sucrose diet. We investigated the beneficial effects of betaine in diabetic db/db mice. Alleviation of endoplasmic reticulum (ER) and oxidative stress was also examined in the livers and brains of db/db mice fed a betaine-supplemented diet. Male C57BL/KsJ-db/db mice were fed with or without 1% betaine for 5 wk (referred to as the db/db-betaine group and the db/db group, respectively). Lean non-diabetic db/+ mice were used as the control group. Betaine supplementation significantly alleviated hyperinsulinemia in db/db mice. Betaine reduced hepatic expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha, a major transcription factor involved in gluconeogenesis. Lower serum triglyceride concentrations were also observed in the db/db-betaine group compared to the db/db group. Betaine supplementation induced hepatic peroxisome proliferator-activated receptor alpha and carnitine palmitoyltransferase 1a mRNA levels, and reduced acetyl-CoA carboxylase activity. Mice fed a betaine-supplemented diet had increased total glutathione concentrations and catalase activity, and reduced lipid peroxidation levels in the liver. Furthermore, betaine also reduced ER stress in liver and brain. c-Jun N-terminal kinase activity and tau hyperphosphorylation levels were lower in db/db mice fed a betaine-supplemented diet, compared to db/db mice. Our findings suggest that betaine improves hyperlipidemia and tau hyperphosphorylation in db/db mice with insulin resistance by alleviating ER and oxidative stress.

Development and efficacy of a mentoring-based career efficacy enhancement program for nursing students

Young-Mi Jung(편집자),In-Young Yoo,Ga-Hyeon Kim,Ha-Eun Park,Ji-Eun Lee,Chae-Rin Lee 한국간호과학회 2019 한국간호과학회 학술대회 Vol.2019 No.10

A Rice Gene Homologous to Arabidopsis AGD2-LIKE DEFENSE1 Participates in Disease Resistance Response against Infection with Magnaporthe oryzae

Jung, Ga Young,Park, Ju Yeon,Choi, Hyo Ju,Yoo, Sung-Je,Park, Jung-Kwon,Jung, Ho Won The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.4

ALD1 (ABERRANT GROWTH AND DEATH2 [AGD2]-LIKE DEFENSE1) is one of the key defense regulators in Arabidopsis thaliana and Nicotiana benthamiana. In these model plants, ALD1 is responsible for triggering basal defense response and systemic resistance against bacterial infection. As well ALD1 is involved in the production of pipecolic acid and an unidentified compound(s) for systemic resistance and priming syndrome, respectively. These previous studies proposed that ALD1 is a potential candidate for developing genetically modified (GM) plants that may be resistant to pathogen infection. Here we introduce a role of ALD1-LIKE gene of Oryza sativa, named as OsALD1, during plant immunity. OsALD1 mRNA was strongly transcribed in the infected leaves of rice plants by Magnaporthe oryzae, the rice blast fungus. OsALD1 proteins predominantly localized at the chloroplast in the plant cells. GM rice plants over-expressing OsALD1 were resistant to the fungal infection. The stable expression of OsALD1 also triggered strong mRNA expression of PATHOGENESIS-RELATED PROTEIN1 genes in the leaves of rice plants during infection. Taken together, we conclude that OsALD1 plays a role in disease resistance response of rice against the infection with rice blast fungus.

P121 : Comparison of the effects between conventional high intensity focused ultrasonography (hifu) and novel hifu for facial lifting: a split-face, evaluator-blinded, randomized pilot study

( Jung Min ),( Ju Yeon Choi ),( Han Saem Kim ),( Jung In Kim ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Heun Joo Lee ),( Yoon Hwan Kim ),( Jae Hui Nam ),( Ho Joo Jung ),( Ji Hye Park ),( Ga Young Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: High intensity focused ultrasonography (HIFU) is proved to be a safe, effective, noninvasive procedure to tighten the facial skin. Recently novel HIFU is introduced, but there has not been research about comparison between novel and conventional HIFU. Objectives: This study was performed to compare the efficacy and safety of conventional HIFU and novel HIFU in tightening the facial skin. Methods: 20 patients with moderate to severe facial wrinkles were randomized to receive HIFU, with one side of the face treated by conventional HIFU and the other side treated by novel HIFU. After 8 weeks of treatment, efficacy of the treatment was evaluated using three forms of assessment: two blinded observers’ evaluation, measuring the width of face and participant’s satisfaction score. All data was subjected to statistical analysis using independent or paired t-test. Results: All 20 patients showed clinical improvement on both treated side. There were no significant difference on both sides in terms of clinical efficacy and patients satisfaction but significantly less pain with novel HIFU treated side. No subject was noted to have any severe complication on both sides. Conclusion: This study suggest that the novel HIFU can be the safe treatment option for the facial lifting.

A clinical study of a novel noninvasive radiofrequency technology for the reduction of submental fat

( Jung In Kim ),( Jae Yoon Lim ),( Ju Yeon Choi ),( Han Saem Kim ),( Jung Min ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Ho Joo Jung ),( Jae Hui Nam ),( Ji Hye Park ),( Hee Jin Park ),( Ga Young Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Background: Recently, Novel radiofrequency (RF) technologywas introduced as a promising tool for non-invasive body and face contouring, which can heats subcutaneous fat up to 450C continuously without surface damage and induces adipocytes apoptosis. Objectives: To evaluate the efficacy and safety of novel noninvasive RF technology for the reduction of submental fat. Methods: Twenty-two subjects with an excessive submental fat received twice treatments at 4-weeks intervals. The thickness of the submental fat, the change of facial contour and subjective satisfaction were assessed at baseline, after treatment, and 8-weeks after last treatment. Results: All subjects showed a decrease in thickness of the submental fat objectively. Subjective satisfaction is also very high and adverse problems were minimal. Conclusion: A novel noninvasive RF technology is effective and safe modality for reduction of submental fat.