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      • KCI등재

        Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection

        Dongliang Yang,Meng Ding,Yanni Song,Yanling Hu,Weijun Xiu,Lihui Yuwen,Yannan Xie,Yingnan Song,Jinjun Shao,Xuejiao Song,Heng Dong 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

        The advent of drug-resistant pathogens results in the occurrence of stubborn bacterial infections that cannot betreated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating the body’s immune systemto eliminate pathogenic bacteria has confrmed promising therapeutic strategies in controlling bacterial infections. Subsequent studies found that antimicrobial immunotherapy has its own benefts and limitations, such as avoidingrecurrence of infection and autoimmunity-induced side efects. Current studies indicate that the various antibacterialtherapeutic strategies inducing immune regulation can achieve superior therapeutic efcacy compared with mono therapy alone. Therefore, summarizing the recent advances in nanomedicine with immunomodulatory functionsfor combating bacterial infections is necessary. Herein, we briefy introduce the crisis caused by drug-resistantbacteria and the opportunity for antibacterial immunotherapy. Then, immune-involved multimodal antibacterialtherapy for the treatment of infectious diseases was systematically summarized. Finally, the prospects and challengesof immune-involved combinational therapy are discussed.

      • KCI등재

        Design 3D garments for scanned human bodies

        Dongliang Zhang,Jin Wang,Yuping Yang 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.7

        We present a 3D garment design method for scanned human bodies. First, a slicing method is proposed to reconstruct a symmetricbody from a scanned human body to make it suitable for garment design. Second, a sketch modeling method is used to interactively createa garment surface based on the symmetric body. Third, seam lines are drawn on the garment surface, and then a flattening algorithmis employed to design 2D patterns. Finally, a seam line template is used to design the same style of garments for different bodies. Experimentsshow that the resulting garment fits the scanned body well. Our method provides an efficient design tool for customizing garmentsin the fashion industry.

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        An Efficient Markov Chain Based Channel Model for 6G Enabled Massive Internet of Things

        ( Wei Yang ),( Xiaojun Jing ),( Hai Huang ),( Chunsheng Zhu ),( Qiaojie Jiang ),( Dongliang Xie ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.11

        Accelerated by the Internet of Things (IoT), the need for further technical innovations and developments within wireless communications beyond the fifth generation (B5G) networks is up-and-coming in the past few years. High altitude platform station (HAPS) communication is expected to achieve such high levels that, with high data transfer rates and low latency, millions of devices and applications can work seamlessly. The HAPS has emerged as an indispensable component of next-generations of wireless networks, which will therefore play an important role in promoting massive IoT interconnectivity with 6G. The performance of communication and key technology mainly depend on the characteristic of channel, thus we propose an efficient Markov chain based channel model, then analyze the HAPS communication system's uplink capability and swing effect through experiments. According to the simulation results, the efficacy of the proposed scheme is proven to meet the requirements of ubiquitous connectivity in future IoT enabled by 6G.

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        Machinability Investigation and Sustainability Assessment of Dry Cutting AISI1045 Steel Using Tools Configured with Shark-Skin-Inspired Structures and WS2/C Coatings

        Xuemu Li,Jianxin Deng,Yang Lu,Ran Duan,Dongliang Ge 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.1

        This paper primarily determined the suitable technique for the preparation of WS 2 /C coating by the analytical hierarchy process (AHP) with a keen focus on the criteria of coating property, deposition process, resource and equipment. Further, some cutting performances of six cutting tools with different treatments, including cutting forces, cutting temperatures, wear mechanisms, tool life, etc. were investigated in dry cutting AISI1045 steel. The optimal lubricating condition for dry cutting process was obtained when using the cutting tools configured with the combination of WS 2 /C coating and shark-skin-inspired structures. Finally, the sustainability assessment was carried out by the calculation of the product sustainability index (PSI). The highest PSI of 78.6% was obtained in case of the dry cutting experiment using WMT-2-N tools, which provided a suggested favorable alternative considering both product and manufacturing process. Thus, dry cutting AISI1045 steel using WMT-2-N tools seems to be an environmentally-friendly machining process and would be helpful to enhance sustainability.

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        Effects of exposure to trace pyriproxyfen on the intestinal bacterial diversity and immune signal pathways of silkworm (Bombyx mori) larvae

        Lu Qingyu,Li Guoli,Lan Huangli,Yu Dongliang,Yin Xingcan,Yang Wenqi,Yang Zehao,He Chunhui,Mo Danmei,Xu Kaizun 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.2

        Silkworm (Bombyx mori) is a widely used lepidopteran model insect. Pyriproxyfen is an insect growth regulator (IGR) that can be used to control pests such as lepidoptera and diptera, and there is no research about its in fluence on the intestinal bacterial diversity and immune signal pathway of non-target lepidopteran insect larvae. In this study, we treated fifth-instar silkworms with trace pyriproxyfen (10 − 4 mg/L). The results showed that the abundance and diversity of silkworm larvae intestinal flora at the level of phylum, class, order, family and genus were all changed. The function prediction result showed that the functional changes mainly focused on tran scription, amino acid transport and metabolism, carbohydrate transport and metabolism, signal transduction mechanisms, energy production and conversion et al. after exposure to trace pyriproxyfen. Furthermore, qRTPCR results showed that trace pyriproxyfen exposure activated the transcriptions of antimicrobial peptides (AMPs) genes regulated by Toll and IMD pathways. This research can lay the foundation for the study on the resistance of lepidopteran insects to pyriproxyfen and other juvenile hormone pesticides.

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