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Surgery for Bilateral Large Intracranial Traumatic Hematomas : Evacuation in a Single Session
Kompheak, Heng,Hwang, Sun-Chul,Kim, Dong-Sung,Shin, Dong-Sung,Kim, Bum-Tae The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.55 No.6
Objective : Management guidelines for single intracranial hematomas have been established, but the optimal management of multiple hematomas has little known. We present bilateral traumatic supratentorial hematomas that each has enough volume to be evacuated and discuss how to operate effectively it in a single anesthesia. Methods : In total, 203 patients underwent evacuation and/or decompressive craniectomies for acute intracranial hematomas over 5 years. Among them, only eight cases (3.9%) underwent operations for bilateral intracranial hematomas in a single session. Injury mechanism, initial Glasgow Coma Scale score, types of intracranial lesions, surgical methods, and Glasgow outcome scale were evaluated. Results : The most common injury mechanism was a fall (four cases). The types of intracranial lesions were epidural hematoma (EDH)/intracerebral hematoma (ICH) in five, EDH/EDH in one, EDH/subdural hematoma (SDH) in one, and ICH/SDH in one. All cases except one had an EDH. The EDH was addressed first in all cases. Then, the evacuation of the ICH was performed through a small craniotomy or burr hole. All patients except one survived. Conclusion : Bilateral intracranial hematomas that should be removed in a single-session operation are rare. Epidural hematomas almost always occur in these cases and should be removed first to prevent the hematoma from growing during the surgery. Then, the other hematoma, contralateral to the EDH, can be evacuated with a small craniotomy.
Two New Species in the Family Cunninghamellaceae from China
( Heng Zhao ),( Jing Zhu ),( Tong-kai Zong ),( Xiao-ling Liu ),( Li-ying Ren ),( Qing Lin ),( Min Qiao ),( Yong Nie ),( Zhi-dong Zhang ),( Xiao-yong Liu ) 한국균학회 2021 Mycobiology Vol.49 No.2
The species within the family Cunninghamellaceae are widely distributed and produce important metabolites. Morphological studies along with a molecular phylogeny based on the internal transcribed spacer (ITS) and large subunit (LSU) of ribosomal DNA revealed two new species in this family from soils in China, that is, Absidia ovalispora sp. nov. and Cunninghamella globospora sp. nov. The former is phylogenetically closely related to Absidia koreana, but morphologically differs in sporangiospores, sporangia, sporangiophores, columellae, collars, and rhizoids. The latter is phylogenetically closely related to Cunninghamella intermedia, but morphologically differs in sporangiola and colonies. They were described and illustrated.
Xu, Heng,Tian, Yan-Na,Dun, Bo-Ying,Liu, Hai-Tao,Dong, Guang-Kuo,Wang, Jin-Hua,Lu, Shang-Su,Chen, Bo,She, Jin-Xiong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.
Fracture toughness improvement of epoxy resins with short carbon fibers
Wei Dong,Fan-Long Jin,박수진,Heng-Chang Liu 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
This study examined the thermal stability and fracture toughness of diglycidylether of bisphenol-A (DGEBA)/short carbon fiber (SCF) composites using several techniques. The thermal stability of the DGEBA/SCF composites was similar to that of neat epoxy resin. The fracture toughness of the composites was significantly improved relative to the neat resin. The SEM micrographs indicated that a relatively rough surface with shear deformation and tortuous cracks was formed, thereby preventing deformation and crack propagation and inducing higher fracture toughness in the DGEBA/SCF composites.
Wei Dong,Hai Bo Shi,Heng Ma,Yan Bo Miao,Tong Jun Liu,Wei Wang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.5
Protein glycation inhibitors from Polygonatum odoratum rhizomes were investigated using a bioassay-guided procedure to characterize active compounds for preventing and treating diabetic complications. The EtOH extract and soluble fractions were evaluated using an in vivo model of renal advanced glycation end-product (AGE) accumulation in streptozotocin-induced diabetic rats and an in vitro bovine serum albumin-glucose assay. Three homoisoflavanones 3-(4’-hydroxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (1), 3-(4’-hydroxybenzyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one (2), and 3-(4’-methoxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (3), isolated from the active CHCl3-soluble fraction of the EtOH extract, were subjected to in vitro bioassays to evaluate their inhibitory activities against AGE formation. All the isolates inhibited AGE formation more effectively than the positive control, aminoguanidine. These results indicate that pending further study these compounds could be used as novel natural product drug for mitigating diabetic complications.
저체온 유발과 정상체온회복에 따른 Cortical Spreading Depression의 변화에 대한 실험적 연구
임동준,박정율,박윤관,정흥섭,주정화,이기찬,이훈갑 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.7
The present study was carried out to evaluate the effcct of hypothermia and rewarming on the pattern of Cortical Spreading Depression(CSD) and predict the resultant vulnerability of the brain. Thirty four Sprague-Dawley rats, either sex, weighing 250-350gm, were used. They were devided into 4 groups, according to the degree of hypothermia and speed of rewarming, Profound Hypothermia & Slow Rewarming(G Ⅰ). Profound Hypothermia & Rapid Rewarming(G Ⅱ), Moderate Hypothermia & Slow Rewarming(G Ⅲ), Moderate Hypothermia & Rapid Rewarming(G Ⅳ). CSD was elicited by local application of KCI and identified by Direct Current Potential(DCP). We estimated the Frequency of DCP. Recovery time of negative shift of DCP, Area of negative shift of DCP according to the change of body temperature. The frequencies of DCP increased after rewarming compared with the normothermic state in all groups, statistical significance (p<0.05) was specially evident in Group Ⅱ (Profound Hypothermia & Rapid Rewarming group), 5.1± 0.3/30min.(mean±standard error) in normothermic state. while 9.3± 0.8/30min in rewarming state. Recovery time(width) of DCP was delayed with hypothermia but decreased with rewarming but delayed state compared with normothermic state in all groups, i.e. 34.7± 1.Osec at normothermic state, 59.9± 4.3sec at 27.5℃, 40± 1.4sec at rewarming state in Group Ⅱ. We can predict that the vulnerability of the brain tissue may be increased during the rewarming state following hypothermia in all groups. Such evidence is more significant in Group Ⅱ (Profound Hypothermia & Rapid Rewarming) during the period of certain time(30-60min) after rewarming.