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Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection
Dongliang Yang,Meng Ding,Yanni Song,Yanling Hu,Weijun Xiu,Lihui Yuwen,Yannan Xie,Yingnan Song,Jinjun Shao,Xuejiao Song,Heng Dong 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
The advent of drug-resistant pathogens results in the occurrence of stubborn bacterial infections that cannot betreated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating the body’s immune systemto eliminate pathogenic bacteria has confrmed promising therapeutic strategies in controlling bacterial infections. Subsequent studies found that antimicrobial immunotherapy has its own benefts and limitations, such as avoidingrecurrence of infection and autoimmunity-induced side efects. Current studies indicate that the various antibacterialtherapeutic strategies inducing immune regulation can achieve superior therapeutic efcacy compared with mono therapy alone. Therefore, summarizing the recent advances in nanomedicine with immunomodulatory functionsfor combating bacterial infections is necessary. Herein, we briefy introduce the crisis caused by drug-resistantbacteria and the opportunity for antibacterial immunotherapy. Then, immune-involved multimodal antibacterialtherapy for the treatment of infectious diseases was systematically summarized. Finally, the prospects and challengesof immune-involved combinational therapy are discussed.
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Pectin oligosaccharides improved lipid metabolism in white adipose tissue of high-fat diet fed mice
Zixin Fan,Xuejiao Chen,Tianzhi Liu,Qianhui Yu,Ziqi Song,Fei Wang,Tuoping Li 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.9
Impacts of pectin oligosaccharide (POS) got from hawthorn fruitage on adiponectin signaling pathway and white adipose metabolism in mice fed with high-fat control. The results showed that POS significantly inhibited the levels of inflammatory cytokines TNF-α and IL-6, and down-regulated expression of CD68. POS dramatically reduced gene expression contents of fatty acid composite concerning enzymes ACC and FAS, as well as TG synthesis-related enzymes SCD-1 and DGAT1 as compared to a high-fat group (HFC). POS dramatically increased expression levels of oxidation-related enzymes of fatty acid ACO, CPT-1, and TG deposition-related enzymes ATGL and HSL as contrast to the high-fat control group. In addition, POS activated adiponectin-mediated AdipoR1/AMPK/PPARα signaling path by upregulating expression levels of AdipoR1, AMPK and PPARα. The results demonstrated that POS can improve lipid metabolism of adipose tissue, and contribute to the creation of functional foods to prevent and treat lipid metabolism disorders.
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Influencing Factors and Contents of Audience Interaction Based Sports Live Broadcast
Lu Huang,Xuejiao Lin,Song, Jeho 한국스포츠학회 2020 한국스포츠학회지 Vol.18 No.4
본 연구는 스포츠 생방송 플랫폼에서 시청자의 상호작용에 영향을 미치는 요소와 내용을 탐구하였다. 문학 방법, 전문가 인터뷰 방법, 앙케이트 조사 방법, 수학 통계 방법, 스포츠 라이브 방송 플랫폼에서 시청자의 상호작용에 대한 영향 요소, 인터랙티브 내용, 구조적 차원을 규정하였다. 요인 분석을 사용하여 라이브 스포츠를 기반으로 청중 상호 작용 의 영향 요인과 내용을 선별하고 분석하였다. 연구를 통해 다음과 같은 결론을 얻었다. 첫째, '적극적 소통능력', '관중 간 고질성', '감정적 지원', '기능적 지원', '경기 관람 장애물' 등이 스포츠 관중의 주요 요소 간 상호작용에 영향을 미쳤다. 스포츠 생방송 플랫폼에서 시청자들 간의 상호작용에 대한 내용 차원은 '매력과 소통', '상호작용과 거부감', '도움행동', '관계발전' 등 4가지로 요약할 수 있다. 이번 연구를 통해 스포츠실황방송 플랫폼의 관리자들에게 이론적 참고자료를 제공 하고, 스포츠생방송 플랫폼의 목표 정비를 위한 근거를 제공하고자 한다. This work explores the influencing factors and content of audience interaction in sports live broadcast platforms. Through literature method, expert interview method, questionnaire survey method and mathematical statistics method, the influencing factors, interactive content and structural dimensions of the audience interaction in the sports live broadcast platform are defined. Use factor analysis to screen and analyze the influencing factors and content of audience interaction based on live sports. Through research, the following conclusions are obtained: First, "active communication ability", "heterogeneity among spectators", "emotional support", "functional support" and "perceived obstacles to watching games" affect the interaction between sports spectators’ major factor. The content dimensions of the interaction between viewers on the sports live broadcast platform can be summarized into four categories: "attraction and communication", "interference and repulsion", "help behavior", and "relationship development". Through this research, it can provide a theoretical reference for the managers of the sports live broadcast platform and provide a basis for the targeted maintenance of the sports live broadcast platform.
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