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- 저자 : Yannan Xie (검색결과 2 건)
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Seismic Behavior of Assembly Joint with CFST Column and H-shaped Steel Beam
Xiushu Qu,Yannan Xie,Guojun Sun,Qingwen Liu,Hui Wang 대한토목학회 2023 KSCE JOURNAL OF CIVIL ENGINEERING Vol.27 No.2
Existing concrete-filled steel tubular (CFST) structures are mostly based on cast-in-situ concrete construction technology. The beam-column joint emphasizes the horizontal connection, while the vertical connection of columns is mostly based on a steel tube connection instead of a precast CFST column connection; this is detrimental to the control of the concrete pouring quality and the full assembly of the structure. Thus, the investigation of an assembly joint that enables the full connection between the beam and CFST column is the key to the improvement of the construction quality and the promotion of the development of the assembled structure. This work proposes an assembly joint between an H-shaped steel beam and a CFST column, and the seismic behavior of the joint was investigated by low-cycle loading experiment. The finite element model of the joint was then established by the numerical analysis method. After verifying the rationality of the finite element model, the influences of both the endplate thickness and the bolt diameter on the energy dissipation performance of the joint were investigated via parametric analysis. The results reveal that with the increase of the endplate thickness and the bolt diameter within a certain range, both the bearing capacity and energy dissipation capacity of the joint will be improved. Moreover, the cooperative bearing mechanism of the column connector and concrete can be fully exerted. Thus, these conclusions indicate the feasibility of the use of the proposed assembly joint in practical engineering applications. Finally, the mechanical mechanism of the assembly joint was studied, and the calculation formula of the joint bending capacity was proposed.
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Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection
Dongliang Yang,Meng Ding,Yanni Song,Yanling Hu,Weijun Xiu,Lihui Yuwen,Yannan Xie,Yingnan Song,Jinjun Shao,Xuejiao Song,Heng Dong 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
The advent of drug-resistant pathogens results in the occurrence of stubborn bacterial infections that cannot betreated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating the body’s immune systemto eliminate pathogenic bacteria has confrmed promising therapeutic strategies in controlling bacterial infections. Subsequent studies found that antimicrobial immunotherapy has its own benefts and limitations, such as avoidingrecurrence of infection and autoimmunity-induced side efects. Current studies indicate that the various antibacterialtherapeutic strategies inducing immune regulation can achieve superior therapeutic efcacy compared with mono therapy alone. Therefore, summarizing the recent advances in nanomedicine with immunomodulatory functionsfor combating bacterial infections is necessary. Herein, we briefy introduce the crisis caused by drug-resistantbacteria and the opportunity for antibacterial immunotherapy. Then, immune-involved multimodal antibacterialtherapy for the treatment of infectious diseases was systematically summarized. Finally, the prospects and challengesof immune-involved combinational therapy are discussed.
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