Risk of Hepatitis B Virus (HBV) Reactivation in HBsAg-Negative, Anti-HBc-Negative Patients Receiving Rituximab for Autoimmune Diseases in HBV Endemic Areas

Lan Ting-Yuan,Lin Yen-Chun,Tseng Tai-Chung,Yang Hung-Chih,Kao Jui-Hung,Cheng Chiao-Feng,Lee Tai-Ju,Huang Shang-Chin,Lu Cheng-Hsun,Li Ko-Jen,Hsieh Song-Chou 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2

Background/Aims: Rituximab is known to be associated with high hepatitis B virus (HBV) reactivation rate in patients with resolved HBV infection and hematologic malignancy. However, data regarding HBV reactivation (HBVr) in rheumatic patients receiving rituximab is limited. To assess the HBVr rate in hepatitis B surface antigen (HBsAg)-negative patients receiving rituximab for autoimmune diseases in a large real-world cohort. Methods: From March 2006 to December 2019, 900 patients with negative HBsAg receiving at least one cycle of rituximab for autoimmune diseases in a tertiary medical center in Taiwan were retrospectively reviewed. Clinical outcome and factors associated with HBVr were analyzed. Results: After a median follow-up period of 3.3 years, 21 patients developed HBVr, among whom 17 patients were positive for hepatitis B core antibody (anti-HBc) and four were negative. Thirteen patients had clinical hepatitis flare, while eight patients had HBsAg seroreversion without hepatitis. Old age, anti-HBc positivity, undetectable serum hepatitis B surface antibody level at rituximab initiation and a higher average rituximab dose were associated with a higher HBVr rate. There was no significant difference in the HBVr risk between rheumatoid arthritis and other autoimmune diseases. Among anti-HBc-negative patients, subjects without HBV vaccination at birth had an increased risk of HBVr (4/368, 1.1%) compared with those who received vaccination (0/126, 0%). Conclusions: In HBV endemic areas where occult HBV is prevalent, anti-HBc-negative patients, may still be at risk for HBVr after rituximab exposure. HBVr may still be considered in HBsAgnegative patients developing abnormal liver function after rituximab exposure, even in patients with negative anti-HBc.

REVERSIBLE AND PSEUDO-REVERSIBLE RINGS

Huang, Juan,Jin, Hai-lan,Lee, Yang,Piao, Zhelin Korean Mathematical Society 2019 대한수학회보 Vol.56 No.5

This article concerns the structure of idempotents in reversible and pseudo-reversible rings in relation with various sorts of ring extensions. It is known that a ring R is reversible if and only if $ab{\in}I(R)$ for $a,b{\in}R$ implies ab = ba; and a ring R shall be said to be pseudoreversible if $0{\neq}ab{\in}I(R)$ for $a,b{\in}R$ implies ab = ba, where I(R) is the set of all idempotents in R. Pseudo-reversible is seated between reversible and quasi-reversible. It is proved that the reversibility, pseudoreversibility, and quasi-reversibility are equivalent in Dorroh extensions and direct products. Dorroh extensions are also used to construct several sorts of rings which are necessary in the process.

The Role of Long Noncoding RNAs in Antiestrogen Resistance in Breast Cancer: An Overview and Update

Lan Huang,Guohua Liang,Qingyuan Zhang,Wenhui Zhao 한국유방암학회 2020 Journal of breast cancer Vol.23 No.2

As a standard treatment, endocrine therapy has dramatically enhanced the prognosis of patients with estrogen receptor (ER)-positive breast cancer, which accounts for nearly 70% of all breast cancers. Antiestrogen drugs such as tamoxifen and aromatase inhibitors are the standard treatment options for ERα-positive breast cancer. However, acquired antiestrogen resistance is still the leading cause of disease recurrence and progression. Evidence has shown that long noncoding RNAs (lncRNAs) play an essential role in the development of antiestrogen resistance in ER-positive breast cancer and can serve as biomarkers or potential therapeutic targets. This review highlights the role of lncRNAs in the development of antiestrogen resistance in breast cancer.

Clinical features of recurrence after hepatic resection for early-stage hepatocellular carcinoma and long-term survival outcomes of patients with recurrence: A multi-institutional analysis

Lan-Qing YAO,Hai-Bo QIU,Jia-Le PU,Yong-Kang DIAO,Chao LI,Timothy M. PAWLIK,Wan Yee LAU,Dong-Sheng HUANG,Feng SHEN,Tian YANG 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

Dynamic Studies on Physiology and Biochemistry in American Seng Seed During Stratification - Part I. Embryo Ratio, Dry Weight Ratio and respiration Rate

Huang, Yao-Ge,Li, Xiang-Gao,Yang, Ji-Xiang,Kuang, Ya-Lan,Yan, Jie-Kun,Cui, Shu-Yu,Liu, Ren-Song,Kim, Hack-Seang The Korean Society of Ginseng 1996 Journal of Ginseng Research Vol.20 No.3

Dynamic parameters of physiology including embryo ratio (ER), embryo length to endosperm length, dry weight ratio between embryo and endosperm (DWR) and respiration rate (RR) in American send (Panax quinquefolium L.) seed were investigated. According to the changes of ER during seed stratification, the duration of embryo afterripening could be divided into three stages as \circled1 embryo slow growth stage (ESGS), ER increased from 7.31% to 20.48% (0.16% day-1): \circled2 embryo rapid growth stage (ERGS), ER increased to 80.98% (0.61% day-1) (75G5+ ERGS=morphological afterripening stage (MP,5)) and \circled3pysiological afterripening stage (PAS), ER Increased to 88.50% (0.094 day-1) only. DWR Increased slowly from 0.20% to 2.76clp (0.016% day-1) in MAS and rapidly to 8.81% (0.061% day-1) in PAS. The RR correlated significantly with ER as well (r=0.8934 > rot, 0.6610). The steep increment of both DWR and RR in PAS indicated that the PAS was not a static stage although the ER was not changed too much. All of these may provide some information for understanding the dormancy mechanisms of American sting seed.

Restorative Justice in Taiwan : An Overview

Huang, Lan Ying 梨花女子大學校 法學硏究所 2010 法學論集 Vol.15 No.1

대만의 법무부가 이제 막 처음으로 “회복적 사법 프로그램”의 도입에 착수하고 있음에도 불구하고, 2000년 이후 이 계획은 공적 담론과 학계 연구의 중심에 있어 왔다. 이러한 회복적 사법 촉구의 배경에는 다음과 같은 것들이 있다. 전통적으로, 식민지배 이후 대만 사회는 공식적이고 투명한 사법기관들을 비공식적인 기관들이 대체하는 ‘안으로는 유교적, 밖으로는 법률 존중주의적’ 사회로 묘사되어 왔다. 대만 사람들에게는 대체적 분쟁해결수단을 널리 활용해 온 오랜 역사가 있으며, 얼마 전부터 정부는 사법적 인권을 고취시키자는 압력도 계속 받고 있다. ‘당사자주의’의 도입은 피해자의 권리 보장에 효과적이지 않은 것처럼 여겨진다. 사형제도 폐지라는 논란이 많은 이슈도 피해자 운동의 또 다른 흐름이다. 복수의 목적을 달성하기 위한 형사사법제도의 개혁은 정부의 우선적인 과제 중 하나다. 이 논문에서는 회복적 사법의 세 가지 실용적인 유형에 대하여 언급하고자 한다: 소년사법제도, 참여식 사법, 그리고 형사사건에 있어서의 중재이다. 끝으로 필자는 2000년 법무부가 추진하였던 회복적 사법 프로그램의 배경에 대하여 살펴보기 위하여, 현재의 법적 구조에 대하여 비판적으로 검토해 보고자 한다. Although the ministry of justice in Taiwan is just beginning to initiate the first “restorative justice programme”, the idea has been the focus of both official discourse and academic investigation since 2000. There are a few forces behind this newly emerged restorative justice urge. Traditionally, post colonization Taiwan society is described as an ‘inwardly Confucian, outwardly legalistic’ (內儒外法) society, in which informal institutions preempted the transplanted formal legal institutions. The Taiwan people have a long history of using alternative dispute resolution mechanism. More recently, the government is under increasing pressure of promoting judicial human right. The introduction of adversary system can not be deemed beneficial of promoting victim’s right. The controversial issue of abolishing death penalty also rises another wave of victim movement. The reform of criminal justice system to serve multiple purposes has become one of the prioritized government agenda. In this article, I describe three practical forms of restorative justice: juvenile justice system (少年司法制度), participatory justice (參與式司法), and mediation service for criminal cases (刑事案件調解). In the end, I critically review the current legal structure to address the background of the 2010 restorative justice programme under Ministry of Justice (法務部修復式司法試行方案).

The biocompatibility and mechanical properties of plasma sprayed zirconia coated abutment

Huang, Zhengfei,Wang, Zhifeng,Yin, Kaifeng,Li, Chuanhua,Guo, Meihua,Lan, Jing The Korean Academy of Prosthodonitics 2020 The Journal of Advanced Prosthodontics Vol.12 No.3

PURPOSE. The aim of this study was to evaluate the clinical performance and reliability of plasma sprayed nanostructured zirconia (NSZ) coating. MATERIALS AND METHODS. This study consisted of three areas of analysis: (1) Mechanical property: surface roughness of NSZ coating and bond strength between NSZ coating and titanium specimens were measured, and the microstructure of bonding interface was also observed by scanning election microscope (SEM). (2) Biocompatibility: hemolysis tests, cell proliferation tests, and rat subcutaneous implant test were conducted to evaluate the biocompatibility of NSZ coating. (3) Mechanical compatibility: fracture and artificial aging tests were performed to measure the mechanical compatibility of NSZ-coated titanium abutments. RESULTS. In the mechanical study, 400 ㎛ thick NSZ coatings had the highest bond strength (71.22 ± 1.02 MPa), and a compact transition layer could be observed. In addition, NSZ coating showed excellent biocompatibility in both hemolysis tests and cell proliferation tests. In subcutaneous implant test, NSZ-coated plates showed similar inflammation elimination and fibrous tissue formation processes with that of titanium specimens. Regarding fatigue tests, all NSZ-coated abutments survived in the five-year fatigue test and showed sufficient fracture strength (407.65-663.7 N) for incisor teeth. CONCLUSION. In this study, the plasmasprayed NSZ-coated titanium abutments presented sufficient fracture strength and biocompatibility, and it was demonstrated that plasma spray was a reliable method to prepare high-quality zirconia coating.

충적과정중 미국인삼 종자의 생리 및 생화하적 지표에 관한 동태학적 연구 III

Huang, Yao-Ge,Li, Xiang-Gao,Kuang, Ya-Lan,Yan, Jie-Kun,Cui, Shu-Yu,Yu, Wen-Bo,Yang, Ji-Xiang,Liu, Ren-Song,Kim, Hack-Seang 고려인삼학회 1997 Journal of Ginseng Research Vol.21 No.1

Dynamic parameters of biochemistry including the POD (peroxidase) activity, contents of DNA and RNA, isozymes of POD and ES (esterase) in American send (Panax quinquefolium L.) seed are reported in the present paper. The dynamic changes of POD activity proved that the PAS (physiological afterripening stage) is a stage in which some substances are prepared for seed germination. The POD activity correlated with ER (embryo ratio) significantly DNA content changed little only within 0.0036∼0.013 mg/ml, which did not correlate with ER. RNA content changed from 0.1539 to 1.0313 mg/ml and correlated significantly with RE during all of the embryo afterripening. None of the POD isozyme band was obtained in ESGS (embryo slowly growth stage), but five bands in ERGS (embryo rapidly growth stage) and six bands in PAS. Four bands of ES isozymes were obtained in ESGS, but six bands in ERGS, particularly, the content of ES isozymes increased in PAS. All of these may provide some information for understanding the dormancy mechanisms of American song seed.

Study on Thermodynamics of Three Kinds of Benzindocarbocyanine Dyes in Aqueous Methanol Solution

Huang, Wei,Wang, Lan-Ying,Fu, Yi-Le,Liu, Ji-Quan,Tao, You-Ni,Fan, Fang-Li,Zhai, Gao-Hong,Wen, Zhen-Yi Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.3

Aggregation behavior of three kinds of benzindocarbocyanine dyes in aqueous methanol solution was studied by UV-Vis absorption spectrum. The results indicated that the three dyes all existed monomer-dimer equilibrium in aqueous methanol solution (concentration range $10^{−5}\;to\;10^{−6}$ M) at 25.0$\sim$41.0 ${^{\circ}C}$ for Dye 1, 28.0$\sim$49.0 ${^{\circ}C}$ for Dye 2 and 26.0$\sim$47.0 ${^{\circ}C}$ for Dye 3. The fundamental property of the three dyes as the dimeric association constant KD, the dimeric free energy ${\Delta$}G_D, the dimeric entropy ${\Delta$}S_D, and the dimeric enthalpy ${\Delta$}H_D were determined. The ${\Delta$}H_D of three dyes: Dye 1, Dye 2 and Dye 3 was -42.5, -15.1 and -18.9 kJ/mol, respectively. The experimental observations were the subject of a theoretical study including the ground-state geometries which were fully optimized using DFT at B3LYP/6-31G level. The effect of dye molecule structure on ${\Delta$}H_D was discussed by theoretical calculations.

폴리아크릴산/H₂O 혼합물에서 H₂O 열적 거동에 미치는 이온의 영향

Lan Guan,Hong Yan Xu,Ding Hai Huang 한국고분자학회 2010 폴리머 Vol.34 No.4