상수원수 수질변화에 따른 전오존 처리효과 및 경제성 평가

최동훈 ( Dong Hoon Choi ),박진식 ( Jin Sik Park ),문추연 ( Choo Yeun Moon ),이재용 ( Jae Yong Lee ),유동춘 ( Dong Choon Ryu ),장성호 ( Seong Ho Jang ),권기원 ( Ki Won Kwon ),이수애 ( Soo Ae Lee ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.4

This study, changes in raw water quality is to indicate on the efficiency of ozone treatment of each pollutant as compared to derive the appropriate operating measures. The appropriate selection for injection rate of pre-ozone and did not inject pre-ozone assess changes in the water. When good water quality, you not injected of pre-ozone to evaluate the economic efficiency of electricity and put the most cost-effective ozone concentration were evaluated. Evaluation remove organic matter and chlorophyll-a concentration level in experiments with each factor of the water DOC> 2.5㎎ / L, THMFP> 70㎍ / L, Chl-a> 30㎎/㎥or less constant process, if you do not need to put pre-ozone showed little impact. It also does not put you in pre-ozone appropriate produce enough power rate savings was calculated as approximately 90 million won. Ability to remove organic materials and the ability to produce disinfection byproducts, and cost-effective decisions by considering the concentration of injection if pre-ozone 1 mg/L was investigated by the appropriate concentration of ozone injection.

서브 - 링의 신드롬 분석을 이용한 하이퍼큐브 진단 알고리즘

김학원(Hak-Won Kim),김동군(Dong-Kun Kim),최문석(Moon-Seok Choi),이충세(Chung-Sei Rhee) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅰ

하이퍼큐브의 정규직이며 계층적인 구조적 특성은 효율적인 진단 알고리즘 개발에 유리하게 적용될 수 있다. Feng et al.의 HADA/IHADA와 Choi와 Rhee의 적응적 큐브 분할 방법은 하이퍼큐브의 전체 노드를 하나의 링으로 임베딩하여 링의 진단 특성을 이용하여 위하여 분할 및 정복 방법을 이용하였다. 또한 Kranakis와 Pelc는 결함을 모두 포함하는 최소의 서브링을 하나의 노드로 하는 하이퍼큐브의 형태로 분할하는 HYP-DIAG 알고리즘을 제안하였다. 또한 최악의 경우에, 테스트 수만을 고려하여 2ⁿ+3n/2의 테스트 수를 갖는 FAST-HYP-DIAG 알고리즘과 병렬 시간만을 고려하여 많아야 11테스트 라운드 이내에 진단을 수행하는 EXPRESS-HYP-DIAG 알고리즘을 제안하였다. 본 논문에서는 HYP-DIAG의 첫 번째 단계에서 얻어진 서브링들의 신드롬을 분석하여 테스트의 수와 테스트 라운드를 모두 고려하는 알고리즘을 제안한다.

데이터 마이닝을 활용한 한국 프로야구 구단의 승패예측과 승률 향상을 위한 전략 도출 연구

김원종 ( Kim Won-jong ),최연식 ( Choi Yeon-sik ),유동희 ( Yoo Dong-hee ) 한국스포츠산업경영학회 2018 한국스포츠산업경영학회지 Vol.23 No.3

본 연구에서는 데이터 마이닝 기법을 활용하여 한국 프로야구의 승패예측모형을 구축하는 실험을 진행하였다. 이를 위해, 2017년에 실시된 한국 프로야구 10개 구단의 전체 경기 중 무승부 경기를 제외한 1,418경기에 대한 자료를 사용하였다. 승패예측모형에는 의사결정나무, 베이즈넷, 인공신경망 알고리즘과 앙상블 기법인 배깅과 부스팅이 사용되었으며, 그 결과 배깅 기법에 인공신경망을 적용한 예측모형에서 가장 높은 예측률인 85.18%를 기록하였다. 다음으로 의사결정나무 기반 예측모형을 활용하여 한국 프로야구 전체 구단에 관한 8개의 승패규칙을 도출하였다. 여기에서 승패규칙은 승패예측에 영향을 미치는 주요 요인들인 팀출루율, 팀타율, 피안타, 안타, 타석, 타수로 표현되며, 도출된 규칙을 바탕으로 구단의 승률 향상에 도움을 주는 전략을 제안하였다. 또한 플레이오프 진출 구단과 미진출 구단에 관한 승리규칙을 각각 4개씩 도출하였고 이를 바탕으로 두 집단에 맞춤화된 승률 향상 전략을 제시하였으며, 실제 구단에서 선수를 영입한 방향과의 비교를 통해 제시된 전략의 활용 가능성을 확인하였다. This study conducted an experiment to develop win-loss prediction models for the Korean professional baseball league using data mining techniques. To this end, we used data on 1,418 games from all games played by the ten Korean professional baseball teams in 2017, except draw games. We developed win-loss prediction models using not only a decision tree, Bayse net, and artificial neural network algorithms, but also ensemble methods, such as bagging and boosting. As a result, first, we found that the artificial neural network-based prediction model using the bagging method reported the best accuracy (85.18%). Second, we derived eight win-loss rules for entire teams from the decision tree-based prediction model. These rules consist of six influential factors: team on base average, team batting average, hit by opponent, hit, plate appearances, and at bat. Using the derived rules, we proposed helpful strategies for improving the winning rate. Third, we derived four winning rules for both playoff teams and non-playoff teams; using the rules we proposed customized strategies for improving the winning rate of the two different groups. Finally, we confirmed the feasibility of the proposed strategies by comparing non-playoff teams’ actual player recruitment strategies.

기존의 치료에 반응하지 않는 다발성 간전이 대장암 환자에서 방사선조사와 병합한 수지상세포 면역치료의 1, 2상 임상시험

최영민(Youngmin Choi),이형식(Hyung-Sik Lee),권혁찬(Hyuk-Chan Kwon),한상영(Sang-Young Han),최종철(Jong-Cheol Choi),정주섭(Ju-Seop Chung),김창원(Chang-Won Kim),김동원(Dong-Won Kim),강치덕(Chi-Duk Kang) 대한방사선종양학회 2008 Radiation Oncology Journal Vol.26 No.2

목 적: 기존치료에 반응하지 않는 다발성 간전이를 동반한 대장암 환자에서 방사선치료와 병합한 수지상세포 면역 치료의 독성과 반응도를 조사하였다. 대상 및 방법: 2004년 5월부터 2006년 11월까지 다발성 간전이가 동반된 대장암 환자들 중에서 항암화학 요법에 반응하지 않은 환자 중 지원자를 대상으로 연구를 시행하였다. 본 임상 시험에 대하여 동아대학교병원과 부산대학교병원의 임상윤리심의위원회의 허가를 획득하였고, 동의서에 서명한 환자들을 임상 시험의 대상으로 등록하였다. 환자의 말초 혈액으로부터 수지상세포를 추출하여 배양하였다. 임상시험 일자에 맞추어서 6×106개의 수지상세포를 바이알(0.5 ml)에 넣어서 디씨백/아이알 주사를 만들었다. 수지상세포 면역치료는 2주 간격으로 간전이암조직에 3회 주사하고, 5주에 내약성 평가를 하였다. 내약성 평가를 통과한 환자에게는 8주에 4번째 수지상세포 면 역치료를 하였다. 병의 악화가 없거나 임상시험에 대한 환자의 동의 철회가 없는 경우에는 5, 6번째 수지상세포면역치료를 각각 12, 16주에 시행하였다. 방사선치료는 수지상세포 면역치료를 주사할 간전이암 부위에 주사하기 전일 및 당일에 4 Gy씩을 조사하였다. 내약성 평가는 3×106개의 수지상세포로부터 시작하여, 12×106개의 수지상세포까지 시행하였다. 내약성 평가의 최대 내성 용량으로 추가 임상시험을 하였다. 수지상세포 면역치료 주사를 맞은 모든 환자들에서 안전성 평가를 하였다. 4회 이상 주사를 맞은 환자들을 대상으로 10주에 치료 반응을 평가하여 유효성을 조사하였다. 결 과: 임상시험에 등록한 24명 중 22명에서 수지상세포 면역치료를 시행하였다. 내성약 평가에는 14명이 등록하여 11명에서 평가를 완료하였다. 시험약과의 관련성이 있을 것으로 생각되는 grade 3 이상의 약물반응으로 인한 이상반응은 없었다. 12×106개의 수지상세포를 내성용량으로 확인하였고, 내성용량인 12×106개 수지상세포 면역치료를 이용하여 8명에서 추가로 시험을 하였다. 치료에 대한 환자들의 내성은 양호하였고, grade 3을 초과하는 치명적인 부작용은 발생되지 않았다. 4회 이상의 수지상세포 면역치료 주사를 받은 환자가 17명이었고, 이 중의15명에서는 종양의 반응도 평가가 이루어졌다. 본 연구의 목적은 안전성 평가이지만, 면역치료의 유효성 평가를 위해, 방사선치료와 수지상세포 면역치료 주사가 시행된 부위 외의 간전이암에서 반응도를 조사 하였다. 면역치료의 반응은 평가가 이루어진 환자들에서 정지성 병변이 4명, 진행성 병변이 11명 이었다. 결 론: 수지상세포 면역치료와 병행한 방사선치료는 이론적으로 국소 및 전신 제어에 상승효과가 있을 것으로 기대할 수 있다. 하지만 기존 치료에 반응하지 않는 매우 진행된 직장암 환자들을 대상으로 한 본 연구에서는 방사선 치료와 병합한 수지상세포 면역치료로 인한 심각한 부작용의 발생은 없었다는 결과와 4예에서의 정지성 병변의 관찰을 보고한다. 수지상세포의 최대 투여 용량, 적절한 투여 방법, 적절한 방사선의 양, 방사선과 수지상 세포의적절한 투여 간격 등에 관한 추가 연구를 통하여, 향후 제 2상, 3상 시험으로서의 진행 여부에 긍정적인 결과를얻을 수 있다고 판단한다. Purpose: To assess the toxicity and tumor response induced by DCVac/IRⓇ dendritic cell (DC) immunotherapy combined with irradiation for refractory colorectal cancer patients with multiple liver metastases. Materials and Methods: Between May 2004 and November 2006, applicants from a pool of refractory colorectal cancer patients with multiple liver metastases were enrolled. The patients were registered after having signed the informed consent form, which had been approved by the Institutional Review Board from the Dong-A University and Busan National University Hospital. DCs were obtained from peripheral blood of each patient, and then cultured in vitro. A total of 6×106 DCs were packed into a vial (DCVac/IRⓇ, 0.5 ml) at the convenience of each patient’s schedule. On the day before and on the day of each vaccination, each patient received a 4 Gy radiation dose to the target tumor. On the day of vaccination, the indicated dose of autologous DCs was injected into the irradiated tumor using ultrasound-guided needle injection procedures. A total of four vaccinations were scheduled at three 2-week intervals and one 4 week interval at the Dong-A University and Busan National University Hospital. If the tumor status was deemed to be stable or responding to therapy, an additional vaccination dose or two was approved at 4 week intervals beyond the fourth immunization. A tolerance test for DCs was conducted by injecting a range of doses (3×106 to 12×106 DCs) after the 3rd injection. Moreover, the maximal tolerable dose was applied to additional patients. Treatment safety was evaluated in all patients who had at least one injection. Treatment feasibility was evaluated by the 10th week by assessing the response of patients having at least 4 injections. For systemic toxicities, the evaluation was performed using the National Cancer Institute Common Toxicity Criteria, whereas adverse effects were recorded using common WHO toxicity criteria. Results: Of the 24 registered patients, 22 received the DCs injections. Moreover, of the 14 patients that applied for the tolerance test, only 11 patients completed it because 3 patients withdrew their testing agreement. A grade 3 or more side effect, which was possibly related to the DC injection, did not occur in additional patients. The 12×106 DC injection was identified as the maximum tolerable dose, and was then injected in an additional 8 patients. Patients tolerated the injection fairly well, with no fatal side effects. In order to assess the feasibility of DC immunotherapy, the response was evaluated in other hepatic lesions outside of the targeted hepatic lesion. The response evaluation was performed in 15 of the 17 patients who received at least 4 injections. Stable and progressive disease was found in 4 and 11 patients, respectively. Conclusion: The DC-based immunotherapy and radiotherapy is theoretically synergistic for the local control and systemic control. The DCVac/IRⓇ immunotherapy combined with irradiation was tolerable and safe in the evaluated cases of refractory colorectal cancer with multiple liver metastases. Future work should include well designed a phase II clinical trials

Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score

( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2

Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)

가감석홍전(加減惜紅煎)으로 호전된 궤양성대장염(潰瘍性大腸炎) 환자(患者) 치험(治驗) 1례(例)

임동석,김남욱,이형호,이영수,홍석,김희철,최창원,Lim, Dong-Seok,Kim, Nam-Uk,Lee, Hyung-Ho,Lee, Yeong-Su,Hong, Seok,Kim, Hee-Chul,Choi, Chang-Won 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.1

Objective : this study is designed to evaluate the effects of an oriental medicine therapy, namely gagam-sukhongjeon, on ulcerative colitis Methods : The Clinical data was analyzed on a patient with ulcerative colitis due to hanyeolchakjab(寒熱錯雜), whose symptoms were combined chillness and fever. The patient visited at the internal medicine department of Dong-Shin University Suncheon Oriental Hospital on February 25, 2006, and go into hospital from February 25, 2006 to March 9, 2006. and revisited from March 18, 2006 to April 5, 2006. The patient was treated with Herbal medicine(gagam-sukhongjeon) Result : After treatment, bloody stool and abdominal pain disappeared in visual analogue scale(VAS), pain disability index(PDI) and verbal rating scale(VRS). Conclusions : This study suggests that gagam-Sukhongjeon is significantly effective in treatment of ulcerative colitis.

Free Paper Session : Liver Surgery / Basic ; Successful mouse hepatocyte culture with sandwich collagen gel formation (초)

( Dong Ho Choi ),( Yong Jin Kim ),( Dan Song ),( Kyung Yul Hur ),( Jae Joon Kim ),( Min Hyuk Lee ),( Chul Moon ),( Jae Young Jang ),( Soung Won Jeong ),( Chul Hyung Cho ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)

Comparative Nutritional Analysis for Genetically Modified Rice, Iksan483 and Milyang204, and Nontransgenic Counterparts

Choi, Hoon,Moon, Joon-Kwan,Park, Byeoung-Soo,Park, Hee-Won,Park, So-Young,Kim, Tae-San,Kim, Dong-Hern,Ryu, Tae-Hun,Kweon, Soon-Jong,Kim, Jeong-Han The Korean Society for Applied Biological Chemisty 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.1

Recently, two glufosinate-tolerant rice varieties, Iksan483 and Milyang204, were developed in Korea generated by adding bar gene to genomes of the conventional rice varieties. Comparative assessment of nutritional composition was conducted with genetically modified rice grains and its conventional counterparts for substantial equivalence. Nutrients including proximates, fatty acids, amino acids, minerals, vitamins, and antinutrients were investigated using several statistical comparisons. The results showed that, except for small differences in a few fatty acids, minerals, and trypsin inhibitor, there was no significant difference between genetically modified rice and conventional counterpart variety with respect to their nutrient composition. Most of measured levels of nutrients were in good compliance with the literature ranges, showing substantial equivalency. The results of principle component analysis demonstrated that the environment affects the nutritional composition and that all differences between the genetically modified and conventional rice varieties are within the range as the differences observed among conventional varieties grown in different years. Therefore, the insertion of bar gene did not change the nutritional composition of genetically modified rice grains.

Fall- and BBS-related differences in muscle strength and postural balance of the elderly

Choi, Jin-Seung,Kang, Dong-Won,Seo, Jeong-Woo,Kim, Dae-Hyeok,Yang, Seung-Tae,Tack, Gye-Rae The Society of Physical Therapy Science 2016 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.28 No.9

<P>[Purpose] The purpose of this study was to compare the differences in muscle strength and postural balance between fallers and non-fallers. We also compared the difference between normal and impaired balance groups using the same subjects and the same variables. [Subjects and Methods] Seventy-one healthy elderly females (age: 75.1 ± 75 years; weight: 57.3 ± 57 kg; height: 150.1 ± 15 cm) who had high levels of physical activity participated [25 fallers (FG) vs. 46 non-fallers (NG); and 52 healthy balance group (HBG) and 19 impaired balance group (IBG) subjects]. To compare the groups, the muscle strengths of 9 muscle groups, and 20 variables of the instrumented standing balance assessment (2 area variables, 9 time-domain variables, and 9 frequency-domain variables) were assessed. [Results] The FG and NG could only be categorized based on the frequency-domain variables of the instrumented standing balance assessment. On the other hand, there were significant differences between HBG and IBG in height, 6 muscle strength, and 2 time-domain variables of the instrumented standing balance assessment. [Conclusion] These results suggest that muscle strength and standing balance are reflected in physical balance ability (i.e., BBS); however they are in sufficient for determining the actual occurrence of falls.</P>

Results of total knee arthroplasty for painless, stiff knees

Choi Young-Joon,Seo Dong-Kyo,Lee Ki Won,Ra Ho Jong,Kang Hyun Wook,Kim Jin Kyung 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-

Stiff knees, like completely ankylosed or arthrodesed knees, can be painless. Total knee arthroplasty (TKA) for these painless, stiff knees is technically demanding. However, it can correct the alignment and advance the range of motion to improve quality of life. So, we reviewed the preoperative and postoperative results of functional and pain scores, range of motion (ROM) and complications in painless, stiff knees treated by TKA.Fifteen painless, stiff knees underwent TKA from January 1998 to January 2017. The mean follow-up period was 15.4 (2.4–22.2) years. All the knees were completely ankylosed or arthrodesed. Clinical outcome and complications were evaluated using medical record review, serial plan radiography, ROM assessment, Knee Society score (KSS), Knee Society function score (FS), and a visual analog scale for pain (VAS). All patients were satisfied with their operated knees. Mean KSS and FS scores were improved from 36 and 50.9 to 76.9 and 67.2, respectively ( P < 0.001 and P = 0.01). The mean ROM increased from 0º preoperatively to 77.6º (15–130) at the final follow-up ( P < 0.001). The mean VAS had worsened from 0 preoperatively to 0.2 postoperatively, however it was not significant ( P = 0.1). Major postoperative complications were reported in five of the knees (33.3%). The results of TKA for painless, stiff knees were satisfactory with improved ROM and quality of life. Although some patients had mild pain and complications postoperatively, they were satisfied with the result. However, our study recommends that surgeons should consider the high rate of complications in the completely ankylosed or arthrodesed knees.A retrospective case series, Level IV.