국소마취제의 피부수송체를 위한 제제개발 및 평가

조미현,김동우,박용근,지웅길 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-

For the dermal drug delivery system of local anesthetics (lidocaine HCl, and benzocaine), the drugs were formulated as hydrogel. The experiments of the formulation design were summarized as below, the lipid-water partition coefficients of drugs were evaluated and the vehicles with different concentrations of ethanol, glycerine and various enhancers were prepared for the formulation of hydrogel. After using these vehicles, hydrogel were formulated. The gelling agent was poloxamer 407. The resulting preparations were evaluated using in vitro drug permeation and drug accumulation in hairless mouse skin. The preparations were also evaluated by their viscosity and stability, In addition, using the tail-flick analgesia test, analgesic activity of the gel was compared with that of commercial cream.

공중보건적 관점에서 비만증과 과체중에 대한 탐색

김수근,양미현,정동혁 圓光大學校 附設 體力科學硏究所 2007 體力科學硏究 Vol.29 No.-

At the other end of the malnutrition scale, obesity is one of today's most blatantly visible - yet most neglected - public health problems. Paradoxically coexisting with undernutrition, an escalating global epidemic of overweight and obesity - "globesity" - is taking over many parts of the world. If immediate action is not taken, millions will suffer from an array of serious health disorders. Generally, although men may have higher rates of overweight, women have higher rates of obesity. For both, obesity poses a major risk for serious diet-related noncommunicable diseases, including diabetes mellitus, cardiovascular disease, hypertension and stroke, and certain forms of cancer. Its health consequences range from increased risk of premature death to serious chronic conditions that reduce the overall quality of life. Obesity and overweight have been spotlighted from the view of public health, since they are associated with generative system and morbid state caused by chronic disease and conditions, resulting in such malignant effects as even death. Although the morbidity of obesity and overweight depends on epidemiologic characters, they have indeed become a serious global issue. It is therefore vastly required to make continued efforts to improve diet and intensity physical activities from the perspective of public health. For this purpose, it is recommended to change environment to prompt such effects and to present proper criteria concerning obesity and overweight. The intervention methods, particularly, should not fail to provide basic principle for conduct of normal as well as obese people.

뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

하나로 노심 특성 변화에 따른 Fission Moly 표적의 설계 평가

조동건,김명현 경희대학교 산학협력기술연구원 2001 산학협력기술연구논문집 Vol.7 No.-

A nuclear characteristics of Mo-99 target was evaluated according to the HANARO core models. Safety of core with fission moly target was evaluated to be assured with the fresh fuel loaded core model, because maximum core fuel temperature was maintained far below the limit of 485℃. Characteristics of design parameters evaluated from fresh fuel loaded core model was consistent to those evaluated from equilibrium core model. Impurity level in 99Mo solution was shown to be affected seriously by core condition. The choice of LEU fuel for target seems to be undesirable and should be examined in detail, because current Cintichem process technology does not satisfy the U.S.P. specification on the alpha impurity decontamination.

실내 마감재의 유독가스 방출에 관한 독성평가

함상근,김홍,강영구,김동현,이영섭 한국산업안전학회 2002 한국안전학회지 Vol.17 No.1

The toxic gases released from a fire can be classified as asphyxiants such as carbon monoxide, and irritants such as hydrochloric acid, etc. It is recognized that the combustion characteristic of interior upholstery is one of the important factors to determine the severity of indoor fires. In this study, several of the mostly used interior upholsteries including wallpaper, veneer board, curtain and floor cover, were selected to be evaluated by using the method of NES 713. The toxicity indices of the experimental samples, which indicate their toxic potentials in a fire were lowered in the order of Wallpaper (Flame Retardant) 8.5 > Floor Cover(Hard) 4.8 > Polyurethane 4.3 > Floor Cover(Soft) 3.5 > PVC 2.8 > Veneer Board 2.3 > Floor Cover(flame retardant) 2.1 > Wallpaper(Promulgation) 1.4 > Curtain 0.9. It is concluded that, among all the tested upholsteries, wallpaper (flame retardant) would release the largest quantity of toxic gases in a fire.

저항트레이닝 프로그램에 있어서 운동처방의 개별화에 대한 탐색

김수근,양미현,정동혁 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

Many factors need to be considered in designing a resistance training program to successfully meet the needs and goals of the trainee, If the trainee is preparing for a sports or particular activity, a general program for that sports is developed, The general program for the sports must then be individualized, however, to address the strengths and weaknesses of each trainee, The prescription of resistance training is both a science and an art, Ultimately, individualized training programs provide for optimal changes in the exercise prescription process and result in the best overall training response for the individual, Although guidelines can be giver, the art of designing effective resistance training programs requires logical exercise prescription followed by evaluation, testing, and interaction with the trainee, Resistance training prescription is a dynamic process that requires the strength and conditioning professional to respond to the trainee's changing adaptation levels and functional capacities with altered program designs to meet the changing training goals, Using a needs analysis, acute program design, chronic program design, and consideration of administrative factors results in the optimal program for any situation, It is then necessary to be creative and search out ways to improve the design of the program and resistance training facility.

전자상거래의 비용우위 효과에 관한 소비자 지각 : 인터넷 쇼핑몰 이용자를 중심으로 Concentrated on Consumers' Perceptions on the Internet Shopping Mall

유동근,서영호,조임현 한국경영과학회 1999 한국경영과학회지 Vol.24 No.4

Since the Internet was applied for commercial purpose, many companies have been making use of the internet in electronic commerce and the internet has brought many changes on consumer and supplier behaviors. It seems that consumers and suppliers can obtain more accurate information rapidly and pay less for the same product/service than in traditional commerce. This study tries to investigate the difference in the cost factors perceived by consumers between traditional commerce and the Internet commerce. Empirical results show that there is no significant difference in consumers' perception of cost factors between traditional commerce and the internet commerce Contrary to general perception, a large number of consumers do no, believe that the internet commerce is generally more economical than traditional commerce. The factors where the consumers think Internet commerce has cost advantages are search cost and purchasing cost. However, consumers are understanding the benefits of the internet commerce and are expecting that internet commerce bring about economic advantages in consumer markets in the near future.

급성 심근 경색에서 시행한 관상 동맥 우회술의 조기 결과

지현근,이원용,김응중,두영철,한규록,오동진,임종윤 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

鎔接殘留應力이 應力比에 따라 疲勞龜裂傳播에 미치는 影響

表東根,李龍福,金鍾鉉,吳湞淵 弘益大學校 1989 弘大論叢 Vol.21 No.2

To examine the effects of the welding residual stress on Mode I fatigue crack propagation behavior, 3mm thickness SS41 steel plate was welded by an Auto-matic Submerged Arc Welding. Initial residual stress and relaxation residual stresses according to each stress ratio were measured. The fatigue crack propagation behavior from the region of compressive residual stress to region of tensile residual stress was analyzed. The results predicted by the Forman's equation using the superposition approach of the respective stress intensity factors for the initial residual stress and for the applied stress according to each stress ratio were compared with experimental data. The validity of the superposition approach was investigated. The conclusion are summerized as follows: 1. When the component is subjected to a constant amplitude cyclic tensile loading, the welding residual stress is reduced as stress ratio increase. 2. As the fatigue crack is propagation through the compressive residual stress field, it was found that the effects of welding compressive residual stress on fatigue crack growth in weldments, and the stress ratio decreases, become larger and delay the fatigue crack growth rate. 3. For negative values of the effective stress ratio, R? in the welding compressive residual stress field, the prediction of fatigue crack growth rate by the Forman's equation were found to be corresponded to experimental data for stress ratio R?0.3, as the effective stress ratio R? approached zero, when the stress ratio R>0.3 the prediction of the fatigue crack growth rate by Forman's equation were found to be impossible.

집단수준에서 변혁적 리더십 및 집단 효능성과 집단성과의 관계에 관한 연구

조임현,유동근 한국경영과학회 2000 韓國經營科學會誌 Vol.25 No.1

The purpose of this paper is to investigate the relationships among transformational leadership, group-efficacy, and group performance. A total of 321 employees of a fire and marine insurance firm in Seoul anonymously completed the Multifactor Leadership Questionnare-Form V. which consists of tree factors(charisma, individualized consideration and intellectual stimulation) for transformational leadership, and two factors(contingent reward and management by exception) for transactional leadership. The sample, which largely consists of sales supervisors and salesmen, includes 41 sales office branches. The findings of the study are as follows Transformational leadership is closely associated with group-efficacy and group performance. That is, there are significant correlations between transformational factors and group-efficacy, between the factors and group performance, and between group-efficacy and group performance. A stepwise multiple regression analysis revealed that transformational leadership augmented the subordinates's extra efforts. It was also found that group-efficacy was mediating the relationship between transformational leadership and group performance. The managerial implications of these findings and future directions jof research are also discussed.