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자가 면역성 갑상선염이 동반된 Addison’s disease 산모에서의 제왕절개술을 위한 마취 관리-증례 보고-
유동근,이상훈,이정현,이미현,정미화,최영룡,최은미 대한마취통증의학회 2013 Anesthesia and pain medicine Vol.8 No.4
Addison's disease is a rare chronic endocrine disorder which results from progressive destruction of the adrenal glands. It is kind of autoimmune polyendocrine syndrome type 2 with autoimmune thyroiditis, and can lead to fatal outcomes when complicated in pregnancy. We report on an anesthetic experience with 38-year-old primigravida with Addison's disease and hypothyroidism who was followed up from the early stage of pregnancy to delivery by a multidisciplinary medical board. Great attention was given to steroid replacement therapy as well as fetal surveillance in order to lower the risk of maternal and fetal mortality. This report describes our experience of the spinal anesthetic management for Cesarean section of a patient with Addison's disease and hypothyroidism.
만성구속스트레스 동물모델에 대한 JG02의 항우울 효과
유동근,서영경,이지윤,김주연,정진형,최정준,정인철 대한한방신경정신과학회 2019 동의신경정신과학회지 Vol.30 No.3
Objectives: As a general emotion, everyone can temporarily experience depression, but depressive disorder is a disease that excessively affects daily life. Among the various causes of depression, the deficiency of monoamine-based neurotransmitters such as serotonin and epinephrine are considered significant. Thus, antidepressants that target monoamines are used frequently. However, side effects such as nausea, vomiting, insomnia, anxiety, and sexual dysfunction are observed. Thus, it is necessary to develop a new therapeutic agent with fewer side effects. In this study, we investigated the antidepressant effect of JG02, used to treat depression by normalizing the flow of qi (氣) in Korean medicine. Methods: C57BL/6 mice were selected and randomly divided into six groups: normal, control, amitriptyline, and JG02 (50, 125, 250 ㎎/㎏), respectively. Except for normal, depression was induced by applying restraint stress at the same time for six hours daily for 14 consecutive days. Saline, amitriptyline or JG02 samples were orally administered two hours before applying the stress. After that, a forced swimming test and an open field test were performed. Additionally, serum corticosterone, serotonin mRNA, BDNF mRNA, and protein in the hippocampal region were measured and compared. Results: JG02 decreased immobility time rate in the FST and increased the zone transition number and travel distance in the OFT. Also, JG02 inhibited the release of serum corticosterone, and increased serotonin, BDNF gene expression, and BDNF protein in the hippocampus. Conclusions: In this study, JG02 showed significant antidepressant effects on the chronic restraint stress mice model. When further research is performed based on JG02, the development of a new antidepressant is considered highly possible.
투명 전도성 산화물 전극으로의 응용을 위한 산화아연(ZnO) 코팅막의 습식 식각 특성연구
유동근,김명화,정성훈,부진효,Yoo, Dong-Geun,Kim, Myoung-Hwa,Jeong, Seong-Hun,Boo, Jin-Hyo 한국진공학회 2008 Applied Science and Convergence Technology Vol.17 No.1
투명 전도성 산화물 전극(transparent conductive oxide electrodes)에 적용하기 위하여 RF 마그네트론 스퍼터링 방법에 의해 유리 기판 위에 산화아연 박막을 증착하였다. 투명 전극으로써 응용되기 위한 최적의 조건으로 기판온도를 상온으로 유지하고 RF power 200 W, 타겟과 기판사이의 거리(Dts)가 30 mm일 때 증착된 산화아연 박막으로부터 가장 낮은 비 저항값($7.4{\times}10^{-3}{\Omega}cm$)을 얻어 낼 수 있었으며, 85% 이상의 높은 투과율을 만족하는 박막을 얻을 수 있었다. 실질적인 소자로써의 응용을 위해 photo lithography를 통한 pattern을 형성, 습식 식각을 통하여 그 특성을 알아보고자 하였다. 습식 식각에서 사용된 식각용액(etchant)으로는 다양한 산 용액(황산, 옥살산, 인산)을 사용하였으며, 산의 농도 변화에 따른 식각특성과 식각시간 및 식각 이미지(표면형상)의 변화를 알아보았다. 결과적으로 산화아연의 습식식각은 산의 종류와 무관하게 산 용액의 농도(즉, pH)에 크게 의존하며, pH가 증가함에 따라 식각율이 지수함수적으로 감소하고 아울러 다양한 식각 이미지가 나타남을 최초로 고찰할 수 있었다. In order to apply for transparent conductive oxide(TCO), we deposited ZnO thin films on the glass at room temperature by RF magnetron sputtering method. Deposition conditions for high transmittance and low resistivity were optimized in our previous studies. Under the deposition condition with the RF power of 200 W, target to substrate distance of 30 mm and working pressure of 5 mTorr, highly conductive($7.4{\times}10^{-3}{\Omega}cm$) and transparent(over 85%) ZnO films were prepared. Highly oriented ZnO film in the [002] direction were obtained with specifically designed ZnO targets. Systematic study on dependence of deposition parameters on electrical and optical properties of the as-grown ZnO films were mainly investigated in this work. And for application tests using these films as transparent conductive oxide anodes, wet chemical etching behaviors of ZnO films were also investigated using various chemicals. Wet-chemical etching behavior of ZnO films were investigated using various acid solutions. The concentrations of these different acid solutions were controlled to study the etching shapes and etching rate. ZnO films were anisotropically etched at various concentrations and wet etching led to crater-like surface structure. Also we firstly found that the etching rate and etching shapes of ZnO films strongly depended on the etchant concentrations (i.e. pH) and the etching rate is exponentially decreased with increasing pH values regardless of the acid etchants.
Radical Scavenger에 의한 PEMFC 고분자 막 e-PTFE 지지체의 전기화학적 열화 완화에 대한 연구
유동근,오소형,이미화,박권필 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
고분자 전해질 연료전지(PEMFC)의 고분자 막은 운전 시 셀 내부에서 생성된 과산화수소와 라디칼에 의해 전기화학적 열화가 일어난다. e-PTFE 지지체가 들어간 강화막(Reinforced membrane)의 경우, 이오노머만 존재하는 표면뿐만이 아니라 내부에 있는 지지체도 라디칼에 의한 열화가 일어난다. 따라서 radical scavenger를 지지체에 담지하여 열화 완화에 도움이 되는지 확인하기 위해 실험을 진행하였다. 본 실험에서 CeO<sub>2</sub>를 radical scavenger로 사용하였으며, IPA에 혼합시켜 스프레이 방법으로 PTFE 지지체에 분산시켜 준비하였다. CeO<sub>2</sub> 담지 지지체를 이용해 강화막, MEA를 제조하여 OCV holding 진행하였고, 막의 열화를 수소투과전류밀도를 측정하여 CeO<sub>2</sub> 담지 지지체 전 후를 비교하였다. 지지체의 열화는 FT-IR과 SEM으로 확인하였다. 가속 내구성 평가 후 CeO<sub>2</sub>가 지지체에 들어간 강화막이 들어가지 않은 강화막 보다 지지체의 CF<sub>2</sub> 피크가 더 높게 나타나 radical scavenger가 지지체 전기화학적 열화 완화에 도움을 주는 것을 확인하였다.