유기용제 폭로가 여성 근로자들의 월경에 미치는 영향

김대환,이채관,김휘동,강동묵,문덕환,김정호,손병철,이창희,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1

유기용제는 산업장에서 널리 사용되고 있다. 특히 여성근로자들의 폭로기회가 증가하고 있으며 이로 인한 자연유산, 수태능력 감소, 월경이상 등이 보고되고 있다. 따라서 유기용제 폭로가 여성근로자들의 월경에 미치는 영향을 보기 위해 설문조사와 월경주기별 여성생식 호르몬(progesterone, estrogen) 분석을 하였다. 그 결과 폭로군에서 progeterone의 억제효과가 유기용제에 폭로되는 여성근로자들의 다양한 월경이상을 초래할 가능성이 있는 것으로 생각된다. ■ Objectives This study was conducted to evaluate the effects of menstrual function in female workers exposed to organic solvents. ■ Methods Rates of menstrual disorders were studied in 87 female workers with exposure to organic solvents(Cn/Hn-value 0.713) in a factory manufacturing shoes and compared with 83 general female workers who had no exposure to organic solvents, Detailed menstrual and reproductive histories were obtained by personal interview using structured questionnaire, and plasma concentrations of progesterone and estrogen were assayed by radioimmunoassay(RIA). ■ Results The rates for menstrual irregularity, menstrual duration, blood clot in menstrual flow and dysmenorrhea were not significantly different in both groups. Number of using menstrual pad was significantly higher and the plasma level of progesterone during 6-11th day of menstrual cycle was significantly lower in the exposed group compared with non-exposed group(P<0.05). ■ Conclusions It seemed to be suppression effect of organic solvents on the reproductive hormones(progesterone and estrogen) in female workers. But there was no evidence that menstrual disorder was likely to result from exposure to organic solvents, because other behavioral, psychological and work related factors may also affect menstrual function.

소규모사업장 용접근로자들의 소음·용접흄·망간 노출에 관한 연구

김동구,문덕환,이채관,박명희,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted for the purpose of investigating the level exposure of welders to noise, welding fume and Manganese(Mn) related to this process. Methods and Material : All subjects in this study were welders engaged in CO2 arc and coated arc welding process especially in small-scale enterprises classified by type of manufacture of ship building, repairing and of other fabricated metal products, which is located in Gimhae and Milyang of Kyeongsang province in south Korea. Air sampling of welding fume was measured, shipped and analyzed on the basis of national institute for occupational safety and health(NIOSH) method in U.S. and work environment measurement method established in south Korea. To measure Noise in the work environment, Noise dosimeter was used on the basis of work environment measurement method established in south Korea. Result : This study was performed during a period from January, 2000 to December, 2001 and Results were as follows: 1. Noise level measured in this work environment was higher than national criteria for permissible exposure limit on health examinations related to hearing loss. 2. The concentration of welding fume and Mn in manufacture of ship building and repairing was higher than those in manufacture of other fabricated metal products. 3. In conditions of existing in ventilation system installed and operated, the concentration of welding fume and Mn was slightly lower than those of not existing. 4. In conditions of existing in sufficient air supply from out door into the work place relied on natural exhaust system, the concentration of welding fume and Mn was slightly lower than those of in not sufficient. 5. In all subjects, a rate of wearing ear plug and respiratory mask for dust and fume was lower than that of not wearing. Conclusion : According to above results, this study suggests that more positive work environment managements such as the use of portable local ventilation system, the supply of highly qualified personal protective equipment, and consecutive education and training related to health protection should be need to acquire suitable health protection program for welders engaged in small-scale enterprises in Korea.

cDNA array 방법을 이용한 망간에 노출된 흰쥐 뇌기저핵의 유전자발현 분석

이채관,노성민,문덕환,,김정호,손병철,김대환,이창희,김휘동,김정원,김종은,안진홍,이채언 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study investigated the gene expression profile in basal ganglia of manganese-exposed rats based on cDNA array analysis. Methods: For cDNA array, 25 male Sprague-Dawley rats (250±25 g) were intraperitoneally injected with 25 ㎎/㎏ B. W./day of MnCl2 (0.3 ㎖) for 10 days. For dose-related gene expression analysis, rats were intraperitoneally injected with 0.2, 1.0, and 5.0 ㎎/㎏ B. W/day of MnCl2 for 10 days. Control rats were injected with an equal volume of saline. RNA samples were extracted from brain tissue and reverse-transcribed in the presence of [α^(32)P]-dATP. Membrane sets of the Atlas Rat 1.2 array Ⅱ and Toxicology array 1.2 kit (Clontech, Palo Alto, CA) were hybridized with cDNA probe sets. Northern blot hybridization method was employed to assess the dose-related gene expression. Results: Fifty-two genes showed significant changes in expression of more than two-fold. Twenty-eight were up-regulated and 24 were down-regulated in the manganese-exposed group compared to the control. Among the 52 genes, 28 genes including nuclear factor I-X1 (NF1-X1), neuroligin 2 and 3, mitochondrial stress-70 protein (MTHSP70), neurodegeneration-associated protein 1 (Neurodap 1), multidrug resistance protein (MDR), and endoplasmic reticulum stress protein 72 (ERP72), were reported for the first time related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia. According to the dose-related gene expression analyses, MTHSP70, Neurodap 1 and ERP72 genes were up-regulated compared to the control even in the group exposed to low manganese dose ( 0.2 ㎎/㎏ B.W./day). Conclusions: Twenty-eight genes detected for the first time in this study were closely related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia and further study of these genes can give some more useful information about the manganese metabolism.

비만 여성을 대상으로 한 해조류 추출물의 국부처치와 운동 병행을 통한 지방분해 효과의 임상적 검정

서태수,이인숙,변재철,김규호,박승한,김유영,김상국,김현정,김상기,신동철,성미영,박종석,김종기,박언휘 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

This study was carried out to test the body fat breakdown during topical seaweed extract treatment and in combination with the aerobic exercise. Of 20 female obesity subjects, ten treated a cream types of seaweed extract(control group) and ten treated a placebo cream(placebo group). Topical treatment of each sample was designed for 4 weeks, and treated with 2 times a day about 10ml on the abdomen and the thigh, respectively. All subjects were participated aerobic dance half hour a day and four times a week. After 4 weeks of topical treatment and exercise, they were measured body fat, skinfold thickness, body circumference. Then venous blood samples were taken and analyzed blood cells, serum enzymes, and serum lipids. There were reduction of body weight, % of body fat, antebrachium, brachium, chest, waist, thigh circumference and abdomen thickness between pre and post treatment in both group. Especially, body weight and % of body fat significantly reduced in the subjects treating the seaweed extract than those treating the placebo. There were significant decrement in total cholesterol and LDL whereas increment in HDL and TBIL in the control group, but no significant difference in the placebo group. In conclusion, there were 7.6% of body fat reduction during 4 weeks of aerobic exercise and 21% of body fat reducement in combination of topical seaweed treatment and exercise, respectively. These results suggest that the topical treatment of seaweed extract should be very effective for fat breakdown. Especially, the body fat breakdown maximized in the combination with the topical seaweed extracts treatment and the aerobic exercise.

경련성 환아 부모들의 인식에 대한 연구

이경화(Kyoung Hwa Lee),서은숙(Eun Sook Suh),김영창(Yong Chang Kim),김창휘(Chang Hwi Kim),이동환(Dong Whan Lee) 대한소아신경학회 1996 대한소아신경학회지 Vol.3 No.2

Convulsive disorder is the most part of the pediatric neurologic disease. As far as the treatment of convulsive disorder concerned, we must consider familys' understanding, and the close cooperation between the epileptic child, parents, and doctors. We compared to Kim's report in 1985, to study the change of parents of epileptic children thinking. A prospective study was undertaken the analysis of 100 epileptic children parents visited to the pediatric dept, of Soonchunhyang university hospital from May to July, 1995. Psychological assessment, questionnaires which contains 17 items were given them, and these items were compared to Kims report in 1985 The results were as follows: 1) Parents of epileptic children answered convulsive disorder has influenced to children growth and development( 60.8% in 1985, 65.0% in 1995 ). 2) For asking the causes of children disease, 40.5% of them in 1985 and 50.0% of them in 1995 answered to uncertain, but only 7.8% of them in 1985 and 7.0% of them in 1995 answered to relation with familial inheritance. 3) The feelings at time of the diagnosis were gloomy or uncomfortable: 52.3% in 1985, 38.0% in 1995 and shameful 28.1% in 1985, 9.0% 1995. parents had belived in the epilepsy was treatable disease: 41.0% in 1995. 4) According to the this survey, patients explained reasons why their children take the medication increased from 23.5% in 1985 to 65.0% in 1995. 5) Only family, knew that their children had the convulsive disorder about 50.3% in 1995 and 22.0% in 1995. Family, patients and other people except family knew that their children had the convulsive disorder about 6.5% in 1985 and 43.0% in 1995. 6) The parents opinion and expectation toward the medical doctors were that they wanted to get full explanation for the disease 81.0% in 1985 and 35.1% in 1995, and others were explantation about toxicity and side effects of the medication and advises for the childrens life and activities.

간척지에서 옥수수 나방류 해충 3종의 발생소장

이휘종,최원영,김상열,서종호,황정동,오성환,정진교,김주일,구현나,김길하 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

Occurrence of three troublesome lepidopterous pests, Ostrinia furnacalis, Helicoverpa armigera and Pseudaletia separata in corn cultivation of the reclaimed land were recorded using sex pheromone traps from 2012 to 2014. In case of O. furnacalis adult, two generations were observed in a year and its occurrence pattern was very regular. The 1st generation showed the highest occurrence in late May-early June and the 2nd generation was in late July-early August. On the other hand, H. armigera occurred at least three times a year but its occurrence was somewhat irregular. H. armigera adult showed the highest occurrence in mid May, late June, early August, respectively in 2012 but their occurrence patterns of the 2nd and 3rd generations were varied in 2013 and 2014. In case of P. separata, a few number of adult were captured during the survey period, indicating few number of P. separata migrated from China. Based on the control effect of O. furnacalis by Etofenprox and Carbofuranin 2012, June 26 treatment showed the highest control rate with 96.8% for Etofenprox, 85.8% for Carbofuran, respectively. Late treatment at June 19 and June 26 significantly decreased the control rate of O. furnacalis and June 26 treatment showed the lowest control rate of 1.9% for Etofenprox. 18.1% for Carbofuran, respectively.

다중 문턱전압 CMOS를 이용한 저 전력 캐리 예측 가산기 설계

김동휘,김정범 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

This paper proposes a low-power carry look-ahead adder using multi-threshold voltage CMOS. The designed adder is compared with conventional CMOS adder. The propagation delay time is reduced by using low-threshold voltage transistor in the critical path. Also, the power consumption is reduced by using high-threshold voltage transistor in the shortest path. Comparing with the conventional CMOS circuit, the proposed circuit is achieved to reduce the power consumption by 14.71% and the power-delay-product by 16.11%. This circuit is designed with Samsung 0.35㎛ CMOS process. The validity and effectiveness are verified through the HSPICE simulation.

최소제곱법을 이용한 4개의 CSL 검측공 위치 결정

김진후,김동휘 東亞大學校 海洋資源硏究所 2006 硏究論文集 Vol.18 No.-

When four boreholes are installed in the cast-in-place pile, coordinates of the boreholes are obtained by using a least squares method, utilizing six hole-to-hole distance measurements. In addition, most probable values of hole-to-hole distances are calculated with coordinates of the boreholes. With the knowledge of borehole coordinates sound velocity of the pile can be obtained more accurately, and the cross section of the pile can be drawn with the drawing program easily. Also, coordinates of the boreholes would be very useful when a horizontal tomography technique is applied for integrity test of the cast-in-place pile.

다발성골수종의 형태학적 분류 및 임상 소견에 관한 연구

김휘준,이동화,이성희 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

1984년 1월부터 1992년 12월까지 9년간 순천향대학병원에서 다발성골수종으로 진단된 28명의 환자를 대상으로 임상 검사 소견 및 생존 기간을 분석하고, 골수천자도말에서 형질세포 분화 정도에 따른 형태학적 분류를 하고, 골수생검상 형질세포 침윤 양샹에 따른 분류를 한 후 이와 같은 분류가 임상 경과 및 예후와 어떤 관련이 있는지를 알아 보았다. 1. 골수천자도말에서 형질세포 분화 정도에 따른 분류를 하여 mature형과 immature형을 비교한 결과 진단 당시 임상 및 혈액학적 변수들간에 유의한 차이는 없었다. 2.골수생검상 형질세포 침윤 양상에 따른 분류를 하여 diffuse형과 packed형 을 비교한 결과 진단 당시 임상 및 혈액학적 변수들간에 유의한 차이는 없었다. 3. 위와 같은 분류가 예후 추정인자로서 의의가 있는지를 알아 보기 위해 평균 생존율을 구해 보았으나 유의한 차이는 없었다. 이상과 같은 결과는 본 연구의 증례가 너무 적었고, 처음 진단이 늦었으며 대부분의 환자가 고령이어서 일찍 치료를 포기한 이유로 생각되며, 추후에 더 많은 증례에 대한 연구가 계속되고 환자에 대한 교육을 실시하여 추적 관찰을 계속한다면 위와 같은 분류 방법이 다발성골수종의 예후를 추정하는데,유용한 지표로 사용될 수 있으리라 사료된다. The maturity of myeloma cells in the bone marrow aspirates and the pattern of infiltratin in the biopsy are known to be highly significant in predicting the prognosis. This study was performed to analyse clinical. hematological, and morphological features of the bone marrow smears and biopsy in multiple myeloma at the time of diagnosis and investigate the correlation between clinical and pathologic findings for the evaluation of survival rate. The subjects for the study were 28 cases of multiple myeloma from January 1984 to December 1992 diagnosed at Soonchunhayang University Hospital. There were no statistical differences between clinical parameters and cell types and pattern of infiltrating in the bone marrow. And there were no statistical differences in survival rate depending on the cell types and pattern of infiltration pattern in the bone marrow. Above findings seemed to be resulted from insufficient subjects and failure of complete follow-up study. However, if a cooperative study of the impact of morphological classification in myeloma is performed in the future, morphological classificatin of myeloma could be considered as a prognostic factor.

Swaging에 의한 Autofrettage 加工의 有限要素解析

李澤淳,金東燮,李輝遠 영남대학교 공업기술연구소 1984 연구보고 Vol.12 No.1

Elastic-Plastic stress analysis has been carried out on an auto-frettage processed cylinder by mechanical push swaging. The analysis using finite element method was based on the incremental stress-strain relationship at the von-Mises yielding criterion and Prandtl-Reuss hypothesis in a axially symmetric plain stress condition. By this method, not only permanent enlargement of inner bore diameter but also residual stress distribution was calculated as a function of mandrel diameter. In consequence, enlargement of an autofrettage processed cylinder has good agreement between theoretical and experimental results. Thus, in autofrettage process the bore size and residual stress can be predicated using this method.