흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

EPC 주강품의 Carbon Pick-up 현상

박익민,김대석,김정훈 한국주조공학회 2005 한국주조공학회지 Vol.25 No.1

미세혈관 협심증 환자의 임상상 및 지표에 관한 연구

박상호,온영근,김현정,이태훈,길효욱,김현건,박수진,송해정,한대희,방덕원,신원용,이내희,김성구,권영주 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Microvascular angina or syndrom X is heterogenous and encompasses different pathogenetic entities. Several studies suggest that microvascular angina have good prognosis and occurs predominantly in postmenopausal women. Lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and fibrinogen are the independent risk factor of acute coronary syndrome and are the chief underlying cause of atherosclerosis. We investigated clinical characteristics and markers in patients with microvascular angina. Methods : We studies 23 patients diagnosed with microvascular angina and 16 control group with negative treadmill exercise test and no significant coronary angiogram. We investigated clinical characteristics in patients group and evaluated symptom during a follow-up period of 4.2± 2.5 month. Exercise time in treadmill exercise test was compared between patients and control group. We assessed the level of markers, such as lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and ESR in two groups. Results : There is no difference in age between two groups. Patients group had a tendency to increase in female, hypertension, DM, and smoking history, but there was no statistical significance difference. Exercise duration time was significantly decreased in patients with microvascular angina (p<0,05). Serum lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholestrol, Triglyceride, ESR, Fibrinogen and Homocystein value were no significant difference between microvascular angina and control group. Only CRP was significantly high in patients with microvascular angina (p<0.05). Conclusion : There was no statistical significance difference in age, sex, hypertension, DM and smoking history between two groups but patients group had a tendency to increase the prevalence in hypertension, DM and smoking history, female. Also, Symptom improvement and disappearance in follow-up was presented in 11 patients of 19(57.9%). Exercise tolerance was worse in patients group than control group. CRP value was significantly higher in patients group than control group. There was no statistical significance difference in lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, ESR and Fibrinogen between two groups.

배관내에서 난류 마찰 저항감소에 관한 연구

박설현,윤정환,서동표,정대훈,오율권 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.1

Polymer drag reduction can offer a attractive way to utilize ready-made facilities in crude-oil transport system without additional large expenditure. Also, drag reduction in two phase flow can be applied to phase change system such as chemical reactor, pool and pump impeller which occurs cavitation. But the research on drag reduction in two phase flow has not been investigated. Therefore, experimental investigations have been carried out to analyze the drag reduction in the single phase and two phase flow. The objectives of the proposed investigation are primarily to identify and develop high performance polymer additives for fluid transportation. And drag reduction will be evaluated in horizontal flow by measuring void fraction, pressure drop, mean liquid velocity and turbulent intensity

좌심실 장축 운동의 기능적 의의 (Ⅰ)

박종훈,전은석,구대회 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

To assess the functional significance of long axis movement which would reflect the fiber orientation of the ventricular muscle, we examined the mitral annulus motion and compared it with standard minor axis movement. M-mode echocardiogram were performed in 24 healthy individuals and 17 mitral valve replaced (MVR) patients with simultaneous EKG and phonocardiogram recordings. The results were as follows : 1. In the controls, the onset of shortening of long axis preceeds that of minor axis (phase difference : 20±3msec, mean± SEM) but in MVR patients this phase difference was reversed (-33±8msec). It means that the spherical shape changes which can be observed in normal controls during isovolumic contraction period were lost in MVR patients. 2. In MVR patients, the time intervals from A2 to the end of shortening of long axis were significantly delayed compared with normal controls (54±3 VS 90±8 msec, P<0.01). 3. In MVR patients, the delayed shortening of long axis was observed in amplitude as well as in time. In summary. we observed the regional nonuniformity between long axis and short axis in normal control and interpreted that it could play a role in modulating ventricular function which was lost in MVR patients.

구조용 7000계 알루미늄 합금의 TIG용접부 특성 연구

박성탁,박지호,정재필,서창제,황선효,김대훈 한밭대학교 산업과학기술연구소 2001 논문집 Vol.5 No.-

통합교육에서의 장애유아의 적응기술에 대한 교사의 인식

박정훈,강대옥,박재국 한국특수아동학회 2003 특수아동교육연구 Vol.5 No.1

본 연구는 통학교육에서 장애유아의 적용기술에 대한 교사의 인식을 조사하기 위한 것으로 통합교육 프로그램을 준비하고, 실제적인 교육을 수행하는데 필요한 기초자료를 제공하고자 하였다. 부산시 유아교육기관의 일반교사 97명과 특수교사 60명을 대상으로 통합교육에 필요한 적용기술에 대한 인식을 설문지를 이용하여 조사한 결과 다음과 같은 주된 결론을 얻었다. 첫째, 통합교육에서 요구되는 적응기술에 대한 인식에서는 일반교사와 특수교사 사이에 차이가 없었으나, 하위 영역에서 특수교사들이 일반교사보다 적응기술의 중요성을 높게 평가하고 있다. 둘째, 통합교육에서 요구되는 적응기술의 하위영역에서 특수교사들은 집단활동 참여기술을 가장 중요하게 인식하고 있으나, 일반교사들은 독립생활기술을 가장 중요하게 인식하고 있다. 셋째, 장애유아 적응기술에 대한 교사변인에 따른 인식차이에서 통합경험이 없는 교사들이 적응기술을 중요하게 인식하고 있으며, 특수교육관련 연구경험이 없는 교사가 연수경험이 있는 교사보다 적응기술을 더 중요하게 인식하고 있다. 넷째, 성공적인 통합교육을 위한 교사의 의견에서는 교사의 긍정적 인식 및 태도를 가장 중요한 요인으로 인식하고 있으며, 학부모의 긍정적인 인식과 일반유아의 이해도 주요하다고 인식하고 있다. n This study aimed to determine teachers recognition of the adaptation skills of handicapped children for mainstream education and to provide basic materials for the successful execution of the programs to be prepared for mainstream education and actual mainstream education. This study considered 97 preschool teachers and 60 special teachers who were selected using random sampling, in Busan Metropolitan City. Questionnaires were distributed and collected, with responses reviewed and analyzed using SPSS Win 10.0. Results show no significant difference in the recognition of general adaptation skills of handicapped children required in mainstream education between special teachers and preschool teachers. In contrast, there is difference between the two groups in the sub-spheres of adaptation skills, in which spheres the importance of adaptation skills was more highly regarded by special teachers in the actual kindergarten education than ordinary kindergarten teachers thought. On the other hand, special teachers valued skills of participating in group activities the most in the sub-spheres of adaptation skills required in mainstream education while preschool teachers prioritized independent skills. To narrow such difference in recognition, correct understanding of and active exchange of information in mainstream education should be developed. In addition, teachers without experience in mainstream education were found to require a higher level of adaptation skills from handicapped children compared to teachers with experience in mainstream education. Likewise, teachers without educational training valued adaptation skills more compared to teachers with educational training. Both special teachers and preschool teachers expected a higher level of adaptation skills from handicapped children compared to mainstream education teachers. This suggests that special teachers or teachers without experience in mainstream education demanded a higher level of adaptation skills than actually necessary in mainstream education. The recognition of teachers also varied depending on the educational institution they belong. Finally, teachers considered the positive recognition and attitude of teachers, positive recognition of students parents, and understanding of children as mojor contributory factors to successful mainstream education.

중학교 화학 분야의 개념 연구에 대한 문제점 분석

朴恩姬,姜대勳,白盛惠,朴國泰,金惠敬,蔡禹기,權鈞 한국교원대학교 과학교육연구소 1999 청람과학교육연구논총 Vol.9 No.1

중학교 화학 분야의 오개념 조사에 사용된 설문지의 문제점을 밝혀, 학생들의 정확한 오개념 조사를 위한 바탕을 마련하고자 한다. 기존의 중학교 화학 분야에 대한 오개념 조사 설문지가 연구 대상 학생들에게 잘못 사용되고 있었으며, 문항 내용 자체에도 오류가 있었음을 지적하고자 하는 것이다. 선행 연구들의 분석 결과들이 오개념이 아니라 무개념임을 확인하기 위하여 중학교 1학년 학생 182명을 대상으로 두 종류의 설문지 A와 B를 투입하여 조사하였다. 설문지 A는 오개념 연구를 위해 선행 연구들에서 사용한 문항들로 이루어진 것으로, 이를 투입한 결과를 선행 연구들의 결과들과 비교하기 위한 것이다. 그리고 설문지 B는 설문지 A에서 응답한 학생들의 구체적인 생각을 알아보기 위하여 새롭게 개발한 것이다. 설문지 A를 통해 얻은 결과와 선행 연구들에서 얻은 결과들을 비교할 때, 전반적으로 일관성이 없게 나타났으며, 중학교 1학년 학생들의 주관식 정답률이 객관식 정답률에 비해 매우 낮게 나타나는 공통점은 있었으나, 문항 자체의 오류들이 발견되었다. 설문지 B를 통해 학생들의 생각을 알아본 결과, 설문지 A에서 과학적 개념과 오개념으로 분류된 학생들 중에서 무개념으로 판단된 경우가 많았다. This study was to clarify the problems of questionnaires related to misconception researches of middle school chemistry and to prepare a ground for the correct misconception research for students. For these purposes, the questionnaires of the misconception researches related to chemistry in middle school were analyzed, and the mistakes of the questions which were used in 7th grade students were found, based on a definition of misconceptions in this study. Also, the errors in contents of the questionnaires were indicated. The results of the analysis revealed that most of the 7th grade students did not have misconceptions contrary to some of the previous researches conclusions. They only had no conceptions related to the contents. In order to support this analysis, two different questionnaire sets (questionnaire set A and B) for 182 7th grade students were used. After obtaining similar results to those of the previous researches by the questionnaire set A, the students' thoughts were examined by the questionnaire set B. From the results of this study, the correct answer rates of subjective questions were very low compared with those of objective questions in the questionnaire set A for 7th grade students. It was hard to find consistency among the results of the researches using the questionnaire set A. And many contents of the questions consisted of the questionnaire set A were not consisted with a definition of misconceptions. There were errors in the contents of the questions, too. The students classified as the having-science-concepts group and the having-misconceptions group by the questionnaire set A were classified as the having-no-concepts group by the questionnaire set B.

자궁외 임신의 임상적 고찰

김대중,박성훈,정혁 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background : This study is a clinical evaluation and statistical analysis on the cases of ectopic pregnancies who were surgically treated and histopathologically confirmed at the department of obstetrics and gynecology at Chosun university from January, 1995 to October, 1999. Results : 1. The hospital incidence of ectopic pregnancy was 1 in 10 deliveries and the most frequently age group was in 30~34 years of ages(33.3%). 2. Nulligravida was in 22.2% and the percentage of cases who had 1, 2, and 3 or more artificial abortion were in 30.0%, 19.8%, and 28.0% respectively and nullipara was in 35.4% and the percentage of cases who had 1, 2, and 3 or more deliveries were in 26.3%, 24.7%, and 13.6% respectively. 3. A previous history of appendectomy was in 12.3% and other abdominal surgeries were in 17.4%, pelvic inflammatory disease in 5.8%. 4. On symptomatology skipped menses was observed in 87.2%, lower abdominal pain in 86.0%, and bloody vainal discharge in 60.9%. 5. The mean duration from the first day of the last menstrual period to the date of operation was about 7 weeks. 6. The urine pregnancy test was positive in 75.5% and culdocentesis in 94.2%, Average serum β -hCG(human chorionic gonadotropin) level was about 3,200mIU/mL. 7. The most common site of ectopic pregnancy was salpinx in 91.7%. In the cases of tubal pregnancy, the lesion was most commonly located at the ampulla portion(82.3%) and ruptured tubal pregnancies were in 54.3%. 8. The amount of intraperitoneal free blood was 101~500ml in 29.2%, 501~1000mL in 31.3% and 1001~2000mL in 26.4%.91. Other abnormal pelvic conditions were noted in 30.5% and adhesion was in 13.6%. 10. The operative procedures were salpingectomy in 80.7%, salpingo-oophorectomy in 6.5%, corneal resection in 6.2%, and were laparoscopic operation in 24.3%, laparotomy in 75.7%. 11. There was no fatal case in 243 ectopic pregnancy.

중학생들의 용해 현상 이해에 대한 연구

강대훈,白盛惠,朴國泰 한국교원대학교 과학교육연구소 2001 청람과학교육연구논총 Vol.11 No.1

이 연구에서는 중학생들의 용해 현상 및 그와 관련된 내용에 대한 이해 실태를 알아보았다. 연구 결과 75% 이상의 학생들이 용해를 입자의 크기 차이로 인하여 한 물질이 다른 물질 사이로 들어가는 현상으로 이해하고 있었으며, 일부 학생들은 용해가 일어나면 용질이 없어지거나 용매에 포함되는 것으로 이해하고 있었다. 또한, 학생들은 용해 현상을 큰 입자 사이로 작은 입자가 들어가는 것으로 이해함으로써 정작 용해가 될 때 부피가 감소하는 이유를 제대로 설명하지 못하였다. 그리고 용해도에 미치는 용질 상호간의 영향에 대한 이해는 매우 낮은 것으로 나타났다. 이와 같은 결과는 중학교 과학 교과서의 용해 관련 개념의 설명이 불충분하고 과학 교사들의 부적절한 모형 사용에 의한 설명 때문으로 생각된다. 따라서, 중학생의 이해 수준에 알맞은 교과서의 설명과 용해 현상을 입자적 관점에서 시각적으로 보여줄 수 있는 적절한 모형의 개발이 요구된다. This study was to examine middle school students' understanding of dissolution. More than 75% students understood that dissolution was caused by small particles' filling the space between large particles due to the difference of size among particles. Some other students responded that solute disappeared or was absorbed in a solvent as the result of dissolution. Besides, they didn't know that space between particles was the reason of the volume's decreasing after the process of dissolution. Instead, they explained that space between particles caused dissolution. And they hardly understood the fact that solutes affect solubility. Students' misunderstanding about the concept of dissolution resulted from the lack of the explanation on the right concept of dissolution in science textbooks and the inappropriate use of the dissolution model by teachers. In conclusion, we need the appropriate explanation in middle school science textbooks that consider the students' level and the development of the appropriate model that demonstrates dissolution in the perspective of particles.