건톳 제조에 관한 연구

정창화,오창경,송대진,김수현,오명철 濟州大學校工科大學産業技術硏究所 1999 尖端技術硏究所論文集 Vol.10 No.1

고품질의 건톳제품을 제조할 목적으로 블랜칭 처리조건, 염도, 색도, 톳의 건조조건 등을 연구하였다. 생톳의 최적 블랜칭 조건은 열탕에서 5초간 처리하였고 이때의 염도는 1.8(NaCl%)로 68%의 염분 제거율을 보였다. 건톳 제조의 최적 건조조건은 열풍건조기로 60 에서 2시간 건조시켰을 때이다. 건톳제품의 수분함량은 10%로 조절하였고 색도는 a(-2.61), b(3.58)이었다. For process dried Hizikia fusiforme product of excellent quality, condition of blanching treatment, salinity, color, and dry condition were investigated. The optimum blanching condition of fresh Hizikia fusiforme was 5 seconds at boiling water. Salinity was 1.8(NaCl%), and effect of salinity elimination was 68%. The optimum drying condition was 2 hours at 60℃ in hot-air drying oven. Moisture content of dried Hijizia fusiforme product was control to 10%, Color was a(-2.61), b(3.58).

일부 종합검진 수검자에서 비만도 및 혈중 지질이 혈압에 미치는 영향

임대식,함정오,김화성,이성수 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

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가변블록과 DCT 분류기를 사용한 CVQ에 관한 연구

정일화,이대영 慶熙大學校 大學院 1994 高凰論集 Vol.15 No.-

The proposed CVQ method is based on a classification technique in the discrete cosine transform(DCT) domain. In this scheme, Less complex regions are segmented into variable sized blocks(4×4, 8×8) and high-detail regions are segmented into 4×4 blocks of various edge classes. And Quad-Tree(QT) method is used for block data transmition.

고사리잎 추출액을 이용한 견직물 염색성

정진순,설정화,장정대 한국의류학회 2003 한국의류학회지 Vol.27 No.3,4

In this study, the characteristics of catechol tannin and pyrogallol tannin contained in Pteridium aquilinum were analysed by IR spectrum. Silk fabrics were dyed with Pteridium aquilinum extracts using various mordants, and their dyeing properties were discussed. Additionally the fastness to the water digestion, perspiration liquid digestion and light irradiation were investigated. IR spectrum of catechol tannin showed bands of O-H at 2417㎝^(-1), C-H at 2930㎝^(-1), C-O at 1722^(-1), C=C at 1644㎝^(-1), CH₂ at 1402㎝^(-1). And IR spectrum of pyrogallol tannin showed bands of O-H at 3409㎝^(-1), C-H at 3003㎝^(-1) and 2933㎝^(-1), C=O at 1701㎝^(-1), C=C at 1582㎝^(-1), CH₂ at 1401㎝^(-1), CO at carboxylic acid and carboxylic acid ester at 1287㎝^(-1) and 1135㎝^(-1). The maximum absorption wavelength of the extracts appeared at 270.0nm and 311.5nm. The optimum conditions for dyeing silk fabric with Pteridium aquilinum extracts were 80℃, 60min. Surface color of the silk fabric dyed with Pteridium aquilinum extracts was 2.7Y. Surface color of the pre-mordanted fabrics with Al, Cu and Fe were 4.3Y, 2.5Y and 4.7Y, respectively. And Surface color of the post-mordanted fabrics with Al, Cu and Fe were 3.7Y, 2.8Y and 0.2GY. The water fastness and the alkaline perspiration fastness were improved in the Al-mordanted silk fabrics. By acidic and alkaline perspiration treatment, △E of the unmordanted fabrics was lower than that of pre-and post-mordanted fabrics. Also after 40hour irradiation, △E of the unmordanted fabrics was lower than that of pre-and post-mordanted fabrics.

건강인에서 결핵균 30-kDa항원이 말초혈액 임파구증식에 미치는 영향

최대경,고석신,김화중,조은경,백태현,신철식 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

T lymphocytes are thought to play a central role in cell mediated immune response. To Study the T lymphocyte proliferative response to 30-kDa antigen purified from Mycobacterium tuberculosis H37Rv, peripheral blood lymphocytes isolated from healthy subjects were stimulated with the 30kDa antigen, crude antigen or PHA. Healthy subjects were divided into three groups so that PPD(+), PPD(±) and PPD(-). The proliferations of lymphocytes were measured by the incroporation of ^3H-thyrnidine. The results were summarized as follows: 1. For the PPD(+) person, at concentration of < 1 ㎍/ml, the proliferative response to 30-kDa antigen resulted in a mild reduction but crude antigen showed relatively rapid reduction. For the PPD(-) person, decreasing the concentration of the both antigens showed rapid reduction of proliferation 2. The lymphocytes proliferations to 30-kDa antigen and crude antigen were significantly increased in PPD(+) group when compared to those in PPD(-) group, but PHA response was no significant difference. 3. The sensitivity and specificity of lymphocyte proliferation assay to 30-kDa antigen and crude antigen when compared with skin test results were 92.3%, 100% and 76.9%, 50%, respectively.

초음파 주파수와 음향밀도에 따른 하수슬러지 전처리 특성

김대용,정연화,김한석,정진희,성낙창 東亞大學校 建設技術硏究所 2008 硏究論文集 Vol.31 No.2

The objective of this study was to investigated the pretreatment characteristics of sewage sludge by ultrasonic process. Excess sewage sludge was sampled from N sewage treatment plant (STP) in B city. The ultrasonic processor was designed to operate with 28 kHz and 40 kHz,independently. During sonication experiment, sludge samples were stirred by agitator. The acoustic densities were changed 33 to 139 W/L by control of current strength. The sonication time was in the range of 10 min and 40 min. The total chemical oxygen demand (TCOD) and soluble chemical oxygen demand (SCOD) of sludge were analyzed with K2Cr207 Closed Reflux Method. The results showed that sonication with 28 kHz of acoustic frequency is better than sonication of 40 kHz in incensement of SCOD/TCOD ratio. Also, the sludge solubilization rates increased as the sonication time and acoustic density increased. The application of dual frequency sonication for sludge pretreatment can be interest for sewage treatment plants having problems in sludge treatment and disposal.

장기투석을 받은 만성 신부전 환자에서 발생한 종양에 관한 고찰

황정화,이혜경,홍현숙,박재성,김대호,권귀향,최득린,황승덕,이희발 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

The authors tried to evaluate tumor occurrence in long-term dialysis patients with chronic renal failure. Among 359 patients, 20 patients (about 5.6%) were diagnosed with malignancy during long-term dialysis from the period of 1983 to 1995 at our nephrology department. The ultrasonographic and computed tomographic findings including the clinical features of 20 patients that were retrospectively reviewed. The mean age of the patients was 53 (37-75)years old and the ratio of male to female was 9:1. Among the 20 cases, 7 cases of hepatoma (35%) were developed. Among them, urinary tract tumors such as renal and bladder cancer were developed in 4 (20%) and 2 (10%) of the cases. Other malignant tumors were lymphoma, stomach cancer, uterine cervical cancer, cholangiocarcinoma, lung cancer, meningioma, and acoustic neuroma one case of each (each of 5.3%). The most common tumor in patients with chronic renal failure, who were receiving long-term dialysis, was hepatoma and the second most common tumor was cancer of the urinary tract such as kidney and bladder.

鉛暴露 作業者의 鉛中毒 早期發見을 위한 集團檢診法 改善方案에 관한 硏究

홍대용,김장락,정주화,최현림,윤형렬 慶尙大學校 1995 論文集 Vol.34 No.1

This study was carried out to evaluate the feasibility of current lead indicators used in screening lead who were sspeted to have been exposed to lead were selected as 'case'and 207 female workers from non-lead industry were selected for 'control'. The results obtained were as follows: 1. The mean values of blood lead for case and control were 31.4㎍/dl, 22.2㎍/dl,respectively. The difference observed in the mean concentration between case and control was statistically signifi-ant(P<0.01) 2. The mean values for blood ZPP by hematofluorometer for case and control were 31.3㎍/dl, 25.4㎍/dl,respectiely. And difference between two groups was statistically significant(P<0.01). 3. No statistically significant correlation was found between working duation and blood lead, blood ZPPlovel. 4. According to the simple correlation analysis,ZPPand urine lead were found to be statistically correlated with blood lead(P<0.01) 5. According to the discriminant analysis using blood lead as a dependent variable, it showed 89.1% predictability when using 40㎍/dl as a cutting value which is used as a screenig cutting value for industry workers health examination, while 81.8% for 30㎍/dl,77.54% for 20㎍/dl, respectively. 6. Lead related simptons which is used for screening the lead ntoxicated patients were used as a dependent variables in multiple regression analysis to find useful lead indicator. And significant independent variables were found to be ZPP, Age, and Hct. 7. Above results suggest that objective evalution of feasibbility of several lead indicators should be developed to correct the disutility of current lead screeng system in Korea.

일부 종합검진 수검자에 비만도 및 혈중 지질이 혈압에 미치는 영향

임대식,함정오'김화성'이성수 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

This study was conducted to evaluate blood pressure associated with body mass index and blood lipids. Study subjects were 3,076 persons (1,623 males and 1,453 females) who visited to General Health Screening Center located in Chonan. Data were collected from 2001 to 2003. Height, weight and blood pressure were measured by a trained nurse. The level of total cholesterol, HDL cholesterol, triglyceride, and fasting blood sugar were selected as biometric test variables. Statistical analysis, such as t-test, simple correlation, and stepwise multiple regression were performed using SAS package program. The mean (standar deviation) of age, BMI, systolic blood pressure, diastolic blood pressure, fasting blood sugar, triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol in study subjects were 48.4 ±11.8 years, 23,7 ± 3.2 kg/m^(2), 124.6 ± 16.3 mmHg, 80.9 ± 10.7 mmHg, 97.6 ± 24.9 mg/㎗, 154.4 ± 105.6 mg/㎗, 203.2 ± 39.2 mg/㎗, 51.0 ± 12.8 mg/㎗, and 121.8 ± 35.6 mg/㎗, respectively. In multiple regression analysis of BMI and blood lipids on systolic blood pressure after controlling for confounders (age, sex, and fasting blood sugar), BMI, HDL cholesterol, and triglyceride were found to be significant positive independent predictors of systolic blood pressure. In multiple regression analysis of BMI and blood lipids on systolic blood pressure after controlling for confounders (age, sex, and fasting blood sugar), BMI, triglyceride, HDL cholesterol, and LDL cholesterol were found to be significant positive independent predictors fo systolic blood pressure. With above results, it was found that BMI and blood lipids were significantly associated with blood pressure.

만성 B형 간질환에서 라미부딘 내성의 임상경과 및 예측인자

박능화,신정우,박종호,방성조,김대현,주광로,김도하 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.4

목적: 라미부딘의 투여기간이 길수록 약제내성 변이형 바이러스의 발생률이 증가하게 된다. 변이형의 장기적인 임상적 의의는 논란이 많다. 본 연구는 B형 간염 바이러스에 의한 만성 간질환자에서 변이형이 생긴 뒤의 임상적 경과와 변이형의 발생을 예측할 수 있는 인자를 알아보고자 하였다. 대상과 방법: 만성 B형 간 질환자로 진단 받은 환자 중 라미부딘 치료도중에 viral breakthrough가 생긴 124명을 대상으로 하였다. 평균 연령은 40세였고 남녀 비는 105:19였다. 치료 전 혈청 평균 ALT치는 223 IU/L, 혈청 평균 AST치는 127 IU/L, 혈청 평균 HBV DNA치 1216 pg/mL, 치료 전 정량적 평균 HBeAg치 259이였다. 라미부딘은 1일 100 ㎎씩 breakthrough가 발생한 124명에게 계속 투여하였으며 1, 2개월 간격으로 간기능 검사, HBeAg, anti HBe, HBV DNA 검사를 시행하였다. 라미부딘 총 평균투여 기간은 30.5개월(범위: 10-59개월)이었으며 breakthrough 후 라미부딘 평균 투여기간은 12.5개월(범위: 1-42개월)이였다. 결과: 라미부딘 투여 환자 519명 중 124명에서 viral breakthrough가 5-41개월 사이에 발생하였으며 누적발생률은 12개월 후 8%, 18개월 후 24%, 24개월 후 36%, 36개월 후 52%였다. Viral breakthrough가 생긴 6개월 이내에 120명에서 혈청 ALT치가 상승하였으나 4명에서는 계속 정상으로 유지되었다. 혈청 ALT치는 대부분 상승한 뒤 5개월 내에 최고치에 도달하였으나 6명에서는 12개월 이후에 최고치에 도달하기도 하였다. ALT치는 72명(65%)에서 치료 전 값 이상으로 상승하였으며, 67명(56%)에서 정상치의 5배 이상, 29예(24%)에서 10배 이상 상승하였다. Breakthrough후에 라미부딘 계속투여로 혈청 ALT치가 정상으로 유지된 경우는 22예(18%)에 불과하였으며 98예는 치료전보다 높게 유지되었고 16예에서는 지속적으로 상승하였다. Breakthrough후의 혈청 ALT치 및 AST치가 치료 전보다 의미 있게 상승하였으나 혈청 HBV DNA치는 차이가 없었다. Breakthrough후에 10명에서 HBeAg의 음전이 있었으나 5예에서는 음전 후에 HBV DNA가 재양전되고 혈청 ALT치가 상승되는 HBeAg 음성 만성 간염형태로 나타났다. Breakthrough와 관련된 예측자로 치료 중 정량적 HBeAg의 변화양상만이 유일하게 의미가 있어 감소 후 증가군 82.5%에서,. 지속적 유지군 23.7%에서 Breakthrough가 발생하였으나 지속적 감소군에서는 단지 3.5%만이 발생하였다. 또한 감소 후 증가군에서 정량적 HBeAg치의 감소 후 재상승시점은 약물투여후 평균 9개월로 HBV DNA가 재양전되는 평균시점인 16개월보다 의미 있게 짧았다. Breakthrough후에 투약을 중지한 예는 40예(33%)였다. 이 중 11예에서 중단전보다 혈청 ALT치가 상승되었으며 8개월 내에 전예에서 발생하였다. 중단시 혈청 ALT치가 치료 전 수치보다 높은 경우에서 중단한 26예 중 25명은 중단 후에 혈청 ALT치가 중단 시보다 낮았지만 치료 전 수치보다 낮은 경우에서 중단한 14명 중 10예에서 중단 후에 중단 시보다 더 높아졌다. 결론: 만성 B형 간염환자에서 라미부딘 투여 중에 발생한 HBeAg후의 임상양상은 상당수에서 급성악화를 보였다. Breakthrough를 예측할 수 있는 인자로는 치료 중 정량적 HBeAg치의 변화양상만이 유일한 인자였으며 HBeAg치가 지속적 감소 후에 다시 증가하는 양상을 보인 경우에는 HBV DNA의 재양전보다 더 빨리 Breakthrough을 예측할 수 있었다. Background/Aims: Long-term treatment with lamivudine causes breakthrough, but the clinical course after lamivudine breakthrough is not well known. The aims of this study were to evaluate the clinical course in lamivudine after breakthrough, and to identify predictive factors of breakthrough. Methods: 124 patients with chronic hepatitis B infection, who represented viral breakthrough during lamivudine therapy, were included. The mean duration of lamivudine therapy and additional lamivudine therapy after breakthrough was 30.5 months and 12.5 months, respectively. Results: The cumulative breakthrough rates at 12, 18, 24 and 36 months were 8, 24, 36 and 52%, respectively. After viral breakthrough, only 4 patients maintained normal ALT levels. 120 patients showed ALT elevation. The number of patients with ALT levels greater than 5 times, and greater than 10 times, the upper normal limit were 67(56%) and 29 (24%), respectively. While still on lamivudine therapy after breakthrough, 98 patients presented ALT elevation. Only 22 had normalized ALT levels. Hepatic decompensation developed in 2 patients. HBeAg seroconversion after breakthrough occurred in 10 patients. The changing pattern of quantitative HBeAg levels during lamivudine therapy was the only predictive factor associated with viral breakthrough. The mean time of turning points in decrescendo-crescendo patterns of HBeAg levels during lamivudine therapy was earlier than viral breakthrough (9 months vs. 17 months). Conclusions: These results suggested that deterioration of hepatic function can usually be observed after breakthrough. The serial monitoring of serum quantitative HBeAg levels may allow an early recognition of viral breakthrough.(Korean J Hepatol 2003;9:293-303)