모유 수유아와 조제 분유 영양아에서 수유 방법에 따른 아미노산 농도 비교 및 혈청 트립토판 농도와 수면 유도와의 관계

정다운,김은영,양은석,박상기,박영봉,문경래 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Objective: Sleep behavior is modulated by serotonergic neurons within the brain, and the synthesis and release of serotonin by such neurons is thought to be influenced by the availability of tryptophan, the amino acid precursor of serotonin. Formula-feeding infants have depressed plasma tryptophan concentration relative to breast milk-feeding infants. Because tryptophan alters sleep waking patterns in adults, a study was designed to determine the difference of sleep latency relative to differences in plasma tryptophan and tryptophan : large neutral amino acid (LNAA) ratio between formula-feeding infants and breast milk-feeding infants. Method: 45 newborns who were born in Chosun University Hospital from December 2002 to December 2003 were selected. The newborns were divided to three group, 15 newborns were fed breast milk and 15 newborns were fed formula A, and last 15 newborns were fed formula B. At 6 weeks and 12 weeks, infants were sampled for measuring of serum amino acid level and tryptophan, tryptophan : LNAA ratio. And we taught infants' parents to measure sleep latency that means the time after a feeding to the first episode of active REM sleep that persist ≥ 1 min. Result: 1) At 6weeks, Serum α-amino-n-butyric acid, citrulline, tryptophan level was higher in formula A group than breastmilk group (P<0.05) and proline level was lower than breast milk group (P<0.05). In formula B group, serum n-amino-n-buryric acid, citrulline, cystine, hydroxylysine, hydroxyproline, isoleucine, leucine, lysine, methionine, phenylalanine, taurine, threonine, valine levels were higher than breastmilk group (P<0.05). And Serum isoleucine, methionine, proline, valine level were higher in formula B group than formula A group (P<0.05). 2) At 12 weeks, serum glutamic acid, methionine, ornithine levels were higher in formula group A than breast milk group (P<0.05). Serum β-alanine, aspartic acid, α-amino-n-butyric acid, ethanolamine, glutamic acid, threonine level were higher in formula B group than breast milk group (P<0.05). Serum β-alanine, ethanolamine levels were higher and arginine level was lower in formula B group than formula A (P<0.05). 3) At 6 weeks, serum tryptophan concentration and tryptophan: LNAA ratio were higher in formula A group (P<0.05). Sleep latency was 21 minutes in formula group A, 24 minutes in breast milk group, 25 minutes in formula B group but there was no statistically significance (P>0.05). 4) At 12 weeks, serum tryptophan concentration and tryptophan: LNAA ratio, time after feeding to the first episode of active REM sleep were no difference with each other group. Conclusion: There is significant difference of serum amino acids between breast-feeding infants and formula-feeding infants. And serum tryptophan and tryptophan: LNAA ratio differ between brest-feeding infants and formula-feeding infants. But there is no association between serum tryptophan, tryptophan: LNM ratio and sleep latency.

노인과 대학생의 낙상 위험 분석

정다현,김예희,김지은,이예영,강현주 순천향대학교 기초과학연구소 2021 순천향자연과학연구 논문집 Vol.27 No.1.2

The purpose of this study was to analyze risk of falls between elderly people and college students. The subjects of this study were 25 people aged 70 years or older and 17 college students located in Asan. We measured sensory, integrated balance, nervous, musculoskeletal system and HQR by FRA system (Inbody, Korea). The results of measurement showed significant differences in sensory system (p<.01), integrated balance (p<.001), nervous system (p<.001), and musculoskeletal system (p<.001) between groups. These results suggest that aging makes difference of function of these systems. In our view, counterplans need to be implemented, including exercise intervention to prevent decreases of fall risk,

근피로 후 세 가지 회복 방법

이예영,김지은,서예은,정다연,강현주 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

Muscle fatigue is a symptom that decreases your muscles’ ability to perform over time. It can be associated with a state of exhaustion, often following excessive sports activity or exercise. While exercise is a common cause of muscle fatigue, this symptom can be the result of other health conditions. Muscle fatigue caused by excessive activity limits activities of daily living and difficult to maintain a stable posture. Therefore, the purpose of this study was to investigate the effect of stretching, icing, and sports massage on muscle fatigue recovery.

사무직 근로자의 수면의 질 및 직무스트레스와 우울과의 관련성

강미나,강수영,권수정,김현주,배재원,이보연,이예진,임의롬,정다영,조한솔 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to understand the degree of depression, sleep quality, job stress and their association among office workers. Method: A self-administered questionnaire was distributed to 147 workers employed in 5 big enterprises, and 5 small and medium enterprises from October 21 to November 21, 2012. The questionnaires included socio-demographic and health-related characteristics, job-related characteristics, sleep quality, job stress (KOSS) and depression (CES-D). Result: Among all subjects, 23.1% was in the depression group (21 points and over in the CES-D score). Depressive level was positively correlated with job stress and quality of sleep. The adjusted odd ratio for the effects of sleep quality and job stress on depression significantly increased in the depression group compared to that of the normal group. Multiple regression analysis revealed that the following factors of influence had combined explanatory powers on depression: BMI, life satisfaction, quality of sleep, and job stress. Conclusion: The study revealed that complicated influences were exerted on the level of depression by variable factors, as well as socio-demographic characteristics, health-related characteristics, quality of sleep, and job stress. Specifically, the level of depression was influenced by the quality of sleep and job stress.

Anti-inflammatory Activity of the Sargassum sagamianum Ethanol Extracts in LPS-induced RAW 264.7 cells

Da-hyun Jeong,Min-ji Kim,Koth-bong-woo-ri Kim,Seul-a Jung,Hyun-jee Kim,Hee-ye Jeong,Ga-yeong Lee,Bo-kyeong Kang,Si-woo Bark,Dong-hyun Ahn 한국식품영양과학회 2012 한국식품영양과학회 학술대회발표집 Vol.2012 No.10

Phytochemical Changes of Fermented White Peony and Potential Effect as a Nutraceutical for Alleviating Psychiatric Disorders

Da Yeong KIM,Hyo Jeong SONG,So Young PARK,Jui CHAKMA,Eun Ji LEE,Na Yeong BEEN,Dong Nyoung OH,Sunjay YOON,Ga Yeong KIM,Ji Eun LIM,Dong Pil KIM,Yun-Jy HEO,Nan Kyung KIM,Jong Min LEE 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

난관의 악성 혼합 뮐러씨 종양

정다정 ( Jeong Da Jeong ),김재욱 ( Kim Jae Ug ),김영태 ( Kim Yeong Tae ),김성훈 ( Kim Seong Hun ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.4

Malignant mixed mullerain tumors (MMMT) are rare neoplasms of the female genital tract that histolotically consist of malignant epithelial and stromal components, arising in the endometirum, followed in decreasing order by the vagina, cervix, and ovary. T

농촌주택 부속사의 적정규모 기준 설정방안

정다영 ( Da-yeong Jeong ),리신호 ( Shinho Rhee ) 한국농공학회 2015 한국농공학회 학술대회초록집 Vol.2015 No.-

건립연도가 50년 이상 된 재래식 농촌주택은 정부와 개인의 요구에 의해 여러 차례 개량과 보수가 거듭되면서도 노후불량주택이라는 문제를 지속적으로 이어오고 있다. 농업의 생산방식의 축소 또는 편기됨에 따라 1960년대에 지어진 부속사들은 여전히 존재하면서 현 실정에 맞도록 증·개축 및 점증부가 되면서 무질서하게 방치되고 있다. 농촌주택의 부속사는 살림채와 별도로 다른 재료와 간이 구조로 필요에 따라 축조되므로 주택의 주변에 산재되어 농촌경관에 이질감을 불러일으키고 있다. 자연환경과 지역의 정체성 및 생활양식을 담아내는 농촌주택을 계획함에 있어 부속사에 대한 적합한 공간구성과 규모산정이 요구된다. 공간구성의 요인을 분석하고 적정규모 최적화를 위해 규모 설정기준을 마련해한다. 농촌주택 부속사의 공간은 기능, 계절, 동선과 기계 점유면적 등에 따라 구성된다. 세부적으로 농기구, 농자재, 농기계, 농약품, 농산물 보관 및 저장 등으로 부속사의 면적을 소요한다. 농사규모와 공간구성요인에 따라 농사소모품창고, 농산물(저온, 실온, 건조)보관창고, 농기계보관창고 등으로 부속사 공간을 크게 분리해 볼 수 있다. 부속사의 공간을 최적으로 계획하기위해 농자재와 기계의 용도와 이용특성, 계절별 사용빈도와 크기에 따라 공간을 분리·통합하고 농산물과 농기계 보관, 살림채와의 접근 생활방식에 따른 기능적 동선체계 등을 조사·분석함으로써 적정규모 기준 설정방안을 제시한다.

RAW 264.7 대식세포에서 지질 다당류에 의한 미세먼지(PM<SUB>2.5</SUB>) 유발 염증 반응 증진에 미치는 ROS-NF-κB 신호 전달 경로의 역할

권다혜(Da Hye Kwon),김다혜(Da Hye Kim),김민영(Min Yeong Kim),황보현(Hyun Hwangbo),지선영(Seon Yeong Ji),박세광(Seh-Kwang Park),정지원(Ji-Won Jeong),김미영(Mi-Young Kim),이혜숙(Hyesook Lee),정재훈(JaeHun Cheong),남수완(Soo-Wan Nam),황혜 한국생명과학회 2021 생명과학회지 Vol.31 No.12

본 연구의 목적은 LPS가 처리된 RAW 264.7 대식세포에서의 염증 반응이 미세먼지(PM2.5)에 의해 더욱 증가될 수 있는지를 조사하는 것이다. 이를 위하여 LPS와 미세먼지(PM2.5)가 단독으로 처리되거나 LPS가 존재하는 조건에서 미세먼지(PM2.5)가 처리된 RAW 264.7 세포에서 염증 매개변수와 ROS의 생성 정도 및 염증 조절 유전자들의 발현 수준을 조사하였다. 본 연구의 결과에 의하면 세포 독성이 없는 범위에서 LPS가 처리된 세포에서 미세먼지(PM2.5)는 염증성 매개 인자(NO 및 PGE₂) 및 cytokine (IL-6 및 IL-1β)의 생성 수준이 각각의 단독 처리군에 비하여 매우 증가되었으며. 이는 이들의 생성에 관여하는 유전자들의 전사 및 번역 수준에서의 발현 증가와 연관성이 있었다. 또한, LPS가 처리된 RAW 264.7 세포에 미세먼지(PM2.5)가 노출되었을 때, 핵에서 NF-κB의 발현이 더욱 증가하였고, 세포질에서는 NF-κB 뿐만 아니라 IκB-α의 발현이 감소되었다. 이러한 결과는 LPS와 미세먼지(PM2.5)의 단독 처리에 비하여 동시 처리된 경우 NF-κB 신호계의 활성이 더욱 증가하여 염증성 유전자들의 전사 활성 촉진에 기여하였음을 의미한다. 나아가 LPS가 처리된 RAW 264.7 세포에서 미세먼지(PM2.5)에 의해 ROS 생성이 크게 증가되었지만 NF-κB 억제제는 ROS의 생성을 감소시키지 못하였다. 그러나, ROS 생성을 인위적으로 억제하였을 경우, 미세먼지(PM2.5)에 의해 증가된 염증 매개 인자의 발현 및 생성과 NF-κB의 활성화가 모두 감소되었다. 따라서, 본 연구의 결과는 LPS가 처리된 RAW 264.7 세포에서 미세먼지(PM2.5)에 의해 유도된 NF-κB 매개 염증 반응의 증가는 ROS 생성 의존적 현상임을 시사한다. The purpose of this study was to investigate whether the inflammatory response in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages could be promoted by particulate matter 2.5 (PM2.5) stimulation. To this end, the levels of inflammatory parameters, reactive oxygen species (ROS) and inflammation-regulating genes were investigated in RAW 264.7 cells treated with PM2.5 in the presence or absence of LPS. Our results showed that the production levels of pro-inflammatory mediators (nitric oxide and prostaglandin E₂) and cytokines (interleukin-6 and -1β) were significantly increased by PM2.5 stimulation in LPS-treated RAW 264.7 cells, which was correlated with increased expression genes involved in their production. In addition, when LPS-treated RAW 264.7 cells were exposed to PM2.5, nuclear factor-kappaB (NF-κB) expression was further increased in the nucleus, and the expression of inhibitor of NF-κB as well as NF-κB in the cytoplasm was decreased. These results suggest that the co-treatment of PM2.5 and LPS further increases the activation of the NF-κB signaling pathway compared to each treatment alone, thereby contributing to the promotion of transcriptional activity of inflammatory genes. Furthermore, although the generation of ROS was greatly increased by PM2.5 in LPS-treated RAW 264.7 cells, the NF-κB inhibitor did not reduce the generation of ROS. In addition, when the generation of ROS was artificially suppressed, the production of inflammatory mediators and the activation of NF-κB were both abolished. Therefore, our results suggest that the increase in the NF-κB-mediated inflammatory response induced by PM2.5 in LPS-treated RAW 264.7 macrophages was a ROS generation-dependent phenomenon.

STT를 활용한 근본적 말하기 습관 분석 및 개선 연구

김다영 ( Da-yeong Kim ),송민경 ( Min-gyung Song ),정수정 ( Su-jeong Jeong ),최서현 ( Hyun-choi Seo ),임성현 ( Sung-hyun Lim ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.2

지금까지 사람들의 말하기 습관을 분석하는 것은 전문가나 다른 사람들의 피드백을 통해 이루어졌다. 이는 평가하는 사람에 따라 다른 결과가 나타날 수 있기 때문에 다소 객관성이 떨어지며 직접 대면이 요구되기 때문에 훈련할 수 있는 시간과 공간에 제약이 있었다. 또 지금까지의 말하기 훈련이라 함은 면접 스피치나 발표 스피치 등 특정 목적을 가지고 진행되었기 때문에 말하기에 있어서의 통합적인 훈련을 받기 어려웠다. 본 연구에서는 가장 기초적인 말하기 습관에 초점을 맞추고 말하기 능력을 ‘어휘력’, ‘계속성’, ‘발음’, ‘속도’라는 4개의 영역으로 나누어 각 영역을 분석하는 알고리즘을 제시한다. 이 알고리즘을 활용한다면 모두 같은 메커니즘을 통해 분석이 이루어지기 때문에 객관성을 보장할 수 있으며 어플리케이션을 활용해 시간과 공간의 제약을 받지 않고 말하기 습관 개선을 위한 훈련을 할 수 있을 것이다.