Chemical constituents from Inula wissmanniana and their anti-inflammatory activities

Chunhui Wang,Xufeng Zhang,Panlei Wei,Xiangrong Cheng,Jie Ren,Shi Kai Yan,Wei Dong Zhang,Hui Zi Jin 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.12

Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol (1) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol (2), onenew flavonolignan 23-o-acetylsilychristin A (3), and onenew thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid (4), along with 13 known compounds,including ten flavonolignans (5–14) and three thymolderivatives (15–17) were isolated from the aerial part ofInula wissmanniana. The structures of new compoundswere elucidated by detailed spectroscopic analysis,including HRESIMS and 2D-NMR spectroscopic data. Allthe compounds were isolated from this plant for the firsttime. The anti-inflammatory activities of the compoundswere tested against LPS-induced NO production in RAW264.7 macrophages.

Molecular Characteristics and Potent Immunomodulatory Activity of Fasciola hepatica Cystatin

Kai Zhang,Yucheng Liu,Guowu Zhang,Xifeng Wang,Zhiyuan Li,Yunxia Shang,Chengcheng Ning,Chunhui Ji,Xuepeng Cai,Xianzhu Xia,Jun Qiao,Qingling Meng 대한기생충학ㆍ열대의학회 2022 The Korean Journal of Parasitology Vol.60 No.2

Cystatin, a cysteine protease inhibitor found in many parasites, plays important roles in immune evasion. This study analyzed the molecular characteristics of a cystatin from Fasciola hepatica (FhCystatin) and expressed recombinant FhCystatin (rFhcystatin) to investigate the immune modulatory effects on lipopolysaccharide-induced proliferation, migration, cytokine secretion, nitric oxide (NO) production, and apoptosis in mouse macrophages. The FhCystatin gene encoded 116 amino acids and contained a conserved cystatin-like domain. rFhCystatin significantly inhibited the activity of cathepsin B. rFhCystatin bound to the surface of mouse RAW264.7 cells, significantly inhibited cell proliferation and promoted apoptosis. Moreover, rFhCystatin inhibited the expression of cellular nitric oxide, interleukin-6, and tumor necrosis factor-α, and promoted the expression of transforming growth factor-β and interleukin-10. These results showed that FhCystatin played an important role in regulating the activity of mouse macrophages. Our findings provide new insights into mechanisms underlying the immune evasion and contribute to the exploration of potential targets for the development of new drug to control F. hepatica infection.

Graphene nanosheet/silicone composite with enhanced thermal conductivity and its application in heat dissipation of high-power light-emitting diodes

Hai Yan Zhang,Yingxi Lin,Danfeng Zhang,Wenguang Wang,Yuxiong Xing,Jin Lin,Haoqun Hong,Chunhui Li 한국물리학회 2016 Current Applied Physics Vol.16 No.12

Heat dissipation from light-emitting diodes (LEDs) has become a serious problem because of the LEDs' high luminosity and power. This problem could be solved by improving the dissipation efficiency of each LED system component. A microwave-reduced graphene nanosheet/silicone (GN/silicone) composite with a high thermal conductivity and stability was prepared by mechanical blending. The thermal conductivity of the composite reaches 2.7 W/(m K) with only 1.5 wt% loading, and is 12 times higher than the pure silicone matrix. When used as a thermal interface material between high-power LED chip module substrates and heat sinks, the thermal conductive GN/silicone composite could decrease the temperature difference between the substrate and shell. It could also improve the system heat transfer efficiency. The temperature gap between the heat slug and the heat sink was less than 2 C with a 1.5 wt% loading of GNs.

Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center

Chunhui Zhou,Hao Zhao,Fan Yang,Luokai Huangfu,Chao Dong,Shuwei Wang,Jianning Zhang 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.2

Background and Purpose Brainstem gliomas (BSGs) in adults are rare brain tumors with dismal outcomes. The aim of this study was to determine the clinical and genetic features in a series of BSGs and their association with the prognosis. Methods Fifty patients who underwent a stereotactic biopsy between January 2016 and April 2018 at a single institution were collected. Data on clinicopathological characteristics were analyzed and factors associated with patient survival were identified using a Cox regression model. Results The median age at diagnosis was 55.5 years, and 62% of the patients were male. Glioblastoma (44%) accounted for the largest proportion of BSGs, and oligodendroglioma (2 of 50) was rarely encountered. The IDH mutation (6 of 44) occurred infrequently in astrocytomas, and IDH-mutant tumors harbored both ATRX loss and MGMT promoter methylation at a relatively low level. Wild-type IDH astrocytomas were identified as having high rates of 1p/19q codeletion (5 of 38) and loss of heterozygosity 1p (8 of 38) or 19q (8 of 38) only. In diffuse midline glioma H3K27M mutant, MGMT promoter methylation occurred in three of four cases. Patients were offered radiotherapy and/or concurrent/adjuvant temozolomide chemotherapy, and their median survival time was 13 months. Multivariate analysis revealed that a low tumor grade, absence of tumor enhancement, duration of symptoms ≥3 months, Karnofsky performance status ≥70, and ATRX loss conferred a survival advantage. Conclusions Adult BSGs showed different molecular genetic characteristics, but also resembled supratentorial gliomas in their clinical features associated with oncological outcomes.

Synthesis and Properties of Optically Active Helical Polyethers Bearing Indole or Carbazole Derivatives

Chunhui Zhao,Kunbing Ouyang,Nian-Fa Yang,Jin Zhang,Zhu Sheng Yang 한국고분자학회 2016 Macromolecular Research Vol.24 No.5

Six optically active oxide propane monomers (1m-6m) were synthesized in a very facile way. The monomers were polymerized using potassium hydroxide (KOH) as an initiator to afford the corresponding polyethers (1p-6p). The polyether (R)-1p (specific rotation, [α]=+331) exhibited optical rotation as large as fourfold that of the monomer (R)-1m ([α]=-10). The specific optical rotation, circular dichroism (CD) and ultraviolet (UV)-visible spectra data showed that the obtained polymers can keep a prevailing helicity of the backbone in solution.

Chemical constituents of the stems of Celastrus rugosus

Ruijie Chang,Chunhui Wang,Qi Zeng,Bin Guan,Wei Dong Zhang,Hui Zi Jin 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.11

Two new sesquiterpene pyridine alkaloids rugosusinesA and B (1 and 2), and thirty-one known compoundswere isolated from the stems of Celastrus rugosus. The structures of new compounds were elucidated bydetailed spectroscopic analysis, including HR-ESI–MS and2D NMR spectroscopic data. All the compounds wereisolated from this plant for the first time. The cytotoxicitiesof these compounds were tested against SKOV3 and MGC-803 cell lines by CCK-8 method.

Crosslinked Proton Exchange Membranes with a Wider Working Temperature Based on Phosphonic Acid Functionalized Siloxane and PPO

Zhihui Wu,Chunhui Shen,Shanjun Gao,Xi Zhu,Mingliang Zhang,Ao Ding 한국고분자학회 2021 Macromolecular Research Vol.29 No.3

A series of proton exchange membranes were prepared by incorporating phosphonic functionalized siloxane into sulfonic poly(2,6-dimethyl-1,4-phenyleneoxide) (SPPO) and imidazole functionalized poly(2,6-dimethyl-1,4-phenyleneoxide) grafted with siloxane (IPPO-Si). Phosphonic acid functionalized siloxane was synthesized from amino trimethyl phosphonic acid (ATMP) and (3-aminopropyl)triethoxysilane (APTES). FTIR results showed that 1-methylimidazole and APTES were successfully grafted onto polyphenylene oxide, and APTES successfully formed Si-O-Si crosslinked networks through hydrolytic crosslinking. The membranes were thermally stable up to 220 °C and exhibited excellent oxidative stability and mechanical performance. We also measured the proton conductivity of the membranes. The results showed that the proton conductivities of the composite membranes increased with the increasing of SPPO content at different degrees under high (100 °C-160 °C) and low (25 °C-80 °C) temperature conditions. Furthermore, the IPPO-SI-P/SPPO-30 has the best conductivity, reaching to 0.1131 S cm-1 at 80 °C, 100%RH and 0.1049 S cm-1 at 160 °C, 5%RH, respectively. Therefore, this novel membrane acts as a potential candidate for proton exchange membranes with a wider applicable temperature (25 °C-160 °C).

Synthesis of CdxZn1-xS@MIL-101(Cr) Composite Catalysts for the Photodegradation of Methylene Blue

Shipeng Yang,Siwei Peng,Chunhui Zhang,Xuwen He,Yaqi Cai 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.10

Nanoparticles of the semiconductor catalyst CdxZn1-xS were embedded into the metal organic framework MIL-101(Cr) to obtain CdxZn1-xS@MIL-101(Cr) nanocomposites. These materials not only possess high surface areas and mesopores but also show good utilization of light energy. The ultraviolet-visible diffuse reflectance patterns of CdxZn1-xS@MIL-101(Cr) nanocomposites showed that Cd0.8Zn0.2S@MIL-101(Cr) possessed good visible light response ability among the synthesized nanocomposites. The photocatalytic performance of the CdxZn1-xS@MIL-101(Cr) nanocomposites were tested via degradation and mineralization of methylene blue in neutral water solution under light irradiation using a 300W xenon lamp. As a result, using Cd0.8Zn0.2S@MIL-101(Cr) as a catalyst, 99.2% of methylene blue was mineralized within 30 min. Due to the synergistic effect of adsorption by the MIL-101(Cr) component and photocatalytic degradation provided by the Cd0.8Zn0.2S component, the Cd0.8Zn0.2S@MIL-101(Cr) catalyst displayed superior photocatalytic performance relative to Cd0.8Zn0.2S and MIL-101(Cr). Furthermore, Cd0.8Zn0.2S@MIL-101(Cr) possessed excellent stability during photo-degradation and exhibited good reusability. The remarkable photocatalytic performance of Cd0.8Zn0.2S@MIL-101(Cr) is likely due to the effective transfer of electrons and holes at the heterojunction interfaces.

Template Synthesis of Nitrogen-Doped Short Tubular Carbons with Big Inner Diameter and their Application in Electrochemical Sensing

Cheng, Rui,Zou, Qiong,Zhang, Xiaohua,Xiao, Chunhui,Sun, Longfei,Chen, Jinhua Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.8

Nitrogen-doped short tubular carbons (N-STCs) with big inner diameter have been successfully synthesized via carbonization of polydopamine (PDA) wrapped halloysite nanotubes (HNTs). The obtained N-STCs have average length of $0.3{\mu}m$ with big inner diameter (50 nm), thin wall (2-3 nm) and large surface area ($776m^2g^{-1}$), and show excellent electrochemical properties. As an example in electrochemical applications, N-STCs were used to electrochemically detect hydrogen peroxide ($H_2O_2$) and glucose. The results showed that the N-STCs modified glassy carbon (N-STCs/GC) electrode had much better analytical performance (lower detection limit and wider linear range) compared to the acid-treated carbon nanotubes (AO-CNTs) based GC electrode. The unique structure endows N-STCs the enhanced electrochemical performance and promising applications in electrochemical sensing.

Template Synthesis of Nitrogen-Doped Short Tubular Carbons with Big Inner Diameter and their Application in Electrochemical Sensing

Rui Cheng,Qiong Zou,Xiaohua Zhang,Chunhui Xiao,Longfei Sun,Jinhua Chen 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.8

Nitrogen-doped short tubular carbons (N-STCs) with big inner diameter have been successfully synthesized via carbonization of polydopamine (PDA) wrapped halloysite nanotubes (HNTs). The obtained N-STCs have average length of 0.3 μm with big inner diameter (50 nm), thin wall (2-3 nm) and large surface area (776 m2 g−1), and show excellent electrochemical properties. As an example in electrochemical applications, N-STCs were used to electrochemically detect hydrogen peroxide (H2O2) and glucose. The results showed that the N-STCs modified glassy carbon (N-STCs/GC) electrode had much better analytical performance (lower detection limit and wider linear range) compared to the acid-treated carbon nanotubes (AO-CNTs) based GC electrode. The unique structure endows N-STCs the enhanced electrochemical performance and promising applications in electrochemical sensing.