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- 저자 : Chunhui Zhao (검색결과 5 건)
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Chunhui Zhao,Kunbing Ouyang,Nian-Fa Yang,Jin Zhang,Zhu Sheng Yang 한국고분자학회 2016 Macromolecular Research Vol.24 No.5
Six optically active oxide propane monomers (1m-6m) were synthesized in a very facile way. The monomers were polymerized using potassium hydroxide (KOH) as an initiator to afford the corresponding polyethers (1p-6p). The polyether (R)-1p (specific rotation, [α]=+331) exhibited optical rotation as large as fourfold that of the monomer (R)-1m ([α]=-10). The specific optical rotation, circular dichroism (CD) and ultraviolet (UV)-visible spectra data showed that the obtained polymers can keep a prevailing helicity of the backbone in solution.
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Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center
Chunhui Zhou,Hao Zhao,Fan Yang,Luokai Huangfu,Chao Dong,Shuwei Wang,Jianning Zhang 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.2
Background and Purpose Brainstem gliomas (BSGs) in adults are rare brain tumors with dismal outcomes. The aim of this study was to determine the clinical and genetic features in a series of BSGs and their association with the prognosis. Methods Fifty patients who underwent a stereotactic biopsy between January 2016 and April 2018 at a single institution were collected. Data on clinicopathological characteristics were analyzed and factors associated with patient survival were identified using a Cox regression model. Results The median age at diagnosis was 55.5 years, and 62% of the patients were male. Glioblastoma (44%) accounted for the largest proportion of BSGs, and oligodendroglioma (2 of 50) was rarely encountered. The IDH mutation (6 of 44) occurred infrequently in astrocytomas, and IDH-mutant tumors harbored both ATRX loss and MGMT promoter methylation at a relatively low level. Wild-type IDH astrocytomas were identified as having high rates of 1p/19q codeletion (5 of 38) and loss of heterozygosity 1p (8 of 38) or 19q (8 of 38) only. In diffuse midline glioma H3K27M mutant, MGMT promoter methylation occurred in three of four cases. Patients were offered radiotherapy and/or concurrent/adjuvant temozolomide chemotherapy, and their median survival time was 13 months. Multivariate analysis revealed that a low tumor grade, absence of tumor enhancement, duration of symptoms ≥3 months, Karnofsky performance status ≥70, and ATRX loss conferred a survival advantage. Conclusions Adult BSGs showed different molecular genetic characteristics, but also resembled supratentorial gliomas in their clinical features associated with oncological outcomes.
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Monitoring persistence change in infinite variance observations
Zhanshou Chen,Zheng Tian,Chunhui Zhao 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.1
In this paper, we adopt a kernel-weighted variance ratio statistic to monitor persistence change in infinite variance observations. We focus on a I(0) to I(1) regime switch for sequences in the domain of attraction of a stable law and local-to-finite variance sequences. The null distribution of the monitoring statistic and its consistency under alternative hypothesis are proved. In particular, a bootstrap approximation is proposed to determine the critical values for the derived asymptotic distribution depends on the unknown tail index. The small sample performance of the proposed monitoring procedures are illustrated by both simulation and application to Sweden/US foreign exchange rate data.
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Yuanqiang Zhou,Zhixing Cao,Jingyi Lu,Chunhui Zhao,Dewei Li,Furong Gao 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.12
Injection molding, a polymer processing technique that converts thermoplastics into a variety of plasticproducts, is a complicated nonlinear dynamic process that interacts with a different group of variables, including themachine, the mold, the material, and the process parameters. As injection molding process operates sequentially inphases, we treat it as a batch process. The review paper discusses the batch nature of injection molding and identifies thethree main objectives for future development of injection molding: higher efficiency, greater profitability, and longer sustainability. From the perspective of system engineering, our discussion centers on the primary challenges for the batchoperation of injection molding systems: 1) Model development in face of product changes, 2) Control strategies in face ofdynamic changes, 3) Data analysis and process monitoring, and 4) Safety assurance and quality improvement, and thecurrent progress that has been made in addressing these challenges. In light of the advancement of new informationtechnologies, this paper provides several opportunities and encourages further research that may break existing capabilitylimits and develop the next generation of automation solutions to bring about a revolution in this area.
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Tian Tian,Xinyu Liu,이응석,Jingyang Sun,Zhonghua Feng,Long-Xuan Zhao,Chunhui Zhao 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.4
A series of nitrogen-containing derivatives ofoleanolic acid and ursolic acid were prepared by a modificationat C-28 position via esterification with 2-hydroxyaceticacid followed by amidation with amines, such aspiperazine, N-methylpiperazine, and alkane-1, 2-diamines,alkane-1, 4-diamines, alkane-1, 6-diamines. In vitroantiproliferative activities of the compounds preparedtowards MCF-7, Hela and A549 cell lines were evaluatedby a MTT method to show that OA-5a, OA-5b, OA-5c andUA-5a showed somewhat improved antiproliferativeactivities against MCF-7, Hela and A549 cells comparingto that of the positive control, gefitinib.
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