Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center

Chunhui Zhou,Hao Zhao,Fan Yang,Luokai Huangfu,Chao Dong,Shuwei Wang,Jianning Zhang 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.2

Background and Purpose Brainstem gliomas (BSGs) in adults are rare brain tumors with dismal outcomes. The aim of this study was to determine the clinical and genetic features in a series of BSGs and their association with the prognosis. Methods Fifty patients who underwent a stereotactic biopsy between January 2016 and April 2018 at a single institution were collected. Data on clinicopathological characteristics were analyzed and factors associated with patient survival were identified using a Cox regression model. Results The median age at diagnosis was 55.5 years, and 62% of the patients were male. Glioblastoma (44%) accounted for the largest proportion of BSGs, and oligodendroglioma (2 of 50) was rarely encountered. The IDH mutation (6 of 44) occurred infrequently in astrocytomas, and IDH-mutant tumors harbored both ATRX loss and MGMT promoter methylation at a relatively low level. Wild-type IDH astrocytomas were identified as having high rates of 1p/19q codeletion (5 of 38) and loss of heterozygosity 1p (8 of 38) or 19q (8 of 38) only. In diffuse midline glioma H3K27M mutant, MGMT promoter methylation occurred in three of four cases. Patients were offered radiotherapy and/or concurrent/adjuvant temozolomide chemotherapy, and their median survival time was 13 months. Multivariate analysis revealed that a low tumor grade, absence of tumor enhancement, duration of symptoms ≥3 months, Karnofsky performance status ≥70, and ATRX loss conferred a survival advantage. Conclusions Adult BSGs showed different molecular genetic characteristics, but also resembled supratentorial gliomas in their clinical features associated with oncological outcomes.

3D Focused Inversion of Near-bottom Magnetic Data from Autonomous Underwater Vehicle in Rough Seas

Zhou Fei,Tao Chunhui,Wu Tao,Zeng Zhaofa,Liu Cai 한국해양과학기술원 2018 Ocean science journal Vol.53 No.2

The observation area of an autonomous underwater vehicle (AUV) often contains undulating terrain in which the shallow portions make a great contribution to near-bottom magnetic data. Magnetic information from varying terrain may be inadvertently removed when traditional topographic correction methods are used to reduce the effect of undulating terrain on inversion results. In this study, we introduce a terrain-weighting matrix into the focused inversion process to overcome this problem. To counteract the natural decay of the potential field, we used the focused inversion with a minimum support function to obtain focused results and depth-weighting function. We also used the interpolation-iteration method to mitigate the influence of the fluctuating observation surface on the inversion results. We verified the effectiveness of the proposed method by conducting model tests using near-bottom data measured along the Southwest Indian Ridge (SWIR) by the AUV, Qianlong II. We obtained the 3D magnetization structure of the oceanic core complex (OCC) area at the 28th segment along the SWIR and concluded that the OCC was primarily composed of gabbroic rock.

Objectives, challenges, and prospects of batch processes: Arising from injection molding applications

Yuanqiang Zhou,Zhixing Cao,Jingyi Lu,Chunhui Zhao,Dewei Li,Furong Gao 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.12

Injection molding, a polymer processing technique that converts thermoplastics into a variety of plasticproducts, is a complicated nonlinear dynamic process that interacts with a different group of variables, including themachine, the mold, the material, and the process parameters. As injection molding process operates sequentially inphases, we treat it as a batch process. The review paper discusses the batch nature of injection molding and identifies thethree main objectives for future development of injection molding: higher efficiency, greater profitability, and longer sustainability. From the perspective of system engineering, our discussion centers on the primary challenges for the batchoperation of injection molding systems: 1) Model development in face of product changes, 2) Control strategies in face ofdynamic changes, 3) Data analysis and process monitoring, and 4) Safety assurance and quality improvement, and thecurrent progress that has been made in addressing these challenges. In light of the advancement of new informationtechnologies, this paper provides several opportunities and encourages further research that may break existing capabilitylimits and develop the next generation of automation solutions to bring about a revolution in this area.

An Optimization Technique for Spatial Compound Joins Based on a Topological Relationship Query and Buffering Analysis in DSDBs with Partitioning Fragmentation

Xinyan Zhu,Chunhui Zhou,Wei Guo,Di Chen,Kezhong Liu 보안공학연구지원센터 2012 International Journal of Database Theory and Appli Vol.5 No.4

5-Fluorouracil delivery from a novel three-dimensional micro-device: in vitro and in vivo evaluation

Na Zheng,Mingyao Zhou,Chunhui Du,Sicen Wang,Wen Lu 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.12

A novel three-dimensional biodegradablemicro-device using microelectromechanical systems technologywas developed for implantable controlled drugdelivery. In order to evaluate the effect of monomercomposition and molecular weight of poly(lactic-coglycolicacid) (PLGA) on the drug release, three 5-Fluorouracilloaded micro-devices, made of 50/50, 27 kDa;50/50, 40 kDa and 75/25 27 kDa PLGA, were preparedand characterized by in vitro and in vivo methods. Thein vitro drug release from three micro-devices followedzero-order kinetics, and PLGA micro-device with thehigher molecular weight and lactide/glycolide ratio tendedto a longer sustained release period. The in vivo releaseresults agreed with the in vitro results and drug releasein vivo was faster than that in vitro for each of microdevices. And three micro-devices showed different tumorinhibition effect in the tumor bearing mice. In addition, theSEM and weight loss experiments showed that PLGAmicro-devices with lower molecular weight and lactide/glycolide ratio had faster degradation. These data providedthe information for the optimization of the novel threedimensionalbiodegradable micro-device to obtain moresuitable systems for controlled release and to meet releaserequirements of different drugs.

Trimethyl-Ammonium Alkaline Anion Exchange Membranes with the Vinylbenzyl Chloride/Acrylonitrile Main Chain

Zhenghan Li,Junjie Chen,JinYue Zhou,YiWen Nie,Chunhui Shen,Shanjun Gao 한국고분자학회 2021 Macromolecular Research Vol.29 No.7

The main chain of polyolefin was synthesized by copolymerization of 4 - vinylbenzyl chloride (VBC) and acrylonitrile (AN), and trimethylamine is used for quaternization to prepare heterogeneous benzyl trimethyl-ammonium anion exchange membranes (Heter-X) and homogeneous benzyl trimethyl-ammonium anion exchange membrane (Homo-X). The results of Fourier-transform infrared (FT-IR), gel permeation chromatography (GPC), and 1H nuclear magnetic resonance (NMR) showed that VBC and AN were successfully copolymerized to form a polymer with a certain molecular weight, and trimethylamine was successfully quaternized. The prepared membranes exhibited good thermal stability and mechanical properties. The theoretical ion exchange capacity (IEC) values of Homo-3 and Heter-3 are the same, but the conductivity at 80 °C were 0.0572 S cm-1 and 0.0505 S cm-1. The results showed that the homogeneous method has a higher degree of quaternization and a more uniform distribution of quaternary ammonium groups, forming a more obvious microphase separation structure, which can also be seen in the atomic force microscopy (AFM) diagram. After being soaked in 1M KOH solution for 480 h, the ionic conductivity of Homo-6 and Heter-6 can still remain 91.4% and 85.5%, and the IEC loss rates were 17.21% and 24.34%. These results indicate that the prepared membranes are promising materials for application in fuel cells.

LiFePO₄ quantum-dots composite synthesized by a general microreactor strategy for ultra-high-rate lithium ion batteries

Wang, Bo,Xie, Ying,Liu, Tong,Luo, Hao,Wang, Bin,Wang, Chunhui,Wang, Lei,Wang, Dianlong,Dou, Shixue,Zhou, Yu Elsevier 2017 Nano energy Vol.42 No.-

<P><B>Abstract</B></P> <P>Due to the relatively slow, diffusion-controlled faradaic reaction mechanisms of conventional LiFePO<SUB>4</SUB> (LFP) materials, which is hard to deliver satisfied capacity for high rate applications. In this work, ultrafine LFP quantum dots (LFP-QDs) co-modified by two types of carbonaceous materials - amorphous carbon and graphitized conductive carbon (graphene) have been successfully synthesized through a novel microreactor strategy. Because of the very limited area constructed by the dual-carbon microreactor for the growth of LFP crystal, it's demension was furthest suppressed to a very small level (~ 6.5nm). Such a designed nano-composite possesses a large specific surface area for charge adsorption and abundant active sites for faradaic reactions, as well as ideal kinetic features for both electron and ion transport, and thus exhibits ultra-fast, surface-reaction-controlled lithium storage behavior, mimicking the pseudocapacitive mechanisms for supercapacitor materials, in terms of extraordinary rate capability (78mAhg<SUP>−1</SUP> at 200C) and remarkable cycling stability (~ 99% over 1000 cycles at 20C). On the other side, due to the quasi-2D structure of the synthesized LFP-QDs composite, which can be used as the basic unit to further fabricate free-standing film, aerogel and fiber electrode without the addition of binder and conductive agent for different practical applications. In addition, to deeper understand its electrochemical behavior, a combined experimental and density functional theoretical (DFT) calculation study is also introduced.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A general microreactor strategy has been developed for structure-optimized Li-contained electrode materials. </LI> <LI> Ultrafine LiFePO<SUB>4</SUB> quantum dots are first reported through the designed microreactor strategy. </LI> <LI> The synthesized G/LFP-QDs@C exhibits ultra-fast, surface-reaction-controlled Li storage behavior. </LI> <LI> A combined experimental and DFT calculation study is introduced to reveal the energy storage mechanism of G/LFP-QDs@C. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Ultrafine LiFePO<SUB>4</SUB> quantum dots (~ 6.5nm) co-modified by two types of carbonaceous materials - amorphous carbon and graphitized conductive carbon (graphene) have been successfully synthesized through a novel microreactor strategy, which exhibit ultra-fast, surface-reaction-controlled energy storage behavior, mimicking the pseudocapacitive mechanisms for supercapacitor materials, in terms of excellent rate capability and outstanding cycling stability.</P> <P>[DISPLAY OMISSION]</P>

Integrated proteomic and metabolomic analyses reveal significant changes in chloroplasts and mitochondria of pepper (Capsicum annuum L.) during Sclerotium rolfsii infection

Liao Hongdong,Wen Xiangyu,Deng Xuelei,Wu Yonghong,Xu Jianping,Li Xin,Zhou Shudong,Li Xuefeng,Zhu Chunhui,Luo Feng,Ma Yanqing,Zheng Jingyuan 한국미생물학회 2022 The journal of microbiology Vol.60 No.5

Infection by Sclerotium rolfsii will cause serious disease and lead to significant economic losses in chili pepper. In this study, the response of pepper during S. rolfsii infection was explored by electron microscopy, physiological determination and integrated proteome and metabolome analyses. Our results showed that the stomata of pepper stems were important portals for S. rolfsii infection. The plant cell morphology was significantly changed at the time of the fungal hyphae just contacting (T1) or surrounding (T2) the pepper. The chlorophyll, carotenoid, and MDA contents and the activities of POD, SOD, and CAT were markedly upregulated at T1 and T2. Approximately 4129 proteins and 823 metabolites were clearly identified in proteome and metabolome analyses, respectively. A change in 396 proteins and 54 metabolites in pepper stem tissues was observed at T1 compared with 438 proteins and 53 metabolites at T2. The proteins and metabolites related to photosynthesis and antioxidant systems in chloroplasts and mitochondria were disproportionally affected by S. rolfsii infection, impacting carbohydrate and amino acid metabolism. This study provided new insights into the response mechanism in pepper stems during S. rolfsii infection, which can guide future work on fungal disease resistance breeding in pepper.

Discrimination of Camellia seed oils extracted by supercritical CO2 using electronic tongue technology

Di Duan,Yong Huang,Ying Zou,Bingju He,Ruihui Tang,Liuxia Yang,Zecao Zhang,Shucai Su,Guoping Wang,Deyi Zhang,Chunhui Zhou,Jing Li,Maocheng Deng 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.10

Analytical method which combines electronictongue technique and chemometrics analysis is developedto discriminate oil types and predict oil quality. All thestudied Camellia oil samples from pressing, n-hexaneextraction and supercritical CO2 extraction (SCCE), weresuccessfully identified by principal component analysis(PCA) and hierarchical cluster analysis (HCA). Furthermore,multi factor linear regression model (MLRM) wasestablished to predict oil quality, which are indicated byacid value (AV) and peroxide value (POV). The practicalpotential of e-tongue for the discrimination and assessmentof Camellia oils has shown promising application in thecharacterization of Camellia oils in the oil qualityevaluation.