한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예

최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.

黃帝內經에서의 瘀血의 認識에 對한 理論的 硏究

崔昇勳 大田大學校 1987 論文集 Vol.6 No.2

컴포넌트 기반 소프트웨어 프로덕트 라인에서의 가변성

최승훈 덕성여자대학교 자연과학연구소 2004 자연과학 논문집 Vol.10 No.-

보다 신뢰성 있는 소프트웨어를 단시간 내에 개발하기 위한 방법으로서 최근에 소프트웨어 프로덕트 라인에 대한 연구가 활발히 진행 중이다. 소프트웨어 프로덕트 라인의 목적은, 미리 구축된 부품들을 소프트웨어 생산시 정해진 방식에 의해 조립함으로써 비슷한 특성을 가지고 있지만 특정 부분이 다른 일련의 소프트웨어들을 보다 빠르게 생산하는데 있다. 소프트웨어 프로덕트 라인을 구축하는데 있어서의 가장 중요한 부분은, 핵심 소프트웨어 자산을 개발하기 위한 기술과 소프트웨어 부품을 조립하여 구체적인 소프트웨어 시스템을 생산하는 기술이다. 핵심 소프트웨어 부품 개발과 조립을 효율적으로 지원하기 위해서는, 소프트웨어 분석 및 설계 단계, 나아가서는 소프트웨어 개발 전 단계에 걸쳐서 제품군에 속하는 멤버들 사이의 차이점을 모델링하고 체계적으로 관리해야 한다. 본 논문에서는 컴포넌트 기반 소프트웨어 프로덕트 라인에서의 가변성을 명 확히 표현하고 지원하기 위한 모델링 기법을 제안한다. 본 논문에서 가변성은, 소프트웨어 아키텍처 상에서의 가변성과 소프트웨어 컴포넌트 상에서의 가변성 으로 분류되며, 변경 지점으로 표현된다. 본 논문의 연구 결과는 소프트웨어 프로덕트 라인을 구성하는 핵심 요소인 소프트웨어 아키텍처와 소프트웨어 컴포 넌트 개발시 가변성을 지원하기 위한 기술 개발에 활용될 수 있다.

十全大補湯의 免疫增强 및 抗癌 效果

崔承勳,吳旼錫,宋泰元,남기열 대전대학교 한의학연구소 2002 혜화의학회지 Vol.11 No.1

Objectives : Sipjundaebo-tang is prepared by ten medical herbs that tone the blood and vital energy, and strengthen health. This prescription has long been used traditionally against anemia, anorexia, extreme exhausion and fatigue. The purpose of this thesis was to review the effects of Sipjundaebo-tang that are about immunopotentiation effects, antitumor activities and potentiation, detoxification of antitumor drugs Methods : We studied the research methods and results of experiments which were selected from Korean, Japaness and American theses were on the topic of immunopotentiation effects, antitumor activities and potetiation, detoxification of antitumor drugs from Sipjundaebo-tang Results and conclusions : Sipjundaebo-tang not only potentiates the effects of the combined use of chemotherapy, but also reduces and elimimate the immunotoxicity of antitumor drugs and radiotherapy. And it strengthen immunity and improve QOL, S/OH of cancer patients.

當歸鬚散이 壓迫으로 인한 白鼠의 外傷瘀血病態模型에 미치는 影響

崔昇勳,安圭錫,李金浩 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

In order to investigate the effects of Dangguixusan on experimental blood stasis model induced by compression, 7.5kg weight was placed on the thigh(4.9㎠) of rats for one hour and 30 minutes. Then the local and hematological changes were measured. The sample groups were orally administrated extracts of Dangguixusan one hour before the compression. The measurements were carried for sample control group Ⅰ 2 hours after inducement and for sample control group Ⅱ 4 hours after inducement. The results are summarized as follows ; 1. Thigh circumference in sample group Ⅰ and Ⅱ decreased significantly when compared to their respective control groups. 2. The dermal temperature in sample group Ⅰ and Ⅱ increased roughly when compared to their respective control groups. In sample group Ⅱ, it decreased much significantly when compared to control group Ⅱ. 3. The platelet count in sample group Ⅰand control group Ⅰ decreased. in sample group Ⅱ and control group Ⅱ increased when compared to their respective control groups. 4 The fibrinogen count in sample group Ⅰ increased significantly when compared to its control group Ⅰ. 5. The prothrombin time in sample group Ⅰ and Ⅱ did not decrease significantly when compared to control groups. 6. The FDP level in sample group Ⅰ and Ⅱ did not decrease significantly when compared to their respective control groups. In conclusion, Dangguixusan has effects on experimental blood stasis model induced by short-term compression. So, Dangguixusan can be used limitedly in the early stage of compression induced blood stasis symptoms. In subsequential experiments, the model should be further investigated.

영암농협의 산지유통전문조직 유통활성화 사업에 관한 고찰 : 완숙 토마토를 중심으로

최훈,이승현 東新大學校 2002 論文集 Vol.12 No.-

The price of fruits and vegetables is very fluctuating according to the unbalance of demand and supply. Thus, price depreciation causes burdens to farmers. Agricultural cooperative needs to be ready to accept the quickly changing marketing environment. The main objective of this study is focused on giving directions how Young-Arms's Agricultural cooperative should set up the new framework so that farmers could be able to receive reasonable prices of matured-tomatoes. In addition this study pointed out guidelines how agricultural cooperative manages producer's organization, group selection and group computing and billing systems. This study also introduced how to improve import of tomatoes to Asian countries as well as how to widen distribution channels domestically. Researchers state that agricultural cooperative will accomplish its goal of effective distribution channel when producer's organization trust cooperative fully.

蔘茸扶正湯의 放射線 照射로 損傷된 組織 恢復 및 造血促進 效果

崔昇勳,安圭錫,金正洙 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.2

현재 서양의학에서 활용되고 있는 항암 요법으로는 外科處置, 化學療法, 放射線療法 및 免疫療法 等이 있으며, 그 중에서는 抗癌劑에 의한 화학요법과 방사선요법이 가장 많이 응용되고 있다. 그런데 이들은 癌細胞뿐만 아니라 正常細胞까지도 殺傷함으로써 腫瘍細胞를 억제하는 동시에 骨髓造血器, 消化系統 및 免疫機能을 포함하는 인체의 정상적인 기능을 손상시키는 문제점으로 그 사용에 제한을 받고 있다. 따라서, 본 연구는 蔘茸扶正湯의 항암요법으로 손상된 조직의 회복 및 조혈촉진 효과를 규명하기 위해 생쥐를 대상으로 하여 실험하였다. 그 결과, 생쥐 비장세포에 대한 增殖效果, 造血促進因子의 分泌能, 방사선에 대한 임파구의 防禦效果, 방사선에 대한 조혈세포 防禦效果, 방사선(9Gy)을 조사받은 생쥐의 生存率 등에서 유의성있는 결과를 얻어내어 아래와 같이 보고하는 바이다. Radiotherapy is an irreplaceable method of cancer treatment. But it has several side effects, especially damages to the hemopoietic and Immune system. Therefore radioprotectors are required to treat cancer successfully. A lot of Herbs and Herbal prescriptions are reported to have radioprotective effects. Above all, those to support the healthy energy and strengthen the body resistance are found more effective. This study was performed to evaluate the radioprotective effects of prescription Shenrong Fuzheng Tang(S. F. T), which consists of 16 kinds of herbs. We investigated proliferation of murine splenocytes, secretion of colony-stimulating-factors(CSFs), immunocompetence after irradiation in-vitro, and Endogenous spleen colony assay, survival assay in-vivo. When splenocytes were cultured with Shenrong Fuzheng Tang (S.F.T) (500㎍/㎖), proliferation was enhanced 5.7 times compared to control cultured with medium alone(P〈0.05) and, showed highest proliferation at 4th day after incubation. In order to evaluate stimulation of hemopoiesis of Shenrong Fuzheng Tang(S.F.T), the supernatant of splenocytes cultured with optimal concentration of Shenrong Fuzheng Tang(S.F.T) was used to measure CSFs secretion. The result showed enhanced secretion of colony-stimulating-factors(CSFs) compared to control(P〈0.05). To evaluate the protective effect of lymphocytes from irradiation, proliferation of splenocytes stimulated by LPS and ConA after incubation with Shenrong Fuzheng Tang(S.F.T) for 24h Prior to Irradiation(1∼3 Gy) was measured. The results showed higher proliferation of Shenrong Fuzheng Tang(S.F.T.) treated cells than that of non-treated cells. And percentage increases of irradiated splenocytes per non-irradiated splenocytes were also higher in Shenrong Fuzheng Tang(S. F. T)-treated cells than control. Endogenous spleen colony assay, to evaluate the protection of hemopoietic cells form irradiation, showed increased number of colonies(p=0.03) in Shenrong Fuzheng Tang(S.F.T) treated murine spleen(10.3±1.9) compared to non-treated murine spleen(3.4±0.8). Survival time of mice irradiated with lethal dose of γ-ray(9Gy) was prolonged in Shenrong Fuzheng Tang(S.F.T) treated group prior to irradiation as compared to non-treated group. According to these results we can suggest that prescription Shenrong Fuzheng Tang(S.F.T) has radioprotective effects and be used to protect the hemopoietic and immune system from damages of anti-cancer radiotherapy.