Nematicidal activity of Phellodendron amurense rhizome-derived materials toward root-knot nematode (Meloidogyne Spp.)

Chang-sub Moon,Kyung-whan Yoon,Tae-kyun Hong,Byung-soo Han,Sung chul Moon,Young-ho Kim,Li-Wei,Dong Woon Lee 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.10

The nematicidal activity of Phellodendron amurense rhizome-derived materials (methanol extract) toward Meloidogyne Spp. second-stage juveniles (J2) and these effects on Cucumis sativus and Cucumis melo. Results were compared with these of fosthiazate. J2 was examined using 24-well plate tests, pot bioassays (C. sativa and C. melo) and Field trials (C. melo). In 24-well plate test with J2, methanol extract of P. amurense exhibited 98.7% and 69.8% mortality at 0.25 and 0.125 mg/ml toward J2, respectively, whereas Fosthiazate showed 100% mortality at 1 mg/ml. In pot bioassays with J2, P. amurense rhizome methanol extract gave 79.5% and 57.4% mortality at 2ℓ/m2(1,000x) and 2ℓ/m2(2,000x)/3kg soil from C. sativa and 73.7% and 53.3% mortality at 2ℓ/m2(1,000x) and 2ℓ/m2(2,000x)/3kg soil from C. melo, respectively. In Field test at C. melo in greenhouse showed 55.1% and 26.9% mortality at 2ℓ/m2(1,000x) and 2ℓ/m2(2,000x) applied soil. P. amurense rhizome-derived materials, merit further study as potential root-knot nematode control agents because of their nematicidal activity.

웹 페이지에서 사용자 입력 값 변조 방지에 관한 연구

유창훈(Chang-hun Yu),문종섭(Jong-sub Moon) 한국정보보호학회 2014 정보보호학회논문지 Vol.24 No.4

인터넷을 통하여 제공되는 대부분의 웹 서비스들은 웹 브라우저를 통하여 사용자에게 제공된다. 웹 브라우저는 텍스트 형태의 웹 페이지를 서버로부터 수신하여 해석하고 사용자에게 보여준다. 웹 브라우저는 추가적으로 설치 할 수 있는 각종 기능들을 통하여 확장성을 제공한다. 하지만 추가로 설치 할 수 있는 기능들도 웹 페이지에 접근하여 내용을 위/변조 할 수 있다는 점에서 웹 브라우저를 통한 웹 서비스는 보안상 문제점을 내포할 수 있다. 웹 브라우저는 웹 페이지 정보를 DOM구조의 형태로 메모리에 저장한다. 웹 페이지의 변조를 방지하기 위한 방법으로는 DOM구조의 특정 부분에 해쉬(hash)값을 적용하는 방법이 있다. 하지만 웹 페이지의 특성상 해쉬를 이용한 대응방안이 효과를 발휘할 수 없는 부분이 있다. 즉, 사용자가 직접 입력하는 부분은 정해진 입력 값이 아니기 때문에 미리 해쉬 값을 계산 해 놓을 수도 없고 따라서 임의로 변조되는 것을 막을 수 없다. 본 논문에서는 웹페이지에 입력되는 사용자 입력 값의 위조나 변조를 방지 또는 탐지하는 방안을 제안한다. 제안 방법은 사용자가 키보드를 사용하여 입력하는 입력 값을 저장 해 놓았다가 웹 브라우저가 입력 값을 전송하는 순간 저장된 입력 값과 전송되는 값을 비교하여 변조 여부를 파악한다. Most of the web-based services are provided by a web browser. A web browser receives a text-based web page from the server and translates the received data for the user to view. There are a myriad of add-ons to web browsers that extend browser features. The browser’s add-ons may access web pages and make changes to the data. This makes web-services via web browsers are vulnerable to security threats. A web browser stores web page data in memory in the DOM structure. One method that prevents modifications to web page data applies hash values to certain parts in the DOM structure. However, a certain characteristic of web-pages renders this method ineffective at times. Specifically, the user-input data is not pre-determined, and the hash value cannot be calculated prior to user input. Thus the modification to the data cannot be prevented. This paper proposes a method that both detects and inhibits any attempt to change to user-input data. The proposed method stores user-input from the keyboard and makes a comparison with the data transmitted from the web browser to detect any anomalies.

고도 이형성증을 동반한 식도 편평세포 유두종 1예

김진오,이문성,이준성,진소영,차상우,심찬섭,유창범,조주영,정인섭,천갑진 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.6

A squamous cell papilloma of esophagus is regarded as a rare tumor, and one of the distal esophagus is known to be not changed into a malignant neoplasm although squamous papilloma of the larynx, cervix and the upper esophagus may be associated with squamous cell carcinoma. We report the first case of a squamous papilloma associated with hig grade dysplasia at the lower esophagus. We think this case may have an important implication in the surveillance and management of esophageal papilloma found at endoscopy.

Generalized Maxwell Stefan 모형을 이용한 유기 템플레이팅 실리카/알루미나 복합막의 CO<SUB>2</SUB>/N<SUB>2</SUB> 혼합물의 투과/분리 기구 해석

문종호(Jong-Ho Moon),김민배(Min-Bae Kim),강병섭(Byung-Sub Kang),현상훈(Sang-Hoon Hyun),이창하(Chang-Ha Lee) 한국가스학회 2004 한국가스학회지 Vol.8 No.3

Gemifloxacin이 미성숙 랫드의 아킬레스건에 미치는 영향

배진규,김영수,김세은,심경미,강성수,조익현,이수한,박창현,엄창섭,정문진,한송이,임성철,배춘식,Bae, Jin-Gye,Kim, Young-Soo,Kim, Se-Eun,Shim, Kyung-Mi,Kang, Seong-Soo,Cho, Ik-Hyun,Lee, Soo-Han,Park, Chang-Hyun,Uhm, Chang-Sub,Jeong, Moon-Jin,Han 한국현미경학회 2006 Applied microscopy Vol.36 No.2

Gemifloxacin은 대부분의 G(-) 세균들과 G(+) 세균들에 대해 강한 활성을 나타내며 미성숙동물에서 비교적 낮은 연골독성 가능성을 가진 합성 fluoroquinolone계 항생제이다. 본 연구는 미성숙 SD계 랫드의 아킬레스건에 gemifloxacin이 미치는 영향을 평가하기 위해 gemifloxacin을 생후 4주 후부터 0(vehicle), 600mg/kg body weight 용량으로 5일 동안 매일 한번씩 경구투여를 하여 ofloxacin과 비교하였다. 아킬레스건의 형태학적 변화를 투과전자현미경을 이용하여 관찰한 결과 부형제만 처치한 대조군과 비교하였을 때, gemifloxacin과 ofloxacin을 처치한 랫드로부터 채취한 샘플에서 초미세구조의 변화가 관찰되었다. quinolone을 처치한 군의 tenocyte에서는 다양한 퇴행성 변화가 관찰되었고, 세포외기질에서 분리된 세포들이 존재하였는데 이는 ofloxacin을 처치한 그룹에서 특히 높았고 gemifloxacin을 처치한 그룹에서는 매우 낮았다. 따라서, gemifloxacin이 아킬레스건과 같은 결합조직 구조물들의 퇴행성 변화를 보다 적게 야기한다는 것을 보여준다. Gemifloxacin is a synthetic fluoroquinolone antimicrobial agent that exhibits potent activity against most Gram-negative and Gram-positive organisms, and has a comparatively low chondrotoxic potential in immature animals. This study examined the effects of gemifloxacin on the Achilles tendons in immature Sprague-Dawley rats treated by oral intubation once daily for 5 consecutive days from postnatal week 4 onward at doses of 0 (vehicle), and 600mg/kg body weight Ofloxacin was used for comparison. The Achilles tendon sperimens were examined by electron microscopy. In comparison with the vehicle-treated controls, there were ultrastructural changes in all samples from the gemifloxacin- and ofloxacin-treated rats. Degenerative changes were observed in the tenocytes, and the cells that detached from the extracellular matrix were recognizable. The degree of degenerative changes and the number of degenerated cells in the Achilles tendon were significantly higher in the treated group than in the control group. Moreover, among the quinolone treated groups, these findings were more significant in the ofloxacin treated group, and less significant in the gemifloxacin treated group. It is unclear what these findings mean with respect to the possible risk ill juvenile patients treated with gemifloxacin or other quinolones. However, these results show that gemifloxacin causes fewer changes in the connective tissue structures.

BcSNPdb: Bovine Coding Region Single Nucleotide Polymorphisms Located Proximal to Quantitative Trait Loci

Moon, Sun-Jin,Shin, Hyoung-Doo,Cheong, Hyun-Sub,Cho, Hye-Young,NamGoong, Sohg,Kim, Eun-Mi,Han, Chang-Su,Sung, Sam-Sun,Kim, Hee-Bal Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.1

Bovine coding region single nucleotide polymorphisms located proximal to quantitative trait loci were identified to facilitate bovine QTL fine mapping research. A total of 692,763 bovine SNPs was extracted from 39,432 UniGene clusters, and 53,446 candidate SNPs were found to be a depth >3. In order to validate the in silico SNPs experimentally, 186 animals representing 14 breeds and 100 mixed breeds were analyzed. Genotyping of 40 randomly selected candidate SNPs revealed that 43% of these SNPs ranged in frequency from 0.009 to 0.498. To identify non-synonymous SNPs and to correct for possible frameshift errors in the ESTs at the predicted SNP positions, we designed a program that determines coding regions by protein-sequence referencing, and identified 17,735 nsSNPs. The SNPs and bovine quantitative traits loci informations were integrated into a bovine SNP data: BcSNPdb (http://snugenome.snu.ac.kr/BtcSNP/). Currently there are 43 different kinds of quantitative traits available. Thus, these SNPs would serve as valuable resources for exploiting genomic variation that influence economically and agriculturally important traits in cows.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

The control of invasive Candida infection in very low birth weight infants by reduction in the use of 3rd generation cephalosporin

Chang, Yu Jin,Choi, Il Rak,Shin, Won Sub,Lee, Jang Hoon,Kim, Yun Kyung,Park, Moon Sung The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.2

Purpose: To evaluate the effectiveness of new management policies on the incidence of invasive Candida infections Methods: This observational study involved a retrospective analysis of the patients' medical records. In total, 99 very low birth weight infants, who were admitted to the neonatal intensive care unit at Ajou University Hospital from January 2010 to December 2011, were enrolled for the study. Period I, defined as the period before the revision of management policies, comprised 57 infants; whereas, period II, defined as the period after the implementation of new management policies, comprised 42 infants. The new management policies entailed a reduction in antibiotic and histamine type 2 receptor blocker (H2 blocker) use, duration of central venous catheterization, and duration of endotracheal intubation. Results: There was a significant overall decrease in the use of antibiotics including 3rd generation cephalosporin and H2 blockers (P<0.05), and a significantly lower incidence of invasive Candida infections in period II as compared to period I (0/42 vs. 6/57, respectively; P=0.037). Comparison between infants with invasive Candida infections (n=6) and those without (n=93) showed that gestational age (odds ratio [OR], 0.909; 95% confidence interval [CI], 0.829 to 0.996; P=0.042) and the duration of 3rd generation cephalosporin use (OR, 1.093; 95% CI, 1.009 to 1.183; P=0.029) were statistically significant risk factors. Conclusion: The new management policies effectively decreased overall use of antibiotics, especially 3rd generation cephalosporin, and H2 blockers, which led to a significantly lower incidence of invasive Candida infections.

Changes in serum levels of receptor activator of nuclear factor-κB ligand, osteoprotegerin, IL-6 and TNF-α in patients with a concomitant head injury and fracture

Lee, Jung Sub,Ryu, Chang Hoon,Moon, Nam Hoon,Kim, Seong-Jang,Park, Shin Young,Suh, Kuen Tak Springer-Verlag 2009 Archives of orthopaedic and trauma surgery Vol.129 No.5

A Study of Motion Analysis using 3D Depth Camera

Young Sub Shin(신영섭),Chang Gi Lee(이창기),Young Moon Kim(김영문),Jong Hyun Kim(김종현) 대한인간공학회 2021 대한인간공학회 학술대회논문집 Vol.2021 No.11

Objective: The aim of this study is to validate motion analysis technology using 3D depth camera for measurement in industrial field. Background: The importance of technology for measurement and analysis of work log is also increasing due to provide worker centered services in various industrial field. The work log measurement technologies’ trend has been changed to the contactless sensor type from existing contact type with wearable, because of usability. Method: In this study, we implemented to collect tasks’ motion data using 3D camera system (camera (N: 8), Vicon, Inc., UK) and depth camera of contactless type (Azure Kinect, Microsoft, Inc., USA). The main joint ((Lower body: Knee, Hip), (Upper limb: Elbow, Shoulder)) angle’s variable trend was compared in 5 tasks (① lifting, ② lowering, ③ pushing, ④ pulling, ⑤ hand operation(screwing)). Results: We compared result between the 3D motion capture system and contactless type’s depth camera. The main joint ((Lower body: Knee, Hip), (Upper limb: Elbow, Shoulder)) angle’s variable trend was compared in 5 tasks, and in the results, the similar angle variable tendency was shown in most joints. Due to the limitation of the depth camera capture range, measurements were performed for each basic motion. Conclusion: It is expected that various services such as customized work management and accident prediction, etc. will be possible through work log management. In the next study, we plan to develop variety of services based on this study.