A study on the dynamic behavior of the Korean next-generation high-speed train

Jeon, Chang-Sung,Kim, Young-Guk,Park, Joon-Hyuk,Kim, Seog-Won,Park, Tae-Won Professional Engineering Publishing Ltd 2016 Proceedings of the Institution of Mechanical Engin Vol. No.

<P>This study describes the dynamic behavior of the HEMU-430X, the Korean next-generation high-speed train. The HEMU-430X was initially analyzed using VAMPIRE, a computer program that is used to examine the dynamics of railway vehicles, based on which it was expected to sway strongly at its tail end. This hunting motion was expected to disappear when the position of the yaw damper was changed. The dynamic behavior of the HEMU-430X was assessed in an on-track test performed using the protocols in the EN14363 standard and measuring the carbody, bogie and axle accelerations; the HEMU-430X was found to satisfy the safety criterion. The hunting motion appeared at speeds of 150, 350 and 387km/h, and countermeasures such as changing the position of the yaw damper, installing carbody dampers, and increasing the damping coefficient of the yaw damper installed on the motor car containing the driver's cab were taken in order to reduce the vibrations. Ultimately, the highest test speed achieved was 421.4km/h. Subsequently, it was found that the critical speed tended to decrease with mileage. This was attributed to excessive lateral damping and a revised design was proposed to solve this problem.</P>

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Characterization of changes in global gene expression in the brain of neuron-specific enolase/human Tau23 transgenic mice in response to overexpression of Tau protein.

Woo, Jong-Min,Park, So Jung,Kang, Ho Il,Kim, Byoung Guk,Shim, Sun Bo,Jee, Seung Wan,Lee, Su Hae,Sin, Ji Soon,Bae, Chang Joon,Jang, Mee Kyung,Cho, Chunghee,Hwang, Dae Youn,Kim, Chuel Kyu D.A. Spandidos 2010 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.25 No.5

<P>Tau is a neuronal phosphoprotein responsible for the formation of the neurofibrillary tangles in Alzheimer's disease. To characterize the changes in global gene expression in the brain of transgenic mice that overexpress human Tau23 protein in response to the increase of Tau23 phosphorylation, total RNA extracted from the hippocampus of 12-month-old transgenic and wild-type mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide microarrays. The microarray results were confirmed by real-time RT-PCR and Western blotting method. It was determined that 43 genes were up-regulated and 8 genes were down-regulated by Tau23 in transgenic mice compared to controls, based on the arbitrary difference in the 2-fold change. Among the up-regulated transcripts, those encoding for transporter and oxidoreductase were dramatically over-represented, followed by those related to regulatory molecule, cytoskeletal protein, signaling molecule, and extracellular matrix protein. Genes encoding for transcription factor, regulatory molecule, miscellaneous function, and chaperone were significantly reduced in the down-regulated group. The major genes in the up-regulated categories included Ecrg4, Folr1, Defb11, Aqp1 and Soctdc1. The major genes in the down-regulated categories were Ncor1, Gpm6a, and Hspd1. These results indicate that the microarray analysis identifies several gene functional groups and individual genes that respond to a sustained increase in Tau23 phosphorylation levels in the brain of transgenic mice. In addition, the results suggest the microarray test is a useful tool for increased understanding of the role of Tau23 protein in regulating neurodegenerative disorders.</P>

갑상선암에 의한 림프절 전이의 CT 진단

주지선,김형진,조영국,임명관,서창해,Ju, Ji-Seon,Kim, Hyeong-Jin,Jo, Yeong-Guk,Im, Myeong-Gwan,Seo, Chang-Hae 대한영상의학회 2001 대한영상의학회지 Vol.45 No.6

목적: 갑상선암의 일차 및 이차 림프절 전이에 대한 CT의 진단적 가치를 평가하고, 갑상선암에 의한 림프절 전이의 다양한 CT 소견을 알아보고자 하였다. 대상과 방법: 갑상선암으로 갑상선절제술 및 경부청소술이 시행된 환자 중 수술 전 CT를 시행한 59명을 대상으로 하였다. 59명 모두에서 일차 림프절 (Level VI)을 제거하는 중앙부청소술이 시행되었고, 21명에서는 총 136 level의 이차 림프절 (Level II-V)을 제거하는 측부청소술이 병행되었다. CT상 기준치 이상의 크기, 균질하고 높은 조영증강, 석회화, 낭성 또는 괴사성변화를 보이는 경우 림프절 전이가 있는 것으로 판정하였다. 이와 같이 분석한 CT 소견을 조직학적 소견과 비교하여 일차 및 이차 림프절 전이에 있어서 CT의 진단능을 평가하였고, 림프절 전이의 진단에 유용한 CT 소견을 알아보았다. 결과: 59명의 갑상선암 환자 중 조직학적으로 경부 림프절 전이는 31명 (53%)에서 진단되었으며 이 중 일차 림프절은 59명 중 30명, 이차 림프절은 136 level 중 44 level에서 전이가 관찰되었다. 일차와 이차 림프절 전이에 대한 CT의 민감도, 특이도, 양성예측도, 음성예측도 및 정확도는 각각 27%와 93%, 100%와 93%, 100%와 87%, 57%와 97%, 그리고 63%와 93%이었다. CT상 기준치 이상의 크기 (n=19), 낭성 또는 괴사성 변화 (n=14), 석회화 (n=8)의 소견 중 한 개 이상의 소견을 보이는 이차 림프절에서는 조직검사상 모두 전이가 발견되었으나, CT상 조영증강만을 보인 25 level의 이차 림프절 중 6 level (24%)에서는 조직학적 전이소견 없이 반응성 림프절로 진단되었다. 결론: 갑상선암의 경부 림프절 전이의 평가에 있어서 CT의 민감도는 일차 림프절에서는 매우 낮았으나 이차 림프절에서는 비교적 높았다. 기준치 이상의 크기, 석회화 및 낭성변화는 갑상선암의 림프절 전이를 예측하는데 매우 유용한 지표로 생각된다. Purpose: To determine the usefulness of CT for diagnosing metastases to primary and secondary echelon lymph nodes (LNs) and to investigate various CT findings of metastatic LNs in thyroid carcinomas. Materials and Methods: We retrospectively reviewed the CT and histologic findings in 59 patients with thyroid carcinomas who had undergone thyroidectomy and neck dissection. Primary echelon LNs (Level VI) were removed by central neck dissection in all patients, and in 21, a total of 136 levels of secondary echelon LNs (Level II-V) were excised away by lateral neck dissection. CT criteria of metastatic LNs included large size, significant homogeneous enhancement, calcification, and cystic change. We evaluated the ability of CT to detect primary and secondary echelon LN metastasis and tried to determine which CT features were useful for the diagnosis of LN metastasis. Results: Histologically, LN metastasis was found in 31 (53%) of 59 patients, including 30 with metastasis to primary echelon LNs. Of the 136 levels of secondary echelon LNs resected in 21 patients, 44 were found at histology to harbor metastatic foci. The sensitivities, specificities, positive and negative predictive values, and accuracies of CT in the diagnosis of metastasis to primary and secondary echelon LNs, respectively, were 27% and 93%, 100% and 93%, 100% and 87%, 57% and 97%, and 63% and 93%. While all secondary echelon LNs with at least one of the following CT criteria-large size (n=19), cystic or necrotic change (n=14), or calcifications(n=8)-were histologically proven to be metastatic, six (24%) of 25 such LNs with a sole sign of significant enhancement at CT were found to be due to reactive lymphadenopathy. Conclusion: Although CT was unable to detect metastasis to primary echelon LNs, it was useful in the detection of secondary echelon LN involvement. Large size, cystic change, and calcification are considered highly reliable signs of metastatic LNs.

Mecillinam의 임상분리 장내세균 대한 시험관내 항균력

김창기,염종화,이상국,이양순,최준용,김준명,이경원,정윤섭 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Background : Mecillinam, an amidinopenicillin antibiotic, has been used to treat urinary tract infections and bacterial enteritis in many countries, In this study, we evaluated in vitro activity of mecillinam against Enterobacteriaceae isolates from urine, and Salmonella and Shigella isolates from patients with bacterial gastroenteritis. Materials and Methods : A total of 308 clinical strains were collected and were comprised of Escherichia coli (n=109), Klebsiella pneumonias (n=52), Enterobacter spp. (n=30), Serratia marcescens (n=30) and Proteus spp. (n=29) isolated from a university hospital in Korea in 2007, and of Salmonella spp. (n=28) and Shigella spp. (n=30) isolated from Korean diarrheal patients from 2001 to 2006. Antimicrobial susceptibility was tested by Clinical laboratory Standard Institute (CLSI) agar dilution method. CLSI breakpoint of mecillinam for E. coli urinary tract isolates was applied to all other isolates. Results : In E. coli, rate of susceptibility to ampicillin was 30%, but 99-100% to amikacin and cefotaxime. Most (96%) of E. coli isolates, including extended-spectrum B-lactamase (ESBL) Producers, were susceptible to mecillinam. All ESBL producers, except for one isolate, were inhibited by ≤4 ug/mL of mecillinam. MIC_90 of mecillinam for K. pneumonias and Enterobacter spp. was 8 ug/mL and 1 ug/mL, respectively, and the susceptibility rate was 92% and 97%, respectively. However, MIC_90 of mecillinam for S. marcescens isolates was >128 ug/mL and most of them were resistant to meclllinam. All Salmonella isolates and 27 of 30 Shigella isolates were susceptible to meclllinam. Conclusion : Mecillinam was active vitro against most Enterobacteriaceae, Salmonella, and Shigella isolates except for S. marcescens. Therefore, mecillinam can be a good alternative agent for treating urinary tract infection and bacterial gastroenteritis.

Breeding of New Strains and Development SCAR Markers for New Cultivars of Hypsizygus marmoreus

Chang-Yun Lee,Hye-jung Lee,Chul-young Jang,Jong-Guk Kim3 한국버섯학회 2012 버섯 Vol.16 No.2

RDA 표준에서의 다중 매체 정보에 관한 연구

김홍일,김국보,장윤석 대진대학교 1994 大眞論叢 Vol.2 No.-

The RDA(Remote Database Access) standard defines a generalized service interface that can be used in a variety of Database Management System environments. This places considerable importance on the management of diverse data types including text, images, audio, and video; these requirements in turn generate the need for a new generation of distributed heterogeneous multimedia database systems In this paper, a set of functional requirements is identified for the RDA standard, Multimedia information and management. A method of the requirements to a RDA is presented, and some briefing of the RDA SQL specialization and multimedia data types are discussed.

디스크 시스템의 설계를 위한 모의 실험에 대한 연구

장윤석,김홍일,김국보 대진대학교 1994 大眞論叢 Vol.2 No.-

I/O subsystems, especially, disk systems are the most important aspect at computer system performance for recent high-performance computer systems. But development of new d s k system consumes very high costs, it performed by simulation, in general. This paper researches accurate disk modeling techniques for basis of accurate simulation, and implements the disk model, and proves the modelled disk can be executed with small deviation, compares with real disk system, by trace-driven simulation The simulation program can widely be used for basic tool to develope new disk systems.

몽타주 자동 작성을 위한 퍼지 의사 결정 시스템의 설계

김국보,김홍일,장윤석 대진대학교 1994 大眞論叢 Vol.2 No.-

It is well known that search method for multimedia information is very difficult problem. In this paper, the implementation of a automatic montage generator using fuzzy decision making system is described and proposed an effective fuzzy inference system based on description data. In addition, some techniques which can improve the retrieval efficiency of a image information are also suggested.

참치 뼈를 이용한 Hydroxyapatite 세라믹 복합체의 합성 및 생체 친화성(제3보) : 인공체액에서의 Hydroxyapatite 세라믹 복합체간의 결합의 전자현미경 관찰 SEM Photographs of Bonding Properties between Hydroxyapatite Ceramics Composites in the Simulated Body Fluid

김세권,최진삼,이창국,변희국,전유진,이응호,박인용 대전산업대학교 반도체기술연구소 1999 半導體技術硏究所報 Vol.1 No.-

참치 뼈에서 추출한 hydroxyapatite를 출발물질로 여러 가지 세라믹 복합체를 제조하여 인공체액에서의 hydroxyapatite 복합체간의 화학결합을 조사하였다. hydroxyapatite 복합체들은 인공체액에서 4주 후부터 화학 결합성질을 나타내었다. 결합강도는 bioglass가 가장 강하게 나타났으며, 조성에 따른 의존성은 관찰할 수 없었다. 인공체액에서 복합체들은 이들의 경계면에서 불균일 핵생성 및 성장에 의해 화학적 결합으로 이루어졌다. Chemical bonding was investigated in the simulated body fluid of several selected hydroxyapatite-containing composites. The hydroxyapatite-containing composites chemically bonded with each other in the simulated body fluid after 4 weeks. Bioglass was strongly bonded in the simulated body fluid, but bonding strength was not depended on composition. Their composite bodies were chemically bonded by heterogeneous nucleation and growth at the interfaces of the specimens in the simulated body fluid.