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      • KCI등재

        Next-Generation Sequencing-Based Transcriptome Analysis of L-Lysine-Producing Corynebacterium glutamicum ATCC 21300Strain

        김홍일,남재영,조재용,이창수,박영진 한국미생물학회 2013 The journal of microbiology Vol.51 No.6

        In the present study, 151 genes showed a significant change in their expression levels in Corynebacterium glutamicum ATCC 21300 compared with those of C. glutamicum ATCC 13032. Of these 151 genes, 56 genes (2%) were up-regulated and 95 genes (3%) were down-regulated. RNA sequencing analysis also revealed that 11 genes, involved in the L-lysine biosynthetic pathway of C. glutamicum, were up- or downregulated compared with those of C. glutamicum ATCC 13032. Of the 151 genes, 10 genes were identified to have mutations including SNP (9 genes) and InDel (1 gene). This information will be useful for genome breeding of C. glutamicum to develop an industrial amino acid-producing strain with minimal mutation.

      • KCI등재후보

        수부 재건에서 귀 뒤쪽 전층피부 이식술의 유용성

        김홍일,이상환,황소민,정용휘,김형도 대한수부외과학회 2014 대한수부외과학회지 Vol.19 No.3

        Purpose: We used the retroauricular area skin as an alternative full-thickness skin donor site in the hand reconstruction surgery. Methods: From January 2006 to March 2013, 55 patients observed more than 1 year, were recruited for the study. In case of requiring the skin graft on hand, we grafted skins were harvested from the retroauricular area on hand. To assess the subjective and objective satisfaction, the patients themselves and three doctors compared the skin graft area’s color with adjacent skin and estimated the donor site scar on a five-point scale. Results: A partial necrosis was seen in one case who received skin graft because of a burn scar contracture, but it was cured with conservative treatment. In other cases, the skin graft was well taken without any specific problems. The retroauricular skin graft showed good color match with adjacent skin and less pigmentation. Donor site scar was not noticeable. As a result, the patient’s sub- jective satisfaction (4.07) and doctor’s objective satisfaction (4.18) about skin graft were very good. And the patient’s subjective satisfaction (4.93) and doc- tor’s objective satisfaction (4.98) about donor site scar were also very good. Conclusion: We obtained the favorable result and the patients satisfaction by using the retroauricular area as a full thickness skin graft donor site in hand. 목적: 저자들은 수부 재건 수술에 새로운 전층 피부이식 공여부로 귀뒤쪽 피부를 사용하였으며 그 결과를 보고하고자한다. 방법: 2006년 1월부터 2013년 3월까지 수부에 피부이식이 필요한 55명의 환자를 대상으로 귀뒤쪽 피부를 이용하여 전층 피부이식술을 실시하였다. 1년 이상 경과 관찰 후 피부이식을 한 부위와 주변 피부의 색감의 차이 및 공여부의 흉터를환자 본인과 의사 3명이 육안적으로 확인하고 5점을 만점으로 하여 만족도를 조사하였다. 결과: 화상 후 형성된 흉터 반흔으로 피부이식을 받았던 1예에서 부분적인 괴사가 있었으나 보존적 치료로 치유되었으며 나머지 54예에서 이식된 피부는 문제없이 생착되었다. 피부이식부에 대한 환자 개인의 주관적 만족도는 4.07, 의사세 명의 평가에 의한 객관적 만족도는 4.18로 결과가 좋았으며, 공여부 반흔에 대한 평가에서도 환자 개인의 주관적 만족도 4.93, 의사 세 명의 평가에 의한 객관적 만족도 4.98로 결과가 매우 좋았다. 결론: 수부 수술에서 후이개부위를 사용한 전층 피부이식술은 주변 피부와 조화가 좋으며, 공여부 흉터 또한 눈에 잘 띄지 않아 미용적으로 우수한 결과를 얻을 수 있는 방법이다.

      • KCI등재

        Characterization of Inverted Polymer Solar Cells with Low-band-gap Polymers as Donor Materials

        김홍일,조정민,신원석,이상규,이종철,문상진,김종학 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.12

        Inverted polymer solar cells with low-band-gap polymers were characterized. Molybdenum trioxide (MoO3) and tungsten trioxide (WO3) were deposited between the active layer and the silver top electrode in inverted polymer solar cells (PSCs) with titanium oxide (TiOx) and indium tin oxide (ITO) as a buffer layer and a cathode, respectively. The performances of different anode buffer layers and three different polymers were compared. The best performance was achieved for the device with poly[N-9″-heptadecanyl-2,7-carbazole-alt-5,5-(5′,8′-di-2-thienyl-2,3-bis(4-octyloxyl)phenyl)quinoxaline] (P2) as a donor polymer and a 20 nm MoO3 layer between the active layer and Ag, that device exhibited a open circuit voltage (Voc) of 0.84 V, a short circuit current (Jsc) of 8.15 mA/cm2, and a fill factor (FF) of 0.41. The overall power conversion efficiency (PCE) for this cell was 2.79%.

      • SPR 기법을 이용한 날개 변형 측정 시스템의 모델링 및 시뮬레이션 프레임워크 개발

        김홍일,윤종민,한재흥,권혁준 한국항공우주학회 2014 한국항공우주학회 학술발표회 논문집 Vol.2014 No.4

        최근 고세장비 날개를 가진 항공기의 안정적인 운용을 위한 비행 중 날개의 3 차원 변형을 획득 기술이 요구 되고 있다. 스테레오 카메라를 이용한 SPR(Stereo Pattern Recognition) 방법이 취급의 간단함과 정확성으로 비행 중 날개의 변형 측정에 적합하다고 판단하였다. 따라서 본 연구에서는 SPR 기법을 묘사하여 카메라의 성능, 카메라의 위치, 날개의 형상 등에 따른 변형 측정 성능을 정량적으로 평가할 수 있는 프레임워크인 SIMS(SPR Interactive Modeling and Simulation)를 개발하였고, 시뮬레이션 예제를 통해 프레임워크의 유효성을 확인하였다. 추후 SIMS 는 공간과 중량 제한이 큰 항공기 탑재를 위해 카메라의 성능 요구 조건 결정 및 카메라 위치 최적화를 위해 활용될 예정이다. Obtaining three dimensional deformation of wing during the flight is required for stable maneuver of aircraft with high aspect ratio wing. SPR(Stereo Pattern Recognition) method by using stereo camera is decided as the most proper method because of its conciseness and accuracy. Therefore, this study developed the framework named SIMS(SPR Interactive modeling and Simulation) to describe SPR system, including camera specifications, camera location, wing shape, so as to evaluate the deformation measurement ability of the system, and then verified its effectiveness by performing simulation examples. In the future, SIMS will be applied to decide required camera specification and to optimize locations of cameras which are loaded to limited environment like aircraft.

      • KCI등재

        지방주입술 후 발생한 표피 낭종 - 1례 보고 -

        김홍일,황소민,송제니퍼김,임광열,정용휘,안성민 대한미용성형외과학회 2011 Archives of Aesthetic Plastic Surgery Vol.17 No.3

        Epidermal inclusion cysts are caused by an implantation of the epidermal elements. Primary or congenital epidermoid cysts are related to implantation of ectoderm at time of closure of the neural groove, or of other epithelial lines. Secondary or acquired epidermoid cysts are usually caused by post traumatic or iatrogenic inclusion of surface epithelium. We are reporting a case of secondary epidermoid inclusion cyst on left nasolabial fold after fat injection, which is extremely rare. A 57-year-old female patient presents with gradually progressive protruding palpable mass on left nasolabial fold. The patient had history of fat injection 1 year before, and mass was found under the previous fat injection site. There was no other history of trauma. The mass was excised and histological examination confirmed the diagnosis of an epidermoid cyst. Secondary epidermoid cysts are rare and occur mainly in the fingers, palms, and soles. The cause of secondary epidermoid cysts has been reported following trauma, radiotherapy, and after surgical procedures such as needle biopsy. During fat injection, needle injection may cause disruption of the epithelium and leading to the occurrence of this cyst. So. we suggest a careful procedure during fat injection. (Archives of Aesthetic Plastic Surgery 17: 181, 2011)

      • KCI등재

        Gender Differences in Diagnostic Values of Visceral Fat Area and Waist Circumference for Predicting Metabolic Syndrome in Koreans

        김홍일,김진택,유성훈,곽수헌,장학철,박경수,김성연,이홍규,조영민 대한의학회 2011 Journal of Korean medical science Vol.26 No.7

        Abdominal fat accumulation is known to be strongly implicated in development of metabolic syndrome (MetS). We examined diagnostic values of obesity-related parameters in 95 men and 185 women, and we determined optimal cutoff values of visceral fat area (VFA) and waist circumference (WC) for predicting the presence of multiple non-adipose components of MetS. Receiver operating characteristic (ROC) curve analysis revealed that VFA was the best indicator of MetS. WC and VFA exhibited similar diagnostic values for men and postmenopausal women, whereas WC was inferior to VFA for premenopausal women (area under ROC curve of VFA and WC was 0.76 and 0.52, respectively; P < 0.001). Optimal cutoff points of VFA and WC for predicting MetS were 136 cm2 and 89 cm in men and 95 cm2 and 82 cm in women, respectively. Subjects with VFA and WC above these cutoff values exhibited increased insulin resistance and increased carotid intima-media thickness. In conclusion, WC has a diagnostic value similar to VFA for predicting MetS in men and postmenopausal women, but not in premenopausal women. Further studies are necessary to develop a simple clinical parameter that reflects visceral fat in premenopausal women.

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